QUALITY OF ORTHOPEDIC REHABILITATION OF PATIENTS WITH POST-TRAUMATIC DEFECTS OF THE UPPER JAW BY CHARACTERISTICS OF BIOCENOSIS OF THE ORAL CAVITY

The aim of the research was to study the dynamics of the microbiota’s features of oral mucosal membrane during orthopedic rehabilitation of patients with removable dentures which has an obturating part with two-layer bases. Materials and methods: To achieve this goal, our bacteriological examination of oral cavity mucosa was performed for 25 patients with partial adentia of the upper jaw and defect of hard palate and alveolar process. Results and conclusions: Of the conducted studies indicate significant shifts in the qualitative and quantitative composition of microbiocenosis in the oral cavity in patients with partial adenia of the upper jaw and a defect of hard palate and alveolar process due to representatives of moraksel, enterobacteria (representatives of the kinds Klebsiella and E. coli). The сomparing of frequency of extraction and the density of microbial colonization showed us the persistence in biotope of representatives near 13 kinds of bacteria and yeast-like fungi of the kind Candida in averages from lg (2,5 ± 0,19) to lg (5,4 ± 0,17) CFU/g. For patients who have been made a two-layered basis, materials of which are based on carboxymethylcellulose and polyvinialacetate in the period of adaptation to removable dentures, showed us that the detection of 5 component associations at 30 days was reduced by 2 times (χ2 = 5,991; ν = 2; p <0,05) . The frequency of removal and density of microbial colonization of the experimental group did not differ statistically. Among patients in the control group, the microbial colonization density increased for Enterococcus spp, for Klebsiella spp and for Candida spp. Yeast-like fungi. A significant decrease in the microbial density of the resident microflora was 1.4 times for Neisseria spp, 1.6 times for Lactobacillus spp (p <0,05).

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Candida spp. occurrence in oral cavities of breastfeeding infants and in their mothers' mouths and breasts

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000200010 ◽

2003 ◽

Vol 17 (2) ◽

pp. 151-155 ◽

Cited By ~ 13

Author(s):

Maria Stella Amorim da Costa Zöllner ◽

Antonio Olavo Cardoso Jorge

Keyword(s):

Oral Cavity ◽

Candida Species ◽

Statistical Difference ◽

Control Group ◽

Biochemical Tests ◽

Candida Spp ◽

Lactating Women ◽

Sabouraud Agar ◽

Breastfed Infants ◽

Yeast Strains

This study aimed to determine the occurrence of Candida spp. in the oral cavity of predominantly breastfed infants and in their mothers' mouths and breasts, as well as in the oral cavity of bottlefed infants and in non-lactating women. One hundred and sixty nine women and eighty-five milk-fed infants took part in this study and were divided into four groups: 1) infants predominantly on breastfeeding (n = 55) and their mothers (n = 55); 2) infants on bottlefeeding (n = 30); 3) non-lactating women on whom oral collections were performed (n = 80) and, 4) non-lactating women on whom breast collections were performed (n = 34). Oral and mammary swabs were cultured on Sabouraud agar dextrose with chloramphenicol. The Candida yeast strains found were isolated and identified through morphological and biochemical tests. Candida species were much less frequent in infants who were predominantly breastfed than in those who were bottlefed. Yeasts were much more frequent on the breasts of lactating women, with statistical difference in relation to the control group.

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Morphological and Radiologic Evaluation of the Human Nasopalatine Duct

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940511400311 ◽

2005 ◽

Vol 114 (3) ◽

pp. 229-232 ◽

Cited By ~ 9

Author(s):

Michael Knecht ◽

Karl-Bernd Hüttenbrink ◽

Thomas Kittner ◽

Thomas Hummel ◽

Thomas Beleites ◽

...

Keyword(s):

Oral Cavity ◽

Nasal Cavity ◽

Hard Palate ◽

Common Finding ◽

Alveolar Process ◽

Resonance Imaging ◽

Maxillary Bone ◽

Rare Finding ◽

The Past ◽

Radiologic Evaluation

In several mammals, a direct connection between the nasal cavity and the oral cavity is a common finding. The structure is named the nasopalatine duct (NPD). It has been hypothesized to be functional in terms of transportation of odorants from the oral cavity to the nasal cavity. In humans, the NPD exists during embryological development. The connection between the nasopalatine infundibulum and the incisive fossa is typically closed at the time of birth. We present the case of a 24-year-old man who presented with a persistent NPD. By means of a thin, soft tube, it was possible to probe the NPD. Magnetic resonance imaging revealed a bony gap between the hard palate and the alveolar process of the maxillary bone with a length of 16 mm and a width of 6 mm. In light of the literature of the past 500 years, this represents a rare finding of a persistent NPD.

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Inhibitory Effect of Lactobacillus plantarum CCFM8724 towards Streptococcus mutans- and Candida albicans-Induced Caries in Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/4345804 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Qiuxiang Zhang ◽

Sujia Qin ◽

Xianyin Xu ◽

Jianxin Zhao ◽

Hao Zhang ◽

...

Keyword(s):

Candida Albicans ◽

Dental Caries ◽

Oral Cavity ◽

Lactobacillus Plantarum ◽

Streptococcus Mutans ◽

Microbial Colonization ◽

Control Group ◽

Scoring Method ◽

Treatment And Prevention

Streptococcus mutans is a recognized cariogenic bacterium and a major producer of biofilm matrix. The presence of Candida albicans in dental plaque with S. mutans enhances the virulence leading to the onset of rampant caries which is similar to early childhood caries (ECC). The purpose of this study was to explore the effect of Lactobacillus plantarum CCFM8724 (CCFM8724) on the treatment and prevention of dental caries induced by S. mutans and C. albicans in vivo. Rats were divided into 6 groups: the control group and model group, 2 treatment groups, and 2 prevention groups (0.02% chlorhexidine or CCFM8724). The fluctuation of microbial colonization and the change of bacteria flora in rat oral cavity after sowing of L. plantarum CCFM8724 were investigated by colony-forming units (CFU) and microflora analysis. The caries of rats were assessed by microcomputed tomography (micro-CT) and Keyes scoring method. The results showed that L. plantarum CCFM8724 in both the treatment and prevention groups could significantly decrease the population of S. mutans and C. albicans in the rats’ oral cavity ( p < 0.001 ), the mineral loss of enamel ( p < 0.05 ), and the scores of caries ( p < 0.05 ). Besides, L. plantarum CCFM8724 exhibited better effects than chlorhexidine. Hence, L. plantarum CCFM8724 was proved to be a potential oral probiotic on caries treatment and prevention in vivo and it may have the prospect of application in dental caries (especially ECC) prevention products.

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Prevalence of yeasts in the oral cavity of children treated with inhaled corticosteroids

Brazilian Oral Research ◽

10.1590/s1806-83242004000300004 ◽

2004 ◽

Vol 18 (3) ◽

pp. 197-201 ◽

Cited By ~ 5

Author(s):

Edson Yukio Komiyama ◽

Patrícia Monteiro Ribeiro ◽

Juliana Campos Junqueira ◽

Cristiane Yumi Koga-Ito ◽

Antonio Olavo Cardoso Jorge

Keyword(s):

Oral Cavity ◽

Inhaled Corticosteroids ◽

Treated Group ◽

Phenotypic Characterization ◽

Control Group ◽

Candida Spp ◽

Significant Statistical Difference ◽

Colony Forming Units ◽

Phosphate Buffered Saline ◽

Prevalent Species

The aim of this study was to observe the prevalence of Candida spp. in the oral cavity of children undergoing treatment with inhaled corticosteroids. Thirty children treated with inhaled corticosteroids and thirty control children were studied. Saliva samples were collected through oral rinses with phosphate buffered saline (PBS). The samples were plated on Sabouraud's dextrose agar and incubated at 37°C for 48 h. After this period, the number of colony-forming units per ml (cfu/ml) of saliva was calculated. The isolates were identified by phenotypic characterization. Candida spp. was isolated from 43.33% of the samples of children treated with corticosteroids, with a mean of 780 cfu/ml of saliva, and from 30% of the samples of the control group, with a mean of 560 cfu/ml of saliva. No significant statistical difference was observed between the groups. C. albicans was the prevalent species in both groups, followed by C. guilliermondii, C. parapsilosis and C. stellatoidea. Furthermore, Rhodotorula rubra and C. lusitaniae were also isolated from the treated group. We concluded that there was no significant increase in the prevalence and number of Candida spp. in the oral cavity of children treated with inhaled corticosteroids.

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The state of the oral microflora in patients with systemic sclerosis

Modern Rheumatology Journal ◽

10.14412/1996-7012-2021-5-39-43 ◽

2021 ◽

Vol 15 (5) ◽

pp. 39-43

Author(s):

M. S. Yesayan ◽

E. I. Selifanova ◽

E. G. Margaryan ◽

T. V. Beketova

Keyword(s):

Systemic Sclerosis ◽

Oral Cavity ◽

Oral Hygiene ◽

Personal Hygiene ◽

Control Group ◽

Quantitative Composition ◽

Normal Microflora ◽

Oral Microflora ◽

Dmft Index ◽

High Level

Systemic sclerosis (SSc) can lead to pathological changes in the maxillofacial region, contributing to the violation of the microbiocenosis of the oral cavity with a predominance of pathogenic microflora.Objective: to study the composition of the oral microflora in patients with SSc. Patients and methods. The composition of the oral microflora was studied in 50 patients with SSc. The control group consisted of 50 subjects without rheumatic diseases. To assess the intensity of dental caries and the level of oral hygiene we used dental indices: the index of caries intensity (Decayed, Missing, and Filled Teeth (DMFT) and the hygienic index (OHI-S).Results and discussion. Microbiological examination in patients with SSc revealed pathogenic Staphylococcus aureus and Candida albicans > 10-6 CFU in equal percentage of cases (18.9%), which was significantly more frequent than in the control group (p=0.049). In the oral cavity in SSc, there were no representatives of normal microflora (lactobacilli). In patients with SSc, the DMFT index was 17.8±7.1 on average, and OHI-S – 2.3±0.7, which corresponds to a very high level of caries intensity and low indicators of oral hygiene, respectively. When analyzing the microflora of the oral cavity in 90% of cases, a dysbiotic shift of the 3rd degree was stated.Conclusion. It can hypothesized that the qualitative and quantitative composition of the microflora of the oral cavity affects the development and severity of inflammatory and destructive pathology of the periodontal and oral mucosa. It is necessary to develop and implement an adapted personal hygiene regimen, including cleansing of the tongue and administration of local probiotics, which, as part of complex therapy, can improve the results of SSc treatment.

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ORTHODONTIC AND ORTHOPEDIC REHABILITATION OF PATIENTS WITH CLEFT OF UPPER LIP, ALVEOLAR SURGERY, HARD AND SOFT PALATE

Ukrainian Dental Almanac ◽

10.31718/2409-0255.4.2018.10 ◽

2018 ◽

pp. 55-59

Author(s):

O.M. Makarova ◽

M.V. Semenyaka ◽

G.M. Balya ◽

V.D. Kuroyedova

Keyword(s):

Soft Palate ◽

Orthodontic Treatment ◽

Speech Disorders ◽

Alveolar Process ◽

Upper Lip ◽

High Tendency ◽

Skeletal Malformation ◽

Lower Jaw ◽

Orthopedic Rehabilitation ◽

Upper Jaw

The problem of children’s rehabilitation with cleft palate is multi edged and complex. The ultimate goal of rehabilitation measures is to restore the anatomical integrity of the tissues of the hard and soft palate, the function of the articulatory and mastication systems, create conditions for correct speech and maximum aesthetic rehabilitation. Orofacial cleft leads to the appearance of functional changes in breathing, sucking, chewing and swallowing. In the process of development of masticatory system, the formation of complex dentoalveolar anomalies in parallel with a significant decrease in masticatory efficiency, weakens the process of sound production, which leads to the formation of stable speech disorders. Such children from childhood form a sense of inferiority, they have reduced social adaptation due to the presence of a cosmetic defect and speech disorders. Optimization of orthodontic and orthopedic rehabilitation of patients with non-incision of the upper lip, alveolar process, hard and soft palate is actual clinical problem of modern dentistry. Typical orthodontic pathology in such patients is the development of the upper jaw with a significant narrowing of the upper dentition (due to cicatricial changes) and, as a result, the formation of a prognosis, often deep, bite. Possibilities for orthodontic treatment of such patients are significantly limited due to postoperative cicatricial changes, skeletal malformation of the upper jaw, partial upper teeth adentia, small alveolar bone volume, low dentoalveolar compensation capacity, high tendency to relapse, therefore, the completion of orthodontic treatment often requires a double denture. We propose to use milled caps and present a clinical case of their application. The stages of manufacturing milled cap are the following: making prints and the manufacture of models; superposition of the facial arch to determine the position of the upper jaw; determination of the central position of the lower jaw (by facial features, with functional tests and subsequent check of the state of the chewing muscles by EMG and the position of the joints with the help of CCPT), plastering the models in the articulator, 3D scanning and digitizing models and digital modeling of the cap with ZIRKONZAHN Scan. To make the cap, Multistratum flexible was used, which is a biocompatible elastic composite material with a low plaque build-up and high aesthetic characteristics, designed for the manufacture of cynoanatomical structures. Caps are recommended to be used day and night, even during meals. Caps are removed only for daily hygiene procedures. Thus, the milled cap allows solving practical problems in non-stunted patients with non-incision of the upper lip, alveolar process, hard and soft palate such as: to provide multiple occlusions without contacts and protected occlusion with stable position of the lower jaw; restore the full function of chewing; ensure maximum retention while maintaining the width of the upper dentition; significantly improve the aesthetics of the smile (the appearance of "white aesthetics") and the face (raising the height of the bite, improving the profile, the step of the lips, reducing the second chin, rotation of the lower jaw clockwise); create optimal conditions for further permanent prosthetics, since digital models can be used as reference points for future permanent non-removable structures. So, removable milled caps are the modern optimal method of temporary long-term prosthetics, which greatly improve the functional and aesthetic status of the patient.

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Dynamics of Microbial Colonization of the Oral Cavity in Newborns

Brazilian Dental Journal ◽

10.1590/0103-6440201302266 ◽

2013 ◽

Vol 24 (4) ◽

pp. 415-419 ◽

Cited By ~ 20

Author(s):

Paulo Nelson-Filho ◽

Izabela Goncalves Borba ◽

Kessia Suenia Fidelis de Mesquita ◽

Raquel Assed Bezerra Silva ◽

Alexandra Mussolino de Queiroz ◽

...

Keyword(s):

Oral Cavity ◽

Host Defense ◽

Staphylococcus Epidermidis ◽

Defense Mechanisms ◽

Mutans Streptococci ◽

Microbial Colonization ◽

Oral Microbiota ◽

Alveolar Process ◽

Colony Forming Units ◽

Hygienic Measures

The host defense mechanisms are not well developed in neonates. The aim of this study was to evaluate the dynamics of microbial colonization of the oral cavity in newborns. Eighty-one samples of the oral microbiota were obtained from 51 healthy newborns 10 min to 53 h after birth by gently rubbing sterile swabs onto the surface of the tongue, cheek mucosa, alveolar process and palate. After microbiological processing, counting of the colony forming units of streptococci, staphylococci and Gram-negative aerobic bacilli was performed. Between 10 min and 8 h, Staphylococcus epidermidis was detected in 30.7% of the samples; between 8 and 16 h, S. epidermidis was detected in 69.5% of the samples and streptococci in 56.5% of the samples; between 16 and 24 h, S. epidermidis, streptococci and S. aureus were detected in 77.78%, 85.18% and 37.03% of the samples, respectively. Between 24 and 53 h, S. epidermidis was detected in 88.89%, streptococci in 94.4% and S. aureus in 33.3% of the samples. Mutans streptococci were not detected in any of the samples. The adoption of strict hygienic measures by the mother and the nursing staff should be emphasized to avoid or at least delay the occurrence of infections caused by microorganisms in newborns. In addition, hospital procedures must be aseptic and invasive interventions must be minimized.

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The use of cellular technologies in the treatment of children with congenital cleft palate

Pediatric Traumatology Orthopaedics and Reconstructive Surgery ◽

10.17816/ptors5431-37 ◽

2017 ◽

Vol 5 (4) ◽

pp. 31-37 ◽

Cited By ~ 1

Author(s):

Yulia V. Stepanova ◽

Margarita S. Tsyplakova ◽

Anna S. Usoltseva ◽

Natela I. Enukashvili ◽

Varvara V. Bagaeva ◽

...

Keyword(s):

Cleft Palate ◽

Alveolar Bone ◽

Maxillofacial Surgery ◽

Control Group ◽

Alveolar Process ◽

Facial Skeleton ◽

Multipotent Stem Cells ◽

Biomedical Technologies ◽

Congenital Cleft ◽

Upper Jaw

Background. Mesenchymal stromal cells (MSCs) are multipotent stem cells capable of differentiation in the osteogenic, chondrogenic, and adipogenic directions that are widely used in the development of new cellular biomedical technologies. Aim. We investigated the effect of MSCs on osteogenesis in the congenital defect of the alveolar process of the upper jaw with the aim of improving the treatment results for children with congenital cleft palate. Materials and methods. At the department of maxillofacial surgery of the Turner Institute for Children’s Orthopedics, 46 patients with a diagnosis of congenital cleft palate were observed in 2017. Six patients with congenital cleft palate in the region of the defect of the hard palate and the alveolar process of the upper jaw underwent uranoplasty and implantation of a mixture (1 : 4) of MSCs and preosteocytes derived from them on the osteogenic membrane. The control group consisted of 40 age-matched patients who underwent the same surgery but without the use of MSCs. The distance between the cleaved portions of the alveolar process of the upper jaw ranged from 0.5–1.0 cm. The follow-up period was 6–9 months. Results. On X-ray examination 6–9 months after the operation in the bone defect area and implantation of MSCs in all patients, tissue with a density corresponding to that of bone was found. In the control group, bone tissue was not formed in the diastasis of the alveolar bone. There were no significant differences in the timing of wound healing and course of the postoperative period. Сonclusion. Tissue engineering helped in the treatment of severe congenital malformations of the maxillofacial area. There are good prospects for using MSCs in the surgical treatment of defects of the facial skeleton.

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DIAGNOSTIC SIGNIFICANCE OF SOME REPRESENTATIVES OF NORMAL MICROBIOME OF THE ORAL CAVITY IN THE DEVELOPMENT OF RECOVERABLE ACTS OF THE ORAL CAVITY IN PATIENTS WITH ACID-DEPENDENT GASTROINTESTINAL DISEASES

The actual problems in dentistry ◽

10.18481/2077-7566-2019-15-4-31-37 ◽

2020 ◽

Vol 15 (4) ◽

pp. 31-37

Author(s):

Irina Galimova ◽

Irina Usmanova ◽

Larisa Gerasimova ◽

Marsel Tuigunov ◽

Yigal Granot ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Oral Cavity ◽

Clinical Manifestations ◽

Gastrointestinal Diseases ◽

Control Group ◽

Candida Spp ◽

Diagnostic Significance ◽

Detection Frequency ◽

Enterococcus Spp ◽

Staphylococcus Spp

Subject. The results of a comprehensive microbiological study of the state of the normobioma of the oral cavity in individuals with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract are considered. The goal is to determine the diagnostic significance of individual representatives of the oral normobioma in patients with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract. Methodology. The study involved 83 patients who were divided into two main and control groups depending on the clinical manifestations of recurrent aphthae of the oral cavity on the background of hypersecretory syndrome. Results. The results of the study showed that in patients of the first and second main groups, in which the manifestations of recurrent aphthae in the oral cavity were accompanied by diseases of the gastrointestinal tract with hypersecretory syndrome, the frequency of allocation of staphylococcal flora was 1.3—1.5 times higher compared to control (p≤0.05), an increase in the proportion of S. aureus — 2.5 times. The detection frequency of S. epidermidis in the control and both clinical groups was 28.0, 27.6 and 31.0 % of cases, respectively, the proportion of hemolytic forms in the control group was 4.0 %, in the first 10.3 % (an increase of 2 5 times), in the second — 17.2 % (4.3 times). The observed changes in the species composition may indicate dysbiosis in the oral cavity, caused not only by the presence of recurrent aphthae, but also by acid-dependent diseases of the gastrointestinal tract. Conclusions. In recurrent aphthae of the oral cavity in patients with acid-dependent diseases of the gastrointestinal tract in the microbiome of the oral cavity against the background of reduced titers of lactobacilli, an increase in representatives of Staphylococcus spp., Enterococcus spp is most often observed. and Candida spp. (1.2 times average), Enterococcus spp. (1.4 times), Staphylococcus spp. and Enterobacteriaceae spp. (1.2 times), Actinobacillus spp. (1.1 times).

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Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

American Journal of Speech-Language Pathology ◽

10.1044/2019_ajslp-19-00095 ◽

2020 ◽

Vol 29 (2) ◽

pp. 864-872

Author(s):

Fernanda Borowsky da Rosa ◽

Adriane Schmidt Pasqualoto ◽

Catriona M. Steele ◽

Renata Mancopes

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Oral Cavity ◽

Pulmonary Disease ◽

Thermal Sensation ◽

Sensory Function ◽

Control Group ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Age Related ◽

Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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