scholarly journals The Difference of Angiopoietin-2 Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

2019 ◽  
Vol 7 (13) ◽  
pp. 2119-2122 ◽  
Author(s):  
Rinang Mariko ◽  
Eryati Darwin ◽  
Yanwirasti Yanwirasti ◽  
Sri Rezeki Hadinegoro
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Sampling Design ◽  
Dengue Infection ◽  
Health Sector ◽  
Hemorrhagic Fever ◽  
Incidence And Mortality ◽  
The Mean ◽  
The Difference ◽  
Angiopoietin 2 ◽  
Very High

BACKGROUND: Dengue infection is one of the problems in the national health sector in Indonesia because the incidence and mortality in Indonesia due to dengue infection is still very high. In 2005 Indonesia became the highest contributor to dengue infection in Southeast Asia (53%) with 95.270 people and 1.298 deaths. AIM: This study aims to analyse differences in angiopoietin-2 levels in dengue hemorrhagic fever (DHF) with and without shock. METHODS: This study was a consecutive sampling design with the research subject was obtained based on the order of admission to the hospital — the serum Angiopoietin-2 levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant. RESULT: The result showed that the mean of Angiopoietin-2 levels in DHF patients with shock was higher than in DHF (p < 0.05). CONCLUSION: This study concluded that there was a difference in the average level of Angiopoietin-2 among DHF patients with shock compared to without shock.

scholarly journals Hyperventilation in Children with Dengue Hemorrhagic Fever (DHF)

2019 ◽  
Vol 31 (9-10) ◽  
pp. 245-56
Author(s):  
Kasim Y. A. ◽  
Anky Tri Rini K. E. ◽  
Sumarmo S. P. S.
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Lung Edema ◽  
Respiratory Problems ◽  
Ventilatory Pattern ◽  
Grade Ii ◽  
Plasma Leakage ◽  
The Difference ◽  
Respiratory Disturbance

Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise. because of plasma leakage through the 'damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state. During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation. The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant. In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaC02 though not significantly.

scholarly journals Comparison of serial blood lactate level between dengue shock syndrome and dengue hemorrhagic fever (evaluation of prognostic value)

2007 ◽  
Vol 47 (4) ◽  
pp. 150 ◽  
Author(s):  
M. Tatang Puspanjono ◽  
Abdul Latief ◽  
Alan R. Tumbelaka ◽  
Sudigdo Sastroasmoro ◽  
Hartono Gunardi
Keyword(s):  
Oxygen Saturation ◽  
Blood Lactate ◽  
Dengue Hemorrhagic Fever ◽  
Lactate Level ◽  
Venous Blood ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Blood Lactate Level ◽  
Cross Sectional ◽  
The Difference

Background Dengue shock syndrome (DSS) mortality is still high.Monitoring of blood lactate level is important to evaluate shock.Objectives The study were to review the difference between bloodlactate level of DSS and that of dengue hemorrhagic fever (DHF),to correlate blood lactate level with hypoxia state as shock riskfactors (PaO 2 , oxygen saturation, and anion gap) and to determinethe cut-off point of blood lactate level to predict shock.Methods The study was carried out at the Department of ChildHealth, Medical School, University of Indonesia, CiptoMangunkusumo Hospital, Jakarta, from January until July 2006.Three mL venous blood specimen was collected from all subjectsfor peripheral blood, blood gasses, serology, and blood lactateexaminations. This study consisted of a retrospective cohort anda cross sectional method. Data were analyzed with Chi-squaretest. Continous data tested using Mann-Whitney method. Toknow the correlation between blood lactate level and shock riskfactors we use logistic regression test.Results In DSS group, 73% shows hyperlactatemia (lactate =2mmol/L). Conversion of lactate means between two groups issignificantly different from day one to day two and three. Therewas a negative correlation between lactate level and pO 2 andoxygen saturation. Oxygen saturation is the only value that hasclinical correlation. Regressions analysis can be applied using Y= 7.05–0.05 X equation. The cut-off point of lactate level asmarker for shock by using ROC curve is 32.015 mmol/L with 70%sensitivity and 83.3% specificity.Conclusions Hyperlactatemia in DSS can be considered as a signfor unappropriate treatment of shock. Blood lactate level can beused as a biochemical marker for tissue hypoxia, to assess severityof the disease, as monitoring of treatment, and has prognosticvalue of DHF cases.

scholarly journals Effect of dengue hemorrhagic fever on thrombomodulin level

2009 ◽  
Vol 49 (5) ◽  
pp. 259
Author(s):  
Hendra Widjaja ◽  
Max F. J. Mantik
Keyword(s):  
Endothelial Cells ◽  
Dengue Hemorrhagic Fever ◽  
Pediatric Patients ◽  
Hemorrhagic Fever ◽  
Cross Sectional Study ◽  
Blood Analysis ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Difference ◽  
Difference Test

Background Thrombocyte and endothelial cells play animportant role in dengue hemorrhagic fever pathogenesis.Thrombomodulin is a part of glycoprotein membrane inendothelial cells. Therefore, thrombomodulin level willincrease if endothelial cells disruption occurs.Objective To acknowledge the correlation between thedegree of dengue hemorrhagic fever and thrombomodulinlevel.Methods This was a cross-sectional study. Subjects werehospitalized pediatric patients with age ranging from oneto 13 year old in pediatric ward at Pro£ Dr. R.D. KandouHospital, Manado, who had fever. Three milliliters of bloodwere taken from vein, and were divided for two tests whichwere routine blood analysis and thrombomodulin analysis.Different data resulted from the dengue hemorrhagic fevergroup were processed, and analyzed statistically using F Testand LSD (least significant difference) test. The relationbetween dengue hemorrhagic fever and thrombomodulinwas analyzed with Spearman correlation coefficient.Results There was a significant result in the difference ofthrombomodulin level on four dengue hemorrhagic fevergroups which were classified according to the severity ofdengue hemorrhagic fever. There was a very significantpositive correlation between the severity of denguehemorrhagic fever and thrombomodulin level in detectingendothelial cells impairment.Conclusion Thrombomodulin level can be used as amarker to detect endothelial cells impairment in denguehemorrhagic fever. Higher grade of dengue hemorrhagicfever will have higher thrombomodulin level.

scholarly journals High Levels of Serum Angiopoietin 2 and Angiopoietin 2/1 Ratio at the Critical Stage of Dengue Hemorrhagic Fever in Patients and Association with Clinical and Biochemical Parameters

2020 ◽  
Vol 58 (4) ◽  
Author(s):  
Maheshi Mapalagamage ◽  
Shiroma M. Handunnetti ◽  
Ananda Rajitha Wickremasinghe ◽  
Gayani Premawansa ◽  
Sharmila Thillainathan ◽  
...  
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Biochemical Parameters ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
Healthy Controls ◽  
Critical Stage ◽  
Positive Correlations ◽  
Angiopoietin 2 ◽  
Disease Stages ◽  
Angiopoietin 1

ABSTRACT Longitudinal changes of serum angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2) associated with endothelial stability in dengue patients with different disease stages were studied. Serum Ang-1 and Ang-2 levels were measured in confirmed dengue fever (DF) patients on admission (DFA, n = 40) and discharge (DFD, n = 20); in dengue hemorrhagic fever (DHF) patients on admission (DHFA, n = 40), at critical stage (DHFC, n = 36), and on discharge (DHFD, n = 20); and in healthy controls (HC, n = 25). DHFC had the highest serum Ang-2 and lowest Ang-1 levels compared to DFA, DHFA, and HC (P < 0.050). The ratio of serum Ang-2/Ang-1 in DHFC was the highest among all study categories tested (P < 0.001). Significant positive correlations were observed between serum Ang-1 and platelet count in DHFA (Pearson r = 0.653, P < 0.001) and between Ang-1 and pulse pressure in DHFC (r = 0.636, P = 0.001). Using a cutoff value of 1.01 for the Ang-2/Ang-1 ratio for DHFC, a sensitivity of 83.2% and a specificity of 81.2% discerning DF from DHF were obtained. Therefore, serum Ang-2/Ang-1 could be used as a biomarker for endothelial dysfunction in severe dengue at the critical stage.

Shock Prognostic Factors in Hospitalized Dengue Hemorrhagic Fever Children

2018 ◽  
Vol 24 (8) ◽  
pp. 6221-6224
Author(s):  
Hindra Irawan Satari ◽  
Rossy Agus Mardani ◽  
Hartono Gunardi
Keyword(s):  
Prognostic Factors ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Health Department ◽  
Abdominal Tenderness ◽  
Diverse Area ◽  
Plasma Leakage

Various clinical manifestations, complex pathogenesis and different virus serotypes in diverse area make us difficult to predict course of disease, even the child admitted in early. Prognostic factors are very important to predict cases progressing to become DSS. Dengue shock syndrome (DSS) occurs in 15.53% of Dengue hemorrhagic fever (DHF) patients with 7.81% mortality rate. Aim: To explore the prognostic factors of shock in hospitalized DHF children regarding the new 2011 WHO dengue virus infection classification guideline. This was a retrospective study using medical records of children age below 18 years old with WHO fulfilled grade 1 and 2 DHF diagnosis from January 2013–December 2016 in Child Health Department of Dr. Cipto Mangunkusumo Hospital, Jakarta. Independent variables were sex, age, nutritional status, secondary dengue infection, leucopenia, abdominal tenderness, gastrointestinal bleeding, hepatomegaly and plasma leakage. Shock was dependent variable. Multivariate analysis was done by using logistic regresion analysis. There were 98 DHF subjects, 5 subjects became DSS during hospitalization. DSS subject characteristics were age of >5 years old, female, malnutrition, abdominal tenderness, hemoconcentration ≥20%, secondary dengue infection, leucocyte ≥5.000 mm3 and thrombocyte <50.000 mm3. Multivaryate analysis showed malnutrition and hepatomegaly were prognosis factors of DSS. Malnutrition and hepatomegaly were prognotic factors of dengue shock syndrome. Clinicians should be more aware with these factors when managed hospitalized DHF patients.

Thyroid activities of non-pregnant, pregnant, post-Partum and newborn swamp buffaloes

1982 ◽  
Vol 98 (3) ◽  
pp. 483-486 ◽  
Author(s):  
A. Pichaicharnarong ◽  
P. Loypetjra ◽  
N. Chaiyabutr ◽  
S. Usanakornkul ◽  
D. J. Djurdjevic
Keyword(s):  
Post Partum ◽  
Late Pregnancy ◽  
Full Term ◽  
Total Serum ◽  
Buffalo Calves ◽  
Swamp Buffaloes ◽  
The Mean ◽  
The Difference ◽  
Average Serum ◽  
Very High

SUMMARYThe average serum T4(D) of nine non-pregnant buffaloes was 5·5 ± 1·4 μg/100 ml. It increased slightly to 6·2 ± 4·2 μg/100 ml in 37 6–7 month pregnant buffaloes. Nevertheless the difference was not significant. When the pregnancy reached 8–9 months, the T4(D) was 9·0 ± 3.8μg/100 ml which was significantly higher than that at 6–7 months (P < 0·01). At full term (9–10 months), T4(D) decreased to 3·6 ± 2–6 μg/100 ml which was significantly lower than that at 8–9 months (P <0·001).In 1 month post-partum buffaloes, the average T4(D) was 5·1 ± 3·4 μg/100 ml, while T4(D) of 1-month-old buffalo calves was very high, i.e. 13·6 ± 3·2 μg/100 ml.The total serum T3 (RIA) of late-pregnant buffaloes decreased markedly from that of 8–9 month pregnant (P< 0·001). At 1 month post-partum, T3 rose to 143·4 ± 33·0 μg/100 ml which was significantly higher than that at late pregnancy (P < 0·001). The mean serum T3(RIA) of 1-month-old buffalo calves was relatively high, i.e. 281·0 ± 106·2 μg/100 ml which was significantly higher than 143·4 ± 33·0 ng/100 ml of their darn buffaloes (P < 0·001) at the same period of time.The RT3U values of 6–7 (35·9 ± 4·2%) and 8–9 (34·7 ± 2·0%) month pregnant animals were highly significantly different from 31·1 ± 3·1 % of the full-term pregnancy (P < 0·001).

scholarly journals Pengaruh Kesehatan Lingkungan terhadap Perubahan Epidemiologi Demam Berdarah di Indonesia

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Ribka Wowor
Keyword(s):  
High Risk ◽  
Environmental Factors ◽  
Dengue Hemorrhagic Fever ◽  
Health Problem ◽  
Human Population ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Hemorrhagic Fever ◽  
Effective Control ◽  
High Risk Population

Abstract: In Indonesia, dengue hemorrhagic fever (DHF) is a serious health problem. Infection of dengue has occurred in Indonesia for the last two decades. It is a self limiting disease, however, its clinical manifestations has become worsened since several years ago. Epidemiologic pattern of dengue infection changes every year, and there is a peak of new cases every 10 years. Nowadays, adolescence and adult individuals belong to the high risk population of this infection. This epidemiologic changing of DHF is influenced by several environmental factors, inter alia: 1) increasing of human population; 2) uncontrolled urbanization; 3) no effective control of mosquitoes in endemic areas; and 4) modernized public transportation.Keywords: environmental sanitation, epidemiology, dengue hemorrhagic fever Abstrak: Di Indonesia, demam berdarah dengue (DBD) masih merupakan masalah kesehatan masyarakat yang penting. Infeksi dengue terjadi secara endemis di Indonesia selama dua abad terakhir. Penyakit ini bersifat self limiting namun dalam beberapa tahun terakhir memperlihatkan manifestasi klinis yang semakin berat sebagai DBD dan frekuensi kejadian luar biasanya semakin meningkat. Pola epidemiologi infeksi dengue mengalami perubahan dari tahun ke tahun, jumlah kasus memuncak setiap siklus 10 tahunan. Kelompok usia yang terserang dengue berubah menjadi kelompok remaja dan dewasa. Perubahan epidemiologi DBD ini turut dipengaruhi oleh faktor kesehatan lingkungan. Faktor-faktor yang memengaruhi peningkatan dan penyebaran kasus DBD sangat kompleks yaitu, antara lain: 1) pertumbuhan penduduk yang tinggi dan cepat; 2) urbanisasi yang tidak terencana dan tidak terkendali; 3) tidak adanya kontrol vektor nyamuk yang efektif di daerah endemis; serta 4) peningkatan sarana transportasi.Kata kunci: kesehatan lingkungan, epidemiologi, demam berdarah dengue

scholarly journals The Difference of sVE-Cadherin Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

2019 ◽  
Vol 7 (14) ◽  
pp. 2277-2281 ◽  
Author(s):  
Rinang Mariko ◽  
Eryati Darwin ◽  
Yanwirasti Yanwirasti ◽  
Sri Rezeki Hadinegoro
Keyword(s):  
Dengue Virus ◽  
Sample Size ◽  
Dengue Hemorrhagic Fever ◽  
Hypovolemic Shock ◽  
Hemorrhagic Fever ◽  
Total Sample ◽  
Research Subjects ◽  
Cross Sectional ◽  
The Difference ◽  
Cross Sectional Design

BACKGROUND: Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction. AIM: This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock. MATERIAL AND METHODS: The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant. RESULTS: The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05). CONCLUSION: This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.

scholarly journals Hubungan Respon Imun Humoral dengan Derajat Trombositopenia pada Pasien Demam Berdarah Dengue

2017 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Fatmawati Fatmawati ◽  
Chandra Wijaya
Keyword(s):  
Immune Response ◽  
Dengue Hemorrhagic Fever ◽  
Humoral Immune Response ◽  
Analytical Study ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Statistical Test ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Fever Patient

The correlation between humoral immune response with the level of of thrombocytopenia on dengue hemorrhagicfever patient The aim of this study was to know the correlation between humoral immune response with the level of ofthrombocytopenia on dengue hemorrhagic fever patient. This is a cross sectional analytical study on internal inpatientsof AwalBros Pekanbaru Hospital in August-November 2008. Population was all internal inpatients of AwalBros PekanbaruHospital with working diagnosis dengue hemorrhagic fever. There were 4 pattern of anti Dengue antibody : IgG-/IgM,IgG-/IgM+, IgG+/IgM-, IgG+/IgM+. Most of patients with IgG+/IgM+ and have secondary dengue infection Thoseresult were analyzed by Friedman statistical test. There isn’t a significant correlation between the level ofthrombocytopenia and anti dengue antibody. It show that there wasn’t a direct correlation between them. It could bedue to a cross reaction between anti dengue antibody with thrombocyte (autoantibody).

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