Evaluation of the Relation of Smoking, Gallstones, and Renal Stones With Sialolithiasis in Patients Referred to Oral Medicine and ENT Department of Tabriz University of Medical Sciences

Background: The exact mechanism of the formation of salivary gland stones is unknown. Elucidating pathophysiology of the formation of salivary stones might prevent both their formation and the need for implementing invasive surgical procedures. Therefore, this study aimed to evaluate the effects exerted by some etiological factors on the formation of salivary gland stones. Methods: In this case–control study, the records of 80 patients with sialolithiasis were studied as a census from April 2011 to June 2019. These patients were referred to the Oral Medicine and the ENT departments of Tabriz University of Medical Sciences. The control group consisted of the same number of the patients with no sialolithiasis. Two groups were compared in terms of stone size, smoking, gallstones, and renal stones. Chi-squared, independent t-test, and Mann-Whitney U test were adopted to examine the quantitative variables. The data were analyzed using SPSS 17. Statistical significance was set at P<0.05. Results: Overall, 96.2% of sialoliths were found in the submandibular gland, of which 78.8% were single. Moreover, 32.5% of the patients with a history of sialolithiasis were smokers, whereas this frequency was 23.8% in the control group. In the case and control groups, 2.5% and 5% of the patients had a history of renal stones, respectively. Only one patient who had undergone a surgical procedure to remove salivary gland stones had a history of gallstones, while none of the patients in the control group had a history of gallstones. Conclusions: The results showed that the formation of salivary gland stones was not associated with smoking, history of renal stones, and gallstones. Furthermore, it was found that the numbers and sizes of salivary stones were not affected by smoking.

Download Full-text

Recurrent Miscarriage and Consanguinity among Omani Women– A Cross Sectional Study

Gynecology & Reproductive Health ◽

10.33425/2639-9342.1141 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Fatma Al Hoqani ◽

Wadha Al Ghafri ◽

Saneya El tayeb ◽

Yahya Al Farsi ◽

Vaidyanathan Gowri

Keyword(s):

Recurrent Miscarriage ◽

Cross Sectional Study ◽

University Hospital ◽

Control Group ◽

P Value ◽

Cross Sectional ◽

Recurrent Miscarriages ◽

Sultan Qaboos University ◽

Chi Squared ◽

History Of

Objective: to determine the prevalence of explained and unexplained recurrent miscarriages (RM) and to find out if there is a significant relationship between recurrent miscarriages and consanguinity. Methods: A cross sectional in which the cases group included all women with RM attending the outpatient clinic at Sultan Qaboos University Hospital from July 2006 to April 2012 and the controls group included women with no history of RM after matching them with cases for age (case to control ratio was 1:1). The main outcome measures were the prevalence of consanguinity in women with or without recurrent miscarriages. Results: During study period a total of 290 women with RM were seen. Of which, 150 (51.7%) women had unexplained RM. Control group with no history of RM were 300 women. Consanguinity rate among cases (49.5%) %) was less than the controls (52.7 %%). Both first cousin and second cousin marriages were more common in the controls than the cases and it was not statistically significant (p value 0.476, chi squared test). Conclusion: In this study we found that more than half of RM cases were unexplained and there was no significant association between RM and consanguinity.

Download Full-text

The Effect of Crystal Dependence on Brain Activity Related to the Perception of Pleasure Using fMRI

Archives of Neuroscience ◽

10.5812/ans.100907 ◽

2021 ◽

Vol 8 (3) ◽

Author(s):

Ali Yoonessi ◽

Seyed Amir Hossein Batouli ◽

Iman Ahmadnezhad ◽

Hamid Soltanian-zadeh

Keyword(s):

Case Control Study ◽

Brain Activity ◽

Economic Status ◽

Smoking History ◽

Control Group ◽

Human Society ◽

Significant Difference ◽

History Of ◽

The Brain ◽

Control Study

Background: Addiction is currently one of the problems of human society. Drug abuse is one of the most important issues in the field of addiction. Methamphetamine (crystal) is one of the drugs that has been abused in recent decades. Methods: In this case-control study, 10 individuals aged 20 to 40 years old with at least 2 years of experience of methamphetamine consumption without any history of drug use or other stimulants from clients and drug withdrawal centers in Tehran City, and 10 healthy volunteers were selected. Age, social status, and economic status of addicts were included in the fMRI apparatus, and 90 selected pleasurable, non-pleasurable, and neutral images (IAPS) were displayed by the projector through an event-related method. The playback time of each photo was 3 s, and after this process, the person outside the device, without the time limit selected the enjoyable and unpleasant images. Results: The results showed that there was no significant difference between the groups in terms of age, alcohol use, and smoking history (P < 0.05). There was no significant difference in terms of the age at first use between members of the methamphetamine-dependent group. Also, the methamphetamine-dependent group showed more brain activity in their pre-center and post-center gyrus than the normal (control) group. Conclusions: According to the results obtained in this study, in general, it can be concluded that there are some areas in the brain of addicts that are activated when watching pleasant photos, while these areas are not active in the brains of normal people.

Download Full-text

Temporal bone Pneumatization in Otosclerosis

Otolaryngology ◽

10.1016/j.otohns.2008.09.004 ◽

2008 ◽

Vol 139 (6) ◽

pp. 850-853 ◽

Cited By ~ 1

Author(s):

Daniel T. Ganc ◽

Robert W. Jyung

Keyword(s):

Temporal Bone ◽

Statistical Significance ◽

Three Dimensional ◽

Neck Surgery ◽

Adult Patients ◽

Control Group ◽

Test Analysis ◽

Temporal Bone Pneumatization ◽

History Of ◽

Temporal Bones

Objectives To determine whether there is a difference in the pneumatization of temporal bones with otosclerosis versus normal temporal bones. Methods A retrospective study of 46 ears from 24 adult patients with otosclerosis and 64 ears from 47 adult patients in a control group. The study group included temporal bone CT scans available from patients with otosclerosis. The control group consisted of patients who had temporal bone CTs for reasons likely unrelated to a history of middle ear disease. Data were obtained with a virtual reality system that allows three-dimensional manipulation and analysis. Results The temporal bone pneumatization for the otosclerosis group was 4.82 ± 2.27 cm3 vs 6.06 ± 2.71 cm3 for the control group. Two-sample t test analysis revealed no statistical significance ( P = 0.059) between pneumatization in the control vs otosclerosis groups. Conclusion There is no difference in temporal bone pneumatization between patients with otosclerosis and a control population. Therefore, temporal bone pneumatization by itself is not an adequate explanation for the apparent protective effect of otosclerosis against otitis media. © 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

Download Full-text

Etiologic Factors in Sialolithiasis

Otolaryngology ◽

10.1177/0194599811415489 ◽

2011 ◽

Vol 145 (6) ◽

pp. 935-939 ◽

Cited By ~ 43

Author(s):

Kevin C. Huoh ◽

David W. Eisele

Keyword(s):

Retrospective Cohort ◽

Statistical Significance ◽

Diuretic Therapy ◽

The United States ◽

Smoking History ◽

Medication History ◽

Initial Attempt ◽

History Of ◽

Uncommon Condition ◽

Unclear Etiology

Objectives. The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States. Study Design. Retrospective, cohort study. Setting. Tertiary university. Materials and Methods. Charts for all patients diagnosed with sialolithiasis between January 2001 and February 2010 were retrospectively reviewed. Demographic factors, smoking history, comorbid medical conditions, and medication history were recorded. Statistical analyses were then performed on the collected data. Population prevalences of smoking, diuretic usage, cholelithiasis, and nephrolithiasis were obtained through literature review. Results. A total of 153 patients with sialolithiasis were identified. Of these patients, 125 (82%) had submandibular sialolithiasis, and 28 (18%) had parotid sialolithiasis. Positive smoking histories were present in 67 individuals (44%). Both the current rate of smoking and the rate of a history of smoking were higher in our cohort when compared with the general population, although the differences did not reach statistical significance. Smoking history did not correlate with the size of the primary sialolith. Diuretic usage in the cohort was observed at a rate of 20%, higher than reported population rates of diuretic use of 8.7%. The prevalences of cholelithiasis and nephrolithiasis were not different from observed population rates. Conclusions. Sialolithiasis is an uncommon condition of unclear etiology. This study represents an initial attempt to quantify the prevalence of smoking and diuretic therapy in a population of patients with sialolithiasis.

Download Full-text

Bilateral Neck Exploration May Not Reduce the Risk of Persistence but Shows a Perspective Advantage

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.520 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A256-A256

Author(s):

Dmitrii Buzanakov ◽

Ilya Sleptsov ◽

Arseny Semenov ◽

Roman Chernikov ◽

Konstantin Novokshonov ◽

...

Keyword(s):

Surgical Treatment ◽

Statistical Significance ◽

Bilateral Neck Exploration ◽

Neck Exploration ◽

True Rate ◽

Bilateral Exploration ◽

Blind Area ◽

Significant Difference ◽

Chi Squared ◽

History Of

Abstract There is still no consensus for an optimal surgical treatment of primary hyperpararthyroidism (PHPT). Virtually, most of the patients could be successfully treated with the selective parathyroidectomy (SPTE) based on preoperative visualization. However, this approach still has a “blind area” of undetected multiglandular disease (MGD). Bilateral neck exploration (BNE) may serve as a reasonable alternative but it meets the higher requirements for the surgical technique. A retrospective cohort study was conducted in order to reveal factors associated with the persistence of PHPT. 587 cases of PHPT patients who had received surgical treatment at SPSU Hospital in 2017–2018 were included. All the patients have at least one preoperative visualization study (neck ultrasound performed by a surgeon) before the operation. In 356 cases two studies were performed (additional 4D CT or MIBI scan) and 116 cases had all three. A surgeon was free to choose a type of the operation (selective or explorative) according to their strategic preferences. Bilateral neck exploration was performed in 160 cases. There was no difference in bilateral exploration rate (p = 0.3896) between the groups (with 1, 2 or 3 studies performed) indicating that the additional visualization does not allow to avoid bilateral exploration. MGD rate accounted for 7.4% (40 cases). It is important that any set of preoperative visualization modalities prove the absence of MGD reliably and select patients for SPTE precisely. Negative predictive value for different combinations of concordant studies (US+MIBI, US+CT and US+CT+MIBI) did not differ significantly and was 96.95%, 97.4% and 97.7% respectively. 26 cases of persistent disease were reported with no significant difference between BNE and SPTE groups. (6 vs 20 respectively, p = 0.792). A history of the thyroid or parathyroid operations was found to be the only factor predicting the higher risk of persistence (OR = 7.98; 95% CI [2.62 - 24.27]), while neither the number of parathyroid glands found during the surgery nor the number of preoperative visualization studies showed statistical significance. Only 47,5% cases of BNE was reported to have all four glands visualized. There rate of failure to found each gland was similar. Surprisingly, the superior parathyroid adenomas (P4) were more likely to be removed (chi-squared 10.378, p = 0.0006) but not in the cases with all four glands visualized intraoperatively (chi-squared 1.822, p = 0.0884). The true rate difference due to a hypothetical feature of parathyroid physiology seems to be not very likely. One may rather suggest than it is not an uncommon for a surgeon to identify a P3 gland as a P4 unless all for glands are visualized. This fact shows a perspective advanantage which may prevent some cases of persistence.

Download Full-text

Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

10.21203/rs.3.rs-414196/v1 ◽

2021 ◽

Author(s):

Xiong Yang ◽

Zhi Li ◽

Shiyong Qi ◽

Linguo Xie ◽

Qiduo Shi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Multivariate Analysis ◽

Kidney Stones ◽

Statistical Significance ◽

Univariate Analysis ◽

Renal Stones ◽

Urinary Stones ◽

Preoperative Imaging ◽

History Of

Abstract To determine the incidence and risk factors of bilateral kidney stones. Utilized the retrospective analysis method on demographic characteristics and clinical data of patients with renal stones in the Second Hospital of Tianjin Medical University. Grouped patients into unilateral and bilateral renal stones according to preoperative imaging and ultrasound examination. Univariate and multivariate analysis methods were used to evaluate the factors that may cause bilateral stones. The study included 7587 patients with kidney stones in total, of whom 4983 had unilateral kidney stones (including 2719 left stones and 2264 right stones), and 2604 had bilateral kidney stones (34.3%). By comparing the unilateral stones group with the bilateral stones group, the univariate analysis demonstrated that weight, body mass index (BMI), history of nephrolithiasis, diabetes mellitus (DM), hypertension, gout, and the maximal stone diameter had statistical significance. Binary logistic regression multivariate analysis demonstrated that BMI, history of nephrolithiasis, diabetes mellitus, hypertension, gout, and the maximal stone diameter were independent risk factors for bilateral urinary stones. This study shows that 34.3% of patients with kidney stones were diagnosed as having bilateral kidney stones; BMI and the maximal stone diameter are positively correlated with the incidence of bilateral kidney stones; Patients with a history of nephrolithiasis, diabetes, hypertension, and gout have a significantly higher risk of having bilateral kidney stones.

Download Full-text

Nephrolepis exaltata Herbal Mask Increases Nasal IgA Levels and Pulmonary Function in Textile Factory Workers

Advances in Preventive Medicine ◽

10.1155/2019/5687135 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Awal Prasetyo ◽

Arindra Adi Rahardja ◽

Dhiva Tsuroya Azzahro ◽

Ika Pawitra Miranti ◽

Indah Saraswati ◽

...

Keyword(s):

Treatment Group ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Smoking History ◽

Control Group ◽

Textile Workers ◽

Significant Difference ◽

Before And After ◽

Post Test ◽

History Of

Background. Chronic occupational exposure in textile workers lowers the pulmonary function and levels of sinonasal IgA. A Nephrolepis exaltata herbal mask can protect the respiratory tract. This study aims to understand the effect of this herbal mask on the IgA levels and pulmonary function in textile workers. Thirty employees were selected for this study. Methods. The pre- and post-test randomized experimental control trials were conducted in a garment industry of Bawen, Semarang, Indonesia. The subjects that qualified to participate (n = 30) fulfilled the inclusion criteria i.e., 20–35 years old, healthy, and willing to be a research subject; and exclusion criteria i.e., having history of alcohol consumption, smoking, history of liver disease, autoimmune disease, cancer, pulmonary and heart disease and/or being pregnant. The subjects were then divided randomly into control group (n = 15), who used regular mask that was rewashed and changed every month for eight weeks, and treatment group (n = 15), who used Nephrolepis exaltata mask that was changed every two days for eight weeks. Pulmonary function tests were carried out using MIR Spirolab III before and after the experiment. IgA levels were measured by nasal wash method using ELISA. Results. IgA levels of the treatment group before and after usage of mask were significantly different (p<0.001) compared to the control group. There were significant difference in FVC of the control group, but no significant difference was observed for FEV1 (p=0.507) and PEF (p=0.001). In the treatment group, all three parameters showed significant differences [FVC (p=0.038), FEV1 (p=0.004), and PEF (p=0.001)]. The means of ΔFVC, ΔFEV1, and ΔPEF were significantly (p<0.05) higher in the treatment group with OR = 5.1 for higher IgA levels. Conclusions. The herbal mask is better in increasing IgA and improving the pulmonary function compared to the regular mask.

Download Full-text

The Differences and Changes of Semi-Quantitative and Quantitative CT Features of Coronavirus Disease 2019 Pneumonia in Patients With or Without Smoking History

Frontiers in Medicine ◽

10.3389/fmed.2021.663514 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xingzhi Xie ◽

Zheng Zhong ◽

Wei Zhao ◽

Shangjie Wu ◽

Jun Liu

Keyword(s):

Smoking Status ◽

Statistical Significance ◽

Left Lung ◽

Ground Glass Opacity ◽

Smoking History ◽

Control Group ◽

Quantitative Ct ◽

Smoking Group ◽

Ct Features

Objective: To assess CT features of COVID-19 patients with different smoking status using quantitative and semi-quantitative technologies and to investigate changes of CT features in different disease states between the two groups.Methods: 30 COVID-19 patients with current smoking status (29 men, 1 woman) admitted in our database were enrolled as smoking group and 56 COVID-19 patients without smoking history (24 men, 32 women) admitted during the same period were enrolled as a control group. Twenty-seven smoking cases and 55 control cases reached recovery standard and were discharged. Initial and follow-up CT during hospitalization and follow-up CT after discharge were acquired. Thirty quantitative features, including the ratio of infection volume and visual-assessed interstitial changes score including total score, score of ground glass opacity, consolidation, septal thickening, reticulation and honeycombing sign, were analyzed.Results: Initial CT images of the smoking group showed higher scores of septal thickening [4.5 (0–5) vs. 0 (0–4), p = 0.001] and reticulation [0 (0–5.25) vs 0 (0–0), p = 0.001] as well as higher total score [7 (5–12.25) vs. 6 (5–7), p = 0.008] with statistical significance than in the control group. The score of reticulation was higher in the smoking group than in the control group when discharged [0.89 (0–0) vs. 0.09 (0–0), p = 0.02]. The score of septal thickening tended to be higher in the smoking group than the control group [4 (0–4) vs. 0 (0–4), p = 0.007] after being discharged. Quantitative CT features including infection ratio of whole lung and left lung as well as infection ratio within HU (−750, −300) and within HU (−300, 49) were higher in the control group of initial CT with statistical differences. The infection ratio of whole lung and left lung, infection ratio within HU (−750), and within HU (−750, −300) were higher in the control group with statistical differences when discharged. This trend turned adverse after discharge and the values of quantitative features were generally higher in the smoking group than in the control group without statistical differences.Conclusions: Patients with a history of smoking presented more severe interstitial manifestations and more residual lesion after being discharged. More support should be given for COVID-19 patients with a smoking history during hospitalization and after discharge.

Download Full-text

PSYLLIUM HUSK TO INCREASE HDL-CHOLESTEROL

The Professional Medical Journal ◽

10.29309/tpmj/2010.17.04.3030 ◽

2010 ◽

Vol 17 (04) ◽

pp. 711-714

Author(s):

SAMINA KARIM ◽

SHAH MURAD ◽

MANZOOR AHMED UNAR ◽

Ghazi Mahmood ◽

Moosa Khan ◽

...

Keyword(s):

Statistical Significance ◽

Hdl Cholesterol ◽

T Test ◽

Controlled Study ◽

Control Group ◽

Medical Sciences ◽

Psyllium Husk ◽

Metallic Taste ◽

The Difference ◽

Basic Medical

Objectives: To examine the effects of Psyllium husk on HDL-Cholesterol. Design: Single blind placebo controlled study. Place and Duration of Study: Study was conducted at department of Pharmacology and therapeutics at Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2006 to July 2006. Patient and Methods: Forty hyperlipidemic patients were included, among which 20 patients were on placebo as control group, and 20 were on Psyllium husk, 3 gram daily, in divided doses for the period of three months. Patients with peptic ulcer, renal disease, hepatic disease, hypothyroidism, diabetes mellitus, and alcoholism were excluded from the study. HDL- Cholesterol was determined by using kit Cat. # 303210040 by Eli Tech Diagnostic, France. Data were expressedas the mean ± SD and “t” test was applied to determine statistical significance as the difference. A probability value of <0.05 was the limit of significance. Results: Two patients were dropped from the study due to low compliance of metallic taste of psyllium husk. Psyllium husk has increased HDL-Cholesterol, in 90 days of treatment, from 34.61±1.85 to 36.77±1.96 (mg/dl), which was highly significant statistically whenpaired “t” test was applied for results. Percentage change was +6.24. Conclusions: It is concluded from this study that Psyllium husk decreases the risk of CHD by increasing HDL-Cholesterol.

Download Full-text

Atrophic Rhinitis and Its Surgical Management

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1091 ◽

2011 ◽

Vol 4 (3) ◽

pp. 127-129

Author(s):

Rohit Sharma ◽

Vinit Kumar Sharma ◽

JP Purohit ◽

Sampan Vishth

Keyword(s):

Flow Rate ◽

Uttar Pradesh ◽

Atrophic Rhinitis ◽

Control Group ◽

Medical Sciences ◽

Medical College ◽

Saccharine Test ◽

History Of ◽

Dermofat Graft ◽

Surgical Treatments

ABSTRACT Objective Clinical evaluation of atrophic rhinitis and comparative study of its surgical treatments. Materials and methods This study was carried out in the Department of ORL-HNS, MLB Medical College and Hospital, Jhansi and Department of ORL-HNS, SRMS Institute of Medical Sciences, Bareilly, Uttar Pradesh, India from June 2006 to May 2011 including the cases of atrophic rhinitis. A total of 40 patients of atrophic rhinitis were included in this study. Thirty-two patients had modified Young's nostril closure and eight patients had dermofat graft obliteration of nasal cavity. Preoperative and postoperative assessment of nasal mucociliary flow rate were also assessed by saccharine test. Fifteen cases were kept in control group to compare the nasal mucociliary flow rate results. Results The results of both surgical modalities were compared at various intervals for 20 months. Conclusion The patients with history of nasal myiasis and septal perforation do better with partial nostril closure while patients, not having history of maggots and septal perforations, had best results with dermofat graft operation. It was seen that after surgical treatment of atrophic rhinitis, either by nostril closure or dermofat grafting, there was improvement in nasal mucociliary flow or, nearly, all patients were symptomatically improved.

Download Full-text