scholarly journals The Difference of sVE-Cadherin Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

2019 ◽  
Vol 7 (14) ◽  
pp. 2277-2281 ◽  
Author(s):  
Rinang Mariko ◽  
Eryati Darwin ◽  
Yanwirasti Yanwirasti ◽  
Sri Rezeki Hadinegoro

BACKGROUND: Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction. AIM: This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock. MATERIAL AND METHODS: The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant. RESULTS: The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05). CONCLUSION: This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.

2007 ◽  
Vol 47 (4) ◽  
pp. 150 ◽  
Author(s):  
M. Tatang Puspanjono ◽  
Abdul Latief ◽  
Alan R. Tumbelaka ◽  
Sudigdo Sastroasmoro ◽  
Hartono Gunardi

Background Dengue shock syndrome (DSS) mortality is still high.Monitoring of blood lactate level is important to evaluate shock.Objectives The study were to review the difference between bloodlactate level of DSS and that of dengue hemorrhagic fever (DHF),to correlate blood lactate level with hypoxia state as shock riskfactors (PaO 2 , oxygen saturation, and anion gap) and to determinethe cut-off point of blood lactate level to predict shock.Methods The study was carried out at the Department of ChildHealth, Medical School, University of Indonesia, CiptoMangunkusumo Hospital, Jakarta, from January until July 2006.Three mL venous blood specimen was collected from all subjectsfor peripheral blood, blood gasses, serology, and blood lactateexaminations. This study consisted of a retrospective cohort anda cross sectional method. Data were analyzed with Chi-squaretest. Continous data tested using Mann-Whitney method. Toknow the correlation between blood lactate level and shock riskfactors we use logistic regression test.Results In DSS group, 73% shows hyperlactatemia (lactate =2mmol/L). Conversion of lactate means between two groups issignificantly different from day one to day two and three. Therewas a negative correlation between lactate level and pO 2 andoxygen saturation. Oxygen saturation is the only value that hasclinical correlation. Regressions analysis can be applied using Y= 7.05–0.05 X equation. The cut-off point of lactate level asmarker for shock by using ROC curve is 32.015 mmol/L with 70%sensitivity and 83.3% specificity.Conclusions Hyperlactatemia in DSS can be considered as a signfor unappropriate treatment of shock. Blood lactate level can beused as a biochemical marker for tissue hypoxia, to assess severityof the disease, as monitoring of treatment, and has prognosticvalue of DHF cases.


2018 ◽  
Vol 5 (3) ◽  
pp. 383
Author(s):  
Sofa Nutrima Rismawati

ABSTRACTFree Number of larvae (ABJ) in RW 15, Wonokusumo Village is 85%. However, the incidence of Dengue Hemorrhagic Fever (DHF) is still high, ie 17 cases. The high incidence rate of DHF is due to the interaction between host, agent and environment. Host in terms of behavior, dengue virus as an agent and environment derived from the surrounding conditions that can cause and trigger the spread of DHF. The purpose of this research is to analyze the relationship of host and environment behavior to the occurrence of DHF in RW 15. This research using cross sectional design. Random sampling using the guy method. How to calculate the method guy is 10% of the population so that obtained a sample of 78 respondents. Primary data collection technique is done through indepth interview and filling questionnaire. Secondary data collection was obtained from Wonokusumo Puskemas report and report from Surabaya City Health Office. The research was conducted in RW 15. The result of bivariate statistic test showed significant relation between knowledge, attitude, action and environment against DHF incidence with p> α, 0,00> 0,05. The conclusion of this research is that there is host and environment interaction to DHF incidence. Suggestion of this research is procurement of work program every month, independent larvae monitoring movement by society and 3M movement plus every week on Thursday and procurement of training of cadre jumantik about how and regulation of dosage of abate powder according to dose.Keywords: host behavior, environment, disease Dengue Hemorrhagic Fever


2009 ◽  
Vol 49 (5) ◽  
pp. 259
Author(s):  
Hendra Widjaja ◽  
Max F. J. Mantik

Background Thrombocyte and endothelial cells play animportant role in dengue hemorrhagic fever pathogenesis.Thrombomodulin is a part of glycoprotein membrane inendothelial cells. Therefore, thrombomodulin level willincrease if endothelial cells disruption occurs.Objective To acknowledge the correlation between thedegree of dengue hemorrhagic fever and thrombomodulinlevel.Methods This was a cross-sectional study. Subjects werehospitalized pediatric patients with age ranging from oneto 13 year old in pediatric ward at Pro£ Dr. R.D. KandouHospital, Manado, who had fever. Three milliliters of bloodwere taken from vein, and were divided for two tests whichwere routine blood analysis and thrombomodulin analysis.Different data resulted from the dengue hemorrhagic fevergroup were processed, and analyzed statistically using F Testand LSD (least significant difference) test. The relationbetween dengue hemorrhagic fever and thrombomodulinwas analyzed with Spearman correlation coefficient.Results There was a significant result in the difference ofthrombomodulin level on four dengue hemorrhagic fevergroups which were classified according to the severity ofdengue hemorrhagic fever. There was a very significantpositive correlation between the severity of denguehemorrhagic fever and thrombomodulin level in detectingendothelial cells impairment.Conclusion Thrombomodulin level can be used as amarker to detect endothelial cells impairment in denguehemorrhagic fever. Higher grade of dengue hemorrhagicfever will have higher thrombomodulin level.


2010 ◽  
Vol 1 (1) ◽  
pp. 44
Author(s):  
Soegeng Soegijanto ◽  
Dian Dwi Sary ◽  
Budi Setiawan ◽  
Atsushi Yamanaka

Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial. The aim of this study is to analyze the role complement activity, TNFα & IL12 in Dengue Virus infection especially in pathogenesis of Dengue Virus infection. Cross sectional study had been done since February 2009 in Dr. Soetomo Hospital Surabaya. Blood Sera of Dengue Virus infection were collected from Dengue Fever, and Dengue Hemorrhagic Fever patient who had been care in Paediatric. Dengue patients and time schedule for taking blood sample for examination CH50, TNFα & IL12 as follow: on the first day on admission, the second day, the third day. Study groups of patients as follow: Dengue Fever, 36; Dengue Hemorrhagic Fever grade I, 37; Dengue Hemorrhagic Fever grade II, 10; Dengue Hemorrhagic Fever grade III, 18; Dengue Hemorrhagic Fever grade IV, 6. In this study found that the higher activity complement which lower level CH50 was more identified on Dengue Shock Syndrome and Dengue Hemorrhagic Fever grade III than Dengue Fever cases. A concept of our study was focusing on manifestation of vascular leakage, measurement of complement activity CH50, TNFα & IL12 and clinical manifestation Dengue Hemorrhagic Fever. The examination of TNFα & IL12 in our study supported the role the activity complement. The conclusion are measurement CH50, TNFα & IL12 can be used as a predictive factor of the degree of Dengue Virus infection


2020 ◽  
Vol 19 (2) ◽  
pp. 111-118
Author(s):  
Esy Maryanti ◽  
Ismawati Ismawati ◽  
Unique Prissilia ◽  
Ardini Yovy Puteri

Latar belakang: Demam berdarah dengue (DBD) merupakan penyakit yang masih menjadi masalah kesehatan di Indonesia yang disebabkan oleh virus dengue dan ditularkan melalui nyamuk Aedes aegypti. Kejadian DBD selalu ada setiap tahun di Pekanbaru dari tahun 2014-2016 terjadi peningkatan kasus, 2017-2018 kasus DBD mulai menurun tetapi diawal tahun 2019 kasus DBD kembali terjadi peningkatan dan sudah ada kematian sehingga memerlukan perhatian yang lebih serius untuk meningkatkan kewaspadaan terhadap penyakit tersebut. Tujuan penelitian ini adalah untuk menganalisis potensi transmisi DBD berdasarkan indeks entomologi dan maya indeks di tiga kelurahan Kecamatan Sukajadi yang merupakan daerah endemis DBD. Metode: Penelitian survei larva Aedes aegypti dengan pendekatan cross sectional yang dilakukan pada bulan Juli 2019 di tiga kelurahan yaitu Kelurahan Kampung Tengah, Kampung Melayu, Kedungsari Kecamatan Sukajadi. Identifikasi larva menggunakan metode single larva method. Hasil: Sebanyak 181 rumah yang disurvey, didapatkan 822 kontainer yang terdiri dari 683 controllable sites dan 139 disposable sites. Angka bebas jentik sebesar 89,5%, container index 3,4%, house index 10,5% dan Breteau index 21%. Status Maya indeks (MI) yang diukur berdasarkan breeding risk index dan hygiene risk index didapatkan sebanyak 55,80% rumah termasuk dalam status sedang dan 15,47% termasuk ke dalam status MI tinggi. Sebaran keberadaan larva Aedes aegypti berdasarkan letak geografis cukup merata di Kelurahan Kampung Melayu dan Kampung Tengah.Simpulan: Berdasarkan hasil indeks entomologi tersebut didapatkan density figure dalam kategori sedang yang artinya wilayah ini mempunyai potensi transmisi sedang untuk kejadian penyakit DBD. ABSTRACT  Title : Transmission Potential of Dengue hemorrhagic fever based on entomology index and maya index in three sub-districts, Sukajadi District, Pekanbaru CityBackground: Dengue hemorrhagic fever (DHF) is a disease still a health problem in Indonesia caused by the dengue virus that is transmitted through Aedes aegypti. The incidence of DHF is always there every year in Pekanbaru form 2014-2016 there was an increase in cases, from 2017-2018 dengue cases began to decline, but in early 2019 dengue cases increased again and there have been deaths so it requires more serious attention.. The objectives of this study was to analyze the potential transmission of DHF based on the entomology index and maya index in three sub-districts of Sukajadi district.Method: The research was a survey of larva Ae.aegypti in July 2019 from 181 houses in the three village of Sukajadi District. Larvae identification using the single larvae method.Result: A total of 181 houses surveyed obtained 822 containers consisting of 683 controllable sites and 139 disposable sites. The larvae free rates is 89.5%, container index 3.4%, house index 10,5% and Breteau index 21%. Maya index is measures based on breeding risk index and hygiene risk index shows that there are 55.8% of houses in the area are classified as moderate and 15.47% are included in high. The distribution of the existence of Ae.aegypti larvae based on the geographical location is quite evenly distributed in Kampung Melayu and Kampung Tengah.Conclusion: It is found that density figure is in the medium, which means that region has moderate transmission potential for the incidence of DHF


2020 ◽  
Vol 5 (1) ◽  
pp. 195
Author(s):  
Yunita Armiyanti ◽  
Nisrina Salsabila Firmansyah ◽  
Angga Mardro Raharjo ◽  
Muhammad Ali Shodikin ◽  
Enny Suswati ◽  
...  

ABSTRACT Tuberculosis is one of the world's health problems even in Indonesia. The immune response that needed to deal with TB can be influenced by other infections, such as helminth infection. The helminth infections induce Th2 immune responses and eosinophilia to eliminate these pathogen. Meanwhile, the Th2 response and eosinophilia can also suppress the Th1 immune response which is very important to eliminate the bacterium M. tuberculosis and make a negative impact on the success of TB therapy. Thus, the eosinophil profile can describe the immune response in TB patients with helminth co-infection. This study aims to determine the prevalence of helminthiasis in TB patients and determine the differences in eosinophil amount in tuberculosis patients with and without helminth co-infection. This study was an observational analytic study with a cross-sectional design conducted at Puskesmas Panti in August 2019-January 2020 using fecal and blood samples from 24 research subjects. Helminth co-infection status was obtained from fecal examination with sedimentation and flotation methods while the number of eosinophils was obtained from leukocyte counts. Data analysis used the Mann Whitney U test to determine differences in the number of eosinophils in the two groups. The results showed there was no difference in the number of eosinophils in TB patients with helminth co-infection and without helminth co-infection (p> 0.05). There is no typical picture of the number of eosinophils in both groups so that eosinophils cannot describe the immune response that arose in TB patients with helminth co-infections in Panti district, Jember.


Author(s):  
Riny Fasli ◽  
Heru Noviat Herdata ◽  
Dora Darussalam ◽  
Bakhtiar Bakhtiar ◽  
Sulaiman Yusuf ◽  
...  

Thalassemia is a congenital blood disorder characterized by reduced production of one or more globin chains. Thalassemia patients lack healthy hemoglobin which the body needs to be properly oxygenated. Blood transfusion is the main treatment for thalassemia patients. Checking hemoglobin levels after transfusion is a common test, but until now there is no definite uniformity of time to carry out these tests, so it will be detrimental to the patient and increase the length of the patient in the hospital. Assessing the difference in time to increase in hemoglobin levels at 1 hour, 6 hours, and 12 hours after blood transfusion in thalassemia patients. This research is an observational analytic study with cross sectional design. This study was conducted by examining the hemoglobin levels of thalassemia patients after 1 hour, 6 hours, and 12 hours after transfusion in thalassemia patients aged 1-18 years with a total sample of 40 people. The statistical analysis used was paired t test. The results showed that 20 men and 20 women and Most were in the age group 10-13 (35%), with an average Hb level at admission of 7.38 g / dL (95% CI). At 1 hour post-transfusion, the patient's mean Hb level increased by 8.97 g / dL (8,59-9,35 g / dL), at 6 hours post transfusion, 8.95 g / dL (8,57-9,32 g / dL), at 12 hours post transfusion increased by 9.60 g / dL (9,17-10,03 g / dL). Significant increase in Hb levels occurred at 1 hour and 12 hours after blood transfusion.


2019 ◽  
Vol 1 (1) ◽  
pp. 38-44
Author(s):  
Vudhya Ulhaq Kafrawi ◽  
Nadia Purnama Dewi ◽  
Prima Adelin

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus. The West Sumatra Health Service reported that the city of Padang was the highest city in the incidence of dengue hemorrhagic fever in West Sumatra. It is known that platelet counts and hematocrit levels are important indicators in determining the occurrence of shock and the severity of the disease. This type of research is a descriptive study using a cross sectional design with a retrospective approach, this study was conducted at the Siti Rahmah Islamic Hospital in Padang. The population in this study were all medical record data of patients who had been diagnosed with dengue hemorrhagic fever by a specialist in internal medicine at the Siti Rahmah Islamic Hospital in Padang period 1 January-31 December 2017, as many as 162 people with 62 samples using Simple random sampling technique. Univariate analysis is presented in the form of a frequency distribution       table. Based on the results of the study, it was found that the highest age was early adulthood, which was 69.4% and the highest sex was women, 58.1%. The highest clinical degree is degree 1, which is 58.1%. Most of the patients had platelet counts <100,000 cells / mm3 is 64.5% with an average platelet count of 87,790 cells / mm3. Most of the normal hematocrit levels were 67.7% with an average hematocrit level of 40.45%. Based on degree 1 most with platelet counts <100,000 cells / mm3 which is 55.6%, at degree 2 mostly with platelet counts <100,000 cells / mm3 which is 76.9% and based on degree 1 most hematocrit levels are normal is 63.9 % and at degree 2 most of the normal hematocrit levels are 73.1%.


Author(s):  
Hilda Irianty ◽  
Norsita Agustina ◽  
Adma Pratiwi Safitri

Abstrak Demam Berdarah Dengue (DBD) merupakan masalah utama penyakit menular di Indonesia. Selama 2015 terdapat 156 kasus Demam Berdarah Dengue (DBD) pada wilayah kerja Puskesmas Guntung Payung Kota Banjarbaru. Tujuan penelitian ini adalah mengetahui hubungan sikap dan upaya pencegahan ibu dengan kejadian Demam Berdarah Dengue (DBD) di Wilayah Kerja Puskesmas Guntung Payung Kota Banjarbaru. Metode penelitian yang digunakan adalah survei analitik dengan desain cross sectional.Hasil penelitian menunjukan bahwa antara sikap ibu dengan kejadian Demam Berdarah Dengue (DBD) mempunyai hubungan yang signifikan karena nilai p = 0,0001 (p<α = 0,05) dan upaya pencegahan ibu dengan kejadian Demam Berdarah Dengue (DBD) mempunyai hubungan yang signifikan karena nilai p = 0,0001 (p<α = 0,05). Disarankan lebih mengoptimalisasi peran tenaga kesehatan dalam memberikan informasi tentang Demam Berdarah Dengue (DBD) sehingga diharapkan pengetahuan ibu menjadi lebih baik tentang cara penularan dan pencegahan penyakit Demam Berdarah Dengue (DBD). Kata-kata kunci :Sikap, upaya pencegahan ibu, kejadian demam berdarah dengue (DBD). Abstract Dengue Hemorrhagic Fever (DHF) is a major problem of infectious diseases in Indonesia. During 2015 there were 156 cases of Dengue Hemorrhagic Fever (DHF) in Puskesmas Guntung Payung Banjarbaru. The purpose of this study was to determine the relationship of attitude and prevention of mother to the incidence of Dengue Hemorrhagic Fever (DHF) in Puskesmas Guntung Payung Banjarbaru. The method used is the analytic survey with cross sectional design. The results showed that the mother's attitude to the incidence of Dengue Hemorrhagic Fever (DHF) has a significant relationship because the value of p = 0.0001 (p <α = 0.05) and prevention of mother to the incidence of Dengue Hemorrhagic Fever (DHF) has a significant relationship because p = 0.0001 (p <α = 0.05).More advisable to optimize the role of health professionals in providing information about Dengue Hemorrhagic Fever ( DHF ) which is expected to be better mothers knowledge about modes of transmission and prevention of Dengue Hemorrhagic Fever ( DHF ). Keywords: Attitudes, prevention of mother, the incidence of dengue hemorrhagic fever (DHF).


2020 ◽  
Vol 4 (1) ◽  
pp. 22-27
Author(s):  
Dyhan Purna Setia ◽  
Ferdinal Ferry ◽  
Dovy Djanas

The aim of this study was to see the difference in the mean ratio of sodium levels between pregnancy with severe preeclampsia and eclampsia. The method in this research is an analytical study using a cross sectional design. The research was conducted in the delivery room Dr. M. Djamil Padang from 15 January 2016 to 31 December 2017. There were 60 patients as research subjects, the sample was divided into 2 groups, namely severe preeclampsia (PEB) and eclampsia. Anamnesis and physical examination were then carried out to obtain data and clinical diagnosis. The data were recorded in a research form that had been provided, then the blood electrolytes were examined for sodium and potassium. Statistical analysis to assess meaning using the T-test. The results showed that in the PEB and Eclampsia groups, it was found that multiparity parity had the highest respondents. This is in accordance with the literature where the incidence of preeclampsia is more often found at gestational age near term. The conclusion of this study there was no significant difference in the mean sodium ratio between preeclampsia, PEB and eclampsia. Keywords: pregnancy condition, PEB, eclampsia, platelet, PT, APTT, and D-Dimer


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