scholarly journals IDENTIFYING FORMULAS TO WOOD-APPLE (Limonia acidissima L) FLAVOR EFFERVESCENT TABLET PRODUCTION IN EXPERIMENTAL

2017 ◽  
Vol 1 (28) ◽  
pp. 89-95
Author(s):  
Tang Thi My Tran ◽  
Toan Quoc Tram ◽  
Van Bach Nguyen ◽  
Tam Minh Le ◽  
Tham Thi Hong Nguyen
Keyword(s):  
Latin Square ◽  
Flow Property ◽  
Fractional Factorial ◽  
Preliminary Evaluation ◽  
Compression Process ◽  
Disintegration Time ◽  
Peg 6000 ◽  
Weight Variation ◽  
Effervescent Tablet ◽  
Limonia Acidissima

This study aims to formulate woodapple flavor effervescent tablets in the lab experiment. Four factors with three levels each were investigated including: acid citric (14%, 16%, 18%), natri-bicarbonate (10%, 14%, 18%), saccharose (45%, 50%, 55%), and PEG 6000 (4%, 5%, 6%). Nine profiles were constructed following a fractional factorial design – the Graeco Latin square. Each profile was then measured based on four characteristics/criteria: (1) - flow properties of wood apple powder (before compression process), (2) - weight variation and (3) - disintegration time (after compression process); and (4) wood-apple effervescent tablets which were rated for overall liking by 105 consumers. The results showed that 8 over 9 profiles have a good flow property, meaning that it is capable of compressing tablets. The weight variation among tablets is less than 5%. In addition to that, the disintegration time of an effervescent tablet, about 1 gram into 200 mL water, is less than 300 seconds (5 minutes). Based on the preliminary evaluation of our internal sensory panel, six over eight profiles were chosen for  taking the tests to the consumers’ liking based on IPM method. The results showed that profile 2 (A.Citric 14%,  NaHCO3 14%, saccharose 50% , PEG 6000 5%,wood apple flavor 16% and vit.C 1%) and profile 5 (A.Citric 16%, NaHCO3 14%, saccharose 50%, PEG 6000 4%, wood apple flavor 15% and vit.C 1%) obtain  maximum liking score rated by the consumers. We expect that the results of this study will benefit R&D staff in food and pharmaceutical companies who want to diversify their local products.

scholarly journals FORMULATION AND EVALUATION OF HERBAL TABLETS CONTAINING NYCTANTHES ARBOR-TRISTS LEAVES

2020 ◽  
pp. 22-24
Author(s):  
PRASHANT CHAVAN ◽  
MALLINATH KALSHETTI ◽  
NIKHIL NAVINDGIKAR
Keyword(s):  
Sodium Alginate ◽  
Flow Property ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Dry Powder ◽  
Disintegration Time ◽  
Alginate Solution ◽  
Weight Variation

Objective: To formulate arthritic pain relieving tablets and evaluation of tablets. Methods: The preparation of dry powder of Nyctanthes arbor-tristis leaves, 1% Acacia solution, 1%HPMC-10 solution, 1% Sodium alginate solution. The wet granulation method was used for the formulation of herbal tablets. Results: Based on the pre-formulation study, the flow property of granules was good. The physical parameters of compressed tablets color were Greenish white for F1 and F3 batch, Dark greenish-white color for F2batch. The weight variation test, hardness, thickness, friability and disintegration time for F1 batch was found to be [497±5%, 3.3±0.17, 4.00±0.005, 0.81%, 28] respectively, For F2 batch [506±5%, 3.13±0.01, 3.66±0.023, 1.43%, 25] respectively, For F3 batch [502.5±5%, 3.13±0.01, 3.96±0.001, 1.8%, 32] respectively. Conclusion: The formulated herbal tablets were used to manage arthritic pain. Based on the results, it is concluded that the formulation and evaluation of herbal tablets were good.

scholarly journals Formulation, Evaluation and Comparison of the Poly Herbal Anti-Diabetic Tablet with the Commercial Tablets

2021 ◽  
pp. 252-263
Author(s):  
N. Chauhan Nidhi ◽  
Mistry Rujuta ◽  
Mandale Drasti ◽  
Ugharatdar Siddik Ismail ◽  
Dadubhai Ezaj ◽  
...  
Keyword(s):  
Moisture Content ◽  
Research And Development ◽  
Flow Property ◽  
Water Soluble ◽  
Disintegration Time ◽  
Chemical Examination ◽  
Weight Variation ◽  
Aconitum Heterophyllum ◽  
Starch Paste

Objective: To formulate a poly herbal anti-diabetic tablet and to evaluate and compare its physicochemical properties with the marketed herbal tablets. Materials and Methods: The poly herbal anti-diabetic tablet was formulated by adding the powder of extract of  Enicostemma littorale in powder of  roots of Aconitum heterophyllum rhizomes of Picrorhiza kurroa and fruits of Piper longum in different proportions to an  aqueous 5 % Starch solution and  Several tests such as visual inspection, ash values, moisture content, Water soluble extractive value and Alcohol soluble extractive value, disintegration time, Uniformity of weight of tablets, Determination of hardness of tablets, Determination of friability of tablets etc and Preliminary phytochemical screening and qualitative chemical examination were performed and compare Laboratory formulated tablets with  commercial tablets. Results: The study showed that Laboratory formulated poly herbal anti-diabetic tablet has good flow property and compressibility. The moisture content of laboratory formulations was found to be 4.8%. Water extractive value was found to be 28.14% W/V result shows that laboratory formulation consisted of higher amount of water soluble substances like carbohydrates. Alcohol extractive value was found to be 20.08% W/V denotes the amount of alcohol soluble constituents present in the formulation. Disintegration of tablet was found to be 3 mins results shows laboratory formulation was within the limit as it was prepared with starch paste (5%w/v) as a binding and disintegrating agent. Disintegration of tablet is not more than 30 minutes.  The laboratory formulation was found to have 3 (Kg/Cm2) hardness, 0.38 % Friability and weight variation within pharmaceutical limits. However, further research and development is required to improve its quality and safety. Conclusion: The aim of this study was to formulate a completely poly herbal antidiabetic tablet. Our Laboratory formulated tablets showed comparable good results as compare to that of marketed tablets but further research and development is required to improve its overall quality.

scholarly journals Formulation, Development and Evaluation of Bisoprolol Sustained Release Tablets

2021 ◽  
Vol 13 (1) ◽  
pp. 209-219
Author(s):  
M. Masum ◽  
M. A. R. Ripon ◽  
D. R. Bhowmik ◽  
M. T. Amin ◽  
S. Arefin ◽  
...  
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Flow Property ◽  
Water Soluble ◽  
Formulation Development ◽  
Drug Release Profile ◽  
Disintegration Time ◽  
Weight Variation ◽  
Compressibility Index ◽  
Poly Ethylene

Bisoprolol is a type of antihypertensive drug (β-blocker). It is a poorly water-soluble and highly permeable drug that belongs to class II biopharmaceutical classification. This investigation represents the formulation development of bisoprolol to sustain the drug release. Different types of polymers like hypromellose, xanthan gum, avicel, poly ethylene glycol (PEG) were used in this study. Three different formulations were developed by using different excipients at various ratios. The granules were evaluated for bulk density, tapped density, flow property whereas tablets were evaluated for thickness, hardness, weight variation, compressibility index, uniformity of content, disintegration time, and drug release profile. The concentration of the diffused drug was measured using a UV-visible spectrophotometer at λmax= 225 nm. Granules showed good flow ability and all the formulations passed the quality. Among all the formulations, F-2 and F-3 showed better efficiency. PEG along with hypermellose, and guar gum showed a good combination for sustaining the drug release

scholarly journals OPTIMIZATION OF ALBENDAZOLE 400 MG TABLET COMPRESSION PROCESS USING DESIGN OF EXPERIMENT (DOE) APPROACH

2021 ◽  
pp. 1-6
Author(s):  
LUCAS PEDROSA D. A. SILVA ◽  
EMERSON MARIO BOLDO
Keyword(s):  
Design Of Experiment ◽  
Quality Attributes ◽  
Critical Parameters ◽  
Control Factor ◽  
Average Weight ◽  
Compression Force ◽  
Compression Process ◽  
Disintegration Time ◽  
Weight Variation ◽  
The Impact

Objective: The present study aims to model and optimize the compression process of the Albendazole 400 mg tablets of a pharmaceutical industry production line to increase the production speed (tablets/h) while maintaining quality requirements. Methods: The study was conducted using the Design of Experiments (DoE) methodology to identify and correlate the critical parameters during the process that affect the maintenance of the compression speed. In order to support the experiments, was tested disintegration time, average hardness, hardness variation, average weight, and friability. Results: Was obtained that quality attributes of disintegration and friability did not generate a significant model but it has been established correlations between Fill-O-Matic speed and main compression force in the responses of weight variation, hardness, and mean hardness. It was found that the main compression force between 6 to 9 kN, the pre-compression force of 1,965 to 5,615 kN, and the speed of 55 RPM for Fill-O-Matic speed are responsible for ensuring that all quality attributes analyzed remain within the expected specification. Conclusion: It was possible to apply the Design of Experiment (DoE) methodology in the compression process of the drug Albendazole 400 mg and to evaluate the impact of the parameters of this step on the formation of the tablet to significantly increasing the productivity of this product. The Fill-O-Matic speed parameter was the main control factor discovered in this study to maintain quality attributes.

scholarly journals Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources

2018 ◽  
Vol 18 (1) ◽  
pp. 30-41
Author(s):  
Puput Andi Apsari ◽  
Dewi Nur Eka Sari ◽  
Aris Perdana Kusuma ◽  
Oktavia Indrati
Keyword(s):  
Citric Acid ◽  
Tartaric Acid ◽  
Antioxidant Properties ◽  
Seed Extract ◽  
Pharmaceutical Dosage Form ◽  
Peg 6000 ◽  
Tartaric Acids ◽  
Weight Variation ◽  
High Concentrations ◽  
Effervescent Tablet

Melinjo seeds (Gnetum gnemon L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract. The effervescent tablet of melinjo seed extract were formulated with variation of citric-tartaric acid 25%:75%, 65%:35%, 50%:50%, 20%:80% and PEG 6000 0%, 2%, 3%, up to 5%. The effervescent tablet were made by melting parts of acids and bases, added with extract and other ingredients. The evaluation included flow and powder tapping, tablet hardness, weight variation, friability, and tablet solubility test. The data were analyzed by comparing approaches based on the requirements of Pharmacopeia Indonesia V andUnited States of Pharmacopeia 36.Variations of equal amount of citric-tartaric acid produced hard effervescent tablets with small friability. The unbalanced acid concentration resulted in higher friability. The greater the concentration of citric acid resulted in the longer solubility of the tablet. The addition of PEG 6000 made the flow time of granules quicker, while higher concentrations would increase the hardness of tablets and accelerate the soluble time. Excessively high concentrations resulted in a high degree of friability. Variation of citric-tartaric acid and PEG 6000 influenced physical properties of granule and effervescent tablet extract of melinjo seeds, such as flowability, hardness, friability, and solubility of the tablet.

scholarly journals Antibiotic evaluation of odontogenic microbiological spectrum of orofacial infection

2018 ◽  
Vol 8 (6) ◽  
pp. 179-182
Author(s):  
Neha Vishnoi ◽  
Sapna Singh ◽  
Ram Singh Bishnoi ◽  
M K Gupta
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Drug Release Profile ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Compression Technique ◽  
Peg 6000 ◽  
Drug Content ◽  
Weight Variation ◽  
Enhanced Solubility

The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of Telmisartan and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of ODT system. A batch process was adopted for the preparation of solid dispersion with each combination of drug and polymer and the finally compressed as tablets by direct compression technique. For the preformulation perspective materials were scrutinized on the basis of solubility profile, drug content, Fourier Transform Infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). The drug polymer ratio 1:4 was selected for further compression process. The prepared batches of ODTs were characterized for micromeritic study, thickness, hardness, weight variation, wetting time, disintegration time, drug content and in vitro drug release profile. The evaluation data for all batches was satisfactory out of them formulation TF3 containing 6% kyron T-314 showed the best results with a value of 29.3 sec and 24.1 sec for wetting and disintegration, respectively. This formulation showed superior drug release of 99.93% over a period of 30 minutes. Keywords: Telmisartan, PEG 6000, Angioten receptor-II antagonist, Solid dispersion, Kyron T-314

FORMULATION AND DEVELOPMENT OF FAST DISSOLVING TABLET OF METOCLOPRAMIDE: AN ANTI-EMETIC DRUG

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Avilash Carpenter ◽  
M.K. Gupta ◽  
Neetesh Kumar Jain ◽  
Urvashi Sharma ◽  
Rahul Sisodiya
Keyword(s):  
Mechanical Strength ◽  
Standard Procedure ◽  
Flow Property ◽  
Storage Conditions ◽  
Angle Of Repose ◽  
Dissolution Time ◽  
Disintegration Time ◽  
Powder Blend ◽  
Standard Curve ◽  
The Stability

Aim: The main of the study is to formulate and develop orally disintegrating fast dissolving tablet of Metoclopramide hydrochloride. Material & Methods: Before formulation and development of selected drug, the standard curve in buffer was prepared and absorbance at selected maxima was taken. Then two different disintegrating agents were selected and drug was mixed with disintegrating agents in different ratio. Various Preformulation parameters and evaluation of tablet i.e. disintegration time, dissolution time, friability, hardness, thickness were measured by standard procedure. Result & Discussion: The angle of repose for all the batches prepared. The values were found to be in the range of 30.46 to 36.45, which indicates good flow property for the powder blend according to the USP. The bulk density and tapped density for all the batches varied from 0.49 to 0.54 g/mL and 0.66 to 0.73, respectively. Carr’s index values were found to be in the range of 23.33 to 25.88, which is satisfactory for the powders as well as implies that the blends have good compressibility. Hausner ratio values obtained were in the range of 1.22 to 1.36, which shows a passable flow property for the powder blend based on the USP. The results for tablet thickness and height for all batches was found to range from 4.45 to 4.72 mm and 3.67 to 3.69 mm, respectively. Hardness or breaking force of tablets for all batches was found to range from 32.8 to 36.2 N. Tablet formulations must show good mechanical strength with sufficient hardness in order to handle shipping and transportation. Friability values for all the formulations were found to be in the range of 0.22 % to 0.30 %. Conclusion: Orally disintegrating tablets were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The formulation was shown to have a rapid disintegration time that complied with the USP (less than one minute). The data obtained from the stability studies indicated that the orally disintegrating mini-tablets of MTH were stable under different environmental storage conditions. Keywords: Formulation & Development, Fast Dissolving Tablet, Metoclopramide, Anti-Emetic Drug, Oral Disintegrating Tablet

The Effect of Superdisintegrants on the Dissolution of Promethazine. HCl Fast Dissolving Tablets

2010 ◽  
Vol 3 (1) ◽  
pp. 867-871
Author(s):  
Ganesh kumar Gudas ◽  
Manasa B ◽  
Senthil Kumaran K ◽  
Rajesham V V ◽  
Kiran Kumar S ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Angle Of Repose ◽  
Content Uniformity ◽  
Disintegration Time ◽  
Enhanced Dissolution ◽  
Weight Variation ◽  
Compressibility Index ◽  
Chemoreceptor Trigger Zone ◽  
Trigger Zone ◽  
Standard Limit

Promethazine.HCl is a potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Promethazine is also believed to inhibit the medullary chemoreceptor trigger zone, and antagonize apomorphine -induced vomiting. Fast dissolving tablets of Promethazine.HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The precompression blend was tested for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Promethazine.HCl was prepared and studied and the formulation S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Promethazine.HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate. 

Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablets for Treatment of Hypertension

2014 ◽  
Vol 7 (2) ◽  
pp. 2450-2458
Author(s):  
Sarika Pundir ◽  
Ashutosh Badola
Keyword(s):  
Kinetic Studies ◽  
Film Coating ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Simultaneous Estimation ◽  
Matrix Tablet ◽  
Release Agent ◽  
Disintegration Time ◽  
Weight Variation

In the present study we have formulated (F1 to F6) matrix tablets of atenolol and indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinized starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated for weight variation, hardness, friability, drug content, disintegration time and in vitro drug release using USP dissolution apparatus type 2 (paddle). It was found that the optimized formulation showed 49.33%, 48.90%, 48.52%, 47.65%, 46.84% and 46.51% release for atenolol in 12 hours respectively. However, indapamide released 49.62%, 49.39%, 48.72%, 48.27%, 47.59% and 47.36% at the end of 12 hr. The IR spectrum study revealed that there is no disturbance in the principal peaks of pure drugs atenolol and indapamide. This confirms the integrity of pure drugs and no incompatibility of them with excipients. The stability studies were carried out for the optimized batch for one months and it showed satisfactory results. The kinetic studies of the formulations revealed that diffusion is the predominant mechanism of drug and release follows Zero-order, Super case II transport.

Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine

2015 ◽  
Vol 8 (2) ◽  
pp. 2881-2888
Author(s):  
Sudarshan Singh ◽  
S S Shyale ◽  
P Karade
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Drug Content ◽  
Weight Variation ◽  
Wetting Time ◽  
Croscarmellose Sodium

The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmellose sodium by sublimating agent such as camphor. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies. The prepared tablets were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry. The disintegration time for the complexed tablets prepared by different concentration of superdisintegrants was found to be in range of 32.54 ± 0.50 to 55.12 ± 0.57 sec and wetting time of the formulations was found to be in range of 28.47 ± 0.67 to 52.19 ± 0.72 sec. All the formulation showed almost 100 percent of drug release within 15 min. Among all the formulation F6 and F7 prepared with 18% croscarmellose sodium and camphor shows faster drug release, respectively 10 min, F6 gives good result for disintegration time, drug release, wetting time and friability. Further formulations were subjected to stability testing for 30 days at temperature of 40 ± 5 ºC/75 ± 5 %RH. Tablets showed no appreciable changes with respect to physical appearance, drug content, disintegration time and dissolution profiles. Results were statistically analyzed by one-way ANOVA at a p < 0.05. It was found that, the data at any point of time are significant at p < 0.05.

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