PARASITIC ABSCESS AS AN INCIDENTAL HISTOLOGICAL FINDING IN THE TREATMENT OF SIGMOID COLON CANCER

Background: A high worldwide incidence of colorectal cancer defines the importance of search not only for effective treatment methods, but also for risk factors for the cancer development and its worst prognosis. The influence of many genetic factors, environmental characteristics and lifestyle features has already been proven, and recently the attention of researchers is being focused on the study of microbiota and, in particular, various parasitic intestinal diseases in the context of risk factors for colorectal cancer.Clinical case presentation: we demonstrate an incidental finding of parasitic invasion signs during the pathomorphological examination of the surgical specimen in a patient without an epidemiological history.Conclusion: Further studies are needed not only to confirm and substantiate the role of micro- and macroorganisms inhabiting the intestine in the development of oncological diseases, but also to identify individual links of pathogenesis, pathological pathways and signaling molecules involved in carcinogenesis. Research like this could help broaden knowledge about both the risk factors and predictors of colorectal cancer and the potential sites for targeted therapy.

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Synchronous NET and colorectal cancer development: a case report

Surgical Case Reports ◽

10.1186/s40792-020-0777-4 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Shinsei Yumoto ◽

Yuji Miyamoto ◽

Takahiko Akiyama ◽

Yuki Kiyozumi ◽

Kojiro Eto ◽

...

Keyword(s):

Colorectal Cancer ◽

Colon Cancer ◽

Systemic Therapy ◽

Multiple Organ ◽

Cancer Development ◽

Sigmoid Colon Cancer ◽

Synchronous Tumors ◽

Case Presentation ◽

The Difference ◽

Rectal Neuroendocrine Tumor

Abstract Background The incidence of synchronous gastrointestinal neuroendocrine tumors (GI-NETs) and colorectal cancer is very low. Case presentation We present a 72-year-old man diagnosed with a rectal neuroendocrine tumor (NET) with multiple organ metastases and simultaneous sigmoid colon cancer. Although the NET was his prognostic factor, he underwent a laparoscopic sigmoidectomy at first because it was expected that the colon cancer would cause obstruction or bleeding during NET treatment. Subsequently, he started taking everolimus. Conclusions We should consider surgical resection of the synchronous cancer before systemic therapy for a GI-NET regardless of the difference in prognosis between synchronous tumors, if the cancer may impair the continuation of systemic therapy.

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Badania przesiewowe w profilaktyce raka jelita grubego

Medycyna Rodzinna ◽

10.25121/mr.2018.21.3.232 ◽

2018 ◽

Vol 21 (3) ◽

Author(s):

Marta Musińska ◽

Marta Minkiewicz ◽

Justyna Wasielica-Berger ◽

Krystian Kidrycki ◽

Krzysztof Kurek

Keyword(s):

Colorectal Cancer ◽

Screening Program ◽

Single Step ◽

Preventive Action ◽

Asymptomatic Patients ◽

Oncological Diseases ◽

History Of ◽

Genetic And Environmental Factors ◽

Therapeutic Tools

Colorectal cancer is the second most frequently diagnosed cancer in Poland as well as in the world. In addition, this cancer is the second cause of death among oncological diseases. Genetic and environmental factors with a documented impact on the development and progression of colorectal cancer have been thoroughly investigated. Every case of colorectal cancer begins with the stage of a nonmalignant polyp, whose progression to invasive malignant tumor lasts about 10 years. This period is long enough to implement appropriate preventive action that allow early detection and treatment of pre-cancerous lesions. Colorectal cancer screening is the process of detecting polypoid lesions in asymptomatic patients with no history of cancers. Colonoscopy has the benefit of diagnostic and therapeutic tools, which allows to detect and remove of premalignant polyps in a single step approach. The aim of this work is to present the role of a screening program in the prevention of colorectal cancer.

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Elderly COVID-19 Pneumonic Patient with both Graded and Movable-weaning off Phenomenon or Yasser's Phenomena in a Surgical Severe Aortic Stenosis; at-home Dilemma Management

Clinical Cardiology and Cardiovascular Interventions ◽

10.31579/2641-0419/132 ◽

2021 ◽

Vol 4 (5) ◽

pp. 01-05

Author(s):

Yasser Elsayed

Keyword(s):

Risk Factors ◽

Aortic Stenosis ◽

Severe Aortic Stenosis ◽

Chest Ct ◽

Dynamic Changes ◽

Case Presentation ◽

Elderly Female ◽

Patient Concerns ◽

Chest Ct Scan

Rationale: Coronavirus disease is a leading remarkable critical pandemic global infection. Graded phenomenon or Yasser's phenomenon is a novel electrocardiographic phenomenon that changes the arrhythmia didactic. It is decisive progress in understanding arrhythmia. The phenomenon is a contemporary vigorous instructor for monitoring and follows up the arrhythmic patients. Movable-weaning off phenomenon or Yasser's phenomenon is another novel electrocardiographic phenomenon characterized by serial dynamic changes in all cases of either Wavy triple or double electrocardiographic signs (Yasser signs) of hypocalcemia. Movable-weaning off phenomenon is a guide for both Wavy triple and double an electrocardiographic. Severe symptomatic aortic stenosis has a bad outcome after the evolution of symptoms, and prompt operative intervention is advisable. Patient concerns: An elderly female COVID-19 pneumonic patient presented to physician outpatient clinic with bilateral peripheral pneumonia and both Graded and Movable-weaning off phenomenon or Yasser's phenomena in severe aortic stenosis. Diagnosis: Elderly COVID-19 pneumonia with both Graded and Movable-weaning off phenomenon or Yasser's phenomena. Interventions: Oxygenation, electrocardiography, chest CT scan, and echocardiography. Outcomes: Gradual dramatic clinical, electrocardiographic, and radiological improvement had happened. Lessons: It denotes the role of the anticoagulants, the antiplatelets, steroids, and antimicrobial therapy in the management of COVID-19 pneumonia with Graded and Movable-weaning off phenomenon or Yasser's phenomena in severe aortic stenosis. The presence of Graded and Movable-weaning off phenomenon or Yasser's phenomena, elderly, and pneumonia, in the case presentation, represent new complicated risk factors especially, with an associated severe sclerotic aortic stenosis. Short title: A case report article in cardiology, critical care, emergency medicine, and infectious diseases

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Temperamental risk factors in young adults with ADHD symptoms

Current Problems of Psychiatry ◽

10.2478/cpp-2020-0013 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Natalia Kajka ◽

Agnieszka Kulik ◽

Maja Wachnicka

Keyword(s):

Risk Factors ◽

Young Adults ◽

Genetic Factors ◽

Diagnostic Interview ◽

Clinical Group ◽

Adhd Symptoms ◽

Hyperactivity Disorder ◽

Temperament Traits ◽

Source Of Information

AbstractIntroduction: In recent years, numerous studies have focused on the analysis of the primary mechanisms and forms of therapy in children and adolescents with attention deficit hyperactivity disorder (ADHD). The analysis of such topics among similarly diagnosed young adults is only beginning to gain popularity. The present article attempts to answer the question of whether the level of individual temperament traits will predict an increase in the severity of ADHD symptoms in young adults.Materials and methods: The questionnaire study involved 111 young adults aged from 18 to 28 (M= 23; SD= 2.12; 70 women and 41 men). Fifty-one people were included in the clinical group, and sixty were qualified for the control one. The participants of the study completed a health questionnaire and a structured diagnostic interview on ADHD symptoms in adults (DIVA 2.0) and a questionnaire for the diagnosis of basic, biologically determined dimensions of human personality (FCZ-KT (R)).Results: The results indicate a significant role of four temperament traits that may be considered as specific risk factors for the aggravation of ADHD symptoms. These include briskness, rhythm, endurance and activity.Conclusions: In Strelau’s Regulatory Theory of Temperament, the variability of temperament traits (in the Polish population) is attributed in 44% to genetic factors. The remaining 56% indicate non-genetic factors. The obtained results may indicate which factors are important in therapeutic work both in the group of young adults with ADHD symptoms, and may also constitute a source of information for parents or teachers regarding younger children with these symptoms.

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Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Toxins ◽

10.3390/toxins13080569 ◽

2021 ◽

Vol 13 (8) ◽

pp. 569

Author(s):

Alfonso Piciocchi ◽

Elena Angela Pia Germinario ◽

Koldo Garcia Etxebarria ◽

Silvia Rossi ◽

Lupe Sanchez-Mete ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cancer Progression ◽

Genetic Factors ◽

Bacterial Toxins ◽

Screening Colonoscopy ◽

Polygenic Risk Score ◽

Chronic Infections ◽

Predisposing Factor ◽

Microbial Dysbiosis

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from Escherichia coli as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas Bacteroides fragilis toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci.

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The role of the family doctor in the early diagnosis of colorectal cancer

Romanian Journal of Medical Practice ◽

10.37897/rjmp.2021.3.2 ◽

2021 ◽

Vol 16 (3) ◽

pp. 307-313

Author(s):

Mihaela Adela IANCU ◽

◽

Gabriela GANEA ◽

Ramona Dorotea CĂLIN ◽

Irina Anca EREMIA ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Family History ◽

Early Detection ◽

Treatment Options ◽

Family Doctor ◽

Tobacco Consumption ◽

Individual Risk ◽

The Family

The incidence of colorectal cancer is increasing. It is currently the third most common cancer, after lung and breast cancer. Despite the increased incidence, recent advances in early detection, performing the screening according to the recommendations and treatment options have reduced colorectal cancer mortality. The role of the family doctor is to advise and to identify non-modifiable risk factors (age, male sex, race, family history, inflammatory bowel disease) as well as modifiable ones (tobacco consumption, low-fiber, high-fat and high carbohydrate diet, a sedentary lifestyle, obesity), in order to avoid these risk factors by developing a personalized plan for the prevention and early detection of colorectal cancer depending on the individual risk. Genetic testing and a more comprehensive family history documentation by the family doctor can enable those with a hereditary predisposition for the colorectal cancer to take preventive measures. Applying evidence-based prevention strategies reduces the prognosis of colorectal cancer and reduces mortality. Colorectal cancer has an increased survival rate if diagnosed early and treated properly.

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Colorectal cancer: a review

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174914 ◽

2017 ◽

Vol 5 (11) ◽

pp. 4667 ◽

Cited By ~ 10

Author(s):

Juan José Granados-Romero ◽

Alan Isaac Valderrama-Treviño ◽

Ericka Hazzel Contreras-Flores ◽

Baltazar Barrera-Mera ◽

Miguel Herrera Enríquez ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Protective Factors ◽

Cause Of Death ◽

Genetic Factors ◽

Colonic Polyps ◽

Diagnostic Methods ◽

Degree Relative ◽

Basis Risk ◽

Intestinal Inflammatory Disease

Colorectal cancer (CCR) is the third most common cancer worldwide in men and women, the second largest cause of death related to cancer, and the main cause of death in gastrointestinal cancer. The risk of developing this cancer is related to bad alimentary habits, smoking, intestinal inflammatory disease, polyps, genetic factors, and aging. Of the patients that are diagnosed with colorectal cancer 90% are older than 50, with a median age of 64 years; however, the disease is more aggressive in patients that are diagnosed at younger ages. According to the American Cancer Association, it was accounted for more than 49,700 deaths in 2015. The goal is to reduce the mortality rate with early diagnosis and treatment. Currently, the survival rate is used to predict a patient’s prognosis. The patient is considered to have a positive familial history if a first-degree relative has been diagnosed with colorectal cancer or colonic polyps before the age of 60, or also if two or more first-degree relatives have been diagnosed with cancer or polyps at any age. There are several methods for detecting colorectal cancer, such as the guaiac test, immunochemical test of stool, DNA stool test, sigmoidoscopy, colonoscopy, and barium enema. The stage in which the cancer is detected determines the prognosis, survival, and treatment of the patient. Provide a review about generalities, genetic basis, risk factors, protective factors, clinical course, diagnostic methods, therapy and survival in colorectal cancer. Conducted research from different databases such as PubMed, Medline, MedScape, on the definition, genetic factors, classification, risk factors, protective factors, diagnostic methods, epidemiology, survival and treatment of colorectal cancer. Articles from 2000 to 2017 were included using the following keywords.

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Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

Cancers ◽

10.3390/cancers12051162 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1162 ◽

Cited By ~ 1

Author(s):

Purushottam Lamichhane ◽

Morgan Maiolini ◽

Omar Alnafoosi ◽

Sedra Hussein ◽

Hasan Alnafoosi ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Family History ◽

Gut Microbiome ◽

Genetic Factors ◽

Bacterial Species ◽

Cancer Epidemiology ◽

Bacterial Strains ◽

Prevention And Treatment ◽

Therapeutic Responses

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment.

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Brain Metastases from Colorectal Cancer: Risk Factors, Incidence, and the Possible Role of Chemokines

Clinical Colorectal Cancer ◽

10.3816/ccc.2009.n.016 ◽

2009 ◽

Vol 8 (2) ◽

pp. 100-105 ◽

Cited By ~ 67

Author(s):

John P. Mongan ◽

Camilo E. Fadul ◽

Bernard F. Cole ◽

Bassem I. Zaki ◽

Arief A. Suriawinata ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cancer Risk ◽

Brain Metastases ◽

Colorectal Cancer Risk ◽

Cancer Risk Factors

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Scar Epidemiology and Consequences

Textbook on Scar Management ◽

10.1007/978-3-030-44766-3_6 ◽

2020 ◽

pp. 45-49

Author(s):

M. El Kinani ◽

F. Duteille

Keyword(s):

Risk Factors ◽

Functional Impairment ◽

Evidence Based Medicine ◽

Genetic Factors ◽

Evidence Based ◽

Epidemiological Factors ◽

Keloid Scars ◽

Based Medicine

AbstractIn this chapter, after a short reminder of the different scars types, epidemiological factors and risk factors are described. The consequences for the patient of an impairment of healing are multiple: aesthetic discomfort, itching, pain, or even functional impairment, especially in the periarticular area, can lead not only to physical but also to psychological and social repercussions.This chapter focuses on the epidemiology of scars, including hypertrophic and keloid scars. The role of mechanobiology looks major as the pathology may start in specific anatomical locations submitted to excessive tension, and the influence of genetic factors, even if not completely confirmed with evidence-based medicine, is highly suspected.

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