scholarly journals Biomarkers for microglia activation in neuropathic pain

2020 ◽  
Vol 24 (1) ◽  
pp. 87-93
Author(s):  
Putu Eka Widyadharma ◽  
Aurelia Vania ◽  
Jimmy FA Barus ◽  
Yudiyanta . ◽  
Thomas Eko Purwata
Keyword(s):  
Neuropathic Pain ◽  
Intensive Care ◽  
Microglia Activation ◽  
Future Research ◽  
Future Studies ◽  
Activated Microglia ◽  
New Therapy ◽  
Promising Target ◽  
Chemical Mediators

Neuropathic pain (NP) is a result of direct disturbances of somatosensory pathways. Its pathophysiology includes various mechanisms. Recent studies have reported an important role of microglia in the NP mechanism. There are several chemical molecules which are involved in microglia activation. The activated microglia will, in turn, enhance some receptors expression that can be used as markers of its activation. Though we still need future studies about precise microglia role in NP mechanism, the chemical mediators that initiate microglia activation and the alteration of some receptors in the activated microglia which have been found from previous studies can be the interesting future research materials and the promising target for a new therapy for NP. Citation: Widyadharma PE, Vania A, Barus JFA, Yudiyanta, Purwata TE. Biomarkers for microglia activation in neuropathic pain. Anaesth pain intensive care 2020;24(1):___ DOI: https://doi.org/10.35975/apic.v24i1. Received – 12 June 2019, Reviewed – 15 September 2019, 29 February 2020, Accepted – 2 March 2020;

scholarly journals PSYCHOGEOGRAPHICAL EXPERIENCE BETWEEN THE SELF AND THE PLACE

2022 ◽  
Vol 7 (1) ◽  
pp. 243-263
Author(s):  
Mohd Fadhli Shah Khaidzir ◽  
Ruzy Suliza Hashim ◽  
Noraini Md. Yusof
Keyword(s):  
Critical Role ◽  
Critical Factor ◽  
The Self ◽  
Future Research ◽  
Future Studies ◽  
Place Meaning ◽  
Solid Foundation ◽  
Self Discovery ◽  
Attachment Place

Background and Purpose: The absence of psychogeographical awareness is a critical factor contributing to the lackadaisical attitudes towards the place and its environment. As a result, it enables an individual to fully experience a location, both physically and intellectually, while also gaining a feeling of self-discovery and self-realisation.   Methodology: The purpose of this study was to examine the responses of a group of individuals who participated in a field observation. 40 participants from a Malaysian university's foundation level were brought to Malacca to experience the environment's geographical scenery at their own leisure. The survey data was then manually transcribed and analysed in accordance with the study's aim.   Findings: Interactions with individuals and observation of features in the countryside and urban surroundings enabled participants to go on a psychogeographical journey that influenced their way of thinking and behaving. All participants felt that the journey had influenced their experiences and perspectives on their thinking and behaviour, highlighting the critical role of this notion in establishing the connection between place and self.   Contributions:  The findings of this study provide a solid foundation for future research in the field of psychogeography. The data may be used as a baseline for future studies to determine whether a comparable impact exists in other locations, with or without significant features like those found in Malacca.   Keywords: Psychogeography, place attachment, place meaning, self-discovery, Malacca.   Cite as: Khaidzir, M. F. S., Hashim, R. S., & Md. Yusof, N. (2022). Psychogeographical experience between the self and the place.  Journal of Nusantara Studies, 7(1), 243-263. http://dx.doi.org/10.24200/jonus.vol7iss1pp243-263

Do Emotions Cause Eating? The Role of Previous Experiences and Social Context in Emotional Eating

2019 ◽  
Vol 28 (3) ◽  
pp. 234-240 ◽  
Author(s):  
Gizem Altheimer ◽  
Heather L. Urry
Keyword(s):  
Social Context ◽  
Emotional Eating ◽  
Negative Emotion ◽  
Negative Mood ◽  
Experimental Studies ◽  
Future Research ◽  
Discrete Emotions ◽  
Future Studies ◽  
Desire To Eat

Emotional eating is defined as an increase in eating following negative emotion. Self-reported emotional eating has been associated with physical-health concerns. However, experimental studies indicate that negative-mood inductions do not reliably lead to increased eating in healthy eaters, not even among those with a high desire to eat when emotional. We argue that experimental studies will help us understand emotional eating only if they account for the following ideas: (a) Emotional eating may require that people learn to associate emotion with eating, (b) emotional eating may follow only specific discrete emotions, and (c) emotional eating may depend on social context. Each of these points suggests a fruitful direction for future research. Specifically, future studies must acknowledge, identify, and account for variations in the extent to which people have learned to associate emotions with eating; assess or elicit strong discrete emotions; and systematically examine the effect of social context on emotional eating.

Role of Family Members in Pain Management in Adult Critical Care

2019 ◽  
Vol 30 (4) ◽  
pp. 398-410 ◽  
Author(s):  
Émilie Gosselin ◽  
Mélissa Richard-Lalonde
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pain Management ◽  
Pain Assessment ◽  
Family Members ◽  
Future Research ◽  
Rigorous Research ◽  
Family Member Involvement

This review describes family member involvement in intensive care unit pain assessment and management and generates implications for clinical practice, education, and future research. A literature review was performed in MEDLINE, PubMed, EMBASE, Cochrane, and CINAHL databases from their inception until April 30, 2019. Only 11 studies addressing the topic were identified, and the current quality of evidence is low. Family members can be involved in pain assessment by describing patients’ pain behaviors and in pain management by selecting and delivering nonpharmacological interventions tailored to patients’ needs, if the family members feel comfortable with this role. More-rigorous research is required to describe the role of family members in patients’ pain assessment and management. Advancing knowledge in this field could improve patients’ and family members’ experiences with pain assessment and management in the intensive care unit.

scholarly journals Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing

2020 ◽  
Vol 21 (23) ◽  
pp. 9115
Author(s):  
Nathan Moreau ◽  
Yves Boucher
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Nerve ◽  
Signaling Pathway ◽  
Nerve Injury ◽  
Hedgehog Signaling ◽  
Future Research ◽  
Chronic Neuropathic Pain ◽  
Desert Hedgehog ◽  
Numerous Cell

The peripheral nervous system has important regenerative capacities that regulate and restore peripheral nerve homeostasis. Following peripheral nerve injury, the nerve undergoes a highly regulated degeneration and regeneration process called Wallerian degeneration, where numerous cell populations interact to allow proper nerve healing. Recent studies have evidenced the prominent role of morphogenetic Hedgehog signaling pathway and its main effectors, Sonic Hedgehog (SHH) and Desert Hedgehog (DHH) in the regenerative drive following nerve injury. Furthermore, dysfunctional regeneration and/or dysfunctional Hedgehog signaling participate in the development of chronic neuropathic pain that sometimes accompanies nerve healing in the clinical context. Understanding the implications of this key signaling pathway could provide exciting new perspectives for future research on peripheral nerve healing.

AatmaNirbhar Bharat Abhiyan: a tool to revive Uttar Pradesh handloom sector

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sabiha Khatoon ◽  
Ayesha Iffat
Keyword(s):  
Economic Condition ◽  
Uttar Pradesh ◽  
The State ◽  
Future Research ◽  
Special Focus ◽  
Content Type ◽  
Future Studies ◽  
The Government ◽  
The Impact

Purpose The study aims to analyse the challenges faced by the Indian Handloom Sector with a special focus on the state of Uttar Pradesh before and during the COVID-19 pandemic. This study further explores the benefits of AatmaNirbhar Bharat Abhiyan for the betterment of the livelihood of the COVID-19–hit handloom weavers and allied workers. Design/methodology/approach A total of 400 handloom weavers and allied workers from ten cities of Uttar Pradesh were contacted through telephone. Descriptive statistics were applied to measure the awareness about the government welfare schemes and the benefits of these schemes. Furthermore, satisfaction and opinion of the handloom weavers and allied workers regarding the benefits and sufficiency of the funds received under these schemes have also been measured. Findings Based on the results, the least awareness has been noted about government welfare schemes. However, a small number of weavers and allied workers were found beneficiaries of the schemes. Additionally, the majority of the respondents were found dissatisfied with the benefits. The COVID-19 pandemic is an addendum to the plight of handloom weavers and allied workers. The measures of AatmaNirbhar Bharat Abhiyan could be used to aid weavers and allied workers to restore their lost revenue. Research limitations/implications This study has limitations. Firstly, the research is limited to the handloom industry of Uttar Pradesh. Future researchers could consider the handloom sector of other states like Maharashtra and Andhra Pradesh, known for hand-woven clothes. Secondly, this study aims to analyse the role of AatmaNirbhar Bharat Abhiyan in improving the living conditions of handloom weavers and allied workers and not to measure the impact of the Abhiyan on handloom weavers or the handloom sector. Researchers could measure the impact in future studies. Thirdly, the authors have not applied any behavioural theory or marketing models such as the Theory of Reasoned Action or the Blackwell model, which may be applied to study the attitude of handloom weavers towards welfare schemes. This may prove to be a potential direction for future research. Additionally, master weavers and handloom cooperatives societies were excluded while collecting the data. Future researchers could consider them to examine the role of the government’s welfare schemes for uplifting the socio-economic condition of the handloom weavers, allied workers, master weavers and the business of cooperative societies. Finally, due to lockdown and travel ban, the authors were forced to limit their survey to telephone only because of which they could not get the qualitative information in full. Researchers for future studies could visit the handloom concentrated areas personally or take the help of an enumerator for data collection. Practical implications The research holds significance for the young and competent designers, handloom weavers and allied workers. Designers could work with and hire handloom weavers of Uttar Pradesh. If designers and weavers work together, it will help them restore their business and generate revenue that they have lost due to the COVID-19 pandemic. Furthermore, policymakers can collaborate with designers, which will help enhance the socio-economic condition of handloom weavers and allied workers, which has deteriorated due to the COVID-19 crisis. Originality/value The research holds significance from the point of view of exploring the challenges faced by handloom weavers and allied workers of the state of UP before and during the COVID-19 period while examining the role of AatmaNirbhar Bharat Abhiyan in setting off these challenges.

The role of history in future studies

2021 ◽  
Author(s):  
Hardi Mika
Keyword(s):  
Common Ground ◽  
Descriptive Analysis ◽  
Scientific Research ◽  
Strong Relationship ◽  
Historical Research ◽  
Future Research ◽  
Human Research ◽  
Future Studies ◽  
Research Fields

"The role of history in future studies History is one of the fields of human research and has a strong relationship with politics, political studies and future studies. Future studies are considered a new field in effective and developed scientific research and have an essential role in politics since they influence each other. Future research fields are enhanced by taking advantage of other human and scientific research fields or using interdisciplinary and multidisciplinary methods. One of the fields that future researchers cannot disregard is historical research. This research focused on the two different directions: the fields of future research and history, i.e., past events, on the one hand, their future and scenarios on the other. The research seeks to answer some main questions: What is the common ground and relationship between history as a field of human research with future research? What is the function and purpose of both fields? What are their common keywords? Where will history assist the science of future research? The importance of the research is that working on the relationship between history and future science will keep history away from the past. It also makes future studies more realistic in identifying and cooperating with politics, political reform, management, and other aspects of society and choosing a better future among futures ahead of any society and individual. Moreover, historical research and academic centers in Kurdistan have been less likely to apply history as a science to understand the future. The research aims to find common ground and the effective relationships between the two fields of futures and history and link them by analyzing their content, tasks and methods. The research methodology is descriptive-analysis and has benefited from historical and comparative methods to explain the definitions, emergence, and common grounds for both research's variables."

What Is the Role of Steroids for Septic Shock in 2021?

2021 ◽  
Vol 42 (05) ◽  
pp. 726-734
Author(s):  
Wagner Nedel ◽  
Thiago Lisboa ◽  
Jorge I.F. Salluh
Keyword(s):  
Septic Shock ◽  
Intensive Care ◽  
Adjunctive Treatment ◽  
Current Evidence ◽  
Low Doses ◽  
Future Studies ◽  
Vascular Responsiveness ◽  
Severe Infections ◽  
Strong Body

AbstractCorticosteroids have been used for decades in the adjunctive treatment of severe infections in intensive care. The most frequent scenario in intensive care is in septic shock, where low doses of glucocorticoids appear to restore vascular responsiveness to norepinephrine. There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response. In this review, we explore the current evidence supporting the use of corticosteroids in septic shock, its benefits, and potential harms. In addition to landmark clinical trials, we will also describe new frontiers for the use of corticosteroids in septic shock which should be explored in future studies.

scholarly journals Microglia: sculptors of neuropathic pain?

2020 ◽  
Vol 7 (6) ◽  
pp. 200260 ◽  
Author(s):  
Harry Ward ◽  
Steven J. West
Keyword(s):  
Nervous System ◽  
Neuropathic Pain ◽  
Structure And Function ◽  
System Structure ◽  
Future Research ◽  
Important Target ◽  
Underlying Mechanisms ◽  
And Function ◽  
Future Therapy

Neuropathic pain presents a huge societal and individual burden. The limited efficacy of current analgesics, diagnostic markers and clinical trial outcome measures arises from an incomplete understanding of the underlying mechanisms. A large and growing body of evidence has established the important role of microglia in the onset and possible maintenance of neuropathic pain, and these cells may represent an important target for future therapy. Microglial research has further revealed their important role in structural remodelling of the nervous system. In this review, we aim to explore the evidence for microglia in sculpting nervous system structure and function, as well as their important role in neuropathic pain, and finally integrate these studies to synthesize a new model for microglia in somatosensory circuit remodelling, composed of six key and inter-related mechanisms. Summarizing the mechanisms through which microglia modulate nervous system structure and function helps to frame a better understanding of neuropathic pain, and provide a clear roadmap for future research.

scholarly journals Intensive Care Unit Built Environments: A Comprehensive Literature Review (2005–2020)

2021 ◽  
pp. 193758672110092
Author(s):  
Stephen Verderber ◽  
Seth Gray ◽  
Shivathmikha Suresh-Kumar ◽  
Damian Kercz ◽  
Christopher Parshuram
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Infection Control ◽  
Family Engagement ◽  
Disaster Mitigation ◽  
Ecological Sustainability ◽  
Future Research ◽  
Comprehensive Review ◽  
Conceptual Clarity

Background: The intensive care environment in hospitals has been the subject of significant empirical and qualitative research in the 2005–2020 period. Particular attention has been devoted to the role of infection control, family engagement, staff performance, and the built environment ramifications of the recent COVID-19 global pandemic. A comprehensive review of this literature is reported summarizing recent advancements in this rapidly expanding body of knowledge. Purpose and Aim: This comprehensive review conceptually structures the recent medical intensive care literature to provide conceptual clarity and identify current priorities and future evidence-based research and design priorities. Method and Result: Each source reviewed was classified as one of the five types—opinion pieces/essays, cross-sectional empirical investigations, nonrandomized comparative investigations, randomized studies, and policy review essays—and into nine content categories: nature engagement and outdoor views; family accommodations; intensive care unit (ICU), neonatal ICU, and pediatric ICU spatial configuration and amenity; noise considerations; artificial and natural lighting; patient safety and infection control; portable critical care field hospitals and disaster mitigation facilities including COVID-19; ecological sustainability; and recent planning and design trends and prognostications. Conclusions: Among the findings embodied in the 135 literature sources reviewed, single-bed ICU rooms have increasingly become the norm; family engagement in the ICU experience has increased; acknowledgment of the therapeutic role of staff amenities; exposure to nature, view, and natural daylight has increased; the importance of ecological sustainability; and pandemic concerns have increased significantly in the wake of the coronavirus pandemic. Discussion of the results of this comprehensive review includes topics noticeably overlooked or underinvestigated in the 2005–2020 period and priorities for future research.

scholarly journals The Emerging Role of T-Cell Immunoglobulin Mucin-3 in Breast Cancer: A Promising Target For Immunotherapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yizi Cong ◽  
Jing Liu ◽  
Gang Chen ◽  
Guangdong Qiao
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Treatment ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Future Research ◽  
Promising Target ◽  
Checkpoint Molecule ◽  
Regulation Mechanisms

Cancer treatment through immune checkpoint receptor blockade has made significant advances in the recent years. However, resistance to the current immune checkpoint inhibitors (ICIs) has been observed in many patients, who consequently do not respond to these treatments. T-cell immunoglobulin mucin-3 (Tim-3) is a novel immune checkpoint molecule emerging as a potential therapeutic target for cancer immunotherapy. Epidemiologic findings reveal that genetic polymorphisms in the Tim-3 gene are associated with increased susceptibility to breast cancer. In patients with breast cancer, Tim-3 is expressed both on immune and tumor cells. Accumulating evidence demonstrates that Tim-3 can notably affect breast cancer treatment outcome and prognosis. Therefore, Tim-3 is being regarded as a high-potential target for improving breast cancer therapy. In this review, we summarize the role of Tim-3 in breast cancer and the regulation mechanisms of Tim-3 to furnish evidences for future research and therapy.

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