scholarly journals Cytokine levels are associated with the severity of varicella infections

2015 ◽  
Vol 9 (02) ◽  
pp. 190-196 ◽  
Author(s):  
Meijun Hao ◽  
Xiaojun Wang ◽  
Jingpei Du ◽  
Lifeng Liu ◽  
Yanmei Jiao ◽  
...  
Keyword(s):  
Skin Infection ◽  
Serum Markers ◽  
Skin Infections ◽  
Laboratory Findings ◽  
Serum Cytokines ◽  
The Past ◽  
Cytokine Levels ◽  
Patients At Risk ◽  
Membrane Extract ◽  
Disease Epidemics

Introduction: Varicella is a highly contagious disease. Epidemics of varicella are seen every year globally and present a threat to public health, especially in China and other developing countries. Methodology: Clinical and laboratory findings of 865 varicella patients admitted to Beijing You’an Hospital, China, between January 2011 and December 2013 were collected and analyzed. Patients with isolated complication were grouped as SI (skin infection, n = 132) and LD (liver damage, n = 89). Two hundred and one patients without complications were grouped as control (mild group). Levels of T-cell subtypes and eight serum cytokines and were also tested. Levels of IFNg and IL-6 were monitored prospectively in another 12 grouped patients. Results: SI was complicated in 21.7% (188/865) of varicella cases, and LD was complicated in 16.8% (145/865). The rates of SI and LD in varicella patients increased rapidly in the past three years. No laboratory findings were associated with SI or LD (all p > 0.05). IL-6 and IFNg levels were correlated with amniotic membrane extract (AME) (p = 0.044 and p = 0.038). Their levels peaked at day 1 of admission, and then started to decline. Conclusions: The incidence of serious complications has become more common in recent years. IL-6 and IFNg may possibly be used as early serum markers for identifying patients at risk of developing complications such as skin infections in varicella.

scholarly journals IL-6 and IFNγ are elevated in severe mumps cases: a study of 960 mumps patients in China

2014 ◽  
Vol 8 (02) ◽  
pp. 208-214 ◽  
Author(s):  
Wen Wang ◽  
Yueke Zhu ◽  
Hao Wu ◽  
Yanmei Jiao ◽  
Nicholas Van Halm-Lutterodt ◽  
...  
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Developing Countries ◽  
T Cell ◽  
Serum Markers ◽  
Laboratory Findings ◽  
Serum Cytokines ◽  
Common Infectious Disease ◽  
Almost All ◽  
Disease Epidemics

Introduction: Mumps is a common infectious disease. Epidemics of mumps are reported globally every year and represent a threat to public health, especially in China and other developing countries. Methodology: Clinical and laboratory findings of 960 mumps patients admitted to Beijing You’an Hospital, China, between January 2010 and December 2012 were collected and analyzed. Patients with isolated complication were selected and grouped as aseptic meningitis/encephalitis (AME) patients (n = 156) and Orchitis patients (n = 72). One hundred and fifty patients without complication were grouped as control. Levels of T cell subtypes and 8 serum cytokines were also tested. Results: Majority of mumps patients were male (76.3%) and younger than 17 years old (76.2%). AME was complicated in 41.6% of mumps cases, and orchitis was in 21.3% (64.7% were left-sided). Unvacinated patients had more chance to have AME or orchitis (p = 0.034 and 0.027). The rates of AME and orchitis in mumps patients rapidly increased during the last three years. No laboratory findings were associated with AME or orchitis (all p > 0.05). Serum IL-10 level was elevated in almost all patients. IL-6 and IFNγ levels were correlated with AME (p = 0.025 and p = 0.018). Their levels peaked at day one after admission, and started to decline thereafter. Conclusions: This study suggests that the incidence of serious complications has become more common in recent years, moreover IL-6 and IFNγ may possibly be used as early serum markers for identifying patients with risk of developing complications in mumps.

Association of staphylococcal skin infections and swimming

1995 ◽  
Vol 31 (5-6) ◽  
pp. 11-17 ◽  
Author(s):  
N. Charoenca ◽  
R. S. Fujioka
Keyword(s):  
Coastal Waters ◽  
Skin Infection ◽  
Antibiotic Sensitivity ◽  
Control Group ◽  
Skin Infections ◽  
Telephone Interviews ◽  
Phage Types ◽  
History Of ◽  
Staphylococcal Skin Infections ◽  
Recreational Use

An association between using coastal waters for recreation and staphylococcal skin infections has been reported by canoe paddlers and several physicians in Hawaii. A retrospective epidemiological/microbiological monitoring study was undertaken to determine the association between S aureus skin infections in youngsters (4 months to 16 years of age) and their exposure to recreational use of coastal waters. Telephone interviews were conducted of 53 patients with such skin infections and 53 similar (controlled for age and sex) patients with no infection. A significant association between skin infection and water exposure was found, the odds showing that those developing skin infection caused by S aureus were 4 times more likely to have had a history of seawater contact than the control group. Moreover, the antibiotic sensitivity patterns and phage types of S aureus isolated from patients were similar to those isolated from seawater at bathing beaches.

scholarly journals The Relationship between Inflammatory Cytokines and Coagulopathy in Patients with COVID-19

2021 ◽  
Vol 10 (9) ◽  
pp. 2020
Author(s):  
Fariba Rad ◽  
Ali Dabbagh ◽  
Akbar Dorgalaleh ◽  
Arijit Biswas
Keyword(s):  
Inflammatory Cytokines ◽  
Interleukin 1 ◽  
Clinical Findings ◽  
Laboratory Findings ◽  
Necrosis Factor Alpha ◽  
Coagulation Parameters ◽  
Increased Risk ◽  
Cytokine Levels ◽  
Α Level ◽  
High Level

Coronavirus disease 2019 (COVID-19), with a broad range of clinical and laboratory findings, is currently the most prevalent medical challenge worldwide. In this disease, hypercoagulability and hyperinflammation, two common features, are accompanied by a higher rate of morbidity and mortality. We assessed the association between baseline inflammatory cytokine levels and coagulopathy and disease outcome in COVID-19. One hundred and thirty-seven consecutive patients hospitalized with COVID-19 were selected for the study. Baseline interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-α) level were measured at time of admission. At the same time, baseline coagulation parameters were also assessed during the patient’s hospitalization. Clinical findings, including development of thrombosis and clinical outcome, were recorded prospectively. Out of 136 patients, 87 (~64%) had increased cytokine levels (one or more cytokines) or abnormal coagulation parameters. Among them, 58 (~67%) had only increased inflammatory cytokines, 12 (~14%) had only coagulation abnormalities, and 17 (19.5%) had concomitant abnormalities in both systems. It seems that a high level of inflammatory cytokines at admission points to an increased risk of developing coagulopathy, thrombotic events, even death, over the course of COVID-19. Early measurement of these cytokines, and timely co-administration of anti-inflammatories with anticoagulants could decrease thrombotic events and related fatal consequences.

Serum cytokines in ANCA-associated vasculitis: Correlation with disease-related clinical and laboratory findings

2021 ◽  
Vol 157 (10) ◽  
pp. 464-472
Author(s):  
Joanna Krajewska Wojciechowska ◽  
Wojciech Krajewski ◽  
Katarzyna Kościelska-Kasprzak ◽  
Tomasz Zatoński
Keyword(s):  
Laboratory Findings ◽  
Serum Cytokines ◽  
Anca Associated Vasculitis

scholarly journals Inflammatory phenotyping predicts clinical outcome in COVID-19

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
H. Burke ◽  
◽  
A. Freeman ◽  
D. C. Cellura ◽  
B. L. Stuart ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Outcome Data ◽  
University Hospital ◽  
Clinical Parameters ◽  
Gm Csf ◽  
Poor Outcome ◽  
Hospitalised Patients ◽  
Cytokine Levels ◽  
Patients At Risk ◽  
Multiplex Cytokine

Abstract Background The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is a major cause of disease severity and death. Identitfying COVID-19 patients with hyperinflammation may identify subgroups who could benefit from targeted immunomodulatory treatments. Analysis of cytokine levels at the point of diagnosis of SARS-CoV-2 infection can identify patients at risk of deterioration. Methods We used a multiplex cytokine assay to measure serum IL-6, IL-8, TNF, IL-1β, GM-CSF, IL-10, IL-33 and IFN-γ in 100 hospitalised patients with confirmed COVID-19 at admission to University Hospital Southampton (UK). Demographic, clinical and outcome data were collected for analysis. Results Age > 70 years was the strongest predictor of death (OR 28, 95% CI 5.94, 139.45). IL-6, IL-8, TNF, IL-1β and IL-33 were significantly associated with adverse outcome. Clinical parameters were predictive of poor outcome (AUROC 0.71), addition of a combined cytokine panel significantly improved the predictability (AUROC 0.85). In those ≤70 years, IL-33 and TNF were predictive of poor outcome (AUROC 0.83 and 0.84), addition of a combined cytokine panel demonstrated greater predictability of poor outcome than clinical parameters alone (AUROC 0.92 vs 0.77). Conclusions A combined cytokine panel improves the accuracy of the predictive value for adverse outcome beyond standard clinical data alone. Identification of specific cytokines may help to stratify patients towards trials of specific immunomodulatory treatments to improve outcomes in COVID-19.

scholarly journals Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xin Li ◽  
Qing-qing Xiao ◽  
Fu-lun Li ◽  
Rong Xu ◽  
Bin Fan ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Meta Analysis ◽  
Serum Marker ◽  
Serum Markers ◽  
Quality Data ◽  
Healthy Controls ◽  
High Quality Data ◽  
The Past ◽  
Before And After ◽  
Heat Syndrome

Objective. To determine whether immunological serum markers IFN-γ, IL-4, IL-17, IL-23, IL-6, TNF-α, and IL-10 are elevated or decreased in patients compared with healthy controls.Methods. A complete search of the literature on this topic within the past 30 years was conducted across seven databases. Seventeen studies including 768 individuals were identified. Differences in serum marker levels between subjects and controls were pooled as MDs using the random-effects model.Results. The pooled MDs were higher in patients than in healthy controls for IFN-γ(MD 24.9, 95% CI 12.36–37.43), IL-17 (MD 28.92, 95% CI 17.44–40.40), IL-23 (MD 310.60, 95% CI 4.96–616.24), and TNF-α(MD 19.84, 95% CI 13.80–25.87). Pooled IL-4 (MD −13.5, 95% CI −17.74–−9.26) and IL-10 (MD −10.33, 95% CI −12.03–−8.63) levels were lower in patients.Conclusion. The pooled analyses suggest that levels of IFN-γ, IL-17, IL-23, and TNF-αare significantly elevated and that levels of IL-4 and IL-10 are significantly decreased in sera of patients with psoriasis vulgaris of blood-heat syndrome. Measuring progression of blood-heat syndrome of psoriasis vulgaris will require additional high-quality data, with a low risk of bias and adequate sample sizes, before and after antipsoriatic therapy.

scholarly journals Polymerase chain reaction compared to other laboratory findings and to clinical evaluation in the diagnosis of cutaneous tuberculosis and atypical mycobacteria skin infection

2009 ◽  
Vol 48 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Cristina Martinez Zugaib Abdalla ◽  
Zilda Najjar Prado de Oliveira ◽  
Mirian N. Sotto ◽  
Kátia Ramos Moreira Leite ◽  
Flávio Canellas Canavez ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Clinical Evaluation ◽  
Skin Infection ◽  
Atypical Mycobacteria ◽  
Chain Reaction ◽  
Laboratory Findings ◽  
Cutaneous Tuberculosis ◽  
Polymerase Chain

scholarly journals Iritable bowel syndrome as the first manifestation of Hashimoto's tireoiditis

2020 ◽  
Vol 17 (2) ◽  
pp. 89-92
Author(s):  
Marijana Jandrić-Kočić
Keyword(s):  
Neuromuscular Disorders ◽  
Intestinal Wall ◽  
Aspiration Biopsy ◽  
American Thyroid Association ◽  
Laboratory Findings ◽  
Dietary Regimen ◽  
The Past ◽  
Follicular Tumor ◽  
One Year ◽  
The Right

Introduction. Hashimoto's thyreoiditis has a complex effect on the gastrointestinal tract, which includes hormone receptor alteration, neuromuscular disorders, myopathies caused by intestinal wall infiltration. Case report. A 44-year-old patient appears in the family medicine clinic due to moderate pain in the lower part of the abdomen present for the past three months, which intensifies before defecation and stops immediately after defecation. He has two to four liquid stools daily in which he has not noticed the presence of mucus or blood for the past two months. He negates earlier illnesses as well as diseases relevant to heredity. Physical examination provides a neat finding. Ultrasound examination of the abdomen is within the age range. Thyroid ultrasound identifies the right flap of a 48x24x10 mm diametre with hypoechogenic calcified nodus 14x12 mm in diameter (meets the criteria of the American Thyroid Association for aspiration biopsy), left flap of 44x20x14 mm diameter. The following are the laboratory findings: TSH 7.66 mIU/l, FT4 6.42 pmol/l, TG 5080 ng/ml, calcitonin 8.94 pg/ml, TG-At 24.99 IU/ ml, TPO-At 500 IU/ml. The patient is instructed on a hygienic dietary regimen and includes spasmolytic and antidiarrheal, and referred to a nuclear medicine specialist who performs an aspiration biopsy (TBSRTC IV follicular tumor). The Oncology Consilium indicates surgery (right-sided lobectomy) with extempore verification and further follow-up. Pathohistological examination of the removed right lobe excludes the presence of malignant disease (struma coloides multinodosa glandulae thyroideae). Antidiarrheal therapy is discontinued and replacement therapy is administered (levothyroxine sodium tablets 50 mcg, qd). Subsequent proctosigmoidoscopy shows a neat finding. One year after surgery the patient is in remission of the disease. Conclusion. Diagnostic evaluation of the thyroid gland in patients with irritable colon syndrome significantly improves quality of life, reduces occupational absenteeism and health care costs.

scholarly journals Diverse etiologies, diagnostic approach, and management of primary adrenal insufficiency in pediatric age

2021 ◽  
Vol 26 (3) ◽  
pp. 149-157
Author(s):  
Han-Wook Yoo
Keyword(s):  
Adrenal Insufficiency ◽  
Adrenocorticotropic Hormone ◽  
Molecular Genetic ◽  
Pediatric Age ◽  
Steroid Biosynthesis ◽  
Primary Adrenal Insufficiency ◽  
Laboratory Findings ◽  
Developmental Abnormalities ◽  
Monogenic Disorders ◽  
The Past

Primary adrenal insufficiency (PAI) in pediatric age is a rare, but potentially fatal condition caused by diverse etiologies including biochemical defects of steroid biosynthesis, developmental abnormalities of the adrenal gland, or reduced responsiveness to adrenocorticotropic hormone. Compared to adult PAI, pediatric PAI is more often the result of genetic (monogenic, syndromic disorders) than acquired conditions. During the past decade, rare monogenic disorders associated with PAI have helped unravel the underlying novel molecular genetic mechanism. The diagnosis of adrenal insufficiency in children and young infancy is often challenging, usually based on clinical suspicion and endocrine laboratory findings. Pediatric endocrinologists sometimes encounter therapeutic difficulty in finding the balance between undertreatment and overtreatment, determining how to optimize the dose over the patient’s lifetime, and maximizing mimicry of normal cortisol secretion with glucocorticoid replacement therapy.

scholarly journals Catheter Related Infections in Pediatric Patients

2019 ◽  
Vol 33 (5-6) ◽  
pp. 108-14
Author(s):  
Herry Garna
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Nosocomial Infections ◽  
Pediatric Patients ◽  
Skin Infection ◽  
Enterobacter Aerogenes ◽  
Klebsiella Pneumonia ◽  
Skin Infections ◽  
E Coli ◽  
Frequent Site

During a 9-month prospective study, from August, 1988 to April, 1989, a total number of 4328 hospitalized pediatric patients at the Department of Child Health, Padjadjaran University, Hasan Sadikin General Hospital Bandung, were observed to identify skin and soft tissue nosocomial infections (not included postoperative), especially catheter related injections. The gastroentestinal tract was the most frequent site of nosocomial infections (44.3%), then subsequently followed by skin infection (22.6%), bacteremia (16.3%) and urinary tract infection (14.1%). The most frequent cause of nosocomial skin infections like phlebitis was IVFD occurring in 82 out of 93 patients (88.2%). The overall phlebitis attact rate was 4.2% . When the duration of infusion is devided into 3 groups of 0-36 hours, 37-72 hours and ≥ 73 hours, then it becomes clear that the longer the duration of infusion, the higher the attack rate (x2=8.07, p<0.05). Klebsiella pneumonia seemed to be the pathogen most frequently associated with nosocomial skin infections (26. 7%), followed by Enterobacter aerogenes (20.0%), and then E. coli, Ps. aeruginosa and S. aureus 13.3% each. It could be concluded that the risk of contracting phlebitis from JVFD with a duration  of ≥ 73 hours was. 1.9 times higher than that of less than 72 hours.

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