scholarly journals Analysis of sporadic cases of invasive listeriosis in a metropolis

2021 ◽  
Vol 97 (6) ◽  
pp. 546-555
Author(s):  
O. L. Voronina ◽  
I. S. Tartakovsky ◽  
N. D. Yuyshuk ◽  
N. N. Ryzhova ◽  
E. I. Aksenova ◽  
...  
Keyword(s):  
At Risk ◽  
Viral Infections ◽  
Comparison Group ◽  
Respiratory Infections ◽  
Risk Groups ◽  
Epidemic Threshold ◽  
Pathogen Virulence ◽  
The Core ◽  
Phylogenetic Lineage ◽  
Listeria Infection

Introduction. Listeriosis is a foodborne infection, especially dangerous for people in at-risk groups. Susceptibility to listeria infection is determined by a complex of reasons: environmental factors, host immune status, and pathogen virulence. The susceptibility to listeriosis can also be aggravated by previous infections, especially viral infections, which demonstrate a steadily increasing number of identified pathogens.The aim of our study was to present molecular and genetic characterization of pathogens causing sporadic invasive listeriosis in a megalopolis, primarily during the peak of influenza and ARVI incidence.Materials and methods. Listeria monocytogenes isolates were collected from 18 hospitalized patients at hospitals in Moscow, from November 2018 to October 2019. The first comparison group was represented by isolates from food products and fish preserves. The second comparison group included previously examined environmental isolates. The clinical isolates were examined by using multilocus sequence typing techniques, including the standard MLST scheme extended by loci of internalin genes. Isolates of the autochthonous genotype (ST7) were compared through whole-genome sequencing and subsequent analysis of the core genome (cgMLST).Results. In cases of invasive listeriosis, 44% of isolates were isolated from patients with listeriosis; 27% of isolates were obtained from patients with meningitis. L. monocytogenes of phylogenetic lineage II prevailed in these groups of cases that occurred when the epidemic threshold for influenza was crossed during the 2018/2019 season. Listeria pneumonia identified in the senior age group occurred during the season of autumn ARVI and was primarily caused by L. monocytogenes of phylogenetic lineage I. The examination of genomes of ST7 isolates demonstrated identity between the core genomes of bacteria isolated from the mother-infant pair. Out of ST7 food isolates most closely related to the clinical ones was the isolate from meat (23 locus differences, the common deletion in the MFS transporter locus). Analyzing invasive listeriosis, the comparison between the list of the identified genotypes and the data from European countries showed that each country had its own specific range of genotypes, though ST7 was detected in all the examined samples.Conclusions. Along with the monitoring of food manufacturing and storage, timely vaccination against seasonal respiratory infections and use of personal protective equipment in public spaces can reduce the risk of listeriosis incidence in at-risk groups.

scholarly journals Clinical and Epidemiological Features of New Polyethiologic Viral Infections

2018 ◽  
Vol 17 (4) ◽  
pp. 4-12
Author(s):  
V. V. Shkarin ◽  
O. V. Kovalyshen ◽  
R. F. Chanysheva ◽  
A. V. Sergeeva ◽  
A. A. Rassokhin
Keyword(s):  
Influenza Virus ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Risk Groups ◽  
Scientific Data ◽  
Review Article ◽  
Human Bocavirus ◽  
Type B ◽  
Human Coronavirus ◽  
Epidemiological Features

The review article summarizes and systematizes scientific data on the pathogens of new respiratory infections discovered in the early XXI century – Human metapneumovirus (HMPV), Human bocavirus (HBoV), Human coronavirus (HCoV). Groups of microorganisms with which they act as associates are identified: other viruses (HMPV – HRSV, Rhinovirus, Adenovirus, HCoV; НBoV– Rhinovirus, HRSV, Rotavirus, Norovirus; HCoV – Influenza virus, Adenovirus and HRSV), and also some bacteria (HMPV – S. pneumoniae, H. influenzae type b; НBoV – S. enteritidis, C. jejune; HCoV – M. pneumoniae, K. pneumoniae). The clinical and epidemiological features of combined forms of infections are analyzed: predominance of moderate course, with risk of complications, risk groups (young children), seasonality (autumn-winter). The complexity of verification of these infections from other viral infections based on the clinical picture is established.

scholarly journals Acute respiratory infections and flu during the COVID-19 pandemic. What to expect in 2021–2022?

2021 ◽  
Vol 5 (11) ◽  
pp. 721-727
Author(s):  
D.V. Usenko ◽  
◽  
N.Kh. Tkhakushinova ◽  
T.T. Shaturina ◽  
L.A. Ledenko ◽  
...  
Keyword(s):  
Viral Infection ◽  
Sodium Alginate ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Antiviral Agent ◽  
Risk Groups ◽  
Control Measures ◽  
Acute Respiratory Infections ◽  
Respiratory Viral Infection ◽  
Syncytial Virus

This paper discusses the spread of the most common causative agents for respiratory viral infections, i.e., respiratory syncytial virus (RSV) and influenza virus (IV), during seasonal peaks and under the COVID-19 pandemic. The COVID-19 pandemic and epidemic control measures reduced the transmission of some respiratory viral pathogens. The authors specify the risks of changes in RSV epidemiology associated with restrictions and their lifting. Possible scenarios of virus "behavior" in 2021–2022 are represented. These scenarios include the return of variants registered at the end of 2019 and the risk of the emergence of a novel strain of zoonotic flu that may result in a novel viral pandemic. It was demonstrated that effective monitoring of causative agent circulation, timely specific prophylaxis (particularly in high-risk groups), and early effective antiviral therapy are crucial irrespective of the possible scenario of respiratory viral infection. Modern principles of complex flu and acute respiratory viral infection treatment using an antiviral agent based on rimantadine and sodium alginate are addressed. KEYWORDS: flu, COVID-19, pandemic, respiratory syncytial infection, children, treatment, rimantadine, sodium alginate. FOR CITATION: Usenko D.V., Tkhakushinova N.Kh., Shaturina T.T. et al. Acute respiratory infections and flu during the COVID-19 pandemic. What to expect in 2021–2022? Russian Medical Inquiry. 2021;5(11):721–727 (in Russ.). DOI: 10.32364/2587-6821-2021- 5-11-721-727.

scholarly journals The bacteriological research in case of acute respiratory infections: actual, informative and effective

2018 ◽  
Vol 22 (2) ◽  
pp. 394-397
Author(s):  
S. I. Klymnyuk ◽  
L .B. Romanyuk ◽  
L .A. Volianska ◽  
E .I. Burbelа ◽  
N. Ya. Kravets ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Family Doctor ◽  
Clinical Manifestations ◽  
Risk Groups ◽  
Symptomatic Therapy ◽  
Acute Respiratory Infections ◽  
Family Doctors ◽  
Opportunistic Bacteria

The most common nosology in the routine work of family doctors is acute respiratory infections. The etiological composition of the acute respiratory viral infections is changing from year to year, which causes difficulties with the use of treatments. Purpose - improvement of tactics of a family doctor for antibiotic therapy of acute respiratory infections. Clinical manifestations of all etiological forms of ARI are similar, which complicates their differentiation. One of the leading - respiratory syndrome, is determined by the local defeat of certain parts of the respiratory tract. The pathogens of these diseases are mainly viruses, but the role of bacteria is also indisputable. According to the results of bacteriological studies with ARI, pathogens often include opportunistic bacteria of the staphylococcus group, streptococci, other aerobic and anaerobic cocci, representatives of the intestinal group and Candida, which can cause antibiotic-resistant forms. The family doctor should establish the diagnosis of respiratory infections, solve the problem of symptomatic therapy and agree on a strategy for the appointment of antibiotics. Most acute respiratory infections even in the absence of antibiotic therapy are recovering. Therefore, the tactics for the appointment of antibiotics should be determined depending on the severity of the disease, the belonging of the patient to certain risk groups. It would be advisable to include the collection of information on previous bacteriological studies and the preliminary history of the use of antibacterial agents, which would allow a family doctor to be better targeted when prescribing antibiotic therapy. The algorithm of the physician's action in the case of acute respiratory infections should be expanded at the point of coordination of the strategy of antibiotic therapy, adding to it the purpose of bacteriological examination in each case of diagnosis of ARI.

scholarly journals The Immunological Role of the Placenta in SARS-CoV-2 Infection—Viral Transmission, Immune Regulation, and Lactoferrin Activity

2021 ◽  
Vol 22 (11) ◽  
pp. 5799
Author(s):  
Iwona Bukowska-Ośko ◽  
Marta Popiel ◽  
Paweł Kowalczyk
Keyword(s):  
Pregnant Women ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Current Knowledge ◽  
Risk Groups ◽  
Virus Particles ◽  
New Type ◽  
Viral Receptors

A pandemic of acute respiratory infections, due to a new type of coronavirus, can cause Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) and has created the need for a better understanding of the clinical, epidemiological, and pathological features of COVID-19, especially in high-risk groups, such as pregnant women. Viral infections in pregnant women may have a much more severe course, and result in an increase in the rate of complications, including spontaneous abortion, stillbirth, and premature birth—which may cause long-term consequences in the offspring. In this review, we focus on the mother-fetal-placenta interface and its role in the potential transmission of SARS-CoV-2, including expression of viral receptors and proteases, placental pathology, and the presence of the virus in neonatal tissues and fluids. This review summarizes the current knowledge on the anti-viral activity of lactoferrin during viral infection in pregnant women, analyzes its role in the pathogenicity of pandemic virus particles, and describes the potential evidence for placental blocking/limiting of the transmission of the virus.

Who’s at risk of entering Social Security Disability Insurance? A comparison of application and allowance rates for groups of at-risk individuals

2020 ◽  
Vol 53 (3) ◽  
pp. 341-352 ◽  
Author(s):  
Kara Contreary ◽  
Todd Honeycutt
Keyword(s):  
At Risk ◽  
Social Security ◽  
Disability Insurance ◽  
Risk Groups ◽  
Evidence Base ◽  
Social Security Disability Insurance ◽  
Program Participation ◽  
Before And After ◽  
Social Security Disability ◽  
Employment Characteristics

BACKGROUND: The U.S. government has implemented several programs to reduce federal expenditures on Social Security Disability Insurance (DI) and help beneficiaries return to work, but the limited success of these efforts has raised interest in approaches that help workers with disabilities remain in the workforce. OBJECTIVE: This paper provides information on individuals at risk of applying for DI benefits to help build the evidence base for policies that provide workers with disabilities support to eliminate the need to apply for and receive DI benefits. METHODS: Using three panels of the Survey of Income and Program Participation matched to SSA administrative data, we describe the employment characteristics of seven groups at risk of applying for DI benefits before and after application, as well as the outcomes of their DI applications. RESULTS: New private disability insurance recipients were more likely to apply for and receive DI than members of other at-risk groups. However, individuals with high healthcare expenditures made up the largest proportion of successful applicants across the at-risk groups considered here. CONCLUSION: While it seems plausible that individuals within an at-risk group who are likely to apply for DI benefits can be identified and provided supports to help them maintain employment, focusing on a specific group to promote employment over DI benefits may have a limited effect on the DI program because applicants come from multiple groups.

scholarly journals Immunological Aspects Related to Viral Infections in Severe Asthma and the Role of Omalizumab

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 348
Author(s):  
Francesco Menzella ◽  
Giulia Ghidoni ◽  
Carla Galeone ◽  
Silvia Capobelli ◽  
Chiara Scelfo ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Severe Asthma ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Antiviral Effect ◽  
Point Of View ◽  
Type I ◽  
Effector Cells ◽  
Viral Spread ◽  
Increased Risk

Viral respiratory infections are recognized risk factors for the loss of control of allergic asthma and the induction of exacerbations, both in adults and children. Severe asthma is more susceptible to virus-induced asthma exacerbations, especially in the presence of high IgE levels. In the course of immune responses to viruses, an initial activation of innate immunity typically occurs and the production of type I and III interferons is essential in the control of viral spread. However, the Th2 inflammatory environment still appears to be protective against viral infections in general and in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as well. As for now, literature data, although extremely limited and preliminary, show that severe asthma patients treated with biologics don’t have an increased risk of SARS-CoV-2 infection or progression to severe forms compared to the non-asthmatic population. Omalizumab, an anti-IgE monoclonal antibody, exerts a profound cellular effect, which can stabilize the effector cells, and is becoming much more efficient from the point of view of innate immunity in contrasting respiratory viral infections. In addition to the antiviral effect, clinical efficacy and safety of this biological allow a great improvement in the management of asthma.

scholarly journals 143. Initial Impact of COVID-19 on Ambulatory Antibiotic Prescribing for Respiratory Viral Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S82-S82
Author(s):  
Zahra Kassamali Escobar ◽  
Todd Bouchard ◽  
Jose Mari Lansang ◽  
Scott Thomassen ◽  
Joanne Huang ◽  
...  
Keyword(s):  
Primary Care ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Urgent Care ◽  
Antibiotic Prescribing ◽  
Specific Rate ◽  
Inclusion Criteria ◽  
Diagnosis Codes ◽  
Control And Prevention ◽  
Viral Respiratory Infections

Abstract Background Between 15–50% of patients seen in ambulatory settings are prescribed an antibiotic. At least one third of this usage is considered unnecessary. In 2019, our institution implemented the MITIGATE Toolkit, endorsed by the Centers for Disease Control and Prevention to reduce inappropriate antibiotic prescribing for viral respiratory infections in emergency and urgent care settings. In February 2020 we identified our first hospitalized patient with SARS-CoV(2). In March, efforts to limit person-to-person contact led to shelter in place orders and substantial reorganization of our healthcare system. During this time we continued to track rates of unnecessary antibiotic prescribing. Methods This was a single center observational study. Electronic medical record data were accessed to determine antibiotic prescribing and diagnosis codes. We provided monthly individual feedback to urgent care prescribers, (Sep 2019-Mar 2020), primary care, and ED providers (Jan 2020 – Mar 2020) notifying them of their specific rate of unnecessary antibiotic prescribing and labeling them as a top performer or not a top performer compared to their peers. The primary outcome was rate of inappropriate antibiotic prescribing. Results Pre toolkit intervention, 14,398 patient visits met MITIGATE inclusion criteria and 12% received an antibiotic unnecessarily in Jan-April 2019. Post-toolkit intervention, 12,328 patient visits met inclusion criteria and 7% received an antibiotic unnecessarily in Jan-April 2020. In April 2020, patient visits dropped to 10–50% of what they were in March 2020 and April 2019. During this time the unnecessary antibiotic prescribing rate doubled in urgent care to 7.8% from 3.6% the previous month and stayed stable in primary care and the ED at 3.2% and 11.8% respectively in April compared to 4.6% and 10.4% in the previous month. Conclusion Rates of inappropriate antibiotic prescribing were reduced nearly in half from 2019 to 2020 across 3 ambulatory care settings. The increase in prescribing in April seen in urgent care and after providers stopped receiving their monthly feedback is concerning. Many factors may have contributed to this increase, but it raises concerns for increased inappropriate antibacterial usage as a side effect of the SARS-CoV(2) pandemic. Disclosures All Authors: No reported disclosures

scholarly journals Innate Immunity in Children and the Role of ACE2 Expression in SARS-CoV-2 Infection

2021 ◽  
Vol 13 (3) ◽  
pp. 363-382
Author(s):  
Mario Dioguardi ◽  
Angela Pia Cazzolla ◽  
Claudia Arena ◽  
Diego Sovereto ◽  
Giorgia Apollonia Caloro ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Viral Disease ◽  
Receptor Expression ◽  
Virus Infections ◽  
Search Terms ◽  
Bibliographic Search ◽  
Meta Analyses

COVID-19 (Coronavirus Disease 2019) is an emerging viral disease caused by the coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which leads to severe respiratory infections in humans. The first reports came in December 2019 from the city of Wuhan in the province of Hubei in China. It was immediately clear that children developed a milder disease than adults. The reasons for the milder course of the disease were attributed to several factors: innate immunity, difference in ACE2 (angiotensin-converting enzyme II) receptor expression, and previous infections with other common coronaviruses (CovH). This literature review aims to summarize aspects of innate immunity by focusing on the role of ACE2 expression and viral infections in children in modulating the antibody response to SARS-CoV-2 infection. This review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles deemed potentially eligible were considered, including those dealing with COVID-19 in children and providing more up-to-date and significant data in terms of epidemiology, prognosis, course, and symptoms, focusing on the etiopathogenesis of SARS-CoV-2 disease in children. The bibliographic search was conducted using the search engines PubMed and Scopus. The following search terms were entered in PubMed and Scopus: COVID-19 AND ACE2 AND Children; COVID-19 AND Immunity innate AND children. The search identified 857 records, and 18 studies were applicable based on inclusion and exclusion criteria that addressed the issues of COVID-19 concerning the role of ACE2 expression in children. The scientific literature agrees that children develop milder COVID-19 disease than adults. Milder symptomatology could be attributed to innate immunity or previous CovH virus infections, while it is not yet fully understood how the differential expression of ACE2 in children could contribute to milder disease.

scholarly journals Sarcopenia and Malnutrition Screening in Female Osteoporosis Patients—A Cross-Sectional Study

2021 ◽  
Vol 10 (11) ◽  
pp. 2344
Author(s):  
Franca Genest ◽  
Dominik Rak ◽  
Elisa Bätz ◽  
Kerstin Ott ◽  
Lothar Seefried
Keyword(s):  
At Risk ◽  
Risk Groups ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Functional Deficits ◽  
Complementary Approach ◽  
Study Results ◽  
Patients At Risk ◽  
Not At Risk

Sarcopenia and malnutrition are important determinants of increased fracture risk in osteoporosis. SARC-F and MNA-SF are well-established questionnaires for identifying patients at risk for these conditions. We sought to evaluate the feasibility and potential added benefit of such assessments as well as the actual prevalence of these conditions in osteoporosis patients. We conducted a cross-sectional, single-center study in female osteoporosis patients ≥ 65 years (SaNSiBaR-study). Results of the sarcopenia (SARC-F) and malnutrition (MNA-SF) screening questionnaires were matched with a functional assessment for sarcopenia and data from patients’ medical records. Out of 107 patients included in the analysis, a risk for sarcopenia (SARC-F ≥ 4 points) and a risk for malnutrition (MNA-SF ≤ 11 points) was found in 33 (30.8%) and 38 (35.5%) patients, respectively. Diagnostic overlap with coincident indicative findings in both questionnaires was observed in 17 patients (16%). As compared to the respective not-at-risk groups, the mean short physical performance battery (SPPB) score was significantly reduced in both patients at risk for sarcopenia (7.0 vs. 10.9 points, p < 0.001) and patients at risk for malnutrition (8.7 vs. 10.5 points, p = 0.005). Still, confirmed sarcopenia according to EWGSOP2 criteria was present in only 6 (6%) of all 107 patients, with only 3 of them having an indicative SARC-F score. Bone mineral density was not significantly different in any of the at-risk groups at any site. In summary, applying SARC-F and MNA-SF in osteoporosis patients appears to be a complementary approach to identify individuals with functional deficits.

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