scholarly journals Metabolic mind and primordial instinct. From biochemistry to the embodiment applied to nutrition. Vegan integrated diet. One step forward.

2020 ◽  
Author(s):  
Tafuri Ranieri Maria ◽  
Fontana Mario
Keyword(s):  
Identity Crisis ◽  
Loss Of Consciousness ◽  
Property A ◽  
Cellular Gene ◽  
Human Race ◽  
Key Points ◽  
The World ◽  
Mind And Body ◽  
One Step ◽  
Selection Of

In this era when the whole world is in a psychotic recession, where Covid-19 feeds on human substrate unprepared for the "pandemic state", the only real salvation is listening to one's metabolism. It is not a title from Hollywood, it is a real lockdown of the human race which, once again in history, demonstrates its ineptitude which, by syllogism, would mean a lack of resilient property. A resilience not in relation to a material, but metaphorically projected to a reflection where man, the only protagonist endowed with intellect, once again makes the same mistakes by entering the usual loop that punctually repeats itself every decade. Mind and body seem to be no longer distinguishable and have lost the structuring quality that their role determined and made possible constructive actions on the world. The distance between observer and observed, between mind and matter, has faded as if to cruelly provoke a loss of consciousness and identity crisis, hindering the creation of new models, theories and correlations that allow to act in this world. Neuroscience is shedding light on crucial aspects of the nervous system, such as the modalities of neuronal growth and selection of unused synapses (Edelman 1987), as well as the effects of learning or repeated and recorded experiences, on metabolism and cellular gene transcription ( Kandel, Schartz, Jessel, 1991). Psychosomatics with a view to multifactoriality and interdependence for mind-body study are the key points for the study presented here.

scholarly journals Restructuring companies under crisis. A real case study

2017 ◽  
Vol 17 (3) ◽  
pp. 141-147
Author(s):  
Hezi Aviram SHAYB
Keyword(s):  
Business Organization ◽  
Important Conclusion ◽  
Success Stories ◽  
Key Points ◽  
The World ◽  
One Step ◽  
Set Up ◽  
The Right ◽  
A Company

Nobody is planning to fail, but many companies are failing because of lack of planning.Real business experience showed during the years that crisis can be prevented, avoided or limited. If detected in time, the risks associated with the crisis can be mitigated and the effects can be diminished, with the condition that the actions required are done fast, in a sharp and accurate manner.            When it comes, a crisis brings intense level of pressure and under these conditions there is no time or room for mistakes. Delays, losing focus and lack of planning will bring a company one step away from failure.             The right way to deal with crisis, if required measures are not done in time, is to minimize the losses and reposition in the best way possible.            Analyzing the success stories of some of the biggest and strongest companies in the world, led to an important conclusion: the majority of these companies were in the situation to face huge crises that threatened their ability to survive in certain moments on their way to success.            With the right planning and by setting a proper organizational structure, the negative aspects of the crisis can be turned into benefits and opportunities for the company.            The most critical challenge for management is to assess the level of exposure to risk of the company and identify the key points to focus on in order to overcome the crisis and create value.             In order to set up a strong plan in dealing with crisis, a business organization needs reliable, efficient and effective tools and this is what this article is all about. 

“To Corrupt a Man in the Midst of a Verse”: Ben Jonson and the Prose of the World

2017 ◽  
Vol 24 (1) ◽  
pp. 46-72
Author(s):  
Jacob Tootalian
Keyword(s):  
Mixed Mode ◽  
Ben Jonson ◽  
Digital Analysis ◽  
Interactive Engagement ◽  
Sentence Level ◽  
Linguistic Patterns ◽  
The World ◽  
Selection Of ◽  
Bartholomew Fair

Ben Jonson's early plays show a marked interest in prose as a counterpoint to the blank verse norm of the Renaissance stage. This essay presents a digital analysis of Jonson's early mixed-mode plays and his two later full-prose comedies. It examines this selection of the Jonsonian corpus using DocuScope, a piece of software that catalogs sentence-level features of texts according to a series of rhetorical categories, highlighting the distinctive linguistic patterns associated with Jonson's verse and prose. Verse tends to employ abstract, morally and emotionally charged language, while prose is more often characterized by expressions that are socially explicit, interrogative, and interactive. In the satirical economy of these plays, Jonson's characters usually adopt verse when they articulate censorious judgements, descending into prose when they wade into the intractable banter of the vicious world. Surprisingly, the prosaic signature that Jonson fashioned in his earlier drama persisted in the two later full-prose comedies. The essay presents readings of Every Man Out of his Humour and Bartholomew Fair, illustrating how the tension between verse and prose that motivated the satirical dynamics of the mixed-mode plays was released in the full-prose comedies. Jonson's final experiments with theatrical prose dramatize the exhaustion of the satirical impulse by submerging his characters almost entirely in the prosaic world of interactive engagement.

The concepts of Ayurveda and Pāli Literature in connection to Psychotherapy

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Kolarkar Rajesh Shivajirao ◽  
Kolarkar Rajashree Rajesh
Keyword(s):  
Mental Disorders ◽  
Laws Of Nature ◽  
Code Of Conduct ◽  
Economic Consequences ◽  
Ultimate Truth ◽  
Traditional System ◽  
The World ◽  
Mind And Body ◽  
The Mind ◽  
The Buddha

The perfect balance of Mind and body is considered as complete health in Pāli literature as well as in Ayurveda. Pāli literature and Ayurveda have their own identity as most ancient and traditional system of medicine in India.The universal teachings of the Buddha are the most precious legacy ancient India gave to the world. The teachings are a practical code of conduct, a way of purity and of gracious living. There is a scientific study of the truth pertaining to mind and matter, and the ultimate truth beyond. In fact, the Buddha should be more appropriately known as a super-scientist who studied the entire laws of nature governing the Universe, by direct personal experience. The Buddha's rational teachings are clearly explained in the Eight-fold Noble Path, divided in three divisions of Sīla (morality), Samādhi (mastery over the mind), Paññā i.e. ‘Pragya' (purification of the mind, by developing insight). In Ayurveda Psychotherapy can be done by Satvavajaya Chikitsa and good conduct. Aim is to augment the Satva Guna in order to correct the imbalance in state of Rajas (Passion) and Tamas (Inertia). Sattvavajaya as psychotherapy, is the mental restraint, or a "mind control" as referred by Caraka, as well as Vagbhata is achieved Dnyan (education), Vidnyan (training in developing skill), Dhairya (development of coping mechanism), Smruti (memory enhancement), Samadhi (concentration of mind). According to WHO, Mental disorders are the common problem. The burden of mental disorders continues to grow with significant impacts on health and major social, human rights and economic consequences in all countries of the world.

Excessive Belching: a Separate Syndrome or Another Symptom of Functional Dyspepsia?

2020 ◽  
Vol 30 (3) ◽  
pp. 55-60 ◽  
Author(s):  
A. A. Sheptulin ◽  
O. A. Storonova
Keyword(s):  
Functional Dyspepsia ◽  
Functional Gastrointestinal Disorders ◽  
High Resolution Manometry ◽  
Published Evidence ◽  
Key Points ◽  
Dyspeptic Symptoms ◽  
The Relationship ◽  
Rome Iv ◽  
Selection Of ◽  
Optimal Treatment Strategy

Aim of review. Interpretation of published evidence on the relationship between the excessive belching syndrome and functional dyspepsia (FD) and their management in patient care.Key points. According to the Rome IV criteria of functional gastrointestinal disorders (FGID), excessive belching in the absence of other dyspeptic symptoms is to be considered a manifestation of the excessive belching syndrome, which can be of gastric or supragastric nature. Combination of high-resolution manometry and impedancemetry allows an accurate diagnosis of belching and selection of optimal treatment strategy. Belching complicated by other symptoms of dyspepsia is to be considered yet another FD symptom according to the Rome IV criteria of FGID. Prokinetics are recommended to relieve belching in such cases.Conclusion. Understanding the relationship between the excessive belching syndrome and FD requires further research.

Introduction

2018 ◽  
Author(s):  
Gianfranco Pacchioni
Keyword(s):  
Industrial Revolution ◽  
Homo Sapiens ◽  
Modern Society ◽  
Full Time ◽  
Human Race ◽  
Hunter Gatherers ◽  
The Past ◽  
The World ◽  
The Universe ◽  
Radical Transformation

About 10,000 years ago, at the beginning of the agriculturalrevolution, on the whole earth lived between 5 and 8 million hunter-gatherers, all belonging to the Homo sapiens species. Five thousand years later, freed from the primary needs for survival, some belonging to that species enjoyed the privilege of devoting themselves to philosophical speculation and the search for transcendental truths. It was only in the past two hundred years, however, with the advent of the Industrial Revolution, that reaping nature’s secrets and answering fundamental questions posed by the Universe have become for many full-time activities, on the way to becoming a real profession. Today the number of scientists across the globe has reached and exceeded 10 million, that is, more than the whole human race 10,000 years ago. If growth continues at the current rate, in 2050 we will have 35 million people committed full-time to scientific research. With what consequences, it remains to be understood. For almost forty years I myself have been concerned with science in a continuing, direct, and passionate way. Today I perceive, along with many colleagues, especially of my generation, that things are evolving and have changed deeply, in ways unimaginable until a few years ago and, in some respects, not without danger. What has happened in the world of science in recent decades is more than likely a mirror of a similar and equally radical transformation taking place in modern society, particularly with the advent ...

Presence, Environment, and Sound and the Role of Imagination

2019 ◽  
pp. 667-681
Author(s):  
Mark Grimshaw-Aagaard
Keyword(s):  
Computer Games ◽  
Virtual World ◽  
Actual World ◽  
Sensory Input ◽  
The World ◽  
Visual Dimension ◽  
The Creation ◽  
First Person Shooter ◽  
Selection Of

Mark Grimshaw-Aagaard addresses the role of sound in the creation of presence in virtual and actual worlds. He argues that imagination is a central part of the generation and selection of perceptual hypotheses—models of the world in which we can act—that emerge from what Grimshaw-Aagaard calls the “exo-environment” (the sensory input) and the “endo-environment” (the cognitive input). Grimshaw-Aagaard further divides the exo-environment into a primarily auditory and a primarily visual dimension and he deals with the actual world of his own apartment and the virtual world of first-person-shooter computer games in order to exemplify how we perceptually construct an environment that allows for the creation of presence.

scholarly journals Peculiarities of promiscuous l-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids

2021 ◽  
Author(s):  
Shan Wang ◽  
Hai Deng
Keyword(s):  
Amino Acids ◽  
Organic Molecules ◽  
Stereoselective Synthesis ◽  
Enantioselective Synthesis ◽  
General Mechanism ◽  
Future Developments ◽  
Key Points ◽  
Biomaterial Science ◽  
One Step ◽  
Harsh Conditions

Abstract The introduction of β-hydroxy-α-amino acids (βHAAs) into organic molecules has received considerable attention as these molecules have often found widespread applications in bioorganic chemistry, medicinal chemistry and biomaterial science. Despite innovation of asymmetric synthesis of βHAAs, stereoselective synthesis to control the two chiral centres at Cα and Cβ positions is still challenging, with poor atomic economy and multi protection and deprotection steps. These syntheses are often operated under harsh conditions. Therefore, a biotransformation approach using biocatalysts is needed to selectively introduce these two chiral centres into structurally diverse molecules. Yet, there are few ways that enable one-step synthesis of βHAAs. One is to extend the substrate scope of the existing enzyme inventory. Threonine aldolases have been explored to produce βHAAs. However, the enzymes have poor controlled installation at Cβ position, often resulting in a mixture of diastereoisomers which are difficult to be separated. In this respect, l-threonine transaldolases (LTTAs) offer an excellent potential as the enzymes often provide controlled stereochemistry at Cα and Cβ positions. Another is to mine LTTA homologues and engineer the enzymes using directed evolution with the aim of finding engineered biocatalysts to accept broad substrates with enhanced conversion and stereoselectivity. Here, we review the development of LTTAs that incorporate various aldehyde acceptors to generate structurally diverse βHAAs and highlight areas for future developments. Key points • The general mechanism of the transaldolation reaction catalysed by LTTAs • Recent advances in LTTAs from different biosynthetic pathways • Applications of LTTAs as biocatalysts for production of βHAAs

Collective Decision-making: FIFA from the Perspective of Public Choice

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Florian Follert ◽  
Lukas Richau ◽  
Eike Emrich ◽  
Christian Pierdzioch
Keyword(s):  
Decision Making ◽  
Public Choice ◽  
Choice Theory ◽  
Collective Decision ◽  
Public Confidence ◽  
Collective Decision Making ◽  
Public Choice Theory ◽  
World Cup ◽  
The World ◽  
Selection Of

AbstractVarious scandals have shaken public confidence in football's global governing body, Fédération Internationale de Football Association (FIFA). It is evident that decision-making within such a collective provides incentives for corruption. We apply the Buchanan-Tullock model that is known from Public Choice theory to study collective decision-making within FIFA. On the basis of this theoretical model, we develop specific proposals that can contribute to combating corruption. Three core aspects are discussed: the selection of the World Cup host, transparency in the allocation of budgets, and clear guidelines for FIFA officials and bodies with regard to their rights and accountability. Our insights can contribute to a better understanding of collective decision making in heterogenous groups.

scholarly journals Theoretical and Empirical Characterization of Water as a Factor: Examples and Related Issues with the World Trade Model

Water ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 459
Author(s):  
Ignacio Cazcarro ◽  
Albert E. Steenge
Keyword(s):  
World Trade ◽  
Low Cost ◽  
Virtual Water ◽  
Considerable Change ◽  
Water Research ◽  
Trade Model ◽  
The World ◽  
Main Model ◽  
Selection Of

This article originates from the theoretical and empirical characterization of factors in the World Trade Model (WTM). It first illustrates the usefulness of this type of model for water research to address policy questions related to virtual water trade, water constraints and water scarcity. It also illustrates the importance of certain key decisions regarding the heterogeneity of water and its relation to the technologies being employed and the prices obtained. With regard to WTM, the global economic input–output model in which multiple technologies can produce a “homogeneous output”, it was recently shown that two different mechanisms should be distinguished by which multiple technologies can arise, i.e., from “technology-specific” or from “shared” factors, which implies a mechanism-specific set of prices, quantities and rents. We discuss and extend these characterizations, notably in relation to the real-world characterization of water as a factor (for which we use the terms technology specific, fully shared and “mixed”). We propose that the presence of these separate mechanisms results in the models being sensitive to relatively small variations in specific numerical values. To address this sensitivity, we suggest a specific role for specific (sub)models or key choices to counter unrealistic model outcomes. To support our proposal we present a selection of simulations for aggregated world regions, and show how key results concerning quantities, prices and rents can be subject to considerable change depending on the precise definitions of resource endowments and the technology-specificity of the factors. For instance, depending on the adopted water heterogeneity level, outcomes can vary from relatively low-cost solutions to higher cost ones and can even reach infeasibility. In the main model discussed here (WTM) factor prices are exogenous, which also contributes to the overall numerical sensitivity of the model. All this affects to a large extent our interpretation of the water challenges, which preferably need to be assessed in integrated frameworks, to account for the main socioeconomic variables, technologies and resources.

scholarly journals The Epidemiological Characteristics of the COVID-19 Pandemic in Europe: Focus on Italy

2021 ◽  
Vol 18 (6) ◽  
pp. 2942
Author(s):  
Giovanni Gabutti ◽  
Erica d’Anchera ◽  
Francesco De Motoli ◽  
Marta Savio ◽  
Armando Stefanati
Keyword(s):  
Social Structures ◽  
World Population ◽  
European Continent ◽  
Key Points ◽  
Reporting Systems ◽  
The World ◽  
Definition Of ◽  
Epidemiological Characteristics ◽  
The Impact ◽  
Epidemiological Situation

Starting from December 2019, SARS-CoV-2 has forcefully entered our lives and profoundly changed all the habits of the world population. The COVID-19 pandemic has violently impacted the European continent, first involving only some European countries, Italy in particular, and then spreading to all member states, albeit in different ways and times. The ways SARS-CoV-2 spreads are still partly unknown; to quantify and adequately respond to the pandemic, various parameters and reporting systems have been introduced at national and European levels to promptly recognize the most alarming epidemiological situations and therefore limit the impact of the virus on the health of the population. The relevant key points to implement adequate measures to face the epidemic include identifying the population groups most involved in terms of morbidity and mortality, identifying the events mostly related to the spreading of the virus and recognizing the various viral mutations. The main objective of this work is to summarize the epidemiological situation of the COVID-19 pandemic in Europe and Italy almost a year after the first reported case in our continent. The secondary objectives include the definition of the epidemiological parameters used to monitor the epidemic, the explanation of superspreading events and the description of how the epidemic has impacted on health and social structures, with a particular focus on Italy.

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