Effects of Preoperative Low-Dose Gabapentin on Postoperative Pain and Sedation of Patients Undergoing General Anesthesia

2021 ◽  
Vol 104 (7) ◽  
pp. 1187-1191

Objective: To study the drug interaction between gabapentin and morphine in surgical patients under general anesthesia. Materials and Methods: Two hundred sixty patients undergoing surgery under general anesthesia were randomized into two groups, A with 130 patients receiving gabapentin 2.0 to 3.5 mg/kg orally for premedication add-on, and B with 130 patients getting morphine 0.1 to 0.2 mg/kg intravenously. After surgery, a co-researcher assessed patients using Ramsay sedation scale (RSS) and pain numeric rating scale (NRS) at 2, 4, 8, 12, 16, and 24-hour intervals. Results: Two hundred thirty-two patients were included the present study without procedural adverse events. There were 120 and 112 patients in gabapentin and morphine group, respectively. The administration dosage of gabapentin and morphine between the two groups showed statistically significant differences (p=0.031). During the emergence, the RSS on the sedation, agitation, drowsiness, and pain scores of gabapentin (1.8±0.4) and morphine (1.7±0.5) appeared statistically significant differences (p=0.032); however, the RSS on that in the post-anesthetic care unit (PACU) were 2.0±0.1and 2.0±0.2, respectively, which showed insignificant differences (p-value 0.283). Conclusion: A small, single oral dose of gabapentin as premedication showed a synergistic effect on intraoperative morphine administration. However, this additive effect was not long lasting through the PACU and might not be suitable for an extended surgery. Keywords: Drug interaction; Gabapentin; Morphine; Anesthesia

Author(s):  
Tasaduq Javed ◽  
Basharat Ahad ◽  
Pushpinder Singh ◽  
Riyaz Ahmad

Background: Spine surgeries particulary spine fusion surgeries provide a unique challenge with respect to postoperative analgesia as the choices to provide analgesia are limited. Uses of NSAIDS and neuroaxial anaesthesia for post-operative analgesia in spine surgeries have been controversial. Patient controlled analgesia with opioids is commonly used and morphine remains the gold standard. The aim of this study was to compare tramadol with morphine for postoperative analgesia in spine surgeries using iv patient controlled analgesia.Methods: A total of 80 adult patients of ASA grade I and 2 undergoing spine surgeries and divided into two groups i.e. morphine group M and tramadol group T with 40 patients in each group were included in the study. pain assessment was done by NRS (numeric rating scale) upto 48 hours postoperatively other parameters like nausea/vomiting and sedation were also noted. Both groups received boluses initially to control pain. Group M patients received 1mg i.v demand dose of morphine with lock out time of 10-15 minutes and in Group T patients PCA device was set to deliver 20mg i.v demand dose of tramadol with lock out time of 10-15 minutes. A bolus of 25mcg fentanyl was given as rescue analgesia in both groups by the nurse if required. No background infusion or four-hour maximal limit was set on PCA pumps.Results: Pain scores remained on lower side in both the groups, though slightly better with morphine and the difference was statistically significant at 4 hours, 12 hours and 24 hours. The total NRS mean value (0-48 hours) of morphine and tramadol is 3.270 and 3.629 with p value of 0.015 which is statistically significant. 7 patients in morphine group received rescue analgesia while it was received by 15 patients in tramadol group with p value of 0.78 which is statistically insignificant. Nausea and Vomiting was encountered more frequently in the tramadol group. Mean mobilization time in patients of tramadol group was 21.72 hours and that of morphine group was 17.10 hours with p value of 0.00 which is highly significant.Conclusions: Morphine and tramadol when used in PCA mode provide adequate pain relief post operatively after spine surgeries with morphine showing slightly better analgesia profile and significantly less nausea and vomiting than tramadol.  


2020 ◽  
Vol 6 (2) ◽  
pp. 164-170
Author(s):  
Dewi Nurlaela Sari ◽  
Aay Rumhaeni

ABSTRAK Sectio caesarea merupakan tindakan alternatif dalam proses persalinan untuk menyelamatkan ibu dan janin. Ibu Bersalin dengan operasi sectio caesarea dilakukan pembedahan pada dinding abdomen dan dinding rahim. Dampak yang paling sering muncul dirasakan oleh postpartum dengan post operasi sectio caesarea adalah  nyeri. Nyeri akan berdampak pada bounding attachment terganggu, mobilisasi terbatas, Activity Daily Living (ADL) terganggu serta berpengaruh  terhadap Inisiasi Menyusui Dini (IMD). Asuhan yang diberikan terbatas pada terapi farmakologi dibandingkan  non farmakologi. Foot massage adalah salah satu terapi non farmakologi yang dapat membantu menutup gerbang di posterior horns dari sumsum tulang belakang dan memblokir bagian dari nyeri ke sistem saraf pusat. Tujuan penelitian ini untuk mengetahui pengaruh foot massage terhadap skala nyeri pada klien post operasi sectio caesarea di RS AMC. Penelitian ini merupakan penelitian pre eksperimen dengan pendekatan one group pre test post test design. Jumlah sampel yang digunakan berjumlah 27 orang dengan menggunakan teknik purposive sampling. Instrumen yang digunakan adalah Numeric Rating Scale (NRS) dan prosedur kerja foot massage. Responden dilakukan foot massage selama 20 menit selama 2 hari. Data di analisis dengan menggunakan uji wilcoxon. Hasil penelitian menunjukkan lebih dari setengah klien post operasi sectio caesarea berada di skala nyeri 6 sebelum dilakukan foot massage dan hampir setengah memiliki skala nyeri 3 sesudah dilakukan foot massage dan didapatkan nilai p value = 0.000, sehingga disimpulkan ada pengaruh foot massage terhadap skala nyeri pada klien post operasi sectio caesarea. Diharapkan rumah sakit dapat menjadikan foot massage sebagai salah satu alternatif manajemen non farmakologi dalam penanganan nyeri.   Kata kunci: Foot Massage; Post Partum; Nyeri; Sectio Caesarea      


2019 ◽  
Vol 8 (2) ◽  
pp. 152
Author(s):  
Adi Antoni ◽  
Yanna Wari Harahap

Abstrak   Latar belakang: Diabetes mellitus (DM) merupakan penyakit kronik dan menjadi masalah global. Salah satu komplikasi yang ditimbulkan dari DM adalah luka kaki diabetic. Langkah awal dalam perawatan luka kaki diabetic adalah mencuci luka. Tujuan penelitian ini adalah mengetahui keefektifan dari rebusan daun jambu biji sebagai cairan pencuci luka terhadap tingkat malodor pada luka kaki diabetic. Metode: Desain penelitian yang digunakan adalah quasy experiment dengan rancangan one group pretests-posttest only. Teknik sampling yang digunakan adalah consecutive sampling dengan jumlah sampel 16 orang. Kriteria sampel yang digunakan adalah klien luka kaki diabetic, tingkat malodor 1-10 dengan NRS. Alat ukur yang digunakan adalah Numeric Rating Scale (NRS). Analisa data yang digunakan dalam penelitian ini menggunakan uji paired t test. Hasil: tingkat malodor sebelum intervensi pencucuan luka menggunakan rebusan daun jambu biji rata-rata sebesar 4.40 dan sesudah intervensi sebesart 2.44 dengan p value < 0.001. Selisih tingkat malodor antara sebelum dan sesudah intervensi sebesar 1.96. Hasil penelitian ini menunjukkan bahwa daun jambu dapat digunakan sebagai cairan pencuci luka dalam mengatasi tingkat malodor pada luka kaki diabetik. Kesimpulan : daun jambu biji dapat digunakan sebagai cairan pencuci luka pada luka kaki diabetic. Perawat diharapkan dapat memanfaatkan daun jambu biji sebagai salah satu alternatif dalam pencucian luka kronik khususnya luka kaki diabetik.   Kata kunci: Daun Jambu Biji, Tingkat Malodor, Luka Kaki Diabetik   Abstract   Background: Diabetes mellitus (DM) is a chronic disease and a global problem. One of the complications that arise from DM is diabetic foot ulcer. The first step in treating diabetic foot ulcer is washing the wound. The purpose of this study was to determine the effectiveness of guava leaf decoction as a washing fluid for malodor levels in diabetic foot ulcer. Method: The research design used was quasy experiment with one group pretests-posttest only design. The sampling technique used was consecutive sampling with a sample of 16 people. Sample criteria used were diabetic foot ulcer clients, malodor level 1-10 with NRS. The measuring instrument used is the Numeric Rating Scale (NRS). Analysis of the data used in this study used paired t test. Results: the level of malodor before intervening in wound washing using guava leaf decoctions on average was 4.40 and after the intervention was 2.44 with p value <0.001. The difference in the level of malodor between before and after the intervention was 1.96. The results of this study indicate that guava leaves can be used as a washing fluid in dealing with malodor levels in diabetic foot ulcer. Conclusion: Guava leaves can be used as a washing fluid for diabetic foot wounds. Nurses are expected to be able to use guava leaves as an alternative in washing chronic wounds, especially diabetic foot injuries.   Key words: Guava Leaf, Malodor Level, Diabetic foot ulcer.


2018 ◽  
Vol 1 (2) ◽  
pp. 120-127
Author(s):  
Yunita Liana

Young women often feel primary dysmenorrhoea because the hormonal cycles experienced are not stable, this can disrupt the concentration and activity of young women. The principle of back to nature is increasingly popular today, the side effects of chemical drugs can cause new problems, it is one of the driving force of the development of traditional medicine. Papaya leaves contain Vitamin E which can reduce dysmenorrhea. In addition, turmeric acids also contain curcumine and anthocyanins that inhibit cyclooxygenase, thereby reducing the occurrence of inflammation during uterine contractions. The aim of this research is to know the effectiveness of papaya leaf stew with acidic turmeric to primary dysmenorrhea. Type of Research is an experimental study with a Pretest-Posttest Control Group Design design. The sample is 30 people. The research was conducted on December 27, 2017 s.d February 24, 2018 at SMP Negeri 46 Palembang. Instrument to measure pain Numeric Rating Scale. The statistical test used by Wilcoxon and Mann Whitney U. Average score of pain before papaya leaves stem 5.40 ± 0.73 while the mean score of pain after given turmeric acid 5.33 ± 0.61 The mean score of pain after being given papaya leaves stew 3.60 ± 0.91 while the mean score of pain after given turmeric acid 4.06 ± 0.79. There was a difference of mean score of dysmenorrhea pain before and after given papaya leaf stem p value = 0.000. There is difference of mean score of dysmenorrhea pain before and after given turmeric acid p value = 0,002. There was no difference of mean score of dysmenorrhea pain before and after given papaya leaf sting and turmeric acid p value = 0,217. The decoction of papaya leaf and turmeric acid have the same effectiveness in reducing primary dysmenorrhea pain.


2021 ◽  
Vol 3 (2) ◽  
pp. 110-116
Author(s):  
Ririn Harini ◽  
Juwitasari Juwitasari ◽  
Lilis Setyowati ◽  
Rifdah Dita Oktavia

Background: Post caesarean section mothers commonly feel pain in the post-operative area during the wound healing process. Most post-operative mothers feel the pain sensation as a disturbance and lowering their quality of sleep.Purpose: To determine pain level and identify the relationship of pain level and sleep quality among mothers who delivered by caesarean section under spinal anaesthesia.Method: The descriptive non-experimental correlative study design identified 50 mothers from Inpatient Ward  Wava Husada Hospital of Kepanjen, Malang, East Java, Indonesia at April 2020. The Post-caesarean section pain level identified by using the Numeric Rating Scale (NRS) and the sleep quality is measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire.Results: 38 mothers (76%) had severe pain level and most of them (43 mothers) had poor sleep quality. The Spearman correlation test showed that there was a relationship between the Post-caesarean section pain level and sleep quality, p value = 0.000 (p <0.05) and r = 0.314.Conclusion: The post-caesarean section pain levels among mothers who delivered by caesarean section under spinal anaesthesia should be identified earlier as we would like to encourage the nursing staff to give further intervention to maintain their sleep quality.


2019 ◽  
Vol 2 (1) ◽  
pp. 23
Author(s):  
Nur Masruroh ◽  
Nur Aini Fitri

Dismenore merupakan nyeri selama menstruasi yang disebabkan oleh adanya kejang pada otot rahim. Terdapat beberapa faktor yang mempengaruhi terjadinya dismenore, diantaranya yaitu asupan nutrisi yang terdiri dari Fe (zat Besi). Tujuan penelitian ini adalah untuk mengetahui hubungan kejadian dismenorea dengan asupan Fe (zat Besi) pada remaja putri .  Jenis penelitian ini adalah analitik observasional dengan rancangan cross sectional. Jumlah sampel sebanyak 112 yang diambil menggunakan teknik propostionate stratified random sampling. Data kejadian dismenore diperoleh dari kuesioner numeric rating scale dan data asupan zat gizi diperoleh dari form semi quantitative food frequency questionaire. Hasil penelitian menunjukkan bahwa sebagian remaja putri memiliki asupan Fe (zat Besi) kurang (50%). Sedangkan kejadian dismenorea yang dialami hampir setengahnya termasuk dalam kategori nyeri ringan (45,5%). Hasil analisis menggunakan uji rank sprearman menunjukkan bahwa ada hubungan kejadian dismenorea dengan asupan Fe (zat Besi) dengan nilai p-value = 0,014. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa semakin tinggi asupan Fe (zat Besi), maka semakin rendah kejadian dismenorea yang dirasakan. Diharapkan remaja putri dapat mencegah dan mengurangi nyeri dengan mengkonsumsi makanan sumber Fe (zat Besi).


2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19646-19646
Author(s):  
S. Subongkot ◽  
S. Khounnikhom ◽  
N. Pratheepawanit Johns ◽  
A. Sookprasert

19646 Background: Pain is among the most common symptoms encountered in cancer patients and remains the first priority of care. Methods: This cross sectional study aimed to explore a pattern of pain management at KKU Hospital by utilizing a numeric rating scale (0–10). Cancer pain patients were categorized based on prior analgesic exposure into two groups; Naïve group, and Routine group. Treatments were defined according to WHO as 1) drug treatment relevant to pain severity, 2) analgesics being prescribed as around-the- clock and 3) analgesics used for break-through pain for patients receiving strong opioid. Results: From Dec 2005 to Jul 2006, 261 patients were enrolled. 93.1% (n=243) were in advanced stages and 88.5% (n=231) were in moderate to severe pain. This pain interfered with patient’s daily life activities mildly to moderately as each pain score increased (p-value<0.01). In Naive group (n=159), 32.7% (n=52) were given analgesics following the WHO on both days 1 and day 3 of admission whereas 40.2% (n=64) patients were not. A decreased pain score was greater (2.61, SD±1.5) in a group following the WHO on day 1. Additionally, a decreased pain score was greater (3.91, SD±1.8) in a group following the WHO on day 3 (p-value <0.0001). This pain score decreased was also clinically significant as pain score reduced more than 3 points. In Routine group (n=102), 32 (31.4%) were given analgesics following the WHO guideline on both day 1 and day 3 of admission. In contrast, 36 (35.3%) were not. A decreased pain score was greater (2.59, SD±1.8) in a routine group following the WHO on day 1. Moreover, a decreased pain score was greater (3.95, SD±1.8) in a group following the WHO on day 3. The clinical significance of pain score reduced was also found on day 3. Of the 261 evaluable patients, the pattern of analgesics usage following the WHO guideline was increased in both groups comparing to at the beginning of the study. Conclusions: The results demonstrated that patients who received pain management following the WHO guideline reported significantly lower pain intensity than those not following the WHO. No significant financial relationships to disclose.


Author(s):  
Lupi Lestari ◽  
Elizeus Hanindito ◽  
Arie Utariani

Introduction: Effective postoperative pain management provides improved patient comfort and satisfaction, earlier mobilization, fewer pulmonary and cardiac complications, reduced risk deep vein thrombosis, fast recovery, and reduced cost of care. Preemptive analgesia, initiated before the surgical procedure to prevent pain in the early postoperative period, has the potential to be more effective than a similar analgesic treatment initiated after surgery. As a part of multimodal analgesia, the use of NSAIDs should always be considered for acute postoperative pain management. NSAIDs can be used preoperatively as a part of the preemptive regimen and for postoperative pain control to increase the efficacy of opioids and reduce its side effects. Material and Method: This research was experimental research with a case-control design of the study. The samples separated into two groups, the first group got ketoprofen suppository before the induction, and the second group didn’t get the ketoprofen suppository The intensity of pain measured with the Numeric Rating Scale (NRS) or Wong-Baker Faces Pain Scale was the variable studied at different postoperative times (30 min, 60 min, 120 min, 2-6 hours, 6-12 hours). The total amount of rescue analgesics (fentanyl) and side effects were other variables of this study. Result and Discussion: The result is ketoprofen suppository as preemptive analgesia administrations can reduce postoperative pain. Numeric Rating Scale was significantly lower in the ketoprofen group compared to the control group (p < 0,05) at 30 min, 60 min, 230 min, 2-6 hours, 6-12 hours. The number of postoperative analgesics needed in the recovery room was significant differences among both groups (p < 0,05). Conclusion: Preemptive analgesia in patients who underwent an operation with general anesthesia with ketoprofen suppository was effectively in blocking noxious stimuli and central sensitization, with subsequent prevention of acute postoperative pain.


2019 ◽  
Vol 11 (2) ◽  
pp. 135-142
Author(s):  
Priyanto Priyanto ◽  
Idia Indar Anggraeni

Nyeri dada merupakan keluhan utama yang sering dirasakan oleh penderita penyakit jantung koroner. Nyeri dada muncul karena suplai oksigen ke miokardium menurun. Terapi murottal Al-Qur’an merupakan terapi religi dimana seseorang akan diperdengarkan ayat-ayat Al-Qur’an selama beberapa menit sehingga akan memberikan dampak positif bagi tubuh seseorang, salah satunya untuk mengurangi rasa nyeri. Penelitian ini bertujuan untuk mengetahui perbedaan tingkat nyeri dada sebelum dan setelah dilakukan terapi murottal Al-Qur’an. Desain penelitian ini menggunakan metode pre-experimental dengan desain one group Pre-test dan Post-test. Metode sampling yang digunakan adalah accidental sampling, dan jumlah sampel sebanyak 17 responden. Instrument penelitian yang digunakana dalah Numeric Rating Scale untuk mengukur skala nyeri sebelum dan setelah terapi murottal Al-Qur’an, pemberiannya sekali selama 20 menit. Uji statistic yang digunakan adalah paired sample T test. Hasil dari penelitian ini menunjukkan bahwa ada perbedaan yang bermakna tingkat nyeri dada sebelum dan setelah dilakukan terapi murottal Al-Qur’an dengan nilai p-value 0,000 (p < α (0,05)). Terapi murottal Al-Qur’an dapat menurunkan skala nyeri dada pasien.   Kata kunci: nyeri dada, terapi murottal al-qur’an THE DIFFERENCE  BETWEEN CHEST PAIN LEVEL BEFORE AND AFTER MUROTTAL AL-QUR'AN THERAPY   ABSTRACT Chest pain is a major complaint that is often felt by people with coronary heart disease. Chest pain occurs because of decreased supply of oxygen to the myocardium. Murottal Al-Qur'an therapy is a religious therapy where someone will be heard verses of Al-Qur’an for a few minutes so it will have a positive impact on one’s body, one of them is to reduce pain. This study aims to find out the difference  between chest pain level before and after murottal Al-Qur'an therapy.This research design used pre-experimental method with one grouppre-test and post-test. The sampling method was accidental sampling, the number of sampling were 17 respondents. The research instrument used the Numeric Rating Scale to measure pain scale before and after murottal Al-Qur'an therapy, giving it once for 20 minutes. The test statistic used is paired sample T test.The results of this study indicate that there are significan differences in chest pain levels before and after murottal Al-Qur'an therapy with a p-value of 0.004 (p <α (0.05)).Murottal Al-Qur'an therapy can reduce the scale of patient's chest pain.   Keywords : chest pain, murottal al-qur’an therapy


2018 ◽  
Vol 14 (1) ◽  
pp. 91
Author(s):  
Khairun Nuhan ◽  
Titi Astuti ◽  
Al Murhan

<p>Prevalensi persalinan <em>sectio caesarea </em>di Indonesia menurut WHO pada tahun 2015 adalah 15,3%. Pada pasien post operasi <em>sectio caesarea</em>setelah anestesi menghilang pasien akan merasakan nyeri, sehingga diperlukan terapi yang efektif dan aman dari efek samping. Terapi Al-Qur’an salah satu bentuk teknik distraksi (pengalihan) secara non farmakologi untuk menurunkan intensitas nyeri yang dirasakan.Keberhasilan menggunakan murrotal 70 % dari penelitian terkait.Penelitian ini menggunakan desain<em>quasi exsperiment</em> dengan pendekatan <em>nonrandomized control grup pretest postests design</em>.Teknik pengambilan sampel dengan menggunakan teknik <em>accidental sampling</em> sebanyak 22 responden (11 responden kelompok perlakuan dan 11 responden kelompok kontrol).Pengumpulan data nyeri menggunakan instrumen <em>Numeric Rating Scale</em> (NRS).Uji statistik menggunakan Wilcoxon dan Mann-Withney. Hasil penelitian terdapat  perbedaan pengaruh terapi murottal Al-Qur’an terhadap penurunan intensitas nyeri pada pasien post operasi SC pada kelompok perlakuan dan kelompok kontrol p-value 0.001. Peneliti menyarankan agar pihak RS mempertimbangkan menggunakan terapi komplementer murottal Al-Qur’an untuk mempersiapkan ibu menghadapi operasi SC menggunakan SOP yang ada.</p>


Sign in / Sign up

Export Citation Format

Share Document