scholarly journals The state of the oral microflora in patients with systemic sclerosis

2021 ◽  
Vol 15 (5) ◽  
pp. 39-43
Author(s):  
M. S. Yesayan ◽  
E. I. Selifanova ◽  
E. G. Margaryan ◽  
T. V. Beketova
Keyword(s):  
Systemic Sclerosis ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Personal Hygiene ◽  
Control Group ◽  
Quantitative Composition ◽  
Normal Microflora ◽  
Oral Microflora ◽  
Dmft Index ◽  
High Level

Systemic sclerosis (SSc) can lead to pathological changes in the maxillofacial region, contributing to the violation of the microbiocenosis of the oral cavity with a predominance of pathogenic microflora.Objective: to study the composition of the oral microflora in patients with SSc. Patients and methods. The composition of the oral microflora was studied in 50 patients with SSc. The control group consisted of 50 subjects without rheumatic diseases. To assess the intensity of dental caries and the level of oral hygiene we used dental indices: the index of caries intensity (Decayed, Missing, and Filled Teeth (DMFT) and the hygienic index (OHI-S).Results and discussion. Microbiological examination in patients with SSc revealed pathogenic Staphylococcus aureus and Candida albicans > 10-6 CFU in equal percentage of cases (18.9%), which was significantly more frequent than in the control group (p=0.049). In the oral cavity in SSc, there were no representatives of normal microflora (lactobacilli). In patients with SSc, the DMFT index was 17.8±7.1 on average, and OHI-S – 2.3±0.7, which corresponds to a very high level of caries intensity and low indicators of oral hygiene, respectively. When analyzing the microflora of the oral cavity in 90% of cases, a dysbiotic shift of the 3rd degree was stated.Conclusion. It can hypothesized that the qualitative and quantitative composition of the microflora of the oral cavity affects the development and severity of inflammatory and destructive pathology of the periodontal and oral mucosa. It is necessary to develop and implement an adapted personal hygiene regimen, including cleansing of the tongue and administration of local probiotics, which, as part of complex therapy, can improve the results of SSc treatment.

scholarly journals Evaluation of Oral Hygiene in Patients with Generalized Periodontitis of II Degree and Stage II Hypertension

2016 ◽  
Vol 23 (4) ◽  
pp. 2016419
Author(s):  
Tetiana Vivcharenko ◽  
Mykola Rozhko
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Main Group ◽  
Stage Ii ◽  
Personal Hygiene ◽  
Control Group ◽  
Poor Oral Hygiene ◽  
Periodontal Tissues ◽  
The Status

Generalized periodontitis is the most common form of periodontal pathology, especially in the second half of life. Nowadays, the problem of periodontal disease is relevant due to its high prevalence, tendency to progression, multifaceted influence on the dentoalveolar system and the whole organism as well as uncertain treatment. Therefore, there is a need to find optimal ways of prevention and treatment of this disease. Close relationships between periodontal pathology and systemic diseases, such as hypertension, which affects every 2nd-3rd adult were determined.The objective of the research was to determine the status of oral cavity hygiene in patients with generalized periodontitis of II degree and stage II hypertension.Materials and methods. The study included 30 patients with generalized periodontitis of II degree and stage II hypertension being treated in the Ivano-Frankivsk Regional Clinical Cardiology Dispensary; the average age ranged from 35 to 54 years (the main group). The control group included 10 patients of the same age without generalized periodontitis and somatic pathology .The status of oral cavity hygiene was determined using the Green Vermillion index. The diagnosis of periodontal disease was made on the basis of the classification proposed by M.F. Danilevskyi. The obtained results were subjected to variation-statistical analysis using statistical package “Stat Soft 6.0”; classical methods of variational statistics were applied; mean values and their reliability were evaluated.Results. The results of examination showed poor oral hygiene in almost all patients. The analysis of hygienic indices showed the following results: in patients of the main group, the Green Vermillion index was 1.99 ± 0.13 points (p<0.001) which corresponds to unsatisfactory level of oral hygiene. In patients of the control group, this index was 1.10 ± 0.17 points which corresponds to satisfactory level of oral hygiene. According to the index, 9 (30.0%) patients of the main group had satisfactory oral hygiene, 12 (40.0%) patients had poor oral hygiene, and in 9 (30.0%) patients, poor oral hygiene was observed.In the control group, 2 (20.0%) patients had good oral hygiene, 6 (60.0%) patients had satisfactory oral hygiene and in 2 (20.0%) patients, unsatisfactory oral hygiene was observed. There were no patients with poor oral hygiene. The analysis of the indicators of the Green Vermillion index showed that in case of the pathological process exacerbation the oral hygiene status in patients deteriorated.Conclusions. The level of oral hygiene in patients of both groups was low due to incorrect selection of personal hygiene products or their untimely replacement. In patients with generalized periodontitis of II degree and stage II hypertension, the level of oral hygiene was lower than in somatically healthy persons: the worse status of oral cavity hygiene – the more pronounced changes in the periodontal tissues. We can suppose that high blood pressure affects the status of the oral cavity, creates a higher risk and exacerbates the periodontal diseases.

scholarly journals Antimicrobial efficacy of Colgate Plax Cool Mint® mouthwash – in vivo studies

2020 ◽  
Vol 33 (4) ◽  
pp. 211-218
Author(s):  
Jolanta Szymanska ◽  
Ewa Olejnik ◽  
Anna Biernasiuk ◽  
Anna Malm
Keyword(s):  
Oral Cavity ◽  
Oral Hygiene ◽  
In Vivo Studies ◽  
Antimicrobial Efficacy ◽  
Control Group ◽  
Study Group ◽  
Oral Microflora ◽  
Plaque Development ◽  
The Impact

Abstract Hygienic procedures in oral cavity, both teeth brushing and using mouthwashes, have an influence on the composition and quantity of oral microflora. The aim of the work was to evaluate the impact of regular use of selected mouthwash on the titer of Lactobacillus and Streptococcus bacteria and Candida yeast-like fungi in the saliva. The evaluation of the influence of Colgate Plax Cool Mint® mouthwash on the number of Lactobacillus and Streptococcus bacteria and Candida yeast-like fungi in the saliva was done. The research included 39 persons at the age of 17±3 months, out of whom 30 people constituted a study group using mouthwash and 9 people – a control group not using mouthwash. The persons from the study group used the mouthwash twice a day for 2–3 minutes for the period of 5 months. The material for the microbiological tests constituted 2 ml of saliva collected three times from the participants: at the beginning of the research – before the use of a mouthwash and respectively, after 2.5 and 5 months from the first test. Colgate Plax Cool Mint®, the most frequently used by the youth in their daily oral hygiene and used in the present study mouthwash, showed effectiveness in reduction of Lactobacillus spp. and S. mutans bacteria, as well as C. albicans yeasts in the saliva of the studied persons, what is undoubtedly connected with inhibition of formation and prevention of oral plaque development.

scholarly journals COMPARATIVE PECULIARITIES OF ORAL HYGIENE INDICES IN CHILDREN OF PRIMARY SCHOOL DEPENDING ON DENTAL HEALTH

2018 ◽  
pp. 27-30
Author(s):  
L.F. Kaskova ◽  
K.M. Popyk ◽  
L.P. Ulasevych
Keyword(s):  
Parental Involvement ◽  
Oral Cavity ◽  
Primary School ◽  
Oral Hygiene ◽  
Dental Health ◽  
Primary School Children ◽  
Personal Hygiene ◽  
Significant Difference ◽  
Permanent Molars ◽  
First Permanent Molars

A study of oral hygiene condition in primary school children based on Fedorov-Volodkina index has revealed that children do not clean their teeth properly enough and the average indicator of the studied group is unsatisfactory. The study based on children’s age indicates that the best oral hygiene condition is found in children aged 9 (satisfactory), whereas the worst – in children aged 8 (unsatisfactory). This, in our opinion, is due to the period of frontal teeth eruption and the discomfort associated with such process. Children clean the frontal area not properly. As children grow older, their personal hygiene skills improve as evidenced by the findings of comparing 6- and 9-year-olds’ indices (р<0.05). It was determined that each child’s index by Green-Vermillion and obtained results allows assessing the condition of oral cavity and cleaning skills. It has been identified significant differences in the oral hygiene condition in children who suffer from caries and in children with healthy teeth. Thus, before teeth brushing 6-year-old children without caries had unsatisfactory oral hygiene condition, children with caries –poor oral hygiene condition, 7-year old children – unsatisfactory one, 8-year-old children – unsatisfactory and poor, 9-year-old children – satisfactory and unsatisfactory respectively. The poorest oral hygiene condition was observed with 6-year-olds with caries. It has been assessed that dental tartar based on the studied indices. The study has revealed insufficient oral hygiene of the frontal and lateral jaw areas in children of primary school. This phenomenon creates cariogenic situation in the oral cavity. Having studied oral hygiene condition in children, it was offered by us to brush teeth with the toothbrush and toothpaste which they use at home. They brushed their teeth under the supervision, but without dentist’s management. Observed results were described in this paper. After brushing, oral hygiene condition has been studied again. When assessing Fedorov-Volodkina index, it was not observed any improvement of the index after teeth brushing in children without caries. In 6-, 7-, and 8-year-old children oral hygiene was unsatisfactory, whereas in 9-year-old children it was satisfactory. Oral hygiene improvement was observed in children who have caries. In 6-year-old children – from poor to unsatisfactory, in 7-, 8-, and 9-year-old children it remained at the same unsatisfactory level, but hygiene index indicators probably decreased (р<0.05). The findings indicate that children with caries do not pay attention to oral hygiene, whereas teeth brushing improve the studied index. Green-Vermillion index enables to determine oral hygiene condition in frontal and lateral jaw areas. After individual teeth brushing this hygiene index values slightly improve compared to original values, however, no significant difference in hygiene level was identified. Findings from studying various hygiene indices indicate that children with caries pay attention to brushing frontal jaw area and absolutely no attention to brushing lateral jaw areas with first permanent molars that have recently erupted, and they are not enough mineralized, and are prone to caries at this age. This encourages a study of teeth brushing skills of children of primary school using the suggested form of child oral hygiene skills followed by development of oral hygiene recommendations for the children of this age group with parental involvement.

scholarly journals POTENTIOMETRIC PARAMETERS IN PATIENTS WITH NON-REMOVABLE ORTHOPEDIC STRUCTURES AND INTRAORAL HALITOSIS

2018 ◽  
pp. 17-20
Author(s):  
O.A. Udod ◽  
A.O. Hlivynska
Keyword(s):  
Oral Cavity ◽  
Physicochemical Parameters ◽  
Oral Fluid ◽  
Personal Hygiene ◽  
Control Group ◽  
Social Maladjustment ◽  
Dental Alloys ◽  
The Third ◽  
Unpleasant Odor ◽  
Bioelectric Potentials

Introduction. The most popular type of dentures is permanent orthopedic structures. However, their use is a serious intervention that changes biological balance in the oral cavity through galvanic, reflex and toxic allergic effects. Because of this, galvanic currents appear in the oral cavity, which have an adverse effect on the oral mucosa and the physicochemical parameters of the oral fluid. As a result of increasing bioelectric potentials in the oral cavity, oral microbiocenosis disorders may occur, the periodontium pathology develops or worsens and an unpleasant odor arises, which in aggregate can cause a social maladjustment of the patient. It is known that the main intraoral factor in the development of halitosis is the unsatisfactory hygienic condition of the oral cavity. Non-removable dentures made from non-noble dental alloys can also significantly affect the development of intraoral halitosis. Objective. To study potentiometric parameters in patients with intraoral halitosis who have fixed orthopedic constructions made of various materials by various technologies. Methods and Materials. 158 people aged 35-55 years with fixed orthopedic constructions in the oral cavity in the amount of 5-8 units with a service life of 2-3 years were examined. Four groups were formed: with stamped-brazed dentures, with cast-denture prostheses from dental alloys, with cast-in-place titanium structures and a control group without disrupting the integrity of the dentition. All patients underwent a sanation of the oral cavity, professional hygiene and anti-inflammatory treatment. In addition, hygienic training of patients with quality control of personal hygiene was conducted. In the course of the study, 35 patients from the first and second groups after the complex treatment were replaced by replacing the existing dentures with orthopedic structures made of titanium. The effectiveness of treatment was assessed by the dynamics of indices of hygiene, PMA, organoleptic assessment of halitosis and potentiometric parameters. Results. As a result of the study, it was found that patients with dentures, manufactured with the help of the stamped-brazed technology, were characterized by high indices of hygiene (1.29 ± 0.18 points) and PMA (66.79 ± 2.48%). The I degree of halitosis was observed in 27 patients (41.5%) of this group, II degree was observed in 35 people (53.8%) and III degree in 3 people (4.6%). In the second group, the hygiene index was 0.97 ± 0.12, the PMA index was 65.57 ± 2.18%. In 33 patients (67.4%) I degree of halitosis was detected, in 16 patients (32.6%) – II degree. In the third group, the hygiene index was 0.84 ± 0.12, the PMA index was 56.23 ± 1.22. Unpleasant odor in the majority of patients in this group (40 people or 90.9%) was determined when approaching a distance of 10 cm, which corresponded to I degree of halitosis. Only 4 patients (9.1%) had halitosis of II degree. In the control group, the KPI index was 12.13 ± 0.24, the level of hygiene was on average 0.81 ± 0.12 points and 55.56 ± 1.13%, respectively. There were no organoleptic signs of halitosis in this group.

scholarly journals Correlation between oral health and severity of respiratory coronavirus infection COVID-19

2021 ◽  
Vol 19 (1) ◽  
pp. 18-22
Author(s):  
A. V. Mitronin ◽  
N. A. Apresian ◽  
D. A. Ostanina ◽  
E. D. Yurtseva
Keyword(s):  
Oral Health ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Chronic Infection ◽  
Viral Infections ◽  
Control Group ◽  
Oral Diseases ◽  
Average Value ◽  
Coronavirus Infection ◽  
Group 1

Aim. To establish the association between the presence of chronic infection in oral cavity and the severity of SARSCoV-2 infection.Materials and methods. The study was conducted among 30 people aged between18 and 22 who had had coronavirus infection from mild to severe cases. The assessment of oral health was carried out with main and additional examination methods, CFE index, PMA index, Greene, Wermillion oral hygiene index.Results. In group 1, the average value of CFE index was 4.2, in the second group – CFE index was twice higher at 7.8. PMA index in patients of group 2 was significantly higher (p> 0.01) and was at the level of 41.5%. In group 1, the PMA index was 13.3%. It was found that 17% of the respondents in the control group and 70% patients in the experimental group had an episodic exacerbation of dental diseases during COVID-19.Conclusions. The data obtained indicates a correlation between oral diseases and the severity of COVID-19. It is necessary to consider that chronic infection in the oral cavity as well as poor oral hygiene can act as a risk of complications of viral infections, in particular, of COVID-19.

Wpływ nadwagi i otyłości na stan zdrowia jamy ustnej dzieci i młodzieży

2019 ◽  
Vol 24 (3) ◽  
Author(s):  
Katarzyna Deszczyńska ◽  
Paweł Piątkiewicz ◽  
Renata Górska
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Weight ◽  
Oral Cavity ◽  
Oral Hygiene ◽  
Overweight And Obesity ◽  
Control Group ◽  
Study Group ◽  
Obese Children ◽  
Periodontal Health

Introduction. Improper eating habits among children and adolescents often lead to overweight and obesity. Research indicates that these are risk factors for many diseases, including diseases in the oral cavity. Aim. To analyse the correlations of selected parameters of dental and periodontal health as well as oral hygiene status in overweight and obese children and adolescents versus control group. Material and methods. The study included 120 patients aged 11-18 years, who were classified into a study group with 60 overweight/obese individuals and a control group of 60 individuals with normal body weight based on BMI (Body Mass Index). Each patient underwent anthropometric measurements, such as height (cm), body weight (kg), which were used to calculate BMI (Body Mass Index). Additional measurements were taken of waist circumference (WC) and hip circumference (HC), to obtain the waist-hip ratio (WHR). Clinical examination of the oral cavity included an assessment of dentition (DMF), oral hygiene API (Approximal Plaque Index) and periodontal tissue (PD – Pocket Depth, CAL – Clinical Attachment Level, %BOP – % Bleeding On Probing) and CPITN (The Community Periodontal Index for Treatment Needs). Results. Statistically significant differences were found between patient groups with BMI ≥ 25 and BMI < 25 in the values of the following parameters: DMF p = 0.005, API p < 0.001, %BOP p < 0.001, PD p < 0.001, CPI p < 0.001. Conclusions. Overweight and obese children were found to have have worse parameters of dental and periodontal health as well as oral hygiene status compared to the group with normal weight. Our observations indicate that overweight and obesity may be potential risk factors for periodontal diseases in the study group.

Salivary Factors Related to Caries in Children with Autism

2019 ◽  
Vol 43 (1) ◽  
pp. 22-26 ◽  
Author(s):  
MC Morales-Chávez ◽  
M Villarroel-Dorrego ◽  
V Salas
Keyword(s):  
Proteolytic Activity ◽  
Study Design ◽  
Oral Hygiene ◽  
Children With Autism ◽  
Control Group ◽  
Autistic Children ◽  
Total Proteins ◽  
P Values ◽  
Salivary Ph ◽  
Dmft Index

Many predisposing factors to caries are present in autism, however, it is unlikely that autistic patients exhibit higher caries indexes than the rest of the population. Objective: To evaluate salivary factors related to caries in autistic patients. Study design: 34 autistics and 34 controls aged between 4–13 years old were included. Decayed, missing, and filled teeth (DMFT) index and oral hygiene simplified index (IHO-S) were assessed, as well as, pH, total proteins, phosphate, calcium and IgA in saliva. All data were analyzed by chi2 and Student t tests for independent samples. P values&lt;0.05 were considered statistically significant. Results: Autistic patients showed less caries than controls (p≤0.001), DMFT was 1±1 and 3±2 respectively (p≤0.001). In relation to IHO-S, values increased (p=0.008) in autistic patients (2.25±0.78) compared to controls (1.79±0.59), however Salivary ph means were similar (7.20±0.48 and 7.27±0.34 respectively). Decreased calcium levels (p=0.013) were observed in autistics (0.621±0.35 mmol/L) compared to controls (0.89±0.51 mmol/L), but phosphate levels were similar (6.17±4.22 M, 5.51±4.86 M respectively). When total proteins of saliva were assessed, autistics showed a slight increment (2.65±1.81 mg/mL) compared to controls (2.24±1.27 mg/mL) and zymography showed a higher proteolytic activity in autistic children. Finally, IgA concentration reached 116.55±90.97 μg/mL in autistics and 161.61 ± 193.37μg/mL (p=0.527) in the control group. Conclusions: Even though patients with autism exhibited a poorer oral hygiene, caries indexes were lower, calcium levels in saliva were found to be lesser and phosphate levels higher.

Oral Hygiene Care in Patients With Advanced Disease: An Essential Measure to Improve Oral Cavity Conditions and Symptom Management

2019 ◽  
Vol 36 (9) ◽  
pp. 815-819 ◽  
Author(s):  
Caterina Magnani ◽  
Chiara Mastroianni ◽  
Diana Giannarelli ◽  
Maria Consiglia Stefanelli ◽  
Valeria Di Cienzo ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Hygiene ◽  
Standard Care ◽  
Symptom Control ◽  
Oral Care ◽  
P Value ◽  
Complex Patients ◽  
High Level ◽  
Oral Conditions ◽  
The Impact

Background: Oral problems are frequent in palliative care and can cause disabling symptoms such as orofacial pain, dysgeusia, and xerostomia. Even if oral care is an essential aspect of nursing, it is often not considered as a priority, especially when various complex patients’ needs have to be managed. Objective: The aim of this study was to describe oral conditions and evaluate the impact of standard oral care on symptom control and patient’s perceived comfort in a sample of terminally ill patients. Method: A prospective cohort study was carried out among 415 patients who were admitted to hospice. Patients were recruited before undergoing standard assisted procedure for oral hygiene care. Oral cavity condition, symptoms, and comfort were assessed at the recruitment (T0) and after 3 days (T2). Results: Seventy-five eligible patients were recruited. The Oral Assessment Guide score was significantly decreased after oral standard care ( P value <.0001). The average time spent by nursing staff for oral hygiene care was 5.3 minutes. Dysgeusia and xerostomia were significantly decreased after oral standard care ( P = .02 and P = .03). Patients reported a high level of comfort (86.6%) after the procedures for oral hygiene care. Conclusion: Patients admitted to hospice had frequent alterations in oral cavity with partial loss of its functions that can compromise their quality of life. Standard procedures for oral hygiene care are simple and fast to perform, and they may improve oral cavity conditions, symptoms control, and patients’ comfort.

EVALUATION OF THE EFFECTIVENESS OF THERAPEUTIC AND PREVENTIVE MEASURES OF DYSBIOSIS IN DENTAL PRACTICE

2020 ◽  
pp. 78-88
Author(s):  
Жанна Владимировна Вечеркина ◽  
Наталья Александровна Шалимова ◽  
Наталия Владимировна Чиркова ◽  
Елена Анатольевна Андреева ◽  
Марина Николаевна Бобешко
Keyword(s):  
Oral Cavity ◽  
Point Of View ◽  
Control Group ◽  
Difficult Situation ◽  
Dental Prostheses ◽  
Oral Microflora ◽  
Removable Plate ◽  
Gastrointestinal Dysbiosis ◽  
The Relationship

Увеличивающаяся тенденция нуждаемости пациентов использования несъемных, съемных зубных протезов, ортодонтических и челюстно-лицевых апппаратов, наблюдающаяся в последние годы, сопряжена с многими проблемами. Использующиеся в практике ортопедической стоматологии зубные протезы и аппараты оказывают побочное действие на слизистую оболочку полости рта (механическое, химико-токсическое, сенсибилизирующее), что приводит к нарушению биоценоза, чрезмерному росту патогенных микроорганизмов и увеличению числа дрожжевых колоний. Установлено также, что при использовании адгезивных препаратов для улучшения фиксации съемных протезов статистически достоверно увеличивается число дрожжевых колоний при количественном посеве по сравнению с контрольной группой пациентов. Еще более сложная ситуация наблюдается у пациентов, уже имеющих хроническое нарушение соотношения нормальной и условно - патогенной микробиоты и нуждающихся в протезировании съемными пластиночными протезами. Эти пациенты, как правило, имеют неудовлетворительную гигиену полости рта и тяжелую сопутствующую патологию, чаще всего сахарный диабет или дисбактериоз ЖКТ. В настоящее время получены убедительные данные о важной роли иммунных нарушений в патогенезе развития кандидоинфекции и антифунгальной резистентности. В частности, дисфункции клеточного звена иммунной системы, что способствует хроническому, рецидивирующему и зачастую торпидному к терапии течению заболевания. Это, в свою очередь, требует выполнения научных исследований в направлении коррекции состояния микрофлоры ротовой полости пользующихся ортопедическими конструкциями. Данная обзорная работа посвящена актуальным на сегодняшний день вопросам применения пре-, пробиотических культур и синбиотиков в комплексном лечении больных с дисбиотическим изменением полости рта, пользующихся ортодонтическими конструкциями, лечебно-диагностическими аппаратами. Целью работы стал всесторонний анализ проблемы целесообразности и эффективности использования вышеназванных средств с точки зрения этиопатогенеза дисбиоза в полости рта The increasing trend of patients ' need to use non-removable, removable dentures, orthodontic and maxillofacial devices, observed in recent years, is associated with many problems. Dental prostheses and devices used in the practice of orthopedic dentistry have a side effect on the oral mucosa (mechanical, chemical-toxic, sensitizing), which leads to a violation of the biocenosis, excessive growth of pathogenic microorganisms and an increase in the number of yeast colonies. It was also found that the use of adhesive preparations to improve the fixation of removable prostheses statistically significantly increases the number of yeast colonies during quantitative seeding compared to the control group of patients. An even more difficult situation is observed in patients who already have a chronic violation of the relationship between normal and opportunistic microbiota and need prosthetics with removable plate prostheses. These patients usually have poor oral hygiene and severe comorbidities, most often diabetes mellitus or gastrointestinal dysbiosis. Currently, there is strong evidence of the important role of immune disorders in the pathogenesis of Candida infection and antifungal resistance. In particular, dysfunction of the cellular link of the immune system, which contributes to the chronic, recurrent and often torpid to therapy course of the disease. This, in turn, requires scientific research in the direction of correlation of the state of the oral microflora using orthopedic structures. This review is devoted to current issues of the use of pre - probiotic cultures and synbiotics in the complex treatment of patients with dysbiotic changes in the oral cavity, using orthodontic structures, medical and diagnostic devices. The aim of the work was a comprehensive analysis of the problem of expediency and effectiveness of the use of the above-mentioned means, from the point of view of the eiopathogenesis of dysbiosis in the oral cavity

scholarly journals 2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind, crossover clinical trial

2018 ◽  
Vol 23 (2) ◽  
pp. 739-746 ◽  
Author(s):  
Natsumi Fujiwara ◽  
Hiromichi Yumoto ◽  
Koji Miyamoto ◽  
Katsuhiko Hirota ◽  
Hiromi Nakae ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Oral Cavity ◽  
Oral Bacteria ◽  
Bacterial Adherence ◽  
Clinical Samples ◽  
Control Group ◽  
Oral Microflora ◽  
Single Blind ◽  
Dna Amounts ◽  
Total Bacteria

Abstract Objectives The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. The aim of this study is to clarify whether MPC-polymer can suppress the bacterial adherence in oral cavity by a crossover design. We also investigated the number of Fusobacterium nucleatum, which is the key bacterium forming dental plaque, in clinical samples. Materials and methods This study was a randomized, placebo-controlled, single-blind, crossover study, with two treatment periods separated by a 2-week washout period. We conducted clinical trial with 20 healthy subjects to evaluate the effect of 5% MPC-polymer mouthwash after 5 h on oral microflora. PBS was used as a control. The bacterial number in the gargling sample before and after intervention was counted by an electronic bacterial counter and a culture method. DNA amounts of total bacteria and F. nucleatum were examined by q-PCR. Results The numbers of total bacteria and oral streptcocci after 5 h of 5% MPC-polymer treatment significantly decreased, compared to the control group. Moreover, the DNA amounts of total bacteria and F. nucleatum significantly decreased by 5% MPC-polymer mouthwash. Conclusions We suggest that MPC-polymer coating in the oral cavity may suppress the oral bacterial adherence. Clinical relevance MPC-polymer can be a potent compound for the control of oral microflora to prevent oral infection.

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