scholarly journals Clinical value of concurrent radiochemotherapy in cervical cancer and comparison of ultrasonography findings before and after radiochemotherapy

2015 ◽  
Vol 14 (2) ◽  
pp. 3633-3639
Author(s):  
W.M. Yan ◽  
X.Z. Li ◽  
Z.L. Yu ◽  
J. Zhang ◽  
X.G. Sun
Keyword(s):  
Cervical Cancer ◽  
Clinical Value ◽  
Concurrent Radiochemotherapy ◽  
Before And After

scholarly journals Plasma Exosomal miRNA Levels after Radiotherapy Are Associated with Early Progression and Metastasis of Cervical Cancer: A Pilot Study

2021 ◽  
Vol 10 (10) ◽  
pp. 2110
Author(s):  
Oyeon Cho ◽  
Do-Wan Kim ◽  
Jae-Youn Cheong
Keyword(s):  
Cervical Cancer ◽  
Pilot Study ◽  
Biological Functions ◽  
Patients With Cancer ◽  
Initial Stage ◽  
Exosomal Mirnas ◽  
Early Progression ◽  
Before And After ◽  
Microenvironmental Factors ◽  
Exosomal Mirna

Plasma exosomal miRNAs are key regulators of cell-cell interactions associated with several biological functions in patients with cancer. This pilot study aimed to investigate the log2 fold change (log2FC) of the expression of exosomal miRNAs and related mRNAs in the blood of patients with cervical cancer to identify prognostic markers better than those currently available. We sequenced plasma exosomal RNA from 56 blood samples collected from 28 patients with cervical cancer, who had been treated with concurrent chemoradiotherapy (CCRT). Changes in the expression of miRNAs and mRNAs before and after CCRT were represented as log2FC. Their biological functions were studied by miRNA-mRNA network analysis, using ingenuity pathway analysis, after the selection of two groups of miRNAs, each associated with early progression (EP) and metastasis, also described as initial stage. Seven patients experienced EP, three of whom died within four months after progression. Reduced levels of miR-1228-5p, miR-33a-5p, miR-3200-3p, and miR-6815-5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. Increased levels of miR-605-5p, miR-6791-5p, miR-6780a-5p, and miR-6826-5p and decreased levels of miR-16-1-3p (or 15a-3p) were associated with the degree of metastasis and led to the systemic activation of myeloid, endothelial, and epithelial cells, as well as neurons, phagocytes, and platelets. Log2FCs in the expression of miRNAs and mRNAs from plasma exosomes after CCRT are associated with EP and metastasis, reflecting unresolved inflammation and systemic microenvironmental factors, respectively. However, this study, supported by preliminary data insufficient to reach clear conclusions, should be verified in larger prospective cohorts.

Quality of training in cervical cancer radical surgery: a survey from the European Network of Young Gynaecologic Oncologists (ENYGO)

2022 ◽  
pp. ijgc-2021-002812
Author(s):  
Nicolò Bizzarri ◽  
Andrei Pletnev ◽  
Zoia Razumova ◽  
Kamil Zalewski ◽  
Charalampos Theofanakis ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Minimally Invasive ◽  
Radical Surgery ◽  
Gynecologic Oncology ◽  
Laparoscopic Approach ◽  
High Volume ◽  
Lymph Node Biopsy ◽  
European Network ◽  
Before And After ◽  
Level Of Training

BackgroundThe European Society of Gynaecological Oncology (ESGO) and partners are committed to improving the training for gynecologic oncology fellows. The aim of this survey was to assess the type and level of training in cervical cancer surgery and to investigate whether the Laparoscopic Approach to Cervical Cancer (LACC) trial results impacted training in radical surgery for gynecologic oncology fellows.MethodsIn June 2020, a 47-question electronic survey was shared with European Network of Young Gynaecologic Oncologists (ENYGO) members. Specialist fellows in obstetrics and gynecology, and gynecologic oncology, from high- and low-volume centers, who started training between January 1, 2017 and January 1, 2020 or started before January 1, 2017 but finished their training at least 6 months after the LACC trial publication (October 2018), were included.Results81 of 125 (64.8%) respondents were included. The median time from the start of the fellowship to completion of the survey was 28 months (range 6–48). 56 (69.1%) respondents were still fellows-in-training. 6 of 56 (10.7%) and 14 of 25 (56.0%) respondents who were still in training and completed the fellowship, respectively, performed ≥10 radical hysterectomies during their training. Fellows trained in an ESGO accredited center had a higher chance to perform sentinel lymph node biopsy (60.4% vs 30.3%; p=0.027). There was no difference in the mean number of radical hysterectomies performed by fellows during fellowship before and after the LACC trial publication (8±12.0 vs 7±8.4, respectively; p=0.46). A significant reduction in number of minimally invasive radical hysterectomies was noted when comparing the period before and after the LACC trial (38.5% vs 13.8%, respectively; p<0.001).ConclusionExposure to radical surgery for cervical cancer among gynecologic oncology fellows is low. Centralization of cervical cancer cases to high-volume centers may provide an increase in fellows’ exposure to radical procedures. The LACC trial publication was associated with a decrease in minimally invasive radical hysterectomies performed by fellows.

scholarly journals Pilot Study Efektifitas Media Video Animasi Terhadap Tingkat Depresi Pasien Kanker Serviks Diagnosa Awal

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dwi Fitriyanti ◽  
Mardiyono Mardiyono ◽  
Yuriz Bakhtiar
Keyword(s):  
Cervical Cancer ◽  
Pilot Study ◽  
Intervention Group ◽  
Initial Diagnosis ◽  
Rank Test ◽  
Control Group ◽  
The World ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Depression Level

Cervical cancer is the cancer that most often attacks women after breastcancer throughout the world. Around the world every two minutes or everyhour a woman dies from cervical cancer. Every patient newly diagnosed withcervical cancer needs to know information about cervical cancer that canaffect the patient's psychological changes in the form of depression. Thepurpose of this study was to determine the effectiveness of education withanimation media to reduce the depression level of cervical cancer patientswith early diagnosis. The method of this research is a pilot study(preliminary study) or testing the feasibility of animation video media on thelevel of depression. Respondent samples in the animated video media trialincluded 10 intervention samples and 10 control samples. The results of theanimation video media research are feasible to be used in subsequent studiesin cervical cancer patients with an initial diagnosis of depression. Dataanalysis using the Wilcoxon Sign Rank Test showed that there was asignificant difference in the level of depression before and after being giveneducation using the animation video media in the intervention group with avalue of p = 0.005 while in the control group with a value p = 0.102. Theconclusion of this study is that the animation video media is feasible to beused in subsequent studies and can effectively be given to cervical cancerpatients with an initial diagnosis of depression.

scholarly journals Knowledge of Health Care Providers on HPV Related Issues in Cervical Cancer

2012 ◽  
Vol 29 (4) ◽  
pp. 213-218
Author(s):  
F Hussain ◽  
MS Flora ◽  
K Nahar ◽  
M Khan
Keyword(s):  
Health Care ◽  
Cervical Cancer ◽  
Cancer Prevention ◽  
Health Care Providers ◽  
Hpv Vaccination ◽  
Cervical Cancer Prevention ◽  
Care Providers ◽  
Before And After ◽  
Post Test ◽  
Cancer Prevention Program

Background: The field of cervical cancer prevention is  rapidly evolving because of identification of Human  Papilloma Virus (HPV) as the necessary cause of disease.  HPV vaccines are now in the market. For successful  triggering of cervical cancer prevention program, HPV  informations should be communicated to health care  providers whose understanding about HPV has lagged  behind the scientific and technical advances.Objective: The objective of this intervention study was to  identify gap and educate health care providers delivering  services to women and adolescents in Medical Colleges on  HPV related issues and vaccination.Methods: The study was done from July 2007 to June 2008  where 3 advocacy workshops were conducted. The  knowledge level of 106 participants were assessed before  and after intervention. Updated informations about HPV  and vaccine was given to participants as intervention.Results: Wide knowledge gap was identified among  participants on HPV related insues, but significant  improvement was observed following intervention. The  pretest and post test score of knowledge was 28.09 and 38.60  respectively showing an average increase of 10 after  intervention.Conclusions: HPV education should be extensively  disseminated to health care providers to obtain public health  benefits of HPV vaccination program. DOI: http://dx.doi.org/10.3329/jbcps.v29i4.11329 J Bangladesh Coll Phys Surg 2011; 29: 213-218

scholarly journals Path of least resistance: how computerised provider order entry can lead to (and reduce) wasteful practices

2018 ◽  
Vol 7 (2) ◽  
pp. e000345 ◽  
Author(s):  
Joseph Choi ◽  
Cori Rebecca Atlin
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Clinical Care ◽  
Work Flow ◽  
Quality Improvement Initiative ◽  
Order Entry ◽  
Clinical Value ◽  
Careful Planning ◽  
Order Sets ◽  
Before And After

BackgroundComputerised provider order entry (CPOE) is rapidly becoming the mainstay in clinical care and has the potential to improve provider efficiency and accuracy. However, this hinges on careful planning and implementation. Poorly planned CPOE order sets can lead to undetected errors and waste. In our emergency department (ED), lactate dehydrogenase (LDH) was bundled into various blood work panels but had little clinical value.ObjectivesThis quality improvement initiative aimed to reduce unnecessary LDH testing in the ED.MethodsA group of ED physicians reviewed CPOE blood work panels and uncoupled LDH in conditions where it was deemed not to provide any clinically useful information. We measured the daily number of LDH tests performed before and after its removal. We tracked the frequency of other serum tests as controls. We also analysed the number of add-on LDH (ie, to add LDH to samples already sent to the lab) as a balancing measure, since this can disrupt work flow and delay care.ResultsThrough this intervention, we reduced the number of LDH tests performed by 69%, from an average of 75.1 tests per day to 23.2 (P<0.0005). The baseline controls did not differ after the intervention (eg, a complete blood count was performed 197.7 and 196.1 times per day preintervention and postintervention, respectively (P=0.7663)). There was less than one add-on LDH per day on average.ConclusionsCPOE care templates can be powerful in shaping behaviours and reducing variability. However, close oversight of these panels is necessary to prevent errors and waste.

scholarly journals Telephone interventions for adherence to colpocytological examination

2017 ◽  
Vol 25 (0) ◽  
Author(s):  
Thais Marques Lima ◽  
◽  
Ana Izabel Oliveira Nicolau ◽  
Francisco Herlânio Costa Carvalho ◽  
Camila Teixeira Moreira Vasconcelos ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Experimental Study ◽  
Educational Intervention ◽  
Educational Interventions ◽  
Inclusion Criteria ◽  
Examination Method ◽  
Before And After ◽  
Quasi Experimental ◽  
Behavioral Group ◽  
Health Education And Promotion

ABSTRACT Objective: to test the effects of behavioral and educational intervention by telephone on adherence of women with inappropriate periodicity to colpocytological examination. Method: quasi-experimental study with a sample of 524 women, selected with the following inclusion criteria: be aged between 25 and 64 years, have initiated sexual activity, have inappropriate periodicity of examination and have mobile or landline phone. The women were divided into two groups for application of behavioral and educational intervention by telephone. It was used an intervention script according to the principles of Motivational Interviewing. Results: on comparing the results before and after the behavioral and educational interventions, it was found that there was a statistically significant change (p = 0.0283) with increase of knowledge of women who participated in the educational intervention. There was no change in the attitude of women of any of the groups and there was an increase of adherence to colpocytological examination in both groups (p < 0.0001), with greater adherence of women participating in the behavioral group (66.8%). Conclusion: the behavioral and educational interventions by phone were effective in the adherence of women to colpocytological examination, representing important strategies for permanent health education and promotion of care for the prevention of cervical cancer.

Sign in / Sign up

Export Citation Format

Share Document