Biosynthesis of Polyglutamic Acid and its Application on Agriculture

2011 ◽  
Vol 183-185 ◽  
pp. 1219-1223 ◽  
Author(s):  
Xiang Yu ◽  
Min Wang ◽  
Qun Hui Wang ◽  
Xu Ming Wang

Poly γ-glutamic acid (γ-PGA) is a kind of water soluble and biodegradable polymer, which is nontoxic toward humans and the environment. Therefore, the potential applications of γ-PGA and its derivatives have been of interest in a broad range such as food, cosmetics, medicine, water treatment and agriculture. This paper summarizes γ-PGA synthesis pathways in microorganisms, producing strains, fermentation parameters, as well as separation and purification methods. In addition, the prospect of γ-PGA application on agriculture was introduced, pointing out the problems and the future trends in research and application of γ-PGA.

Holzforschung ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Xiaodi Wang ◽  
Yongchao Zhang ◽  
Luyao Wang ◽  
Xiaoju Wang ◽  
Qingxi Hou ◽  
...  

AbstractAn efficient separation technology for hydrolysates towards a full valorization of bamboo is still a tough challenge, especially regarding the lignin and lignin-carbohydrate complexes (LCCs). The present study aimed to develop a facile approach using organic solvent extraction for efficiently fractionating the main components of bamboo hydrolysates. The high-purity lignin with only a trace of carbohydrates was first obtained by precipitation of the bamboo hydrolysate. The water-soluble lignin (WSL) fraction was extracted in organic solvent through a three-stage organic solvent extraction process, and the hemicellulosic sugars with increased purity were also collected. Furthermore, a thorough characterization including various NMR techniques (31P, 13C, and 2D-HSQC), GPC, and GC-MS was conducted to the obtained lignin-rich-fractions. It was found that the WSL fraction contained abundant functional groups and tremendous amount of LCC structures. As compared to native LCC of bamboo, the WSL fraction exhibited more typical LCC linkages, i.e. phenyl glycoside linkage, which is the main type of chemical linkage between lignin and carbohydrate in both LCC samples. The results demonstrate that organic phase extraction is a highly efficient protocol for the fractionation of hydrolysate and the isolation of LCC-rich streams possessing great potential applications.


2001 ◽  
Vol 675 ◽  
Author(s):  
Jeong-Seo Park ◽  
Han-Chang Kang ◽  
Kurt E. Geckeler

ABSTRACTAs [60]fullerene is a very hydrophobic macromolecule, there have been a number of attempts to make it more hydrophilic for biomedical applications. By attaching hydrophilic moieties such as poly(oxyethylene)(POE) chains and cyclodextrin molecules to [60]fullerene, novel water-soluble and biocompatible materials have been successfully prepared [1,2].The synthesis of novel macrocyclic fullerene conjugates which are water-soluble is reported. The telechelic fullerene derivatives have been prepared via addition reaction of POE-based arms with covalently bonded β-cyclodextrin (CD) to [60]fullerene. To this end, a mono-tosylated CD derivative has been prepared in pyridine and then reacted with an amino-functional POE in the presence of triethylamine. The subsequent reaction of [60]fullerene with the hydrophilic POE-conjugated CD-derivative yielded the macrofullerene after separation and purification procedures.The macrocyclic [60]fullerene derivatives obtained were soluble in water and characterized by UV-VIS and FT-IR spectroscopy as well as light scattering measurements and thermogravimetric analysis.


Author(s):  
Rita N Wadetwar ◽  
Tejaswini Charde

Objective: The objective of the present work was the preparation of fast-dissolving film of tramadol HCl (TMH) using water-soluble polymer, to achieve faster onset of action, to improve patient compliance, ease of dosing, and bypass the first-pass metabolism. Methods: TMH oromucosal wafers were prepared using pullulan as natural, biodegradable polymer, and propylene glycol as plasticizer by solvent casting method. Formulation batches were prepared using 32 full-factorial designs. The prepared TMH oromucosal wafers were characterized for morphology, uniformity of weight, drug content, folding endurance, in vitro disintegration time (DT), % moisture content, surface pH, in vitro % drug release, ex vivo permeation studies, compatibility studies (differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray diffraction), and stability studies.Results: Optimized batch of mouth-dissolving film of TMH containing pullulan as polymer showed 98.67±0.11% drug release at 6 min. It showed better folding endurance 88 No. of folds, in vitro DT 5.11 s, surface pH 6.84±0.12 pH, thickness 0.17±0.11 mm, and percentage content uniformity 98.45±0.48%. Stability studies carried out for the best formulation FDF5 revealed that the formulation was stable.Conclusion: The results obtained in this research work clearly indicated a promising potential of fast-dissolving oral films using natural biodegradable polymer, pullulan which gave rapid drug delivery and rapid onset of action of centrally acting drug, TMH for patients suffering from pain.


Author(s):  
RUCHI AGRAWAL ◽  
ABID RAZA ◽  
OM PRAKASH PATEL

Objective: This review article explores solid dispersions (SDs) as one of the suitable approaches to formulate poorly water-soluble drugs. The objective of this review on SD techniques is to explore their utility as a feasible, simple, and economically viable method for augmentation of dissolution of hydrophobic drugs. Methods: Various types of SDs are classified and compared. Use of surfactants to stabilize the SDs and their potential advantages and disadvantages has been discussed. Different techniques for preparing and evaluating SDs are appraised along with discussions on scalability and industrial production. Review of the current research on SD along with future trends is also offered. Results: Based on the various researches, SDs offer an efficient means of improving bioavailability while concurrently contributing to lower toxicity and dose-reduction. Conclusion: Solid-dispersions have been and continue to be one of the key technologies for solving the issue of poor solubility for newer hydrophobic molecules which are being discovered. This would give a new lease of life for such drugs enabling them to be delivered in an effective way.


2021 ◽  
pp. 246-278
Author(s):  
M. Dhiman

The present review highlights the different types of nano ferrites and their surface modified composites as an alternative adsorbent in waste water treatment. In this review, the recent progresses and potential applications of SFNPs/SFNCs for the removal of organic and inorganic contaminants through adsorption routes are critically reviewed. There are number of water purification techniques but the adsorption is one of the simplest, effective and economical method for wastewater purification. Adsorption isotherm models, kinetic models, thermodynamic parameters and adsorption mechanism have also been discussed. The present article lists different type of adsorbents and reviews state-of-the-art of the removal of different pollutants from water. The efforts have been made to discuss the sources of contamination and toxicities of pollutants. The possible techniques of recovery and reuse, toxicity, research gaps and the future perspective of SFNPs are also discussed in brief. Based on this review, it is possible to conclude that SFNPs and their derivative composites have unlimited capacity in addressing array of problems encountered in water and wastewater treatment. The present study highlights the future areas of research for waste water treatment.


Food Research ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 557-562
Author(s):  
M.D. Lieu ◽  
T.T.H. Hoang ◽  
H.N.T. Nguyen ◽  
T.K.T. Dang

Anthocyanin is a water-soluble color compound of the flavonoid which was successfully encapsulation in Saccharomyces cerevisiae by plasmolysis, ethanol, and ultrasound treatments using alone or in combination in the first time. Treatment agents significantly enhanced the encapsulation efficiency of anthocyanin fluid. The encapsulation yield (EY) of the combined factors was higher than the individual impact factors. Ethanol 10% (v/v) and ultrasound 180 seconds for the highest EY 40.22±0.67%, then ethanol 10% (v/v) and NaCl 10% (w/v) for EY 36.45±0.35%, NaCl 10% and ultrasound for EY 32.14±0.98% lowest. The color stability evaluation of the capsules was carried out at 80°C for 30 minutes. The color lost rate was determined by the spectrometer. The color loss of samples with the un-treatment yeast was 20.45±1.21%, higher than the treated sample. This suggests that anthocyanin encapsulation by yeast cell is efficient in overcoming the effects of high temperatures and having potential applications in food processing.


2021 ◽  
Vol 21 (4) ◽  
pp. 2647-2652
Author(s):  
Yanchen Ji ◽  
Guoxin Song ◽  
Ruiqi Yang ◽  
Longhua Ding ◽  
Aizhu Wang ◽  
...  

In this work, CeO2 nanocrystal-decorated TiO2 nanobelt for forming a CeO2@TiO2 heterostructure. CeO2 plays a dual role in improving photocatalytic activity, not only by promoting the separation and transfer of photogenerated charge carriers, but also by increasing visible light absorption of the photocatalyst as a photosensitizer. The as-prepared CeO2@TiO2 heterostructure demonstrates the performance of organic degradation and H2 production (about 17 μmol/h/g, which is about 2.5 times higher than that of pure TiO2 nanobelts). Our work provides a facile and controllable synthesis method for high performance photocatalyst, which will have potential applications in synthesis clean/solar fuel, and photocatalytic water treatment.


2020 ◽  
Vol 1 (1) ◽  
pp. 51-79
Author(s):  
Ludovic Llanes ◽  
Pascal Dubessay ◽  
Guillaume Pierre ◽  
Cédric Delattre ◽  
Philippe Michaud

In the last decades, many studies have been conducted on new materials to meet a growing industrial demand and to move scientific research forward. Superabsorbents are good examples of materials that have generated special attention in many fields for their ability to absorb and retain water up to 1000 times of their dry weight. They found many applications in hygiene products and other products, for a fast growing market of USD 9.58 Billion in 2019. Most of them are composed of synthetic polymers, which are often not environmentally friendly. Therefore, natural superabsorbents and particularly those based on polysaccharides have received a recent increased interest for their biodegradability, biocompatibility, and renewability. This review focuses on polysaccharide-based superabsorbents, on their properties, synthesis methods, and characterization. Their potential applications in many fields, such as biomedical and hygiene, agriculture, water treatment, and the building sector, are also reported with an interest in products already marketed.


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