Setting Behavior of Fast-Setting Calcium Phosphate Cement with Mineral Phase of Bone

2007 ◽  
Vol 280-283 ◽  
pp. 1567-1570
Author(s):  
Jian Pan ◽  
Jie Mo Tian ◽  
Li Min Dong ◽  
Chen Wang
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Calcium Phosphate Cement ◽  
Setting Time ◽  
Xrd Analysis ◽  
X Ray Diffraction ◽  
Mineral Phase ◽  
Setting Process ◽  
Powder Xrd Analysis ◽  
Change Of Microstructure

The setting behavior of fast-setting calcium phosphate cement (FSCPC) with mineral phase of bone was investigated to evaluate the possible value of the CPC for medical and dental application. Various aspects of the setting behavior such as setting time, mechanical strength and phase change of cement with time were measured by the Vicat needle method, diametral tensile strength measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The change of microstructure during the setting process was observed by Scanning Electron Microscope (SEM). The setting time of the CPC was 10-15min. As a result of its fast setting, set specimens of FSCPC showed high mechanical strength. Powder XRD analysis revealed faster conversion of FSCPC into HAP. SEM observation showed that the specimens are mainly formed with micropores and crystallites, and the phase composition of the set specimens is mainly low-crystallinity HAP at last.

Effect of Protein Addition on the Setting Behaviour of a Calcium Phosphate Cement

2006 ◽  
Vol 309-311 ◽  
pp. 841-844
Author(s):  
S. Chauhan ◽  
M.P. Hofmann ◽  
R.M. Shelton
Keyword(s):  
Compressive Strength ◽  
Liquid Phase ◽  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Bovine Serum ◽  
Setting Time ◽  
Monocalcium Phosphate ◽  
Foetal Bovine Serum

This study investigated the influence of the addition of various proteins to the liquid phase (albumin, fibrinogen and foetal bovine serum (FBS)) on the mechanical strength and setting time of a brushite forming calcium phosphate cement. Additions of 1wt% protein to the liquid phase led to a deterioration in compressive strength of the set cement by up to 50%. The setting time was not affected by adding albumin and FBS but was increased by 50% with admixtures containing fibrinogen. The conversion of the reactants, β-tricalcium phosphate and monocalcium phosphate, to brushite was found to be unaffected by addition of up to 10wt% proteins.

Effect on Mechanical Strength of Tricalcium Phosphate Cement by Additions of Sodium Alginate

2012 ◽  
Vol 727-728 ◽  
pp. 1181-1186 ◽  
Author(s):  
W.T. Coelho ◽  
Juliana Machado Fernandes ◽  
Rafaela Silveira Vieira ◽  
Mônica Beatriz Thürmer ◽  
Luis Alberto Santos
Keyword(s):  
Aqueous Solution ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
Calcium Phosphate Cement ◽  
Bone Substitutes ◽  
Alpha Phase ◽  
X Ray Diffraction ◽  
X Ray

The Calcium Phosphate Cement (CPC) are bone substitutes with great potential for use in orthopedics, traumatology and dentistry due to its biocompatibility, bioactivity and osteoconductivity, and form a paste that can be easily shaped and placed into the surgical site. However, CPCs have low mechanical strength, which equals the maximum mechanical strength of trabecular bone. In order to assess the strength and time to handle a CPC composed primarily of alpha phase, were added sodium alginate (1%, 2% and 3% wt) and an accelerator in an aqueous solution. The cement powder was mixed with liquid of setting, shaped into specimens and evaluated for apparent density and porosity by Archimedes method, X-ray diffraction and compressive strength. A significant increase in compressive strength by adding sodium alginate was verified.

An Evaluation of Bioactive Glass/Calcium Phosphate Cement Composite, Synthesized via Sol-Gel Method

2016 ◽  
Vol 720 ◽  
pp. 162-166
Author(s):  
M. Shahrezaee ◽  
Majid Raz ◽  
M. Sanati ◽  
Ali Sadeghi ◽  
Farbod Tondnevis ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Calcium Phosphate Cement ◽  
Setting Time ◽  
Sol Gel ◽  
Cement Composite ◽  
Xrd Analysis ◽  
Amorphous Structure ◽  
Gel Method ◽  
Sol Gel Method

In this study four types of calcium phosphate cement/bioactive glass composites has been synthesized via mixing and sol-gel method and the effect of hydroxyapatite/tricalcium phosphate ratio to its mechanical properties and setting time was investigated. The prepared samples were characterized using X-ray diffraction (XRD), foureir transform infra-red spectroscopy (FTIR), scanning electron microscopy (SEM), mechanical testing and setting time measurement. XRD analysis showed amorphous structure of the prepared bioactive glass. But the patterns of the prepared composite had sharp peaks because of their crystalline structure. FTIR analysis indicated that the composites had carbonated calcium phosphate structure. SEM micrographs illustrated amorphous calcium phosphate particles with irregular shapes. With increasing the HA/TCP ratio, Young's modulus and compressive strength of the composites increased from 179 to 453 MPa and from 20 to 38 MPa respectively. The setting time of the samples decreased with increasing the HA/TCP ratio from 22 to 18 minutes.

Effect of Silk Fibroin on the Properties of Calcium Phosphate Cement

2011 ◽  
Vol 175-176 ◽  
pp. 100-104 ◽  
Author(s):  
Biao Wang ◽  
Rui Juan Xie ◽  
Qiong Wan ◽  
Yang Wang ◽  
Yang Yang Huang
Keyword(s):  
Calcium Phosphate ◽  
Silk Fibroin ◽  
Calcium Phosphate Cement ◽  
Setting Time ◽  
Testing Machine ◽  
X Ray Diffraction ◽  
Acicular Crystal ◽  
Silk Fibroin Fiber ◽  
Universal Testing ◽  
Distinct Increase

To improve the physicochemical properties of calcium phosphate cement (CPC), silk fibroin (SF) in the different forms were added into CPC. The structure of the composites was studied by X-ray diffraction. The setting time was investigated by ISO Cement Standard Consistency Instrument. Scanning Electron Microscope was used to observe the surface morphology. Mechanical properties of samples were tested by Instron Universal Testing Machine. The results indicated that acicular crystal of hydroxyapatite (HA) was formed in the hardening body of both CPC with SF and the pure CPC. Addition of SF had no significant effect on the structure of SF/CPC composite. The setting time of CPC with SF was significantly shorter than that of the pure CPC (30.3 mins). The setting time of CPC by adding silk fibroin powder I (SFP) and silk fibroin fiber (SFF) was greatly shortened, which was only 11.7 minutes. The setting time of CPC with SFP decreased approximately by 1/3, while the setting time of the CPC with SFF decreased nearly by 1/2. With the adding of SF, the compressive strength of CPC increased significantly. There was a distinct increase in the work-of-compressive of CPC with the adding of SFF.

Self-Setting Biphase Porous Calcium Phosphate Cement

2007 ◽  
Vol 336-338 ◽  
pp. 1615-1617
Author(s):  
Jian Pan ◽  
Jie Mo Tian ◽  
Li Min Dong ◽  
Chen Wang ◽  
Qing Feng Zan
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Setting Time ◽  
Xrd Analysis ◽  
Weight Percent ◽  
Sem Observation

This work has achieved a novel self-setting biphase porous calcium phosphate cement (CPC). This biphase porous CPC is mainly formed by α-tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP). The influence of the weight percent (wt%) of β-TCP of the powder was studied. The setting time is mainly 10-30min, and increasing with the weight percent of β-TCP. Powder ray diffraction (XRD) analysis showed that most α-TCP have turned to low-crystallinized HA after immersed in Simulated Body Fluid (SBF) of 37°C for 7 days. SEM observation showed that the resultants are mainly formed with micropores and microcrystallites, and more micropores turned out in cements with more β-TCP after immersed in SBF for 8 weeks.

scholarly journals A bone replacement-type calcium phosphate cement that becomes more porous in vivo by incorporating a degradable polymer

2021 ◽  
Vol 32 (7) ◽  
Author(s):  
Akiyoshi Shimatani ◽  
Hiromitsu Toyoda ◽  
Kumi Orita ◽  
Yuta Ibara ◽  
Yoshiyuki Yokogawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Alginic Acid ◽  
Setting Time ◽  
Zealand White Rabbit ◽  
Control Group ◽  
Degradable Polymer ◽  
Low Viscosity ◽  
Bone Replacement

AbstractThis study investigated whether mixing low viscosity alginic acid with calcium phosphate cement (CPC) causes interconnected porosity in the CPC and enhances bone replacement by improving the biological interactions. Furthermore, we hypothesized that low viscosity alginic acid would shorten the setting time of CPC and improve its strength. CPC samples were prepared with 0, 5, 10, and 20% low viscosity alginic acid. After immersion in acetate buffer, possible porosification in CPC was monitored in vitro using scanning electron microscopy (SEM), and the setting times and compressive strengths were measured. In vivo study was conducted by placing CPC in a hole created on the femur of New Zealand white rabbit. Microcomputed tomography and histological examination were performed 6 weeks after implantation. SEM images confirmed that alginic acid enhanced the porosity of CPC compared to the control, and the setting time and compressive strength also improved. When incorporating a maximum amount of alginic acid, the new bone mass was significantly higher than the control group (P = 0.0153). These biological responses are promising for the translation of these biomaterials and their commercialization for clinic applications.

scholarly journals Enhanced Osteogenesis of Dental Pulp Stem Cells In Vitro Induced by Chitosan–PEG-Incorporated Calcium Phosphate Cement

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2252
Author(s):  
Jae Eun Kim ◽  
Sangbae Park ◽  
Woong-Sup Lee ◽  
Jinsub Han ◽  
Jae Woon Lim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Zeta Potential ◽  
Mechanical Strength ◽  
Calcium Phosphate Cement ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Ion Trapping ◽  
Alizarin Red

The use of bone graft materials is required for the treatment of bone defects damaged beyond the critical defect; therefore, injectable calcium phosphate cement (CPC) is actively used after surgery. The application of various polymers to improve injectability, mechanical strength, and biological function of injection-type CPC is encouraged. We previously developed a chitosan–PEG conjugate (CS/PEG) by a sulfur (VI) fluoride exchange reaction, and the resulting chitosan derivative showed high solubility at a neutral pH. We have demonstrated the CPC incorporated with a poly (ethylene glycol) (PEG)-grafted chitosan (CS/PEG) and developed CS/PEG CPC. The characterization of CS/PEG CPC was conducted using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The initial properties of CS/PEG CPCs, such as the pH, porosity, mechanical strength, zeta potential, and in vitro biocompatibility using the WST-1 assay, were also investigated. Moreover, osteocompatibility of CS/PEG CPCs was carried out via Alizarin Red S staining, immunocytochemistry, and Western blot analysis. CS/PEG CPC has enhanced mechanical strength compared to CPC, and the cohesion test also demonstrated in vivo stability. Furthermore, we determined whether CS/PEG CPC is a suitable candidate for promoting the osteogenic ability of Dental Pulp Stem Cells (DPSC). The elution of CS/PEG CPC entraps more calcium ion than CPC, as confirmed through the zeta potential test. Accordingly, the ion trapping effect of CS/PEG is considered to have played a role in promoting osteogenic differentiation of DPSCs. The results strongly suggested that CS/PEG could be used as suitable additives for improving osteogenic induction of bone substitute materials.

Fabrication and evaluation of calcium phosphate cement scaffold with controlled internal channel architecture and complex shape

2007 ◽  
Vol 221 (8) ◽  
pp. 951-958 ◽  
Author(s):  
X Li ◽  
D Li ◽  
B Lu ◽  
L Wang ◽  
Z Wang
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Complex Shape ◽  
X Ray Diffraction ◽  
X Ray ◽  
Precise Control ◽  
Internal Channel ◽  
Channel Architecture

The ability to have precise control over internal channel architecture, porosity, and external shape is essential for tissue engineering. The feasibility of using indirect stereo-lithography (SL) to produce scaffolds from calcium phosphate cement materials for bone tissue engineering has been investigated. The internal channel architecture of the scaffolds was created by removal of the negative resin moulds made with SL. Scanning electron microscopy (SEM) showed highly open, well-interconnected channel architecture. The X-ray diffraction examination revealed that the hydroxyapatite phase formed at room temperature in the cement was basically stable up to 850 °C. There was no phase decomposition of hydroxyapatite, although the crystallinity and grain size were different. The ability of resulting structure to support osteoblastic cells culture was tested in vitro. Cells were evenly distributed on exterior surfaces and grew into the internal channels of scaffolds. To exploit the ability of this technique, anatomically shaped femoral supracondylar scaffolds with 300-800 μm interconnected channels were produced and characterized.

Effect of Heat Setting Methods on Structures and Properties of High Strength Polyvinyl Alcohol Fibre

2015 ◽  
Vol 815 ◽  
pp. 643-648
Author(s):  
Yin Zhu ◽  
Jiong Xin Zhao
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Polyvinyl Alcohol ◽  
Setting Time ◽  
High Strength ◽  
Single Fibre ◽  
X Ray Diffraction ◽  
Heat Setting ◽  
Heat Treated ◽  
Setting Process

The effect of heat setting methods on the structures and mechanical properties of high strength polyvinyl alcohol (PVA) fibre is studied in this article. The microstructure and mechanical properties of heat treated PVA fibre is investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), and single fibre electronic tensile strength tester. Results show that the heat setting method with constant tension is a good heat setting method which can largely enhance the tensile strength of PVA fibre. During the heat setting process, the mechanical properties of PVA fibre are greatly affected by the temperature, tension and setting time. When the temperature is 220°C, tension is 5cN/dtex and setting time is 90sec, the tensile strength of PVA fibre increases from 12.0cN/dtex to 16.4cN/dtex in compare with the PVA fibre without heat setting

Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute

2006 ◽  
Vol 309-311 ◽  
pp. 857-860 ◽  
Author(s):  
Q. Yao ◽  
Dong Xiao Li ◽  
K.W. Liu ◽  
Bo Zhang ◽  
H. Li ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Ph Value ◽  
Porous Scaffold ◽  
Setting Time ◽  
Primary Study ◽  
In Situ Composite ◽  
Setting Process ◽  
Main Material

This study was to develop an injectable biocompatible and porous calcium phosphate collagen composite cement scaffold by in situ setting. TTCP was prepared as main material of the CPC powder, and the collagen solution was added into the phosphoric acid directly to form the liquid phase. The injectable time (tI), setting time (tS) and setting temperature (TS), along with the PH value were recorded during the setting process. The compressive strength, morphology and porosity were tested. With the increase of collagen, this novel CPC get a tI of 5mins to 8mins, tS of 20mins to 30mins, compressive strength from 1.5MPa to 4MPa, and the porosity from 40% to 60%. This study gave a possibility to form a porous scaffold of collagen/CPC composite with the nature of injectability and setting in situ.

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