FEATURES OF THE COURSE OF PREGNANCY / CHILDBIRTH / POSTPARTUM PERIOD IN WOMEN WITH POSITIVE RESULTS FOR COVID-19

2021 ◽  
pp. 10-14
Author(s):  
S.Sh. Isenova ◽  
G. Zh. Bodykov ◽  
A.S. Shukirbaeva ◽  
M.O. Kubesova ◽  
M.U. Davranova ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Clinical Symptoms ◽  
Diagnostic Methods ◽  
Doppler Studies ◽  
X Ray ◽  
Archival Material ◽  
Pregnancy And Childbirth ◽  
Positive Results

A retrospective analysis was carried out according to the archival material of the center of perinatology and pediatric cardiac surgery in Almaty for 2020. The analysis was carried out in pregnant women with COVID-19, a total of 150 stories were examined. The features of the course of pregnancy and childbirth were assessed by studying the data of laboratory diagnostic methods of research, clinical symptoms, X-ray, ultrasound, Doppler studies. The study highlights the features of pregnancy, childbirth and the postpartum period in women infected with COVID-19.

scholarly journals Peculiarities of pregnansy and childbirth in patients with a burdened gynecological anamnesis

2020 ◽  
Vol 5 ◽  
pp. 5-10
Author(s):  
T. P. Andriichuk ◽  
A. Ya. Senchuk ◽  
V. I. Chermak
Keyword(s):  
Retrospective Study ◽  
High Risk ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Control Group ◽  
Careful Monitoring ◽  
Pregnancy And Childbirth ◽  
History Of ◽  
High Level ◽  
Adaptive Reactions

The objective: to study the features of pregnancy, childbirth, postpartum period, fetal status and newborns in patients with a history of chronic salpingo-оophoritis.Materials and methods. Conducted a retrospective study of 150 birth histories and neonatal development maps. All patients were divided into two groups. The main group includes 100 patients with chronic salpingo-оophoritis, for which they received anti-inflammatory treatment from 1 to 3 times before pregnancy. The control group included 50 pregnant women who did not suffer from chronic salpingo-оophoritis.Results. Our analysis of pregnancy, childbirth, fetal and neonatal status in women with chronic salpingo-оophoritis indicates that such patients have a complicated obstetric and gynecological and somatic history, which forms an unfavorable basic condition of organs and systems, imperfect adaptation to pregnancy, high risk of failure of adaptive reactions. The result is a violation of the formation and development of the mother-placenta-fetus system and, as a consequence, a high level of complications during pregnancy, childbirth and perinatal pathology.Conclusion. Patients suffering from chronic salpingo-oophoritis should be considered at high risk of possible complications during pregnancy and childbirth. This category of women needs quality preconception training and careful monitoring during pregnancy.

scholarly journals Strategy of Medical Care for Pregnant Women with Congenital Heart Disease

2021 ◽  
pp. 64-69
Author(s):  
S. O. Siromakha ◽  
Yu. V. Davydova ◽  
A. O. Tarnavska ◽  
N. I. Volkova ◽  
N. B. Nakonechna
Keyword(s):  
Cardiac Surgery ◽  
Cardiovascular Risk ◽  
Medical Care ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Congenital Heart ◽  
Adverse Outcomes ◽  
Long Term Results ◽  
Increased Risk

Grown-up congenital heart (GUCH) is a global challenge nowadays. The strategy of medical care for GUCH women dur-ing pregnancy, childbirth and the postpartum period is a topic of active discussion in the expert community. These patients have significantly increased risk of maternal and perinatal loss. A national obstetric cardiology and cardiac surgery multi-disciplinary team (OCCS) established in academic institutions in 2013 has provided medical support to 896 GUCH pregnant women over the last 7 years. In total, GUCH patients accounted for 36% of the cohort of all the examined pregnant women. Of these, 474 (53%) were primigravid. The mean age of the patients at the time of the first visit was 27.3 ± 5.7 years. Patients with uncorrected CHD accounted for 66.2% (n = 593), and 33.8% (n = 303) of pregnant women had undergone correction, including hemodynamic correction of complex CHD in 5 patients. Risk stratification was performed using several scores (mWHO, ZAHARA, CARPREG) for the comprehensive assessment of cardiovascular risk and prediction of pregnancy, deliv-ery, and postpartum period course. 82 patients were classified as having high cardiovascular risk (CVR) after the stratifica-tion. They needed admission to the cardiac surgery facility to receive different types of medical care. There were 2 (2.4%) cases of maternal loss and 3 (3.8%) cases of adverse perinatal outcomes in this group of patients. The article presents the algorithms for multidisciplinary care strategy choice in GUCH pregnant women with high CVR and their routing principles developed by the OCCS. These algorithms significantly reduced adverse outcomes of pregnancy and childbirth in this group of patients. Long-term results were evaluated in 69 patients (86.3%). The follow-up period ranged from 1 to 91 months, on average 34.4 ± 23.6 months. There were no long-term maternal losses or repeated cardiac surgeries. There was one case of unexplained death of a child 8 months after birth. The strategy of multidisciplinary medical care of a high-class GUCH pregnant woman should be personalized depending on the clinical data and in accordance with the ESC 2018 guidelines.

scholarly journals Connective tissue dysplasia: new horizons of the problem

2019 ◽  
Author(s):  
Tat'iana Sergeevna Fadeeva
Keyword(s):  
Vitamin D ◽  
Connective Tissue ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Preventive Measures ◽  
Optimal Plan ◽  
Pregnancy And Childbirth ◽  
Program Step ◽  
Adverse Pregnancy ◽  
Period Of Gestation

The work raises questions of predicting the complications of pregnancy and childbirth and adverse conditions in the fetus in the presence of UCTD in the expectant mother, who also need to be studied, especially from the standpoint of mathematical modeling of the disease. It is also necessary to develop a common tactic for providing medical and social assistance and treatment and diagnostic services to pregnant women suffering from UCTD, which will make the outcome of childbirth more favorable and improve the subsequent prognosis for mother and newborn. In the literature there is practically no assessment of the course of pregnancy and the outcome of childbirth, depending on the severity of UCTD. Little is known about the role of a connective tissue metabolism marker - hydroxyproline, trace elements (magnesium) and vitamins (D3) in pregnant women suffering from UCTD, and the medical tactics regarding such patients are not clearly defined. Despite numerous successes in the study of the causes of complications during pregnancy and childbirth in women suffering from UCTD, a unified approach to their management during the prenatal stage has not yet been developed. Therefore, the search for possible predictors for the timely prediction of adverse pregnancy and childbirth outcome in such patients is becoming increasingly important. This will make it possible to develop an optimal organizational and methodological base and subsequently improve the prognosis for women and their offspring. Thus, in contrast to the existing standard approach, we have proposed a comprehensive management of patients suffering from UCTD, including the timely identification of patients from the risk group, clarification of their condition using such markers as magnesium and hydroxyproline, additional intake of magnesium and vitamin D preparations. Optimal plan managing the period of gestation, childbirth, and a pathogenetically reasoned set of treatment and preventive measures for women with UCTD, will not only improve the outcomes of pregnancy and childbirth, but also contribute to the health of the future generation. 1. UCTD affects the course of pregnancy, childbirth and the condition of the newborn. The degree of exposure is largely determined by the severity of the underlying disease. In severe UCTD, the prevalence of spontaneous miscarriage and preterm labor was significantly higher, and endometritis and severe anemia were more common in the postpartum period. Severe asphyxia on the Apgar scale at the 1st and 5th minutes, congenital heart defects, morphofunctional immaturity, conjugation jaundice and convulsive syndrome were more common in the fetus. 2. A low content of magnesium and hydroxyproline is associated with the occurrence of complications during childbirth and a decrease in the anthropometric characteristics of the newborn. Taking magnesium preparations reliably affects the concentration of this trace element and hydroxyproline in the blood of pregnant women suffering from UCTD. 3. Therapy with magnesium preparations is an effective tool in patients suffering from UCTD, as it helps to improve well-being during pregnancy, improves the course of the postpartum period and reduces the prevalence of chronic fetal hypoxia. 4. Vitamin D and magnesium supplements have a beneficial effect on pregnancy and the fetus, reducing the prevalence of pre-eclampsia and chronic intrauterine hypoxia of the fetus, reducing the incidence of morphofunctional immaturity and conjugation jaundice of the newborn. 5. The created computer program “STEP DST” can be applied in the clinical practice of obstetrician-gynecologists and health care organizers. The obtained individual forecast of the probability of development of complications of reproduction allows us to outline the optimal plan for managing the period of gestation, childbirth and the postpartum period, to prescribe a pathogenetically based set of therapeutic and preventive measures for women suffering from UCTD.

scholarly journals CLINICAL PROPERTIES AND DIAGNOSTIC METHODS OF COVID-19 INFECTION IN PREGNANCIES: META-ANALYSIS

2020 ◽  
Author(s):  
Banu Uygun-Can ◽  
Bilge Acar-Bolat
Keyword(s):  
Pregnant Women ◽  
Clinical Features ◽  
Retrospective Studies ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Diagnostic Methods ◽  
Imaging Features ◽  
Medical Evidence ◽  
Rt Pcr ◽  
Pcr Diagnosis

AbstractWe aimed to summarize reliable medical evidence by the meta-analysis of all published retrospective studies that examined data based on the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by clinical symptoms, molecular (RT-PCR) diagnosis and characteristic CT imaging features in pregnant women. MEDLINE PubMed, SCOPUS, ISI Web of Science, Clinical Key, and CINAHL databases were used to select the studies. Then, 384 articles were received, including the studies until 01/MAY/2020. As a result of the full-text evaluation, 12 retrospective articles covering all the data related were selected. A total of 181 pregnant cases with SARS-CoV-2 infections were included in the meta-analysis within the scope of these articles. According to the results, the incidence of fever was 38.1% (95% CI: 14.2–65%), and cough was 22% (95% CI: 10.8–35.2%) among all clinical features of pregnant cases with SARS-CoV-2 infection. So, fever and cough are the most common symptoms in pregnant cases with SARS-CoV- infection, and 91.8% (95% CI: 76.7–99.9%) of RT-PCR results are positive. Moreover, abnormal CT incidence is 97.9% (95% CI: 94.2–99.9%) positive. No case was death. However, as this virus spreads globally, it should not be overlooked that the incidence will increase in pregnant women and may be in the risky group. RT-PCR and CT can be used together in an accurate and safe diagnosis. In conclusion, these findings will provide important guidance for current studies regarding the clinical features and correct detection of SARS-CoV-2 infection in pregnant women, as well as whether it will create emergency tables that will require the use of a viral drug.

Pregnancy and Childbirth in Women with Confirmed COVID-19

2021 ◽  
Vol 6 (3) ◽  
Keyword(s):  
Pregnant Women ◽  
Placental Abruption ◽  
Multiple Pregnancy ◽  
Severe Form ◽  
Lung Damage ◽  
Mild Form ◽  
Pregnancy And Childbirth ◽  
The Impact ◽  
Positive Results ◽  
Obstetric Department

Introduction: A new viral infection, dubbed “COVID-19” in the spring of 2020, became pandemic. Data on the impact of Covid-19 on pregnant women and childbirth are scarce and contradictory. Purpose: to study the peculiarities of the course and outcome of labor in women with positive results from COVID-19. Materials and Methods: An analysis of 222 birth histories of women with laboratory-confirmed COVID-19 PCR directed to delivery to the specialized obstetric department of the Fergana city medical association for October-December 2020 is presented. Results: A mild form of infection was in 70,2%, moderate - in 21.2%, severe - in 8.1%, and critical - in 0.5%. The frequency and nature of the upper and lower respiratory tract lesions, SPO2 parameters and lung damage, as well as the age of pregnant women, parity, the presence of somatic and obstetric pathology are presented. The frequency of delivery by weight section was 25.2%, preterm birth - 9.5%. Conclusions: In most pregnant women the severe form of COVID-19 is characterized by bilateral pneumonia with ARS and anemia in 100% of cases, the frequency of miscarriage in them is high and reaches 37%. The condition of pregnant women with COVID-19 aggravated the development of severe preeclampsia, premature placental abruption, and multiple pregnancy

Issues of safe correction of gastroduodenal symptoms during pregnancy

2022 ◽  
pp. 66-74
Author(s):  
Yuliya Yurievna Chebotareva ◽  
◽  
Elena Nikolaevna Veselova ◽  
Yuriy Alekseevich Petrov ◽  
◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Pregnant Women ◽  
Critical Analysis ◽  
Clinical Symptoms ◽  
Diagnosis And Treatment ◽  
First Line ◽  
Pregnancy And Childbirth ◽  
Study Evaluation ◽  
Complicated Course ◽  
Effect Of Treatment

Extragenital diseases make a great effect on the complicated course of pregnancy and childbirth. The lack of pregravidar preparation and somatic diagnostics lead to miscarriage, preeclampsia, and placental disorders. Therefore, the development of various algorithms for the management of pregnant women suffering from diseases of the gastrointestinal tract and the safe correction of various gastroduodenal symptoms, which is sometimes characteristic of the gestation period, are relevant. The purpose of the study: evaluation and critical analysis of modern data in the field of diagnosis and safe correction of various gastroduodenal symptoms during pregnancy. Materials and methods. Collection of modern Russian and foreign literature sources on the correction of gastroduodenal pathology during pregnancy, generalization and critical analysis of this problem. Results. Heartburn, constipation, flatulence are the most common complaints during pregnancy. The causes of their occurrence are physiological features during gestation, aimed at the most favorable gestation of the fetus. The first-line preparations are alginates created on the basis of alginic acid of brown alga. Antacids have a number of disadvantages. Proton pump inhibitors are prescribed extremely rarely and cautiously during pregnancy. In case of constipation in pregnant women, it is recommended to prescribe lactulose preparations together with defoamers. Prebiotics perfectly regulate the work of the intestine. The etiology, mechanisms of occurrence, clinical symptoms, differential diagnosis and treatment of intrahepatic cholestasis of pregnant women were analyzed. Its possible prognoses and risks for the mother and fetus, the possibilities of diagnosis and correction are determined. Diseases of the gastrointestinal tract in pregnant women cause difficulties in diagnosis and treatment. For the most optimal course of pregnancy, there are sufficiently effective gastroenterological drugs recommended so that the effect of treatment is maximized and the side effect is minimized.

scholarly journals PARVOVIRUS INFECTION IN PREGNANT WOMEN: SOME ASPECTS OF CLINICAL PROGRESSION AND DIAGNOSTICS

2018 ◽  
Vol 22 (1) ◽  
pp. 87-92
Author(s):  
N.P. Bondarenko ◽  
V.P. Lakatosh ◽  
M.I. Antonyuk ◽  
O.A. Kochmaruk
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Fetal Loss ◽  
Diagnostic Methods ◽  
Screening Tests ◽  
Seasonal Prevalence ◽  
Diagnostic Systems ◽  
Course Of Disease ◽  
Blood Samples ◽  
Screening Programs

Human parvovirus (B19V) infection is a well-known fetotropic agent that may lead to a fetal loss. Nevertheless, the routine testing for B19V is not included into antenatal or preconception screening programs, and some authors find it a reason of delay in management of pregnancies complicated by B19V. The aim of our research was to reveal practicability of B19V screening tests in pregnant women in certain population, and also to assess the proportion between asymptomatic and manifest forms of B19V infection in our population, whether some diagnostic methods and their combinations are useful in testing, and to investigate correlation between clinical symptoms in fetus and laboratory parameters of expectant mother. The observation of 129 pregnant women (patients of Perinatal Centre in Kyiv) with suggested B19V infection in different terms of gestation was conducted. Diagnostic systems used were: ELISA test (DRG) and immunoblot testing system EUROIMMUN (Germany), and DNA detection of B19V in mother’s blood samples was conducted with the use of PCR. In addition, we turned our attention to epidemiologic cyclicity of B19V infection, seasonal prevalence and other ordinary for infection processes characteristics. In observed population the incidence of B19V infection had no correlation with the terms of gestation; more significant correspondence was observed with cyclicity waves (2 years of low morbidity were followed by periods increased morbidity), seasonal prevalence, environment of pregnant women (the professional and household one). Except of apparent but nonspecific general blood changes, in 46/129 (35,6%) pregnant women the acute B19V infection was diagnosed with the use of PCR with the presence of B19V DNA in blood samples and negative or uncertain serological results. In 85,1% (40/47)cases of symptomatic fetus injury B19V DNA load was found in mother’s blood samples, and that was the difference when compared with the group of women with asymptomatic course of disease, in which the viral load was found in 32,6% (16/49) of cases. The long-term viremia in mothers was found in cases of fetal infection (B19V DNA until 120 days) associated with seroconversion. The results of this study demonstrated some certain particularities of clinical course of disease in observed population except of common features of B19V, and revealed reasonability of combined laboratory testing if suspecting B19V infection. Further achievements in B19V infection research will provide better algorithms and methods of diagnosing; will lead to effective prophylaxis as well as for the development of novel therapeutic options.

scholarly journals Clinical Properties and Diagnostic Methods of COVID-19 Infection in Pregnancies: Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Banu Uygun-Can ◽  
Bilge Acar-Bolat ◽  
Kyousuke Takeuchi
Keyword(s):  
Pregnant Women ◽  
Clinical Features ◽  
Retrospective Studies ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Diagnostic Methods ◽  
Imaging Features ◽  
Medical Evidence ◽  
Rt Pcr ◽  
Pcr Diagnosis

We aimed to summarize reliable medical evidence by the meta-analysis of all published retrospective studies that examined data based on the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by clinical symptoms, molecular (RT-PCR) diagnosis, and characteristic CT imaging features in pregnant women. The MEDLINE, PubMed, Scopus, ISI Web of Science, ClinicalKey, and CINAHL databases were used to select the studies. Then, 384 articles were received, including the studies until 01/May/2020. As a result of the full-text evaluation, 12 retrospective articles covering all the data related were selected. A total of 181 pregnant cases with SARS-CoV-2 infections were included in the meta-analysis within the scope of these articles. According to the results, the incidence of fever was 38.1% (95% CI: 14.2-65%) and cough was 22% (95% CI: 10.8-35.2%) among all clinical features of pregnant cases with SARS-CoV-2 infection. So, fever and cough are the most common symptoms in pregnant cases with SARS-CoV-2 infection, and 91.8% (95% CI: 76.7-99.9%) of RT-PCR results are positive. Moreover, abnormal CT incidence is 97.9% (95% CI: 94.2-99.9%) positive. No case was death. However, as this virus spreads globally, it should not be overlooked that the incidence will increase in pregnant women and maybe in the risky group. RT-PCR and CT can be used together in an accurate and safe diagnosis. In conclusion, these findings will provide important guidance for current studies regarding the clinical features and correct detection of SARS-CoV-2 infection in pregnant women, as well as whether it will create emergency tables that will require the use of a viral drug.

scholarly journals Risk Factors, Clinical Symptoms, Laboratory Findings and Imaging of Pregnant Women Infected with COVID-19 in North of Iran

2020 ◽  
Vol 23 (12) ◽  
pp. 856-863
Author(s):  
Soudabeh Kazemi Aski ◽  
Seyedeh Hajar Sharami ◽  
Fatemeh Hosseinzadeh ◽  
Ezat Hesni ◽  
Seyedeh Fatemeh Dalil Heirati ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Laboratory Finding ◽  
The Body ◽  
Shortness Of Breath ◽  
Laboratory Findings ◽  
Pregnancy And Childbirth ◽  
Severe Stage

Background: Due to the physiological changes in the body during pregnancy, the increased susceptibility to viral infections during this period and also the high prevalence of coronavirus disease 2019 (COVID-19) in the Guilan province, Iran, this study aimed to evaluate risk factors, clinical symptoms, laboratory findings and imaging of pregnant mothers with COVID-19. Methods: In this descriptive study, 70 pregnant women aged 17–41 years with COVID-19 who were hospitalized from early March to late April 2020 were enrolled. Sampling was performed by census and from all hospitals in Guilan. The research instruments included a researcher-made questionnaire, including demographic characteristics, clinical symptoms, medical examinations, and paraclinical results. Data were analyzed with SPSS version 16. Frequency and percent were used to describe qualitative variables; for quantitative variables, if they were normally distributed, mean and standard deviation were used, and if they were non-normal, median and interquartile range (IQR) were used. Results: The most severe symptoms recorded in mothers at the time of hospitalization were fever (47%), shortness of breath (16%) and cough (15%), respectively. One of 68 (1%) was in the severe stage of the disease and two mothers (2%) were in critical condition and admitted to the intensive care unit and finally died. Fifty-five of 66 women (83%) had lymphopenia, 22 of 42 (52%) tested positive on PCR, and 30 of 33 (90%) had an increase in lactate dehydrogenase (LDH) levels.Results showed that 15 of 32 patients who gave birth had preterm delivery (46%). Conclusion: The most common manifestations of the disease in pregnant women were fever, cough and shortness of breath, and in some cases muscle pain. The most common laboratory finding in infected mothers was lymphopenia. Complications of pregnancy and childbirth in women included an increase in cesarean delivery.

Diagnosis of helicobacter pylori infection: problems and prospects

2020 ◽  
pp. 54-59
Author(s):  
A. S. Molostova ◽  
N. S. Gladyshev ◽  
A. V. Svarval ◽  
R. S. Ferman ◽  
A. B. Karasyova ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Urease Activity ◽  
Diagnostic Methods ◽  
Study Group ◽  
Biochemical Method ◽  
Antimicrobial Drugs ◽  
Non Invasive ◽  
Number Of Patients ◽  
Pcr Method ◽  
Positive Results

(HP) infection was performed using invasive and non-invasive methods. The study group consisted of 95 patients with dyspepsia. HP infection was detected in 47 patients (49.4 %). The expediency of using a set of diagnostic methods for detecting HP (PCR, immunochromatographic, bacteriological and method for determining urease activity) is proved. Most often (100 %) in patients HP infection was detected in biopsies using the PCR method. Somewhat less frequently it was detected when examining biopsies with an invasive biochemical method (AMA RUT Reader) (82 %) and fecal immunochromatographic method (83 %). Despite the fact that helicobacteriosis was detected bacteriologically in a small number of patients (24 %), this method is of particular value, since it allows you to assess the sensitivity to antimicrobial drugs and probiotics, and does not give false positive results.

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