scholarly journals Uji Stabilitas Fisik Sediaan Masker Gel dari Ekstrak Alga Merah (Poryphyra sp)

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Aurina Megawati Numberi
Keyword(s):  
Red Algae ◽  
Antimicrobial Agents ◽  
Physical Stability ◽  
Stability Test ◽  
Homogeneity Test ◽  
Study Program ◽  
Safety Test ◽  
Time Test ◽  
Dispersion Test ◽  
Smirnov Test

ABSTRAKNumberi, Aurina M. 2019. UJI STABILITAS FISIK SEDIAAN MASKER GEL DARI EKSTRAK ALGA MERAH (Poryphyrasp).Skripsi Program Studi Farmasi, Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Cenderawasih Jayapura.Tumbuhan Alga merah ini berasal kampung Sarwandori kepulauan Yapen, Serui. Kandungan kimia dalam alga merah antara lain alkaloid, terpen, dan flavonoid yang berfungsi sebagai, anti kanker, dan anti mikroba. Sediaan masker merupakan salah satu bentuk sediaan semi solida yang mampu melekat pada permukaan tempat pemakaian dalam waktu yang cukup lama sebelum sediaan ini dicuci atau dihilangkan. Tujuan penelitian ini adalah untuk mengetahui mutu fisik sediaan masker gel ekstrak alga merah dan formula terbaik. Selanjutnya metode eksperimen dilakukan untuk mengetahui uji stabilitas fisik berupa uji organ oleptik berupa warna bau dan bentuk, uji ph, uji iritasi, uji daya lekat, uji daya sebar, uji homogenitas, uji proteksi, uji keamanan, uji waktu kering dan uji penyimpanan selama 31 hari. Analisis data menggunakan SPSS Kolmogrov-Smirnov Test, ANOVA oneway, danT-Test. Hasil yang didapat pada uji organ oleptik masker berwarna bening coklat, memiliki uji homogenitas ketiga sediaan masker tidak mengalami penggumpalan, uji daya sebar berkisaran dari 741-0,59 cm, uji daya lekat berkisar antara 0,865 detik dan 0,551 detik, uji daya proteksi dari ketiga formula masker baik, uji pH hari ke 0 bernilai5,33 dan hari ke 31 bernilai 7,12, uji waktu kering hari ke 0 bernilai 4-50 menit dan hari ke 31 bernilai 15-30 menit ,uji keamanan dari 30 relawan hanya ada 3 orang relawan yang mengalami iritasi ringan dari formula I hari ke 0 sampai hari ke 31 relawan mengalami iritasi, semua pengujian dilakukan 3 kali replikasi. Dari Ketiga formula stabil, dan F II merupakan formula terbaik .Kata kunci : Ekstrak alga merah, Masker Gel, Stabilitas Fisik. ABSTRACTNumberi, Aurina, M. 2019. Physical Stability Test of Mask Gel Preparations Form Red Algae (Poryphyra sp) Extract. Unpublished Undergraduate Thesis, Pharmacy Study Program, Department of Pharmacy, Faculty of Mathematics and Science, Cenderawasih University. Red algae. This plant originated the Sarwandori Village, Yapen Islands (Serui). Chemical content in red algae including alkaloids, terpenes and flavonoids that function as anticancer and antimicrobial agents. mask preparation is a form of semi-solid preparation mask algae red and the best formula to the surface of the application for a long time before the preparation is washed or removed. The research in purposes of study were to determine physical quality and stability as well as the effect of the red algae mask base concentration , The proceed with a carried out experimental method to determine the physical stability test in the form of sorganoleptic test in the form of color and odor shape, pH test, irritation test, stickiness test, scattering test, homogeneity test, protection test, safety test, dry time test and storage test for 31 days. Data analysis using SPSS Kolmogrov-Smirnov test, ANOVA oneway, and T-Test. The results obtained in the organoleptic test were clear brown clear masks, had a homogeneity test of thee mask preparations which did not undergo collection, dispersion test ranged from 741 to 0.59 cm, adhesion tests ranged from 0.865 seconds and 0.551 seconds, the protective power of the three formulas good mask, pH test day 0 was worth 7.12, dry time test day 0 is worth 4-50 minutes and the to 31 days is worth 15-30 minutes safety test from 30 volunteers there were only 3 volunteers who were irritated, all testing was done 3 times. Three stable formulas F II, is the best formula.Keywords : Red Algae (Poryphyrasp), Extract Physical, Stability Gel             

scholarly journals FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN MIANA (Coleus Scutelleroides (L.) Benth.) DENGAN BERBAGAI BASIS

2021 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Indriyani Arman,Hosea Jaya Edy, Karlah L.R Mansauda
Keyword(s):  
Physical Stability ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
Adhesion Test ◽  
Physical Quality ◽  
Test Parameters ◽  
Different Types ◽  
Time Test ◽  
Dispersion Test ◽  
The Stability

AbstractMiana leaves (Coleus Scutelleroides (L.) Benth.) contained flavonoid compounds that has antioxidants properties. This study aimed to formulate peel-off gel mask ethanol extract from Miana leaves became peel-off gel mask that is physically stable and to knows the type of base that form a formulation with good physical quality based on the test parameters of physical properties and the stability of preparation. Formulation  of peel-off gel mask ethanol extract of miana leaves used three different types of base, they are HPMC, Carbopol, and Na.CMC. Each formula is differentiated based on base of concentration which were HPMC 4%, carbopol 1%, and Na.CMC 3%. Evaluation to predict the physical stability of the preparation included organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and dry time test. In stability test, each formula is placed at temperature 27 oC for 28 days and made observation on the 1st, 7th, 14th, 21th, and 28th day. Based on the result, the ethanol extract of Miana leaves can be formulated into a peel-off mask and formulation with HPMC and Carbopol base has a good physical quality and physically stable compared to Na.CMC base.Keywords: Miana Leaves, Peel-Off Gel Mask, Stability Teh  AbstrakDaun Miana (Coleus Scutelleroides (L.) Benth.) memiliki kandungan senyawa flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun Miana menjadi masker gel peel-off yang stabil secara fisik serta mengetahui jenis basis yang membentuk formulasi sediaan masker dengan mutu fisik yang baik berdasarkan parameter uji sifat fisik dan stabilitas sediaan. Formulasi sediaan masker gel peel-off  ekstrak etanol daun Miana dibuat dengan menggunakan tiga jenis basis yang berbeda yaitu HPMC, karbopol, dan Na.CMC. Masing-masing formula dibedakan berdasarkan basis konsentrasi yaitu HPMC 4%, karbopol 1%, dan Na.CMC 3%. Evaluasi yang dilakukan terhadap stabilitas fisik sediaan masker gel peel-off meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji waktu mengering. Uji stabilitas dilakukan pada suhu kamar (27 oC) selama 28 hari dan dilakukan pengamatan pada hari ke 1, 7, 14, 21, dan 28. Hasil uji stabilitas fisik sediaan masker gel peel-off ekstrak etanol daun Miana dapat diformulasikan dalam bentuk sediaan masker gel peel-off , dan formula masker dengan basis HPMC dan karbopol memiliki mutu fisik yang baik dan stabil secara fisik dibandingkan dengan basis Na.CMC.Kata kunci: Daun Miana, Masker gel peel-off, Uji Stabilitas.

scholarly journals Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk.)

2020 ◽  
Vol 13 (2) ◽  
pp. 115-122
Author(s):  
S Slamet ◽  
Bibah Dewi Anggun ◽  
Dwi Bagus Pambudi
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Physical Stability ◽  
Stability Test ◽  
Stability Parameters ◽  
Cycling Test ◽  
Dispersion Test ◽  
Gel Preparation ◽  
The Stability ◽  
Moringa Leaf Extract

Abstrak. Tanaman kelor mempunyai khasiat sebagai antibakteri. Penambahan ekstrak daun kelor (Moringa oleifera Lamk.) di dalam sediaan gel diperkirakan dapat mempengaruhi stabilitas fisik sediaan tersebut. Penelitian ini bertujuan menguji stabilitas fisik sediaan gel yang mengandung ekstrak daun kelor (Moringa oleifera Lamk.) pada berbagai konsentrasi (1%, 3% dan 5%). Uji stabilitas fisik sedian gel dilakukan setelah penyimpanan selama 14 hari pada suhu ruangan dan uji cycling test (2o±40o C). Parameter stabilitas adalah organoleptis, uji daya sebar, uji daya lekat, pH, viskositas dan cycling test. Hasil ketiga formulasi menunjukkan stabilitas yang sesuai persyaratan sediaan gel diuji pada pengamatan organoleptis, daya sebar, daya lekat, pH, viskositas dan hasil uji cycling test.       Kata kunci : Gel, Kelor, Stabilitas Fisik   Physical Stability Test Formula Ready Gel Moringa Leaf Extract (Moringa Oleifera Lamk.)   Abstract. Moringa plants have efficacy as an antibacterial. The addition of moringa leaf extract (Moringa oleifera Lamk.) preparation required to affect the physical stability of the preparation. The study aims to test the physical stability of gel preparations containing Moringa oleifera Lamk. Leaf extract at various concentrations (1%, 3% and 5%). gel formula physical stability test was carried out after storage for 14 days at room temperature and the cycling test (2o ± 40o C). The stability parameters are organoleptic, dispersion test, adhesion test, pH, viscosity, cycling test. The results of the three formulations showed that stability according to the requirements of the gel preparation. Gel preparation tested on observations of organoleptic, spreadability, adhesion, pH, viscosity, and cycling test results.  Keyword: Gel, Moringa, Physical Stability

scholarly journals Development and Stability Studies of Novel Liposomal Vancomycin Formulations

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Krishna Muppidi ◽  
Andrew S. Pumerantz ◽  
Jeffrey Wang ◽  
Guru Betageri
Keyword(s):  
Particle Size ◽  
Encapsulation Efficiency ◽  
Antimicrobial Agents ◽  
Preparation Method ◽  
Physical Stability ◽  
Liposomal Formulations ◽  
Promising Strategy ◽  
Activity Variable ◽  
Distribution Studies

A promising strategy to improve the therapeutic efficiency of antimicrobial agents is targeted therapy. Although vancomycin has been considered a gold standard for the therapy of MRSA pneumonia, clinical failure rates have also been reported owing to its slow, time-dependent bactericidal activity, variable lung tissue penetration and poor intracellular penetration into macrophages. Liposomal encapsulation has been established as an alternative for antimicrobial delivery to infected tissue macrophages and offers enhanced pharmacodynamics, pharmacokinetics and decreased toxicity compared to standard preparations. The aim of the present work is to prepare vancomycin in two different liposomal formulations, conventional and PEGylated liposomes using different methods. The prepared formulations were optimized for their particle size, encapsulation efficiency and physical stability. The dehydration-rehydration was found to be the best preparation method. Both the conventional and PEGylated liposomal formulations were successfully formulated with a narrow particle size and size distribution and % encapsulation efficiency of and , respectively. Both the formulations were stable at C for 3 months. These formulations were successfully used to evaluate for their intracellular killing of MRSA and in vivo pharmacokinetic and bio-distribution studies.

scholarly journals FORMULASI SEDIAAN KRIM KOMBINASI EKSTRAK DAUN SELEDRI (Apium graveolens L.) DAN DAUN JATI (Tectona grandis Linn.F) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 259
Author(s):  
Riska Tuloli ◽  
Hosea Jaya Edi ◽  
Imam Jayanto
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Leaf Extract ◽  
Tectona Grandis ◽  
Test Method ◽  
Apium Graveolens ◽  
Homogeneity Test ◽  
Cycling Test ◽  
Physical Tests ◽  
Dispersion Test

ABSTRACT Celery plants (Apium graveolens L.) and teak plants (Tectona grandis Linn.f) are plants that contain flavonoids, tannins, and saponins and has antibacterial activity against Staphylococcus aureus. This study aims to test the antibacterial effectiveness of combination of celery and teak leaf cream and evaluate cream with parameters of physical tests (organoleptic, homogeneity, pH, spreadability, adhesion) and physical stability with cycling test method. This study used an experimental laboratory method by making 5 variations concentration of extracts. Celery and teak leaf extract was extracted by maceration method. Antibacterial test used the wells method. Results of the evaluation of physical tests for organoleptic test (odor: a typical combination of extracts;color: brown;shape: semi-solid), homogeneity test (homogeneous), average of pH test is 6.02, dispersion test is 4.27 cm, adhesion test is 18.42 seconds. Based on the results of this study, concluded that the combination of celery leaf and teak leaf extract can be formulated into a cream. The cream of combination of celery and teak leafs extract are bacteriostatic and has antibacterial activity with an average diameter for formulation I 13.4 mm, formulation II 9.23 mm, formulation III 16.23 mm, formulation IV 11 mm, and formulation V 12.06 mm. Keywords : Celery (Apium graveolens L.), Teak (Tectona grandis Linn.f), Antibacterial, Cream. ABSTRAK Tanaman seledri (Apium graveolens L.) dan tanaman jati (Tectona grandis Linn.f) merupakan tanaman yang mengandung flavonoid, tanin dan saponin dan memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Penelitian ini bertujuan untuk menguji aktivitas antibakteri sediaan krim kombinasi ekstrak daun seledri dan daun jati serta mengevaluasi sediaan krim dengan parameter uji sifat fisik (uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat) dan stabilitas fisik dengan metode cycling test. Penelitian ini menggunakan metode eksperimental laboratorium dengan membuat 5 variasi konsentrasi ekstrak. Ekstrak diperoleh dengan cara maserasi. Uji antibakteri dilakukan dengan metode sumuran. Hasil evaluasi sifat fisik untuk uji organoleptik (bau: khas kombinasi ekstrak;warna:coklat;bentuk:setengah padat), uji homogenitas (susunan homogen), rata-rata uji pH 6,02, daya sebar 4,27 cm, daya lekat 18,42 detik. Berdasarkan hasil penelitian disimpulkan bahwa kombinasi ekstrak daun seledri dan daun jati dapat diformulasikan menjadi sediaan krim. Sediaan krim kombinasi ekstrak daun seledri dan daun jati bersifat bakteriostatik dan memiliki aktivitas antibakteri dengan diameter rata-rata untuk formula I 13,4 mm, formula II 9,23 mm, formula III 16,23 mm, formula IV 11 mm, dan formula V 12,06 mm. Kata Kunci : Seledri (Apium graveolens L.), Jati (Tectona grandis Linn.f), Antibakteri, Krim

The Application of the Smirnov Test in the Homogeneity Test for Non-Normal Distribution Temperature Series

2012 ◽  
Vol 516-517 ◽  
pp. 530-535
Author(s):  
Xin Jie Deng ◽  
Yang Sheng You ◽  
Yan Ying Chen ◽  
Xue Mei Yang
Keyword(s):  
Normal Distribution ◽  
Classical Method ◽  
Temperature Series ◽  
Homogeneity Test ◽  
Test Results ◽  
Standard Normal Homogeneity Test ◽  
Standard Normal ◽  
Better Than ◽  
Smirnov Test

The homogeneity test is the first stage to revise the climate records. Its accuracy will directly affect the follow-up work. The classic method SNHT (Standard Normal Homogeneity Test) can only be applied in climatic sequences obey normal distribution, but lots of non-normality climate sequences need to be examined. In this paper, the Smirnov Test was introduced to test the homogeneity of the temperature series, which is a classical method for distribution test, and it can apply for the temperature sequences obey any distribution. The homogeneity test results by testing Chongqing Municipality's temperature sequences show that: the Smirnov Test is better than SNHT

FORMULASI GELHAND SANITIZER DARI KITOSAN DENGAN BASIS NATRIUM KARBOKSIMETILSELULOSA

2017 ◽  
Vol 1 (1) ◽  
pp. 31
Author(s):  
Supomo Supomo ◽  
Yullia Sukawati ◽  
Fredi Basyar
Keyword(s):  
Phase Separation ◽  
Side Effect ◽  
Physical Stability ◽  
Biocompatible Polymers ◽  
Homogeneity Test ◽  
Consistency Test ◽  
Hand Sanitizer ◽  
Gel Preparation ◽  
Dispersive Power ◽  
Chitosan Gel

Chitosan has been widely used in industrial, food, pharmaceuticals and agriculture. Chitosan is a natural biocompatible polymers means that as nature does not have the side effect, non-toxic, can not be easily digested and broken down by microbes (biodegradable). This study aims to determine whether the chitosan may be formulated into dosage gel hand sanitizer that meets the requirements of the physical stability of the gel.Chitosan is formulated with 3 varying concentrations of Na CMC basis of 3%, 4.5% and 6%. Tests conducted gel formulation is the physical stability test which includes organoleptic test, homogeneity, pH test, test dispersive power, viscosity test and test consistency. Testing is done every week for 4 weeks of storage.Results of testing physical properties of chitosan gel hand sanitizer has the shape and color stable but the resulting aroma change during storage. pH gel meet the requirements, the consistency test of phase separation does not occur, the homogeneity test showed no homogeneous gel, gel dispersive power does not meet the requirements, the viscosity of the gel preparation third formula does not meet the requirements of viscosity gel

scholarly journals PERBEDAAN KEMATANGAN EMOSI REMAJA DITINJAU DARI STRUKTUR KELUARGA

2013 ◽  
Vol 3 (2) ◽  
pp. 93
Author(s):  
Farokhatin Nashukah ◽  
Ira Darmawanti
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Single Parent ◽  
Homogeneity Test ◽  
Test Technique ◽  
Emotional Maturity ◽  
Single Parent Families ◽  
Normality Test ◽  
Kolmogorov Smirnov ◽  
Smirnov Test

A family has a great influence on children's emotional patterns because the family is the first social group for children to learn and express themselves as human beings in a social interaction with their groups. The background of this study is the problem of adolescent emotional maturity attainment. Subjects in this study were devided into two groups which overall are 121 adolescents aged between 16 and 20 years old. This study uses simple random sampling technique with predetermined characteristics and scale of emotional maturity as an instrument. Test the assumptions used in this study are normality test using one sample Kolmogorov-Smirnov test technique and homogeneity test using homogenity of variance test technique. The normality test shows the value of adolescents of complete families is 0,789 and the value of adolescents of single parent families is 0,982. Significance value >0.05, then the variable of emotional maturity is declared normally. Homogenity test shows the value is 0,499. Significance value >0,05, then the variable of emotional maturity is declared homogeneous. Results of this study shown that adolescent emotional maturity of single parent families has a mean of 148,71 emotional maturity that is higher than a mean of the emotional maturity of a complete family of 143,77. Based on analysis data using t-test known that the significance value is 0,013 (p >0.05), the result shows that the study hypothesis is accepted. It is concluded that there is difference of emotional maturity among adolescents influenced by their different family structures.Abstrak: Keluarga memiliki pengaruh besar terhadap pola emosi anak karena keluarga merupakan kelompok sosial pertama untuk anak belajar dan menyatakan diri sebagai manusia sosial. Tujuan dalam penelitian ini adalah untuk mengetahui perbedaan kematangan emosi remaja ditinjau dari struktur keluarga, yaitu keluarga lengkap dan keluarga dengan orang tua tunggal (single parent). Peneliti menggunakan teknik simple random sampling dengan karakteristik yang telah ditentukan. Subjek pada penelitian ini adalah dua kelompok yang secara keseluruhan berjumlah 121 sampel dengan rentang usia 16-20 tahun. Instrumen penelitian yang digunakan adalah skala kematangan emosi. Uji asumsi menggunakan uji normalitas menggunakan teknik one sample Kolmogorov-Smirnov test dan uji homogenitas menggunakan teknik test of homogenity of variance. Diketahui bahwa uji normalitas remaja dari keluarga lengkap sebesar 0,789, dan pada remaja dari keluarga single parent sebesar 0,982. Nilai signifikansi >0,05, maka variabel kematangan emosi dinyatakan berdistribusi normal. Diketahui bahwa uji homogenitas dengan nilai sebesar 0,499. Nilai signifikansi >0,05, maka variabel kematangan emosi dinyatakan homogen. Hasil penelitian ini menunjukkan bahwa kematangan emosi remaja dari keluarga single parent memiliki rata-rata skor kematangan emosi 148,71 yang lebih tinggi daripada rata-rata skor kematangan emosi keluarga lengkap yang sebesar 143,77. Berdasarkan analisis data yang dilakukan dengan menggunakan Uji-t, diketahui bahwa nilai signifikansi sebesar 0,013 (p >0,05) yang menunjukkan hipotesis penelitian diterima sehingga peneliti menyimpulkan bahwa ada perbedaan kematangan emosi remaja ditinjau dari struktur keluarga.

scholarly journals COMBINATION OF POWER AND KWL STRATEGIES TO TEACH WRITING

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Ichsanira Purwandari ◽  
Sri Wiyanah
Keyword(s):  
English Language ◽  
Alternative Hypothesis ◽  
Language Education ◽  
Research Problem ◽  
Homogeneity Test ◽  
English Language Education ◽  
Study Program ◽  
Normality Test ◽  
Post Test ◽  
The University

The aim of the study was to identify the effectiveness of using the combination of POWER and KWL to teach writing of fourth semester students at English Language Education Study Program in the University of PGRI Yogyakarta. It is based on the research problem that the students got difficulties on writing because they used ineffective strategy. The research used experimental research design. This research was conducted in 3 stages: data collection, action and data analysis. The data were collected through test, observation, and questionnaire. The data were analyzed using the steps of: normality test, homogeneity test, inferential analysis, determining hypothesis testing, and conclusion.The hypothesis is determined into the Null hypothesis (H0) and Alternative Hypothesis (Ha). H0 is accepted if the significance value >0.05 and Ha is rejected. The result of this research presented that the combination of POWER and KWL strategy was effective to teach writing at the university level. The control group’s mean score on the pre-test was 56,22 increased to 57,88 in post-test with gained point 1,59. The experiment group’s mean score on pre-test was 57,33 increased to 60,89 on post-test with gained point 3,66.

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