FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN MIANA (Coleus Scutelleroides (L.) Benth.) DENGAN BERBAGAI BASIS

AbstractMiana leaves (Coleus Scutelleroides (L.) Benth.) contained flavonoid compounds that has antioxidants properties. This study aimed to formulate peel-off gel mask ethanol extract from Miana leaves became peel-off gel mask that is physically stable and to knows the type of base that form a formulation with good physical quality based on the test parameters of physical properties and the stability of preparation. Formulation of peel-off gel mask ethanol extract of miana leaves used three different types of base, they are HPMC, Carbopol, and Na.CMC. Each formula is differentiated based on base of concentration which were HPMC 4%, carbopol 1%, and Na.CMC 3%. Evaluation to predict the physical stability of the preparation included organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and dry time test. In stability test, each formula is placed at temperature 27 oC for 28 days and made observation on the 1st, 7th, 14th, 21th, and 28th day. Based on the result, the ethanol extract of Miana leaves can be formulated into a peel-off mask and formulation with HPMC and Carbopol base has a good physical quality and physically stable compared to Na.CMC base.Keywords: Miana Leaves, Peel-Off Gel Mask, Stability Teh AbstrakDaun Miana (Coleus Scutelleroides (L.) Benth.) memiliki kandungan senyawa flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun Miana menjadi masker gel peel-off yang stabil secara fisik serta mengetahui jenis basis yang membentuk formulasi sediaan masker dengan mutu fisik yang baik berdasarkan parameter uji sifat fisik dan stabilitas sediaan. Formulasi sediaan masker gel peel-off ekstrak etanol daun Miana dibuat dengan menggunakan tiga jenis basis yang berbeda yaitu HPMC, karbopol, dan Na.CMC. Masing-masing formula dibedakan berdasarkan basis konsentrasi yaitu HPMC 4%, karbopol 1%, dan Na.CMC 3%. Evaluasi yang dilakukan terhadap stabilitas fisik sediaan masker gel peel-off meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji waktu mengering. Uji stabilitas dilakukan pada suhu kamar (27 oC) selama 28 hari dan dilakukan pengamatan pada hari ke 1, 7, 14, 21, dan 28. Hasil uji stabilitas fisik sediaan masker gel peel-off ekstrak etanol daun Miana dapat diformulasikan dalam bentuk sediaan masker gel peel-off , dan formula masker dengan basis HPMC dan karbopol memiliki mutu fisik yang baik dan stabil secara fisik dibandingkan dengan basis Na.CMC.Kata kunci: Daun Miana, Masker gel peel-off, Uji Stabilitas.

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FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

PHARMACON ◽

10.35799/pha.8.2019.29289 ◽

2019 ◽

Vol 8 (2) ◽

pp. 261

Author(s):

Meyla C. M. Pratasik ◽

Paulina V. Y. Yamlean ◽

Weny I Wiyono

Keyword(s):

Experimental Method ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Adhesion Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Dispersion Test ◽

The Right

ABSTRACT Sesewanua Leaves (Clerodendron squamatum Vahl.) have the potential to be made as skin care cosmetic preparations but must be in the right formulation to achieve the desired effect. The aim of this study was to determine the physical stability of a cream from Sesewanua leaf extract. This study used a experimental method by making ethanol extract of Sesewanua leaves with a concentration of 0.5% and physical stability test. Physical evaluation was carried out before and after cycling test through organoleptic observation, homogenety test, pH test, dispersion test, adhesion test, viscosity test, centrifugation test and cream type determination. The results of the physical evaluation showed that F1 without Sesewanua leaf extract and F2 with Sesewanua leaf extract creams met the requirements of physical stability, so can be concluded that Sesewanua leaf extract can be formulated into cream preparations with concentration of 0.5% which is physically stable before and after cycling test. Keywords: Sesewanua Leaves, Cream, Physical Stability ABSTRAK Daun Sesewanua (Clerodendron squamatum Vahl.) berpotensi untuk dibuat sebagai sediaan kosmetik perawatan kulit namun harus dengan formulasi yang tepat agar mencapai efek yang diinginkan. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sediaan krim ekstrak daun sesewanua. Penelitian ini menggunakan metode eksperimental dengan membuat krim ekstrak etanol daun Sesewanua dengan konsentrasi 0,5% dan uji stabilitas fisik. Evaluasi fisik dilakukan sebelum dan sesudah cycling test melalui pengamatan organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas, uji sentrifugasi dan penentuan tipe krim. Hasil evaluasi fisik menunjukkan krim F1 tanpa ekstrak daun Sesewanua dan F2 dengan ekstrak daun Sesewanua memenuhi persyaratan stabilitas fisik. Berdasarkan hasil penelitian dapat disimpulkan ekstrak daun sesewanua dapat diformulasi menjadi sediaan krim dengan konsentrasi 0,5% yang stabil secara fisik sebelum dan sesudah cycling test. Kata Kunci : Daun Sesewanua, Krim, Stabilitas Fisik

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Uji Stabilitas Fisik Sediaan Masker Gel dari Ekstrak Alga Merah (Poryphyra sp)

Majalah Farmasetika ◽

10.24198/mfarmasetika.v5i1.24066 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Aurina Megawati Numberi

Keyword(s):

Red Algae ◽

Antimicrobial Agents ◽

Physical Stability ◽

Stability Test ◽

Homogeneity Test ◽

Study Program ◽

Safety Test ◽

Time Test ◽

Dispersion Test ◽

Smirnov Test

ABSTRAKNumberi, Aurina M. 2019. UJI STABILITAS FISIK SEDIAAN MASKER GEL DARI EKSTRAK ALGA MERAH (Poryphyrasp).Skripsi Program Studi Farmasi, Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Cenderawasih Jayapura.Tumbuhan Alga merah ini berasal kampung Sarwandori kepulauan Yapen, Serui. Kandungan kimia dalam alga merah antara lain alkaloid, terpen, dan flavonoid yang berfungsi sebagai, anti kanker, dan anti mikroba. Sediaan masker merupakan salah satu bentuk sediaan semi solida yang mampu melekat pada permukaan tempat pemakaian dalam waktu yang cukup lama sebelum sediaan ini dicuci atau dihilangkan. Tujuan penelitian ini adalah untuk mengetahui mutu fisik sediaan masker gel ekstrak alga merah dan formula terbaik. Selanjutnya metode eksperimen dilakukan untuk mengetahui uji stabilitas fisik berupa uji organ oleptik berupa warna bau dan bentuk, uji ph, uji iritasi, uji daya lekat, uji daya sebar, uji homogenitas, uji proteksi, uji keamanan, uji waktu kering dan uji penyimpanan selama 31 hari. Analisis data menggunakan SPSS Kolmogrov-Smirnov Test, ANOVA oneway, danT-Test. Hasil yang didapat pada uji organ oleptik masker berwarna bening coklat, memiliki uji homogenitas ketiga sediaan masker tidak mengalami penggumpalan, uji daya sebar berkisaran dari 741-0,59 cm, uji daya lekat berkisar antara 0,865 detik dan 0,551 detik, uji daya proteksi dari ketiga formula masker baik, uji pH hari ke 0 bernilai5,33 dan hari ke 31 bernilai 7,12, uji waktu kering hari ke 0 bernilai 4-50 menit dan hari ke 31 bernilai 15-30 menit ,uji keamanan dari 30 relawan hanya ada 3 orang relawan yang mengalami iritasi ringan dari formula I hari ke 0 sampai hari ke 31 relawan mengalami iritasi, semua pengujian dilakukan 3 kali replikasi. Dari Ketiga formula stabil, dan F II merupakan formula terbaik .Kata kunci : Ekstrak alga merah, Masker Gel, Stabilitas Fisik. ABSTRACTNumberi, Aurina, M. 2019. Physical Stability Test of Mask Gel Preparations Form Red Algae (Poryphyra sp) Extract. Unpublished Undergraduate Thesis, Pharmacy Study Program, Department of Pharmacy, Faculty of Mathematics and Science, Cenderawasih University. Red algae. This plant originated the Sarwandori Village, Yapen Islands (Serui). Chemical content in red algae including alkaloids, terpenes and flavonoids that function as anticancer and antimicrobial agents. mask preparation is a form of semi-solid preparation mask algae red and the best formula to the surface of the application for a long time before the preparation is washed or removed. The research in purposes of study were to determine physical quality and stability as well as the effect of the red algae mask base concentration , The proceed with a carried out experimental method to determine the physical stability test in the form of sorganoleptic test in the form of color and odor shape, pH test, irritation test, stickiness test, scattering test, homogeneity test, protection test, safety test, dry time test and storage test for 31 days. Data analysis using SPSS Kolmogrov-Smirnov test, ANOVA oneway, and T-Test. The results obtained in the organoleptic test were clear brown clear masks, had a homogeneity test of thee mask preparations which did not undergo collection, dispersion test ranged from 741 to 0.59 cm, adhesion tests ranged from 0.865 seconds and 0.551 seconds, the protective power of the three formulas good mask, pH test day 0 was worth 7.12, dry time test day 0 is worth 4-50 minutes and the to 31 days is worth 15-30 minutes safety test from 30 volunteers there were only 3 volunteers who were irritated, all testing was done 3 times. Three stable formulas F II, is the best formula.Keywords : Red Algae (Poryphyrasp), Extract Physical, Stability Gel

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FORMULASI DAN UJI EFEKTIVITAS ANTIFUNGI KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium polianthum (Wight) Walp.) TERHADAP JAMUR Candida albicans

PHARMACON ◽

10.35799/pha.10.2021.34033 ◽

2021 ◽

Vol 10 (2) ◽

pp. 841

Author(s):

Sheren N. Lolowang ◽

Paulina V.Y. Yamlean ◽

Karlah L.R. Mansauda

Keyword(s):

Candida Albicans ◽

Antifungal Activity ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Average Diameter ◽

Statistical Test ◽

Adhesion Test ◽

Physical Evaluation ◽

Dispersion Test

ABSTRACT Bay leaf (Syzygium polianthum (Wight) Walp.) are used as natural medicinal ingredients because contain compounds such as flavonoid, saponin and tannin that can inhibit the growth of fungal. The purpose of this study was to test the antifungal effectiveness of bay leaf ethanol extract cream and evaluate the preparation of physical stability. The research that was carried out was laboratory experimental. Bay leaf extract was obtained by maceration using 96% ethanol. The cream preparation was made with variations in the concentration of Bay leaf ethanol extract formula 1%; 3%; 6% and 9%. The method used to test the antifungal effectiveness is the well method. The result of the antifungal test showed an average diameter value for formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm and formula IV (9%) 15 mm. Statistical test of ethanol extract cream of Bay leaf produced the largest inhibiton zone of 15 mm at a concentration of 9%. Physical evaluation showed that the cream preparations met organoleptic requirements, homogeneity, pH 4.83, dispersion test 5.30 cm, adhesion test 7.01 seconds. It can be concluded that the ethanol extract of bay leaf can be formulated into a cream preparation that is physically stable and has strong antifungal activity. Keywords: Bay Leaf, Antifungal Cream, Candida albicans ABSTRAK Daun Salam (Syzygium polianthum (Wight) Walp.) dimanfaatkan sebagai bahan obat alami karena memiliki kandungan senyawa flavonoid, saponin dan tannin yang dapat menghambat pertumbuhan jamur. Penelitian ini bertujuan menguji efektivitas antijamur sediaan krim ekstrak etanol daun salam dan mengevaluasi kestabilan fisik sediaan. Penelitian yang dilakukan bersifat eksperimental laboratorium. Ekstrak daun Salam diperoleh dengan cara maserasi menggunakan etanol 96%. Sediaan krim dibuat dengan variasi konsentrasi formula ekstrak daun Salam 1%; 3%; 6% dan 9%. Metode yang digunakan untuk uji efektivitas antijamur yaitu metode sumuran. Hasil pengujian antijamur menunjukkan nilai diameter rata-rata pada formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm dan formula IV (9%) 15 mm. Uji statistika krim ekstrak etanol daun salam menghasilkan zona hambat terbesar yaitu 15 mm pada formula IV konsentrasi 9%. Evaluasi fisik menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptik, homogenitas, pH 4.83, daya sebar 5.30 cm, dan daya lekat 7.01 detik. Dapat disimpulkan bahwa ekstrak etanol daun salam dapat diformulasikan menjadi sediaan krim yang stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci: Daun Salam, Krim Antijamur, Candida albicans

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FORMULASI DAN UJI STABILITAS SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL BUAH MENTIMUN (Cucumis sativus L.)

Journal of Pharmaceutical Care Anwar Medika ◽

10.36932/jpcam.v3i2.43 ◽

2021 ◽

Vol 3 (2) ◽

pp. 110-125

Author(s):

Yani Ambari ◽

◽

Hanik Endah Paramita ◽

Arista Wahyu Ningsih ◽

◽

...

Keyword(s):

Physical Stability ◽

Ethanol Extract ◽

Homogeneity Test ◽

Adhesion Test ◽

Cucumis Sativus L ◽

Antibacterial Compounds ◽

Hand Sanitizer ◽

Cucumber Fruit ◽

Gel Preparation ◽

Made In

Hand Sanitizers generally contain chemicals in the form of alcohol and triclosan. However, the use of these two ingredients can cause danger if they are used continuously, therefore the Hand Sanitizer antiseptic product was innovated using ethanol extract of cucumber fruit which contains antibacterial compounds to reduce the use of both ingredients. The purpose of this study was to make a Hand Sanitizer gel formulation from ethanol extract of cucumber fruit and to determine the physical stability of the preparation during storage. Hand Sanitizer Gel of cucumber fruit ethanol extract is made in three formulations withdifferent extract concentrations, namely F1 (1.5%), F2 (2.5%), and F3 (3.5%). The results of the organoleptic test included the three formulations, namely that the three of them did not change during storage. The results of the homogeneity test included F1 and F2 which were stated to be homogeneous while F3 was not homogeneous. The results of the pH test included that during storage the three had decreased until week 3 and increased thepH again at week 4. The results of the spreadabilitytest of the three preparations met the requirements for the gel preparation, but in the adhesion test the three preparations did not meet the adhesion requirements of the gel preparation.

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Formulasi Sediaan Krim Dari Ekstrak Kulit Pisang Kapas (Musa paradisiaca Linn).

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.786 ◽

2021 ◽

Vol 1 ◽

pp. 1035-1045

Author(s):

D Dananirroh ◽

Urmatul Waznah ◽

W Wirasti ◽

S Slamet

Keyword(s):

Ethanol Extract ◽

Banana Peel ◽

Homogeneity Test ◽

Herbaceous Plant ◽

Test Results ◽

Adhesion Test ◽

Banana Plant ◽

Musa Paradisiaca ◽

Physical Evaluation ◽

Dispersion Test

AbstractMusa paradisiaca Linn, also known as the banana plant in Indonesia, is a herbaceous plant that belongs to the Musaceaa family. Cotton banana peel (Musa paradisiaca Linn.) can be used as a wound medicine. For use, it is still simple, namely by applying the inside of the banana peel to the injured body part, and by scraping the banana peel from the inside to bandage the wound. For this reason, it is necessary to develop a dosage form of this cotton banana peel so that it is easier and provides comfort in its use. Purpose: To find out the skin of cotton banana (Musa paradisiaca Linn) is formulated in cream preparations. The method in this study was experimental, the sample was extracted by maceration using 96% ethanol as solvent. The viscous extract obtained was used at concentrations of 0.08%, 0.10%, and 0.12%. The results showed that cotton banana peel extract (Musa paradisiaca Linn) could be made as a cream and fulfilled the physical evaluation of the preparation. The results of the homogeneity test were that the preparations were made homogeneous, the pH of the cream was obtained at pH 5-7 still fulfilling the skin pH range of 4-7, the adhesion test results obtained more than 5 seconds, the dispersion test results obtained 6-7 cm, the viscosity test at formula I is 3564 – 4253 cPas, Formula II is 4042 – 4746 cPas, Formula III is 4466 – 5254 cPas. The conclusion of this study, the formulation of the ethanol extract cream of cotton banana peel (Musa paradisiaca Linn) met the requirements for physical evaluation of the preparation including homogeneity test, pH test, organoleptic test, dispersibility test, adhesion test, viscosity test and stability test.Keywords: Formulation, banana peel, cream, evaluation. AbstrakMusa paradisiaca Linn atau dikenal dengan nama tumbuhan pisang di Indonesia adalah tumbuhan herba yang termasuk dalam keluarga Musaceaa. Kulit buah pisang kapas (Musa paradisiaca Linn.) dapat digunakan sebagai obat luka. Untuk penggunaan masih sederhana yaitu dengan mengoleskan bagian dalam dari kulit buah pisang pada bagian tubuh yang luka, dan dengan cara mengorek kulit buah pisang dari dalam untuk membalut luka. Untuk itu perlu adanya pengembangan bentuk sediaan dari kulit pisang kapas ini sehingga lebih memudahkan dan memberikan kenyamanan dalam penggunaannya. Tujuan Untuk mengetahui kulit buah pisang kapas (Musa paradisiaca Linn) diformulasikan dalam sediaan krim. Metode pada penelitian ini dilakukan secara eksprimental, sampel di ekstraksi dengan cara maserasi dengan menggunakan pelarut etanol 96%. Ekstrak kental yang diperoleh digunakan pada konsentrasi 0.08%, 0.10%, dan 0.12%. Hasil penelitian menunjukkan bahwa ekstrak kulit pisang kapas (Musa paradisiaca Linn) dapat dibuat sebagai krim dan memenuhi evaluasi fisik sediaan. Hasil uji homogenitas bahwa sediaan yang dibuat homogen, pH krim diperoleh pH 5-7 masih memenuhi kisaran pH kulit 4-7, uji daya lekat hasil yang diperoleh lebih dari 5 detik, uji daya sebar hasil yang diperoleh 6 – 7 cm, uji viskositas pada formula I yaitu 3564 – 4253 cPas, Formula II yaitu 4042 – 4746 cPas, Formula III yaitu 4466 – 5254 cPas. Kesimpulan pada penelitian ini, formulasi sediaan krim ekstrak etanol kulit pisang kapas (Musa paradisiaca Linn) memenuhi syarat evaluasi fisik sediaan meliputi uji homogenitas , uji pH, uji organoleptis, uji daya sebar, uji daya lekat, uji viskositas dan uji stabilias.Kata kunci: Formulasi, kulit pisang, krim, evaluasi.

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FORMULASI SEDIAAN LOTION SARI KERING HERBA PEGAGAN (Centella asiatica(L.) URBAN ) DENGAN VARIASI KONSENTRASI EMULGATOR SPAN 60 DAN TWEEN 60

Media Farmasi ◽

10.32382/mf.v16i1.1424 ◽

2020 ◽

Vol 16 (1) ◽

pp. 1

Author(s):

Arisanty Arisanty ◽

Santi Sinala ◽

Muli Sukmawaty ◽

Andi Masna

Keyword(s):

Centella Asiatica ◽

Physical Quality ◽

Accelerated Storage ◽

Before And After ◽

Quality Stability ◽

Dispersion Test ◽

The Stability ◽

Tween 60 ◽

Span 60

Gotu Kola (Centella asiatica (L.) Urb) is a plant widely grown and scientifically proven to be an antioxidant. This study makes a lotion formula containing dried Gotu kola herb with varying concentrations of emulgator span 60 and tween 60. It determines the concentration of span 60 and tween 60, producing lotions with the most stable physical quality and accelerated storage methods. The lotion was prepared using a concentration of Centellaasiatica (L.) Herbaceous Dry Herb extract of 1% and an Emulgator span 60 and tween 60 in a concentration variation of 5%, 7.5%, and 10%. The stability of the lotion was determined based on quality observations. The physical condition before and after the storage is accelerated for six cycles at a temperature of 5oC and 35oC in organoleptic, homogeneous, pH, viscosity, diffusion power, and emulsion type. The research results show the physical quality stability of formula I (5% emulgator) did not meet the requirements of the dispersion test before storage was accelerated. In contrast, the formula with a 7.5% emulgator met the physical quality requirements of the preparation before and after storage was accelerated. Additionally, the 10% emulgator did not meet the requirements of the dispersion test after accelerated storage. The type of emulsion in all three formulas is the M / A type. The most stable physical quality of the three preparations is a formula with a 7.5% emulgator.Keywords: Lotion, Gotu kola (Centella asiatica (L.) Urb), physical quality, span, and tween.Pegagan (Centella asiatica(L.)Urb) merupakan tanaman yang banyak tumbuh di Indonesia dan telah terbukti secara ilmiah memiliki kemampuan sebagai antioksidan. Penelitian ini bertujuan untuk membuat formula lotion yang mengandung sari kering herba pegagan (Centella asiatica(L.) Urban) dengan variasi konsentrasi emulgator span 60 dan tween 60, dan untuk mengetahui konsetrasi span 60 dan tween 60 yang menghasilkan lotion dengan mutu fisik yang paling stabil dengan metode penyimpanan dipercepat. Sediaan dibuat lotion dengan konsentrasi sari Kering Herba Pegagan (Centellaasiatica(L.) Urban ) sebesar 1% dan Emulgator span 60 serta tween 60 dengan variasi konsentrasi 5%, 7,5%, dan 10% kemudian stabilitas sedian lotion ditentukan berdasarkan pengamatan mutu fisik sebelum dans sesudah penyimpanan dipercepat selama 6 siklus pada suhu 5oCdan 35oC yang meliputi organeleptis, homogentias, pH, viskositas, daya sebar, dan tipe emulsi. Hasil penelitian pada pengujian kestabilan mutu fisik formula I (emulgator 5%) tidak memenuhi syarat pada uji daya sebar sebelum penyimpanan dipercepat, sedangkan Formula dengan emulgator 7,5% memenuhi persyaratan mutu fisik sediaan sebelum maupun sesudah penyimpanan dipercepat, dan formula dengan emulgator 10% tidak memenuhi syarat pada uji daya sebar setelah penyimpanan dipercepat, untuk tipe emulsi pada ketiga formula tersebut merupakan tipe emulsiM/A. Mutu fisik yang paling stabil dari ketiga sediaan tersebut adalah formula dengan emulgator 7,5%.Kata kunci : Lotion, herba pegagan (Centella asiatica (L.) Urb), mutu fisik, span dan tween.

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FORMULASI DAN UJI EFEKTIVITAS KRIM ANTIBAKTERI EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽

10.35799/pha.8.2019.29257 ◽

2019 ◽

Vol 8 (1) ◽

pp. 225

Author(s):

Nurul S Majid ◽

Paulina V. Y. Yamlean ◽

Gayatri Citraningtyas

Keyword(s):

Staphylococcus Aureus ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Inhibition Zone ◽

Quality Test ◽

Antibacterial Compounds ◽

Artocarpus Heterophyllus ◽

Test Parameters

ABSTRACT Jackfruit leaves contain saponins, flavonoids and tannins. Which are know to have antibacterial compounds. The purpose of this study is to make cream of jackfruit leaf extract with a concentration of 5%, 10% and 15% and test the quality of preparations of jackfruit leaf extract cream and there is antibacterial effectiveness against Staphylococcus aureus bacteria. The method used is the ethanol extract of Jackfruit leaves by formulating it as an M/A type cream. The results showed the cream of jackfruit leaf extract fulfilled all the physical stability tests of the cream and in the antibacterial testing of cream of Jackfruit leaf extract could inhibit the effectiveness of Staphylococcus aureus bacteria. As concluded, the Jackfruit leaf extract Conclusions obtained by jackfruit leaf extract can be formulated as a cream with a concentration of 5%, 10% and 15%, and cream preparations meet the cream quality test parameters, for testing the effectiveness of antibacterial to the biggest inhibition zone Staphylococcus aureus is 10.5 mm at 15% concentration. Keywords: Jackfruit leaves, cream antibacterial, Staphylococcus aureus. ABSTRAK Daun Nangka memiliki kandungan saponin, flavonoid dan tannin yang berperan sebagai senyawa antibakteri. Tujuan penelitian ini yaitu membuat krim ekstrak daun Nangka dengan konsentrasi 5%, 10% dan 15%, menguji mutu dan efektivitas antibakteri krim ekstrak daun Nangka terhadap bakteri Staphylococcus aureus. Metode yang digunakan yaitu ekstrak etanol daun Nangka dengan memformulasikan sebagai krim dengan tipe M/A. Hasil penelitian menunjukkan krim ekstrak daun Nangka memenuhi semua uji kestabilan fisik krim dan dalam pengujian antibakteri krim ekstrak daun Nangka dapat menghambat efektivitas bakteri Staphylococcus aureus. Kesimpulan yang diapat ekstrak daun Nangka dapat diformulasikan sebagai krim dengan konsentrasi 5%, 10% dan 15%, dan sediaan krim memenuhi parameter uji kualitas krim, untuk pengujian efektivitas antibakteri terhadap Staphylococcus aureus zona hambat terbesar yaitu 10,5 mm pada konsentrasi 15%. Kata kunci: Daun Nangka, krim antibakteri, Staphylococcus aureus.

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FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis Benth) SEBAGAI ANTIBAKTERI

PHARMACON ◽

10.35799/pha.8.2019.29356 ◽

2019 ◽

Vol 8 (4) ◽

pp. 801

Author(s):

Yulita Ni Nyoman Tri Sukartiningsih ◽

Hosea Jaya Edi ◽

Jainer P. Siampa

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Physical Stability ◽

Homogeneity Test ◽

Adhesion Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Gel Preparation ◽

Ethanol Extracts

ABSTRACT Kaliandra Leaf (Calliandra surinamensis Benth) contains flavonoid compounds, saponins and tannins which are able to inhibit the antibacterial activity. This study aims to test the antibacterial effectiveness of gel preparation of ethanol extracts of kaliandra leaf to obtain the greatest formula, and prove the Kaliandra leaf gel preparation has good physical stability. This study uses a laboratory experimental method. Gel formula is made as many as 5 formulas with variations in the concentration of 2%, 3%, 4%, 5%, and 6% of w : v. Kaliandra leaf extraction was carried out by maceration method using 96% ethanol. The antibacterial test of the ethanol extracts of Kaliandra leaf gel using the method of welling against Staphylococcus aureus bacteria produced a moderate inhibition of 7.0 ± 0.63 mm at a concentration of 6%. The physical evaluation of the preparation includes organoleptic test, homogeneity test, syneresis test, scatter power test, adhesion test, pH test, cycling test, and sterility test. All tests are carried out before and after the cycling test. The results of the study on the preparation fulfilled the physical evaluation requirements before and after the cycling test. It can be concluded that the concentration of 6% of ethanol extracts of Kaliandra leaves could be formulated as a gel preparation that is physically stable and has moderate antibacterial activity. Keywords: Kaliandra (Calliandra surinamensis Benth), Gel preparations, Staphylococcus aureus antibacterial. ABSTRAK Daun Kaliandra (Calliandra surinamensus Benth) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas antibakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kaliandra untuk mendapatkan formula terbesar, serta membuktikan sediaan gel daun Kaliandra mempunyai stabilitas fisik yang baik. Penelitian ini menggunakan metode ekperimental laboratorium. Formula sediaan gel dibuat sebanyak 5 formula dengan variasi konsentrasi 2%, 3%, 4%, 5%, dan 6% b/v. Ekstraksi daun Kaliandra dilakukan dengan metode maserasi menggunakan etanol 96%. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri staphylococcus aureus menghasilkan daya hambat yang sedang yaitu 7,0±0,63 mm pada konsentrasi 6%. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji sineresis, uji daya sebar, uji daya lekat, uji pH, uji cycling test, dan uji sterilitas. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan sesudah cycling test. Dapat disimpulkan pada kosentrasi 6% ekstrak etanol daun Kaliandra dapat diformulasi sebagai sediaan gel yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang. Kata kunci : Kaliandra (Calliandra surinamensis Benth), Sediaan Gel, Antibakteri Staphlococcous aureus.

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FORMULASI DAN EFEK ANTIBAKTERI MASKER PEEL-OFF EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphlococcous epidermidis

PHARMACON ◽

10.35799/pha.8.2019.29393 ◽

2019 ◽

Vol 8 (3) ◽

pp. 686

Author(s):

Regita Daimunon ◽

Paulina V. Y. Yamlean ◽

Imam Jayanto

Keyword(s):

Staphylococcus Epidermidis ◽

Ethanol Extract ◽

Homogeneity Test ◽

Power Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Time Test ◽

Ethanol Extracts ◽

Muntingia Calabura

ABSTRACT Kersen leaf (Muntingia calabura L.) contains flavonoids, saponins and tannins, which could inhibit bacterial activity. This study aimed to formulate, evaluate, and to test the effectiveness of antibacterial preparations for the Kersen leaf ethanol extracts mask. This study uses the experimental method by testing the parameters of the physical evaluation requirements for the masker. Physical evaluation of preparations included organoleptic test, homogeneity test, pH test, scattering power test, dry time test, sticky test and cycling test, all tests were carried out before and after cycling test. The results of the preparation study meet the requirements of physical evaluation before the cycling test but after the cycling test is is not in accordance to the requirements for the preparation of the peel-off mask. The antibacterial test of mask peel-off ethanol extract of Kersen's leaves on Staphylococcus epidermidis bacteria produced a moderate inhibition. So it can be concluded that the ethanol extracts of Kersen leaves at a concentration of 20%. can be formulated as a peel-off mask that is physically stable and has moderate antibacterial activity.Keywords: Kersen, Peel-off mask, Antibacterial, Staphlococcous epidermidis ABSTRAK Daun Kersen (Muntingia calabura L.) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan masker peel-off ekstrak etanol daun Kersen. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik masker peel-off. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu sediaan mengering, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test namun setelahnya tidak sesuai dengan persyaratan sediaan masker peel-off. Penelitian uji antibakteri masker peel-off ekstrak etanol daun Kersen pada bakteri staphylococcus epidermidis menghasilkan daya hambat yang sedang. Dapat disimpulkan pada kosentrasi 20% ekstrak etanol daun Kersen dapat diformulasi sebagai sediaan masker peel-off yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang .Kata kunci : Kersen, Masker peel-off, Antibakteri, Staphlococcous epidermidis

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UJI EFEKTIVITAS FORMULASI SEDIAAN KRIM EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminafe L.) TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽

10.35799/pha.9.2020.30030 ◽

2020 ◽

Vol 9 (3) ◽

pp. 443

Author(s):

Stephany P. Pangemanan ◽

Hosea J. Edy ◽

Erladys M. Rumondor

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Physical Stability ◽

Ethanol Extract ◽

Experimental Methods ◽

Banana Peel ◽

Physical Test ◽

Cycling Test ◽

Test Parameters ◽

Peel Extract

ABSTRACT Goroho Banana Skin (Musa acuminafe L.) is a plant that contains flavonoid compounds, saponins and tannins that can inhibit bacterial growth. This study aims to test the antibacterial effectiveness of ethanol extract cream of goroho banana peel and evaluate the preparations using parameters of physical properties and physical stability. This research uses laboratory experimental methods. Cream formula is made with a variety of ethanol extract concentrations of Goroho Banana peel 2.5%, 5%, 7.5%, 10%, 12.5%. Goroho Banana peel extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Goroho Banana peel using wells method on Staphylococcus aureus bacteria resulted in inhibition of 7.03 ± 3.29 mm at a concentration of 12.5%. All tests are carried out before and during the cycling test. The results obtained before and during the cycling testshowed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.807 (4.5-6.5), cream adhesion 9.63 seconds (<4 seconds), cream spread 4, 53 cm (5-7 cm). It can be concluded that the ethanol extract of Goroho Banana peel cream meets stable physical test parameters and has moderate antibacterial activity. Keywords: Goroho Banana Peel (Musa acuminafe L.), Antibacterial, Cream. ABSTRAK Kulit Buah Pisang Goroho (Musa acuminafe L.) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol kulit buah pisang goroho dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik dan stabilitas fisik. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol kulit buah Pisang Goroho 2,5%, 5%, 7,5%, 10%, 12,5%. Ekstrak kulit buah Pisang Goroho diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol kulit buah Pisang Goroho menggunakan metode sumuran pada bakteri Staphylococcus aureus menghasilkan daya hambat 7,03±3,29 mm pada konsentrasi 12,5%. Semua pengujian dilakukan sebelum dan selama cycling test. Hasil penelitian yang didapat sebelum dan selama cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,807 (4,5-6,5), daya lekat krim 9,63 detik (<4 detik), daya sebar krim 4,53 cm (5-7 cm). Dapat disimpulkan bahwa sediaan krim ekstrak etanol kulit buah Pisang Goroho memenuhi parameter uji fisik stabil dan memiliki aktivitas antibakteri yang sedang. Kata kunci : Kulit Buah Pisang Goroho (Musa acuminafe L.), Antibakteri, Krim.

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