scholarly journals Risk of dyslipidemia among children undergoing routine medical examinations in a secondary health care facility in Benin City, Edo State

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Izehiuwa G. Enato ◽  
Kingsley I. Akhimienho ◽  
Kenneth Atoe
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Total Cholesterol ◽  
Old Age ◽  
Healthy Children ◽  
Age Group ◽  
Lipid Levels ◽  
Benin City ◽  
Cholesterol Levels ◽  
Elevated Lipid

Dyslipidemias in children are a diverse group of disorders that include monogenic disorders as well as dyslipidemias caused by a variety of factors. Although cholesterol levels in healthy children differ with age, a potential link to the development of dyslipidemia may be important to determine the likelihood of an early diagnosis. In this cross-sectional study, 220 seemingly healthy children aged 1 to 12 years were studied in Benin City, Nigeria, to determine the pattern of lipid profile. An enzymatic method was used to analyze serum lipids from blood samples obtained from the participants. The level of dispersion of data needed to assess the risk of early childhood dyslipidemia was described using the 95th percentile scale. In the 1-3 years old age group, at least 95 percent of the boys had total cholesterol levels below 132 mg/dL, compared to 124 mg/dL among the girls of the same age. Similarly, total cholesterol levels in the 7-9 year old age group were 127 mg/dL in boys and 110 mg/dL in girls. These levels could serve as a guideline for children of the study’s age group who appear to be in good health. Elevated triglycerides levels were found in male children under the age of three years, as well as in the 10-12 age brackets. Increases in triglycerides in the girls, on the other hand, were not age- or time-dependent. In general, the lipid profiles shown in the results were low, particularly in the 4-6 year old age group. A significant modifiable risk factor for cardiovascular disease in children is elevated lipid levels. The results of this study demonstrate the importance of routinely screening children for dyslipidemia. Elevated lipid levels are a major modifiable risk factor for cardiovascular disease in children. The findings of this research can be used as a basis for screening children for dyslipidemia because it provides a 95th percentile in lipid profiles of seemingly healthy children.

Cigarette Smoking-Associated Changes in Blood Lipid and Lipoprotein Levels in the 8-to 19-Year-Old Age Group: A Meta-Analysis

PEDIATRICS ◽  
1990 ◽  
Vol 85 (2) ◽  
pp. 155-158
Author(s):  
Wendy Y. Craig ◽  
Glenn E. Palomaki ◽  
A. Myron Johnson ◽  
James E. Haddow
Keyword(s):  
Total Cholesterol ◽  
Old Age ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Low Density ◽  
Age Group ◽  
Cholesterol Levels

In this meta-analysis it was demonstrated that, when compared with nonsmokers of similar age, smokers in the 8- to 19-year-old age group have significantly higher serum levels of triglyceride (+11.8%), very-low-density lipoprotein (VLDL)-cholesterol (+12.4%) and low-density lipoprotein (LDL)-cholesterol (+4.1%) and significantly lower serum levels of high-density lipoprotein (HDL)-cholesterol (-8.5%) and total cholesterol (-3.7%). All of these smoking-associated changes are in the same direction as those found in adults, with the exception of total cholesterol levels, which are significantly increased in adult smokers. The extent to which mean triglyceride, LDL-cholesterol, and HDL-choles-terol levels are shifted is significantly greater in the 8-to 19-year-old smokers than in adult smokers. The changes in mean total cholesterol levels among smokers in both age groups represent only the net shifts in the lipoprotein fractions and are therefore likely to be a less sensitive indicator of the possible lipid-related excess coronary artery disease risk in smokers.

Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak

2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
High Fat Diet ◽  
Oxygen Therapy ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>

Abstract P102: Variability In Lipid Levels And Risk For Cardiovascular Disease: An Electronic Health Record-based Population Cohort Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Sheila M Manemann ◽  
Suzette J Bielinski ◽  
Ethan D Moser ◽  
Jennifer L St. Sauver ◽  
Paul Y Takahashi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Electronic Health Record ◽  
Total Cholesterol ◽  
Index Date ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Health Record ◽  
Lipid Levels ◽  
Population Cohort ◽  
Increased Risk

Background: Larger within-patient variability of lipid levels has been associated with an increased risk of cardiovascular disease (CVD). However, measures of lipid variability are not currently used clinically. We investigated the feasibility of calculating lipid variability within a large electronic health record (EHR)-based population cohort and assessed associations with incident CVD. Methods: We identified all individuals ≥40 years of age who resided in Olmsted County, MN on 1/1/2006 (index date) without prior CVD. CVD was defined as myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention or stroke. Patients with ≥3 measurements of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and/or triglycerides during the 5 years before the index date were retained in the analyses. Lipid variability was calculated using variability independent of the mean (VIM). Patients were followed through 9/30/2017 for incident CVD (including CVD death). Cox regression was used to investigate the association between quintiles of lipid VIMs and incident CVD. Results: We identified 18,642 individuals (mean age 60; 55% female) who were free of CVD at baseline and VIM calculated for at least one lipid measurement. After adjustment, those in the highest VIM quintiles of total cholesterol had a 25% increased risk of CVD (Q5 vs. Q1 HR: 1.25, 95% CI: 1.08-1.45; Table). We observed similar results for LDL-C (Q5 vs. Q1 HR: 1.20, 95% CI: 1.04-1.39) and HDL-C (Q5 vs. Q1 HR: 1.25, 95% CI: 1.09-1.43). There was no association between triglyceride variability quintiles and CVD risk. Conclusion: In a large EHR-based population cohort, high variability in total cholesterol, HDL-C and LDL-C was associated with an increased risk of CVD, independently of traditional risk factors, suggesting it may be a target for intervention. Lipid variability can be calculated in the EHR environment but more research is needed to determine its clinical utility.

scholarly journals Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors

2021 ◽  
Author(s):  
Maria J. Iglesias ◽  
Larissa D. Kruse ◽  
Laura Sanchez-Rivera ◽  
Linnea Enge ◽  
Philip Dusart ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Risk Factor ◽  
Total Cholesterol ◽  
Body Mass ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factor ◽  
Venous Disease

Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor treatment response. Approach and Results: We used affinity proteomics to identify EC proteins circulating in plasma that were associated with cardiovascular disease risk factor exposure. Two hundred sixteen proteins, which we previously predicted to be EC-enriched across vascular beds, were measured in plasma samples (n=1005) from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) pilot. Thirty-eight of these proteins were associated with body mass index, total cholesterol, low-density lipoprotein, smoking, hypertension, or diabetes. Sex-specific analysis revealed that associations predominantly observed in female- or male-only samples were most frequently with the risk factors body mass index, or total cholesterol and smoking, respectively. We show a relationship between individual cardiovascular disease risk, calculated with the Framingham risk score, and the corresponding biomarker profiles. Conclusions: EC proteins in plasma could reflect vascular health status.

scholarly journals Adherence and its impact on the reduction of lipid peril of patients seen in the form of telemedicine at a state university in Costa Rica

2015 ◽  
Vol 7 (2) ◽  
pp. 137-142
Author(s):  
Karla Rojas Suárez ◽  
Lourdes Rojas Espinoza
Keyword(s):  
Cardiovascular Disease ◽  
Costa Rica ◽  
Total Cholesterol ◽  
Age Groups ◽  
Costa Rican ◽  
State University ◽  
Test Results ◽  
Adherence To Treatment ◽  
Cholesterol Levels ◽  
Laboratory Results

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Costa Rica is no exception, with high levels of cholesterol and triglycerides in all age groups, and lack of adherence to treatment as one of the main challenges. We analyze the variation in test results of lipid pro le in one control and one telemedicine group in the staff of a Costa Rican university. We followed 62 patients aged 20-70 years, with tests done after fasting 12 hours, and 6 months to a year between samples. A questionnaire was used to calculate rates of factors that affect the variation in laboratory results. The patients had greater commitment to self care in the telemedicine group, achieving a reduction in total cholesterol levels, with little or no variation in other lipoproteins, and a slight increase in triglyceride levels.

Sex difference in types and distribution of risk factors in ischemic and hemorrhagic stroke

2017 ◽  
Vol 13 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Alijan A Ahangar ◽  
Payam Saadat ◽  
Behzad Heidari ◽  
Seyedeh T Taheri ◽  
Shayan Alijanpour
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Sex Difference ◽  
Cause Of Death ◽  
Associated Factors ◽  
Hemorrhagic Stroke ◽  
Age Group

Background Stroke is the second leading cause of death worldwide and is associated with several risk factors with variable risk factor distribution by population. We report the types and frequency of the associated factors of stroke in north Iran. Methods Consecutive patients with stroke were recruited from 2014 to 2015. The two groups of ischemic and hemorrhagic stroke were compared with respect to age, sex, the prevalence, and distribution of the risk factors. Results Among 230 patients (84.3% ischemic stroke) with mean age of 61.2 years, hypertension (73%), diabetes mellitus (53%), cardiovascular disease (51%), and dyslipidemia (47%) were the most frequent risk factors. Hypertension was significantly more prevalent in males compared with females (88% vs. 60%, OR = 4.91, 95% CI: 2.48–9.71). Hypertension, smoking, and opioid consumption were associated with hemorrhagic stroke. Dyslipidemia was significantly higher in ischemic stroke (OR = 2.65, 95% CI: 1.21–5.8). Overall, 84.3% of stroke occurred in patients aged >50 years (92.8% of women vs. 74.5% of the men, OR = 4.43, 95% CI: 1.93–10.16, p = 0.001). Conclusion Stroke was more prevalent in females; hypertension was more prevalent in males. In the age group less than 50 years old, stroke is more prevalent in men.

scholarly journals Total cholesterol and HDL cholestrol as risk factor of prediabetes and diabetes in palembang city

2018 ◽  
Vol 14 (2) ◽  
pp. 118-124
Author(s):  
Gresi Elyantari ◽  
Suryadi Tjekyan ◽  
Novrikasari Novrikasari ◽  
Zulkarnain Zulkarnain ◽  
Rostika Flora ◽  
...  
Keyword(s):  
Risk Factor ◽  
Total Cholesterol ◽  
Absolute Risk ◽  
P Value ◽  
Diabetes Incidence ◽  
Early Prevention ◽  
Chi Square ◽  
Cell Dysfunction ◽  
Cholesterol Levels ◽  
Biomedical Measurement

This study aims to determining the incidence of prediabetes and diabetes with total cholesterol and HDL as risk factor for the incidence of prediabetes and diabetes in the Palembang city. The research design was used by crossectional with 329 respondent, data was conducted by home visit and biomedical measurement of blood sugar and total cholesterol. The data were analyzed using chi-square. The results of the study showed that the incidence of pre-diabetes 19,8% and the incidence of diabetes14%. There was a significant relationship between total cholesterol and the incidence of prediabetes(p value= 0.003) and diabetes (0,137). the increasing of total cholesterol levels can be an early predictor of pancreatic β cell dysfunction. Prediabetes can increase the absolute risk to diabetes. by knowing lipid profile as risk factor of pre-diabetes, early prevention program can be conducted to decrease the diabetes incidence.

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