scholarly journals Life-Cycle Assessment of the Breezhaler® Breath-Actuated Dry Powder Inhaler

2021 ◽  
Vol 13 (12) ◽  
pp. 6657
Author(s):  
Brett Fulford ◽  
Karen Mezzi ◽  
Andy Whiting ◽  
Simon Aumônier

The Breezhaler® dry powder inhaler (DPI) has a low carbon footprint compared with other inhalation therapies, consistent with the literature on other DPIs. This life-cycle assessment was conducted in France, Germany, the UK, and Japan using a “cradle-to-grave” technique to evaluate six environmental impact categories (global warming potential; acidification; ozone depletion; use of resource, minerals, and metals; eco-toxicity; and freshwater use) associated with the use of the Breezhaler®. Three variants of the Breezhaler® (30-day packs with and without the digital companion and a 90-day pack without the digital companion) were evaluated to identify major hotspots in the device life-cycle and to provide realistic solutions to reduce the environmental impact. Although no single life-cycle stage dominated the climate change impact of the 30-day device with the digital companion, the inhaler’s raw materials and packaging contributed to 96% of the resource depletion impact for the 30-day device without the digital companion. For the 90-day device without the digital companion, packaging contributed 42–62% of the impact across all categories. Overall, the Breezhaler® inhaler with the 90-day pack had the lowest environmental impact. The environmental impact of the device did not vary significantly among the considered markets. Further studies are needed to assess the impact of active pharmaceutical ingredients and improvement in clinical outcomes on the environment.

2021 ◽  
Vol 25 (1) ◽  
pp. 71-111
Author(s):  
Shadia Moazzem ◽  
Enda Crossin ◽  
Fugen Daver ◽  
Lijing Wang

Abstract This study presents the environmental impact of apparel consumption in Australia using life cycle assessment methodology according to ISO14040/14044:2006. Available published references, the Ecoinvent v3 dataset, the Australian life cycle assessment dataset and apparel country-wise import data with the breakdown of apparel type and fibre type were used in this study. The environmental impact assessment results of the functional unit were scaled up to the total apparel consumption. The impact results were also normalized on a per-capita/year basis. The Total Climate Change Potential (CCP) impact from apparel consumption of 2015 was estimated to be 16 607 028 tonnes CO2eq and 698.07 kg CO2eq/per capita-year. This study also assessed the impact of acidification potential (AP), water depletion (WD), abiotic resource depletion potential (ADP) - fossil fuel and agricultural land occupation (ALO) using the same methodology. The market volume of cotton apparel in Australia is 53.97 %, which accounts for 45 %, 96 %, 40 %, 46 % and 79 % of total CCP, WD, ADP, AP and ALO impact, respectively. Apparel broad categories of cotton shirt, cotton trouser, polyester shirt and polyester trouser have a high volume in the apparel market as well as a high environmental impact contribution. These high-volume apparel products can be included in the prioritization list to reduce environmental impact throughout the apparel supply chain. It was estimated that from 2010 to 2018 the per capita apparel consumption and corresponding impact increased by 24 %.


Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 873
Author(s):  
Francisco Javier Flor-Montalvo ◽  
Agustín Sánchez-Toledo Ledesma ◽  
Eduardo Martínez Cámara ◽  
Emilio Jiménez-Macías ◽  
Jorge Luis García-Alcaraz ◽  
...  

Natural stoppers are a magnificent closure for the production of aging wines and unique wines, whose application is limited by the availability of raw materials and more specifically of cork sheets of different thickness and quality. The growing demand for quality wine bottle closures leads to the search for alternative stopper production. The two-piece stopper is an alternative since it uses non-usable plates in a conventional way for the production of quality caps. The present study has analyzed the impact of the manufacture of these two-piece stoppers using different methodologies and for different dimensions by developing an LCA (Life Cycle Assessment), concluding that the process phases of the plate, its boiling, and its stabilization, are the phases with the greatest impact. Likewise, it is detected that the impacts in all phases are relatively similar (for one kg of net cork produced), although the volumetric difference between these stoppers represents a significant difference in impacts for each unit produced.


2021 ◽  
Vol 13 (9) ◽  
pp. 5322
Author(s):  
Gabriel Zsembinszki ◽  
Noelia Llantoy ◽  
Valeria Palomba ◽  
Andrea Frazzica ◽  
Mattia Dallapiccola ◽  
...  

The buildings sector is one of the least sustainable activities in the world, accounting for around 40% of the total global energy demand. With the aim to reduce the environmental impact of this sector, the use of renewable energy sources coupled with energy storage systems in buildings has been investigated in recent years. Innovative solutions for cooling, heating, and domestic hot water in buildings can contribute to the buildings’ decarbonization by achieving a reduction of building electrical consumption needed to keep comfortable conditions. However, the environmental impact of a new system is not only related to its electrical consumption from the grid, but also to the environmental load produced in the manufacturing and disposal stages of system components. This study investigates the environmental impact of an innovative system proposed for residential buildings in Mediterranean climate through a life cycle assessment. The results show that, due to the complexity of the system, the manufacturing and disposal stages have a high environmental impact, which is not compensated by the reduction of the impact during the operational stage. A parametric study was also performed to investigate the effect of the design of the storage system on the overall system impact.


2021 ◽  
Vol 13 (13) ◽  
pp. 7386
Author(s):  
Thomas Schaubroeck ◽  
Simon Schaubroeck ◽  
Reinout Heijungs ◽  
Alessandra Zamagni ◽  
Miguel Brandão ◽  
...  

To assess the potential environmental impact of human/industrial systems, life cycle assessment (LCA) is a very common method. There are two prominent types of LCA, namely attributional (ALCA) and consequential (CLCA). A lot of literature covers these approaches, but a general consensus on what they represent and an overview of all their differences seems lacking, nor has every prominent feature been fully explored. The two main objectives of this article are: (1) to argue for and select definitions for each concept and (2) specify all conceptual characteristics (including translation into modelling restrictions), re-evaluating and going beyond findings in the state of the art. For the first objective, mainly because the validity of interpretation of a term is also a matter of consensus, we argue the selection of definitions present in the 2011 UNEP-SETAC report. ALCA attributes a share of the potential environmental impact of the world to a product life cycle, while CLCA assesses the environmental consequences of a decision (e.g., increase of product demand). Regarding the second objective, the product system in ALCA constitutes all processes that are linked by physical, energy flows or services. Because of the requirement of additivity for ALCA, a double-counting check needs to be executed, modelling is restricted (e.g., guaranteed through linearity) and partitioning of multifunctional processes is systematically needed (for evaluation per single product). The latter matters also hold in a similar manner for the impact assessment, which is commonly overlooked. CLCA, is completely consequential and there is no limitation regarding what a modelling framework should entail, with the coverage of co-products through substitution being just one approach and not the only one (e.g., additional consumption is possible). Both ALCA and CLCA can be considered over any time span (past, present & future) and either using a reference environment or different scenarios. Furthermore, both ALCA and CLCA could be specific for average or marginal (small) products or decisions, and further datasets. These findings also hold for life cycle sustainability assessment.


Energies ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3820
Author(s):  
Mélanie Douziech ◽  
Lorenzo Tosti ◽  
Nicola Ferrara ◽  
Maria Laura Parisi ◽  
Paula Pérez-López ◽  
...  

Heat production from a geothermal energy source is gaining increasing attention due to its potential contribution to the decarbonization of the European energy sector. Obtaining representative results of the environmental performances of geothermal systems and comparing them with other renewables is of utmost importance in order to ensure an effective energy transition as targeted by Europe. This work presents the outputs of a Life Cycle Assessment (LCA) performed on the Rittershoffen geothermal heat plant applying guidelines that were developed within the H2020 GEOENVI project. The production of 1 kWhth from the Rittershoffen heat plant was compared to the heat produced from natural gas in Europe. Geothermal heat production performed better than the average heat production in climate change and resource use, fossil categories. The LCA identified the electricity consumption during the operation and maintenance phase as a hot spot for several impact categories. A prospective scenario analysis was therefore performed to assess the evolution of the environmental performances of the Rittershoffen heat plant associated with the future French electricity mixes. The increase of renewable energy shares in the future French electricity mix caused the impact on specific categories (e.g., land use and mineral and metals resource depletion) to grow over the years. However, an overall reduction of the environmental impacts of the Rittershoffen heat plant was observed.


2019 ◽  
Vol 8 (4) ◽  
pp. 304 ◽  
Author(s):  
Björn Koch ◽  
Fernando Peñaherrera ◽  
Alexandra Pehlken

Including criticality into Life Cycle Assessment (LCA) has always been challenging to achieve but desirable to accomplish. In this article, we present a new approach for the evaluation of resource consumption of products by building comparison values based on Life Cycle Impact Assessment (LCIA) combined with weighted criticality values to show the direct impacts of criticality on LCA results. For this purpose, we develop an impact indicator based on the Abiotic Depletion Potential (ADP) of natural resources and use the two main parameters defined by the EU to determine the criticality of a material - the economic importance and the supply risk – in our case studies to build the Criticality Weighted Abiotic Depletion Potentials (CWADPs), one for each parameter. These indicators allow identifying and measuring the impacts of criticality when comparing the results of resource depletion using the ADP methodology and the results that incorporate criticality. The comparison of the CWADPs to the corresponding EU criticality values and its thresholds it reflects the equivalent criticality of the assessed product. This information reflects the impacts of criticality on LCA and assesses the total resource consumption of critical materials in a system.Keywords: Life Cycle Assessment, criticality, resources, materials, sustainability indicator


Author(s):  
Bayu Sukmana ◽  
Isti Surjandari ◽  
Muryanto . ◽  
Arief A. R. Setiawan ◽  
Edi Iswanto Wiloso

Firstly global warming issue caused by greenhouse gas emissions (CO2) which comes from human activities. Along with increasing of daily need, that humans of activities food produce is also increase, include of tofu. Tofu is a traditional Indonesian specialty made from soybeans and used as a side dish. The purpose of this study was to determine the impact of global warming from tofu products on Mampang Prapatan's Small Tofu and Medium Enterprises. The method used in this study is the Life Cycle Assessment (LCA) method with the help of Simapro 8.4 software with a 1 kg tofu functional unit. The data collected in this study is the average data of tofu production for 3 months, namely January - March 2018. The LCA data in this study include the process of soybean cultivation, transportation processes for shipping soybeans, water, fuel wood, and electricity use. The limitations of this study are from cradle (soybean cultivation) to gate (tofu products).The results showed that UKM Mampang Prapatan has the potential impact of global warming with a value of 3.84 kg CO2-eq, while the value of global warming in the production process knows the scenario of wastewater treatment and the use of Liquefied Petroleum Gas (LPG) as fuel for boiling pulp 4.49 kg CO2-eq soybeans. Based on the results of this study, greenhouse gas (CO2) emissions are issued; the intervention that can be done is to optimize the use of raw materials for production to reduce the impact of CO2-eq kg global warming.


2021 ◽  
Vol 12 (5) ◽  
pp. 6504-6515

With the development of additive manufacturing technology, 3D bone tissue engineering scaffolds have evolved. Bone tissue engineering is one of the techniques for repairing bone abnormalities caused by a variety of circumstances, such as injuries or the need to support damaged sections. Many bits of research have gone towards developing 3D bone tissue engineering scaffolds all across the world. The assessment of the environmental impact, on the other hand, has received less attention. As a result, the focus of this study is on developing a life cycle assessment (LCA) model for 3D bone tissue engineering scaffolds and evaluating potential environmental impacts. One of the methodologies to evaluating a complete environmental impact assessment is life cycle assessment (LCA). The cradle-to-grave method will be used in this study, and GaBi software was used to create the analysis for this study. Previous research on 3D bone tissue engineering fabrication employing poly(ethylene glycol) diacrylate (PEGDA) soaked in dimethyl sulfoxide (DMSO), and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) as a photoinitiator will be reviewed. Meanwhile, digital light processing (DLP) 3D printing is employed as the production technique. The GaBi program and the LCA model developed to highlight the potential environmental impact. This study shows how the input and output of LCA of 3D bone tissue engineering scaffolds might contribute to environmental issues such as air, freshwater, saltwater, and industrial soil emissions. The emission contributing to potential environmental impacts comes from life cycle input, electricity and transportation consumption, manufacturing process, and material resources. The results from this research can be used as an indicator for the researcher to take the impact of the development of 3D bone tissue engineering on the environment seriously.


2013 ◽  
Vol 4 (2) ◽  
pp. 103-109 ◽  
Author(s):  
E. Klaversma ◽  
A. W. C. van der Helm ◽  
J. W. N. M. Kappelhof

Waternet, the water cycle company of Amsterdam and surrounding areas, uses the life cycle assessment (LCA) method to evaluate the environmental impact of investment decisions and to determine the potential reduction of direct and indirect greenhouse gas (GHG) emissions of different alternatives. This approach enables Waternet to fulfil its corporate objective to improve sustainability and to become climate neutral by 2020. Three example studies that give a good overview of the use of LCAs at Waternet and problems encountered are discussed: phosphate removal and recovery from wastewater, pH correction of drinking water with carbon dioxide (CO2) and materials for drinking water distribution pipes. The environmental impact assessments were performed in SimaPro 7 using the ReCiPe method and the Intergovernmental Panel on Climate Change Global Warming Potential (IPCC GWP) 100a method. The Ecoinvent 2.0 and 2.2 databases were used for the material and process data. From the examples described, it can be concluded that only the phosphate removal case had a significant effect on the climate footprint. The article discusses applications and limitations of the LCA technique. The most important limitation is that the impact of water consumption and the possible impact of effluent compounds to surface water are not considered within the used methods.


2020 ◽  
Vol 993 ◽  
pp. 1473-1480
Author(s):  
Yan Jiao Zhang ◽  
Li Ping Ma ◽  
Shi Wei Ren ◽  
Meng Chi Huang ◽  
Ying Wang ◽  
...  

With the emphasis of national policies on green manufacturing and the recognition of the people for green development, expanding the green assessment of products will be the general trend. In this study the life cycle assessment method was used to compile a list of resources, energy consumption and pollutant emissions during the life cycle of typical ordinary gypsum plasterboard and functional phase-change gypsum plasterboard, the key environmental impact indicators of both products during the life cycle calculated, the key stages affecting the environmental performance of products analyzed and identified, and the difference in environmental impacts between phase-change gypsum plasterboard and ordinary gypsum plasterboard compared and analyzed, for guiding the selection of green building materials and the development of ecological building materials. The results show that the global warming potential of phase-change gypsum plasterboard is 3.42 kgCO2 equivalent/m2, the non-renewable resource depletion potential is 2.25×10-5 kgSb equivalent/m2, the respiratory inorganic is 1.97×10-3 kgPM2.5 equivalent/m2, the eutrophication is 1.21×10-3 kgPO43- equivalent/m2, and the acidification is 9.47×10-3 kgSO2 equivalent/m2. Compared with ordinary gypsum plasterboard, the phase-change gypsum plasterboard shows the biggest increase by 874.03% in non-renewable resource depletion potential. The major environmental impact of ordinary gypsum plasterboard in the life cycle is mainly from energy use, and the transport process is the main stage of eutrophication. The use of phase-change materials in the phase-change gypsum plasterboard is the main stage causing environmental impact.


Sign in / Sign up

Export Citation Format

Share Document