scholarly journals Preparation of a Cage-Type Polyglycolic Acid/Collagen Nanofiber Blend with Improved Surface Wettability and Handling Properties for Potential Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3458
Author(s):  
Sofia El-Ghazali ◽  
Hisatoshi Kobayashi ◽  
Muzamil Khatri ◽  
Duy-Nam Phan ◽  
Zeeshan Khatri ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Biomedical Applications ◽  
Structural Integrity ◽  
Polyglycolic Acid ◽  
Electrospinning Process ◽  
Surface Wettability ◽  
Practical Utilization ◽  
Electrospinning Method ◽  
Nitrogen Treatment ◽  
Surgical Operations

Electrospun biobased polymeric nanofiber blends are widely used as biomaterials for different applications, such as tissue engineering and cell adhesion; however, their surface wettability and handling require further improvements for their practical utilization in the assistance of surgical operations. Therefore, Polyglycolic acid (PGA) and collagen-based nanofibers with three different ratios (40:60, 50:50 and 60:40) were prepared using the electrospinning method, and their surface wettability was improved using ozonation and plasma (nitrogen) treatment. The effect on the wettability and the morphology of pristine and blended PGA and collagen nanofibers was assessed using the WCA test and SEM, respectively. It was observed that PGA/collagen with the ratio 60:40 was the optimal blend, which resulted in nanofibers with easy handling and bead-free morphology that could maintain their structural integrity even after the surface treatments, imparting hydrophilicity on the surface, which can be advantageous for cell adhesion applications. Additionally, a cage-type collector was used during the electrospinning process to provide better handling properties to (PGA/collagen 60:40) blend. The resultant nanofiber mat was then incorporated with activated poly (α,β-malic acid) to improve its surface hydrophilicity. The chemical composition of PGA/collagen 60:40 was assessed using FTIR spectroscopy, supported by Raman spectroscopy.

scholarly journals Design and Analysis of Mechanical Microswimmers

2021 ◽  
Keyword(s):  
Drug Delivery ◽  
Reynolds Number ◽  
Minimally Invasive ◽  
Human Body ◽  
Biomedical Applications ◽  
Head Capsule ◽  
Ansys Fluent ◽  
Capsule Type ◽  
Spherical Head ◽  
Surgical Operations

The fascinating field in present civilization scenario at the edge of science is micro-swimmers, which is a combination of bio physics with self-propulsion mechanisms involving swimming strategies at low Reynolds number. These micro swimming robots offer many advantages in biomedical applications such as drug delivery to some specific locations in our human body and also conducting some surgical operations like opening of blocked arteries etc. In recent times, blocked arteries become a major case in the medical world. This is can be diagnosed by Angioplasty (is a minimally invasive, endovascular procedure to widen narrowed or obstructed arteries or veins, typically to treat arterial atherosclerosis) method. So this is the main reason to choose the aorta as our domain for analysis purpose. This paper presents a micro-swimmer with three different heads they are spherical head, Capsule type head and Tapered cylindrical or elliptical head and modelled using SOLIDWORKS and analysis in ANSYS FLUENT.

scholarly journals Electrospun Nylon-6 Nanofibers and Their Characteristics

2020 ◽  
Vol 9 (1) ◽  
pp. 9-19
Author(s):  
Ida Sriyanti ◽  
Meily P Agustini ◽  
Jaidan Jauhari ◽  
Sukemi Sukemi ◽  
Zainuddin Nawawi
Keyword(s):  
Fiber Diameter ◽  
Peak Shift ◽  
Nylon 6 ◽  
Electrospinning Process ◽  
Electrospinning Technique ◽  
Fiber Concentration ◽  
Air Filters ◽  
Xrd Pattern ◽  
Electrospinning Method ◽  
Small Wave

The purposes of this research were to investigate the synthesized Nylon-6 nanofibers using electrospinning technique and their characteristics. The method used in this study was an experimental method with a quantitative approach. Nylon-6 nanofibers have been produced using the electrospinning method. This fiber was made with different concentrations, i.e. 20% w/w (FN1), 25% w/w (FN2), and 30% w/w (FN3). The SEM results show that the morphology of all nylon-6 nanofibers) forms perfect fibers without bead fiber. Increasing fiber concentration from 20% w/w to 30% w/w results in bigger morphology and fiber diameter. The dimensions of the FN1, FN2, and FN3 fibers are 1890 nm, 2350 nm, and 2420 nm, respectively. The results of FTIR analysis showed that the increase in the concentration of nylon-6 (b) and the electrospinning process caused a peak shift in the amide II group (CH2 bond), the carbonyl group and the CH2 stretching of the amide III group from small wave numbers to larger ones. The results of XRD characterization showed that the electrospinning process affected the changes in the XRD pattern of nylon-6 nanofiber (FN1, FN2, and FN3) in the state of semi crystal. Nylon-6 nanofibers can be used for applications in medicine, air filters, and electrode for capacitors

Characterization and Modeling of Micro Swimmers With Helical Tails and Cylindrical Heads Inside Circular Channels

2013 ◽  
Author(s):  
Alperen Acemoglu ◽  
F. Zeynep Temel ◽  
Serhat Yesilyurt
Keyword(s):  
Biomedical Applications ◽  
Stokes Equations ◽  
Relative Size ◽  
The Finite Element Method ◽  
Robot Interaction ◽  
Free Swimming ◽  
Micro Robot ◽  
Angular Velocities ◽  
Minimal Damage ◽  
Surgical Operations

Micro swimming robots offer many advantages in biomedical applications, such as delivering potent drugs to specific locations in targeted tissues and organs with limited side effects, conducting surgical operations with minimal damage to healthy tissues, treatment of clogged arteries, and collecting biological samples for diagnostic purposes. Reliable navigation techniques for micro swimmers need to be developed to improve the localization of robots inside the human body in future biomedical applications. In order to estimate the dynamic trajectory of magnetically propelled micro swimmers in channels, that mimic blood vessels and other conduits, fluid-micro robot interaction and the effect of the channel wall must be understood well. In this study, swimming of one-link robots with helical tails is modeled with Stokes equations and solved numerically with the finite element method. Forces acting on the robot are set to zero to enforce the force-free swimming and obtain forward, lateral and angular velocities that satisfy the constraints. Effects of the number of helical waves, wave amplitude, relative size of the cylindrical head of micro swimmer and the radial position on angular and linear velocity vectors of micro swimmer are presented.

scholarly journals Influence of the SolubleInsoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable ChitosanBased Hydrogels for Biomedical Application

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 214 ◽  
Author(s):  
Carla Palomino-Durand ◽  
Marco Lopez ◽  
Frédéric Cazaux ◽  
Bernard Martel ◽  
Nicolas Blanchemain ◽  
...  
Keyword(s):  
Viscoelastic Properties ◽  
Biomedical Applications ◽  
Structural Integrity ◽  
Biomedical Application ◽  
Water Soluble ◽  
Self Healing ◽  
Indirect Contact ◽  
Polyelectrolyte Complexes ◽  
Anionic Polymers ◽  
The Difference

Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double–syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear–thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.

scholarly journals Emulsion-based systems for fabrication of electrospun nanofibers: food, pharmaceutical and biomedical applications

RSC Advances ◽  
2017 ◽  
Vol 7 (46) ◽  
pp. 28951-28964 ◽  
Author(s):  
Nooshin Nikmaram ◽  
Shahin Roohinejad ◽  
Sara Hashemi ◽  
Mohamed Koubaa ◽  
Francisco J. Barba ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Electrospun Nanofibers ◽  
Bioactive Materials ◽  
Electrospinning Method

Encapsulation of bioactive materials and drugs using the emulsion electrospinning method.

Electrospinning of Regenerated Silk Fibroin/Polybutylene Terephthalate Blended Mats and their Surface Wettability

2012 ◽  
Vol 531-532 ◽  
pp. 531-534
Author(s):  
Yun Qian Cao ◽  
Qin Fei Ke ◽  
Xiang Yu Jin ◽  
Sha Sha Guo
Keyword(s):  
Silk Fibroin ◽  
Fiber Diameter ◽  
Contact Angles ◽  
Surface Wettability ◽  
Electrospun Fibers ◽  
Average Fiber Diameter ◽  
Polybutylene Terephthalate ◽  
Regenerated Silk Fibroin ◽  
Electrospinning Method ◽  
Nanofiber Membranes

In this paper, regenerated silk fibroin/polybutylene terephthalate blended mats were prepared using electrospinning method with different blending ratios. The influence of regenerated silk fibroin/polybutylene terephthalate ratio on the morphology behaviors, fiber diameter and the surface wettability of the blended mats were studied. The morphology of the electrospun fibers were characterized by SEM. The average fiber diameter and its distribution can be obtained from the SEM pictures using software Image J. The average fiber diameter was 280nm to 486nm and it changed with the blending ratio. The contact angles and penetration times were used to characterize the surface wettability of the nanofiber membranes. It was found that with the increase of regenerated silk fibroin amount, the surface contact angles and penetration times decreased, which meant that the wettability was greatly improved.

scholarly journals Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Materials ◽  
2020 ◽  
Vol 13 (10) ◽  
pp. 2407 ◽  
Author(s):  
Alexa-Maria Croitoru ◽  
Denisa Ficai ◽  
Anton Ficai ◽  
Natalia Mihailescu ◽  
Ecaterina Andronescu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Electrospun Nanofibers ◽  
Natural Compounds ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Bioactive Constituents ◽  
Electrospinning Method

The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process.

scholarly journals Surface properties and bioactivity of TiO 2 nanotube array prepared by two-step anodic oxidation for biomedical applications

2019 ◽  
Vol 6 (4) ◽  
pp. 181948 ◽  
Author(s):  
Zhaoxiang Peng ◽  
Jiahua Ni
Keyword(s):  
Cell Adhesion ◽  
Electron Microscope ◽  
Impedance Spectroscopy ◽  
Surface Energy ◽  
Anodic Oxidation ◽  
Biomedical Applications ◽  
Nanotube Array ◽  
Measuring Device ◽  
X Ray ◽  
Cell Adhesion And Proliferation

A highly ordered TiO 2 nanotube array has been prepared on a commercial pure titanium substrate in a hydrofluoric (HF) electrolyte using a DC power source through two-step anodic oxidation. The morphology, composition, wettability and surface energy of the nanotube array have been characterized by using a field-emission scanning electron microscope (FE-SEM), a transmission electron microscope (JEM-2010) with energy-dispersive X-ray spectrometer EDX (INCA OXFORD), X-ray diffraction method, an atomic force microscope (AFM), an optical contact angle measuring device and the Owens method with two liquids. The electrochemical behaviours of anodic oxidation films with different structures have been investigated in Sodium Lactate Ringer's Injection at 37±1°C by potentiodynamic polarization curve and electrochemical impedance spectroscopy. The formation mechanism of the nanotube array and the advantages of two-step oxidation have been discussed according to the experimental observation and the characterized results. Meanwhile, the structural changes of nanotubes are analysed according to the results of impedance spectroscopy. Cytotoxicity testing and cell adhesion and proliferation have been studied in order to evaluate the bioactivity of the nanotube array film. The diameters of nanotubes are in the range of 120–140 nm. The nanotube surface shows better wettability and higher surface energy compared to the bare substrate. The nanotube surface exhibits a wide passivation range and good corrosion resistance. The growth of the nanotube array is the result of the combined action of the anodization and field-assisted dissolution. The nanotube array by two-step oxidation becomes more regular and orderly. Moreover, the nanotube array surface is non-toxic and favourable to cell adhesion and proliferation. Such nanotube array films are expected to have significant biomedical applications.

scholarly journals TiO2 NPs Assembled into a Carbon Nanofiber Composite Electrode by a One-Step Electrospinning Process for Supercapacitor Applications

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 899 ◽  
Author(s):  
Bishweshwar Pant ◽  
Mira Park ◽  
Soo-Jin Park
Keyword(s):  
Electrode Material ◽  
Carbon Nanofiber ◽  
Titanium Dioxide Nanoparticles ◽  
Scale Up ◽  
Carbon Composite ◽  
Electrospinning Process ◽  
Tio2 Nps ◽  
Electrospinning Method ◽  
One Step ◽  
Supercapacitor Applications

In this study, we have synthesized titanium dioxide nanoparticles (TiO2 NPs) into carbon nanofiber (NFs) composites by a simple electrospinning method followed by subsequent thermal treatment. The resulting composite was characterized by state-of-the-art techniques and exploited as the electrode material for supercapacitor applications. The electrochemical behavior of the as-synthesized TiO2 NPs assembled into carbon nanofibers (TiO2-carbon NFs) was investigated and compared with pristine TiO2 NFs. The cyclic voltammetry and charge–discharge analysis of the composite revealed an enhancement in the performance of the composite compared to the bare TiO2 NFs. The as-obtained TiO2-carbon NF composite exhibited a specific capacitance of 106.57 F/g at a current density of 1 A/g and capacitance retention of about 84% after 2000 cycles. The results obtained from this study demonstrate that the prepared nanocomposite could be used as electrode material in a supercapacitor. Furthermore, this work provides an easy scale-up strategy to prepare highly efficient TiO2-carbon composite nanofibers.

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