scholarly journals Comparing coping styles, personality traits, and resiliency in multiple sclerosis patients

2021 ◽  
Vol 23 (2) ◽  
pp. 62-67
Author(s):  
Amir Mahdi Katani ◽  
Shahnaz Mohammadi ◽  
Zahra Davoodi ◽  
Somaye Shahmoradi
Keyword(s):  
Multiple Sclerosis ◽  
Personality Traits ◽  
Healthy Subjects ◽  
Coping Styles ◽  
Control Group ◽  
Case Group ◽  
Ways Of Coping Questionnaire ◽  
Resilience Scale ◽  
Multiple Sclerosis Patients ◽  
Control Study

Background and aims: Multiple sclerosis (MS) is a common neurological disorder with complex etiology, which is highly affected by psychological factors. These factors should to be identified to help patients with MS (PwMS). This study aimed to compare coping styles, personality traits, and resiliency in PwMS and healthy subjects. Methods: In this case-control study, we selected 75 PwMS from the members of Tehran MS Society in 2016 as case group and 75 healthy subjects as control group. To collect data, we used the Ways of Coping Questionnaire (WOCQ), Big Five Factor Inventory–Revised, and Conner-Davidson Resilience Scale (CD-RISC). Multivariate analysis of variance (MANOVA) and independent T-Test were used to analyze the data. Results: The results indicated that PwMS use emotion-focused coping styles more often (44.53±9.13, P=0.008) and problem-focused coping styles less often (39.84±5.79, P=0.001) compared to control group. Also, they showed higher scores in neuroticism (32.10±4.80, P=0.001) and lower scores in extraversion and conscientiousness (27.46±7.12, P=0.005 and 32.98+±5.72, P=0.008, respectively). The resiliency levels in these patients were also lower than healthy subjects (68.13±13.90, P=0.021). Conclusion: Our findings indicated that PwMS are more likely to use emotional coping strategies in stressful situations compared to healthy individuals. Moreover, data confirmed that a maladaptive personality configuration, which is specified by high neuroticism, along with low extraversion, conscientiousness, and agreeableness are somehow related to MS.

scholarly journals Anxiety as one of the factors determining the rate of multiple sclerosis progressing

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 5-9
Author(s):  
A. A. Skorometz ◽  
L. G. Zaslavsky
Keyword(s):  
Multiple Sclerosis ◽  
Healthy Subjects ◽  
Early Stage ◽  
Control Group ◽  
Reactive Anxiety ◽  
Multiple Sclerosis Patients ◽  
Working Out

Results of psychologic examination of 61 patient with multiple sclerosis diagnosed by Poser criteria are described. In most part of patients an increased level of both egocentric and reactive anxiety in comparison with findings of control group of healthy subjects and group of patients with some other neurologic pathology is with certainty determined. It is found that multiple sclerosis in patients with intense egocentric (congenital) anxiety is taking more malignant course. It is concluded that conducting psychologic testing of multiple sclerosis patients on the early stage for probable assessment of the further course of the disease and working out of more individual tactics of treatment is expedient.

scholarly journals Characteristic Personality Traits of Multiple Sclerosis Patients—An Unicentric Prospective Observational Cohort Study

2021 ◽  
Vol 10 (24) ◽  
pp. 5932
Author(s):  
Eugenia Irene Davidescu ◽  
Irina Odajiu ◽  
Delia Tulbă ◽  
Camelia Cucu ◽  
Bogdan Ovidiu Popescu
Keyword(s):  
Multiple Sclerosis ◽  
Personality Traits ◽  
Patient Group ◽  
Matched Control ◽  
The Elderly ◽  
Tobacco Consumption ◽  
Control Group ◽  
Matched Control Group ◽  
Edss Score ◽  
Multiple Sclerosis Patients

Background and objectives: Multiple sclerosis (MS) patients tend to present peculiar personality traits that highly impact their quality of life. Our study aimed to determine which personality traits are more common in MS patients compared to a sex- and age-matched control group. Methods and materials: Patients with relapsing–remitting MS along with a sex- and age-matched control group were included. All subjects completed the DECAS Personality Inventory and an additional form including demographic characteristics. Data (including descriptive statistics and univariate and multivariate analysis) were analyzed using SPSS. Results: 122 subjects were included, out of which 61 were in the patient group, mostly females (71.31%) with a mean age of 42.06 ± 10.46 years. Mean duration of disease was 10.18 ± 5.53 years and mean EDSS score was 2.09; 36% of patients were treated with Interferon-beta 1a. Subjects in the patient group presented significantly lower scores for extraversion (p = 0.036), specifically those with higher EDSS score, even after adjusting for possible confounders (age, sex, marital status, early retirement, alcohol, and tobacco consumption). Additionally, regarding orientation in life, MS patients were more often philosophers (p = 0.001), especially young males, whereas the dominant emotional feeling was less common, the actor profile (p = 0.022). Regarding task involvement, MS patients were often passive and compassionate concerning other people. Higher EDSS score also correlated with avoidant (p = 0.006) and melancholic (p = 0.043) personality traits. Subjects with higher education associated more often pragmatic, experimenter, popular, and optimist traits, whereas the elderly had actor, authoritarian, and experimenter profiles. Conclusions: Some MS patients may have reduced levels of extraversion and specific personality traits compared to age- and sex-matched subjects. Determining the exact personality profile might help the neurologist to establish a better therapeutic alliance and to apply specific interventions.

scholarly journals Serum leptin and body mass index in a sample of Egyptian multiple sclerosis patients

2020 ◽  
Vol 56 (1) ◽  
Author(s):  
Mohamed A. Abd Elhafeez ◽  
Dina A. Zamzam ◽  
Mohamed M. Fouad ◽  
Hala M. Elkhawas ◽  
Hend A. Abdel Rahman
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
Clinical History ◽  
Control Group ◽  
Case Group ◽  
Serum Leptin ◽  
Disability Status ◽  
Degree Of Disability ◽  
Multiple Sclerosis Patients

Abstract Background The adipose tissues release pro-inflammatory cytokines such as leptin that can be considered a link between obesity and autoimmunity. This study aimed to investigate a possible correlation between BMI, serum leptin, and multiple sclerosis (MS). Methods This case-control study recruited consecutively 169 patients from our MS Unit and 50 healthy controls. Clinical history and examination with Expanded Disability Status Scale (EDSS) scoring were done for all patients. Calculation of body mass index (BMI) and measurement of serum leptin level were done for patients and controls. Results The case group had significantly higher BMI (mean of 26.85 ± 6.06 versus 19.55 ± 1.62; P < 0.001) and higher serum leptin levels (median [IQR] of 280 pgm/ml [175–525] versus 102.5 pgm/ml [80–125]; P < 0.001) compared to the control group. Serum leptin levels did not have a correlation with either disease activity or degree of disability. Conclusions MS patients had significantly higher BMI and higher serum leptin levels compared to controls.

scholarly journals Association between multiple sclerosis and dietary patterns based on the traditional concept of food nature: a case-control study in Iran

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohammad Hossein Sharifi ◽  
Parisa Keshani ◽  
Alireza Salehi ◽  
Amir Mohammad Jaladat ◽  
Zahra Mirzaei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Principal Component ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Traditional Concept ◽  
Food Patterns ◽  
Control Study

Abstract Introduction It remains a matter of debate whether traditional concepts regarding the nature of food affect the development and progression of multiple sclerosis (MS).To date, there are limited studies that have investigated the association between MS and dietary patterns based on the categories of food nature (hot, cold, or balanced) defined in traditional medicine. Method This case-control study was conducted from October 2019 to February 2020. In total, 60 patients diagnosed with MS within the preceding 6 months and referred to our neurology outpatient clinic were included in our case group. The control group included 180 patients who were referred to the same center for general or orthopedic surgery. Dietary intake was assessed in both groups through a reliable and valid semi-quantitative food frequency questionnaire. Data were assessed using principal component analysis. Results The mean age of the participants was 44.9 ± 17.33 years. The analysis showed that four food patterns were distinguished (eigenvalue > 1), namely “additives and cold-natured foods”, “hot and balanced foods and nuts”, “dairy and legumes”, and “hot and balanced starches”. These food patterns explained 57.8% of the total variance. After adjusting all confounding factors, individuals in the highest quartile and medium quartile of “additives and cold-natured foods” had an elevated MS risk compared with the lowest quartile (OR = 7.21, 95%CI = 2.01–12.38 and OR = 3.37, 95%CI = 1.02–11.35, respectively). Furthermore, individuals in the highest quartile of the “hot and balanced foods and nuts” group were protected against MS compared with its lowest quartile (OR = 0.28, 95%CI = 0.08–0.90). Moreover, a protective effect against MS was seen in the highest quartile of the “hot and balanced starches” group relative to its lowest quartile (OR = 0.34, 95%CI = 0.12–0.98). No significant association was found between “dairy and legumes” and the risk of MS. Conclusion This study revealed that dietary patterns based on the traditional concept of food nature might be associated with the risk of developing MS. This represents the first work in this area, so further research is recommended.

Zinc deficiency is an independent risk factor for prehypertension in healthy subjects

2019 ◽  
pp. 1-6 ◽  
Author(s):  
Sara C. Nevárez-López ◽  
Luis E. Simental-Mendía ◽  
Fernando Guerrero-Romero ◽  
Jorge A. Burciaga-Nava
Keyword(s):  
Blood Pressure ◽  
Zinc Deficiency ◽  
Healthy Subjects ◽  
Serum Zinc ◽  
Control Group ◽  
Case Group ◽  
Zinc Levels ◽  
And Control ◽  
Control Study ◽  
Apparently Healthy

Abstract. Objective: To assess whether zinc deficiency is associated with prehypertension (preHTN) in apparently healthy subjects. Design: Apparently healthy women and men, aged 20 to 60 years were enrolled into a case-control study. Individuals with and without preHTN were allocated into the case and control groups, respectively. Hypertension, liver disease, renal disease, smoking, pregnancy, diabetes, malignancy, hypernatremia, hypomagnesemia, medical treatment, and use of supplements containing zinc were exclusion criteria. PreHTN was defined by systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) of 120–139 mmHg and/or of 80–89 mmHg, respectively, and the zinc deficiency by serum zinc levels < 74 μg/dL in men and < 70 μg/dL in women. Results: In total, 142 subjects (90 women and 52 men) were enrolled and allocated in the case (n = 71) and control (n = 71) groups. In the overall population, the frequency of zinc deficiency was 11.1%; individuals in the case group showed significant higher frequency of zinc deficiency as compared with the control group (16.9% vs 5.5%, p = 0.04). The logistic regression analysis showed a significant association between zinc deficiency and preHTN (OR = 4.61; 95% CI: 1.24–17.12, p = 0.02). Conclusion: Our results suggest that zinc deficiency is associated with the presence of preHTN in apparently healthy subjects.

Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients

2019 ◽  
Vol 19 (5) ◽  
pp. 357-363 ◽  
Author(s):  
Maryam Ahmadi ◽  
Farshid Fathi ◽  
Saloomeh Fouladi ◽  
Fereshteh Alsahebfosul ◽  
Mostafa Manian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Frequency Distribution ◽  
Healthy Subjects ◽  
Demyelinating Disease ◽  
Critical Role ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
High Resolution Melt ◽  
Multiple Sclerosis Patients

Background:Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also, multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Against this background, IL-33 and IL1RL1 play a critical role in autoimmune and inflammatory disorders. Here, we explored the IL-33 serum level and two potential genetic variants in the IL33 gene and its receptor in Iranian asthma and MS patients.Results:The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05). The frequency distribution of the genotype in rs10204137 variant of IL-33 gene in MS patients and healthy subjects was significantly different (p = 0.013).Methods:This study consisted of asthma (n=140) and MS patients (n=140), and healthy subjects (n=72). Genotyping was carried out in two genetic polymorphisms, rs1342326 variant of IL-33 and rs10204137SNP variant of IL-33 receptor genes, using High- Resolution Melt Real- Time PCR based method. The level of serum IL-33 was also measured using enzyme-linked immunosorbent assay method.Conclusion:Our findings demonstrated that asthma and MS patients had a higher level of IL-33, and IL-33 receptor genetic polymorphism was associated with MS. Further studies in a larger multicenter setting are needed to explore the value of this marker as a risk stratification biomarker.

scholarly journals Evaluation of Sleep Quality in Patients with Multiple Sclerosis: A Case-Control Study

2021 ◽  
Author(s):  
Ghasem Fattahzadeh-Ardalani ◽  
Esmaeil Ghoreishi ◽  
Abolfazl Atalu ◽  
Mortaza Delkhosh-Reihany ◽  
Vahid Abbasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sleep Quality ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Poor Sleep ◽  
Chi Square ◽  
Increased Risk ◽  
Control Study

Background and Objective: Studies indicate that people with multiple sclerosis (MS) are at increased risk of sleep disorders and the resulting negative outcomes. The aim of this study was to evaluate sleep quality in patients with MS. Materials and Methods: In this case-control study, 110 patients with all confirmed types of MS as a case group and 110 healthy subjects as control group were evaluated in terms of sleep quality using Pittsburgh Sleep Quality Index (PSQI). The data collected was analyzed using t-test and chi-square tests. Results: Total score of PSQI was significantly higher in patients with MS than that of the control group (7.32 ± 2.78 vs. 5.30 ± 2.00, P = 0.001). Furthermore, PSQI scores of patients with MS was significantly higher than that of the control group in subscales including sleep latency (1.14 ± 0.99 vs 0.85 ± 0.91, P = 0.029), sleep duration (1.09 ± 0.80 vs. 0.83 ± 0.88, P = 0.048), habitual sleep efficiency (1.15 ± 0.92 vs. 0.85 ± 0.83, P = 0.017), sleep disturbance (1.25 ± 0.96 vs 0.96 ± 0.88, P = 0.013), use of sleep medication (0.69 ± 0.94 vs. 0.33 ± 0.65, P = 0.001), and daytime dysfunction (0.88 ± 0.93 vs. 32.2 ± 0.69, P = 0.001). Conclusion: Patients with MS had a significantly more improper sleep quality compared to the control group. So, poor sleep quality has a negative effect on daily activities and social communication of these patients and generally reduce their quality of life (QOL).

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamad Reza Nikouei Moghaddam ◽  
Monireh Movahedi ◽  
Maryam Bananej ◽  
Soheil Najafi ◽  
Nahid Beladi Moghadam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Uric Acid ◽  
Vitamin D3 ◽  
Chronic Inflammatory Disease ◽  
Toxic Effects ◽  
Control Group ◽  
Therapeutic Effects ◽  
Mannuronic Acid ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

2018 ◽  
Vol 15 (1) ◽  
pp. 74-78
Author(s):  
Mohammadali Nazarinia ◽  
Asghar Zare ◽  
Mohammad javad Fallahi ◽  
Mesbah Shams
Keyword(s):  
Systemic Sclerosis ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Control Group ◽  
Lung Involvement ◽  
Serum Homocysteine ◽  
The Mean ◽  
Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

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