scholarly journals Pharmacognostic, antioxidant and acute toxicity studies of Vitellaria paradoxa stem bark and root extracts

2021 ◽  
Vol 14 (1) ◽  
pp. 111-119
Author(s):  
Y. Nuhu ◽  
H. Haruna ◽  
M.M. Namadina ◽  
S. Haruna ◽  
M.H. Abdulrazak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Medicinal Plants ◽  
Acute Toxicity ◽  
Stem Bark ◽  
The Body ◽  
Rich Source ◽  
Root Extract ◽  
Vitellaria Paradoxa ◽  
Isolation And Characterization ◽  
Antioxidant Agents

Most of biochemical reactions in the body generates Reactive Oxygen Species (ROS)which are involved in the pathogenesis of oxidative stress-related disorders like diabetes,nephrotoxicity, cancer, cardiovascular disorders, inflammation and neurological isorders. Antioxidants are used to protect the cells or tissues against potential attack by ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. The study was carried out to ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. The study was carried out to determine Pharmacognostic, antioxidant and acute toxicity of Vitellaria paradoxa root and stem bark. The Vitellaria paradoxa was extracted with water and methanol, screened for their phytochemical properties and antioxidant effects. Chemo-microscopical studies revealed the presence of cellulose cell wall, lignin, calcium oxalate crystals, tannins, starch and mucilage while calcium carbonate was absent in the stem bark but present in the root. The average moisture contents were 7.30% and 6.80% in stem bark and root respectively. The water and ethanol/alcohol extractives were 24.0% and 20.0% for stem while 25.50% and 19.0% for the root respectively. Alkaloid, flavonoids, saponins, tannins, steroids, triterpenes, carbohydrate and phenols were detected in both aqueous and methanol extracts while anthraquinones was absent in all the extracts. The DPPH radical scavenging ability of the extract showed the following trend Ascorbic acid ˃ Stem bark extract˃ Root extract. Toxicity of the samples was expressed as LD50, it was found above 5000 mg/kg and did not cause mortality in all the tested rats. These results suggested that Vitellaria paradoxa root and stem bark have moderate antioxidant potentials. Further study is necessary for isolation and characterization of active antioxidant agents which can be used to treat various oxidative stress related diseases.

PHARMACOGNOSTIC, ANTIOXIDANT AND ACUTE TOXICITY STUDY OF Ficus sycomorus (Linn) (Moraceae) ROOT AND STEM BARK

2020 ◽  
Vol 4 (2) ◽  
pp. 605-614
Author(s):  
Murtala M. Namadina ◽  
H. Haruna ◽  
U. Sanusi
Keyword(s):  
Acute Toxicity ◽  
Radical Scavenging ◽  
Stem Bark ◽  
The Body ◽  
Toxicity Study ◽  
Bark Extract ◽  
Root Extract ◽  
Acute Toxicity Study ◽  
Radical Scavenging Ability ◽  
Phytochemical Components

Most of biochemical reactions in the body generates Reactive Oxygen Species (ROS), which are involved in the pathogenesis of oxidative stress-related disorders like diabetes, nephrotoxicity, cancer, cardiovascular disorders, inflammation and neurological disorders when they attack biochemical molecules like proteins, lipids and nucleic acid. Antioxidants are used to protect the cells or tissues against potential attack by ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. In this study, phytochemical components, antioxidant and acute toxicity study of the methanol extract of stem bark and root of F. sycomorus were carried out using standard methods. Findings from this study revealed the presence of some diagnostic microscopical features such as calcium oxalate, starch, gum/mucilage, lignin, Aleurone grain, suberized/Cuticular cell wall and inulin but calcium carbonate was absent in stem bark but present in the powdered root. Quantitative physical constants include moisture contents (6.40% and 7.82%), ash value (7.20% and 9.30 %) in stem bark and root respectively. Carbohydrates, alkaloid, flavonoids, saponins, tannins, glycoside, steroid, triterpenes and phenols were present in all the extracts. They were found to exhibit potent 1,1,-diphenyl 2-picryl hydrazyl (DPPH) free scavenging activity. The DPPH radical scavenging ability of the extracts showed the following trend Ascorbic acid < stem bark extract˃ root extract. The LD50 of the methanolic stem bark and root extracts were found to be greater than 5000 mg /kg and is considered safe for use. Nonetheless, further

scholarly journals In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schum.)

2020 ◽  
Vol 25 ◽  
pp. 2515690X2093798 ◽  
Author(s):  
Gervason Moriasi ◽  
Anthony Ireri ◽  
Mathew Piero Ngugi
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Plant Extracts ◽  
Antioxidant Activities ◽  
Stem Bark ◽  
The Body ◽  
Antioxidant Power ◽  
Isolation And Characterization ◽  
Piliostigma Thonningii

Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Free radicals attack biologically important biomolecules, impairing their functioning, thereby initiating and exacerbating diseases. As a comeback, antioxidant therapies have been proposed as novel approaches to ameliorating oxidative stress–associated diseases including chronic ones. Antioxidants are thought to employ multifaceted and multitargeted mechanisms that either restore oxidative homeostasis or prevent free radical buildup in the body, which overwhelm the endogenous defenses. Plants have been used for many ages across time to manage human diseases, and have a host of antioxidant phytocompounds. Piliostigma thonningii is traditionally used for the management of inflammation, malaria fever, rheumatism, and insanity, among other diseases caused by a disturbed redox state in the body. In this study, in vitro antioxidant activities of the methanolic and aqueous stem bark extracts of P. thonningii were evaluated using the in vitro antilipid peroxidation, the 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical scavenging, and the ferric reducing antioxidant power assay methods. The obtained results revealed remarkable antioxidant activities of the studied plant extracts as evidenced by the low IC50 and EC50 values. These antioxidant activities could be due to the presence of antioxidant phytochemicals like flavonoids, carotenoids, tannins, and phenols, among others. Therefore, the therapeutic potency of this plant could be due to its antioxidant properties. This study recommends in vivo antioxidant efficacy testing of the studied plant extracts, as well as isolation and characterization of bioactive antioxidant compounds that are potent against oxidative stress.

scholarly journals Identification and characterization of phytoconstituents of ethanolic root extract of Clitoria ternatea L. utilizing HR-LCMS analysis

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
K N Jiji ◽  
P Muralidharan
Keyword(s):  
Nervous System ◽  
Medicinal Plants ◽  
The Body ◽  
Major Constituent ◽  
Root Extract ◽  
Active Metabolites ◽  
Clitoria Ternatea ◽  
Intellectual Capacity ◽  
Identification And Characterization

Medicinal plants act as a vital source in improving health and overcoming the side effects of modern-day medicine. Many evidence-based reports are present in the literature about the benefits of medicinal plants. Clitoria ternatea L. belongs to the family Fabaceae and is known to be one of the important Ayurvedic medicinal plant whose uses are specified mainly for the modification of nervous system activities. ‘Medhyarasayana’ is one of the Ayurvedic formulations which is used to promote the intellectual capacity, revive the body and nervous tissue, Clitoria ternatea serves as a major constituent of ‘Medhyarasayana.’ Identification and characterization of active metabolites of C. ternatea will help to isolate the important phytoconstituents responsible for the central nervous system effects, isolated components can be utilized in future for the formulation of new medicine for various neurodegenerative disorders. In the present study, the phytochemical evaluation of the ethanolic root extract of C. ternatea (EECT) was performed using the HR-LCMS technique. Preliminary qualitative phytoconstituents analysis showed the presence of tannins, alkaloids, saponins, steroids, carbohydrate, protein, flavonoids and triterpenoids in the ethanolic root extract. Almost 42 compounds were identified when the EECT subjected to HR-LCMS analysis.

scholarly journals ANTI-DIABETIC EFFECT OF ETHANOL EXTRACT OF Copaifera salikounda (HECKEL) AGAINST ALLOXAN-INDUCED DIABETES IN RATS

2021 ◽  
Vol 58 (2) ◽  
Author(s):  
Chinyere Aloke ◽  
Emmanuel Igwe ◽  
Nwogo Obasi ◽  
Pascal Amu ◽  
Egwu Ogbonnia
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
The Body ◽  
Albino Rats ◽  
Dependent Manner

Accumulating evidences have reinforced the use of medicinal plants in the treatment of various ailments as a result of negative side effects associated with conventional drugs. Plant components such as phenols and flavonoids with antioxidant potential have confirmed protective roles against oxidative stress-induced degenerative diseases like diabetes mellitus (DM). The current study was carried out to investigate the effect of seed pod ethanol extract from Copaifera salikounda (SPEECS) in alloxan-induced diabetic rats. SPEECS was obtained by maceration of seed pod powder in absolute ethanol for 72 h, filtered, concentrated and dried in-vacuo. Gas chromatography-mass spectrometry (GC–MS) technique was used to quantitatively elucidate the chemical constituents of SPEECS. Twenty-four male albino rats were randomly allocated into four groups (n=6): normal control, DM control, DM + 200 mg/kg SPEECS and DM + 400 mg/kg SPEECS groups. DM was induced in the Wistar albino rats through intraperitoneal injection of 200 mg/kg body weight of alloxan. After 14 days of treatment, the body weight changes and the fasting blood glucose level were determined in the different groups. Also, serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), total protein (TP), malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were estimated. The GC-MS results confirm nine bioactive compounds with 9-octadecenoic acid (55.75%) being most abundant. SPEECS (200 and 400 mg/kg) administration significantly (P 0.05) caused gain in weight, decreased fasting blood glucose and reversed the elevated liver function enzymes (ALT, AST, ALP) while total TP and ALB were markedly elevated relative to DM control group. Furthermore, SPEECS attenuated the activities of SOD and CAT while the level of MDA was significantly (P 0.05) decreased in dose dependent manner in comparison to the DM control. This study indicated that SPEECS can alleviate hyperglyceamia of DM. Key words: Copaifera salikounda; oxidative stress; medicinal plants; diabetes mellitus; phytochemicals; orthodox ANTIDIABETIČNI UČINEK EKSTRAKTA ETANOLA Copaifera salikounda (HECKEL) NA SLADKORNO BOLEZEN, SPROŽENO Z ALLOXAN-om, PRI PODGANAHIzvleček: Obstaja vedno več dokazov, ki poudarjajo uporabnost zdravilnih rastlin pri zdravljenju različnih bolezni, tudi zaradi različnih negativnih stranskih učinkov, povezanih s konvencionalnimi zdravili. Rastlinske sestavine kot so fenoli in flavonoidi z antioksidativnim potencialom, imajo po nekaterih raziskavah zaščitno vlogo pred degenerativnimi boleznimi, ki jih povzroča oksidativni stres, kot je sladkorna bolezen diabetes mellitus (DM). Študija je bila izvedena z namenom raziskovanja učinka etanolnega semenskega ekstrakta iz rastline Copaifera salikounda (SPEECS) pri podganah s sladkorno boleznijo, ki jo je povzročil alloxan. SPEECS je bil pridobljen z maceracijo praška semen v prahu v absolutnem etanolu 72 ur ter nadaljnjo filtracijo, koncentracijo in sušenjem v vakuumu. Za kvantitativno ugotavljanje kemijskih sestavin SPEECS je bila uporabljena tehnika plinske kromatografije in masne spektrometrije (GC-MS). Štiriindvajset samcev podgan Wistar je bilo naključno razporejenih v štiri skupine (n=6): normalna kontrola, kontrola DM, DM + 200 mg/kg SPEECS in DM + 400 mg/kg SPEECS. DM je bil pri podganah sprožen z intraperitonealno injekcijo 200 mg/kg telesne mase alloxana. Po 14 dneh zdravljenja so bile pri različnih skupinah določene spremembe telesne teže in nivo glukoze v krvi (na tešče). Poleg tega so avtorji raziskave izmerili še nekatere serumske biokemične parametre kot so ravni alaninske aminotransferaze (ALT), aspartatne aminotransferaze (AST), alkalne fosfataze (ALP), albumina (ALB), skupnih proteinov (TP), malondialdehida (MDA), superoksiddismutaze (SOD) in katalaze (CAT). Rezultati GC-MS so v izvlečku SPEECS pokazali devet bioaktivnih spojin, v katerih je največ 9-oktadecenojske kisline (55,75%). SPEECS (200 in 400 mg/kg) je povzročil znatno (P 0,05) povečanje telesne mase, znižanje glukoze v krvi na tešče in znižal raven encimov pokazateljev jetrne funkcije (ALT, AST, ALP), medtem ko je bila raven TP in ALB pri podganah, ki so prejemale SPEECS izrazito povišana v primerjavi z DM kontrolno skupino. Zdravljenje s  SPEECS je tudi oslabilo aktivnosti SOD in CAT, medtem ko se je raven MDA znatno zmanjšala (P 0,05) v primerjavi s kontrolno skupino DM. Ta študija je pokazala, da lahko SPEECS ublaži hiperglikemijo pri sladkorni bolezni pri podganah.Ključne besede: Copaifera salikounda; oksidativni stres; zdravilne rastline; sladkorna bolezen; fitokemikalije; ortodoksni

scholarly journals Battle between plants as antioxidants with free radicals in human body

2020 ◽  
Vol 9 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Fatemeh Jamshidi-kia ◽  
Joko Priyanto Wibowo ◽  
Mostafa Elachouri ◽  
Rohollah Masumi ◽  
Alizamen Salehifard-Jouneghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Human Body ◽  
Defense Mechanisms ◽  
Natural Antioxidants ◽  
Redox Status ◽  
The Body ◽  
Antioxidant Agents ◽  
Endogenous Antioxidants

Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of the body, resulting in an incidence of various diseases. If the endogenous antioxidants do not stop the production of reactive metabolites, they will be needed to bring about a balance in redox status. Natural antioxidants, for example plants, play an important part in this context. This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body. For this purpose, to better understand oxidative stress, the principles of free radical production, the role of free radicals in diseases, antioxidant defense mechanisms, and the role of herbs and diet in oxidative stress are discussed.

scholarly journals Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague

2020 ◽  
Vol 9 (1) ◽  
pp. 39-46
Author(s):  
Teshome Gonfa Hordofa
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Bioactive Compounds ◽  
Common Cold ◽  
Stem Bark ◽  
Spectroscopic Methods ◽  
Insufficient Information ◽  
Isolation And Characterization ◽  
Reported Data

Warburgia ugandensis Sprague is one of the medicinal plants traditionally used to treat a number of diseases like asthma, cough, diarrhea, common cold, stomachache and toothache in Ethiopia. However, there is still insufficient information on the isolation and evaluation of bioactive compounds from this plant species. Extraction, purification and isolation of the stem bark of this plant by dichloromethane and chloroform as solvents afforded two sesquiterpenes; namely, WU-1 (ugandensidial) and WU-2 (cinnamolide-3β-acetate) respectively. The structural elucidations of these bioactive compounds were accomplished by using a variety of spectroscopic methods (IR, UV and NMR). The spectroscopic results compared with the reported data in the literature.

scholarly journals Herbal Oil and its Anti-arthritic Activity

2019 ◽  
Vol 9 (3) ◽  
pp. 47-50
Author(s):  
Dinesh Babu J ◽  
Vinaya J ◽  
Sravan Kumar P ◽  
Akhila CR
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Elderly Patients ◽  
Plant Extract ◽  
Subcutaneous Tissue ◽  
Stem Bark ◽  
The Body ◽  
Severe Damage ◽  
The World ◽  
Oil Formulation

Inflammation and arthritis are interrelated conditions that are caused by each other. This disorder majorly occurs in elderly patients. It is a major problem in the world that affects the joints and causes inflammation in the joints causing pain and tenderness in the joints. This is mainly triggered by the inflammation caused by the malfunctioning of the immune system of the own body. This disease leads to severe damage to the cartilage of the joints in the body. This will lead to the ankylosing of the joints and resulting in the pain of the joints. There are few other diseases like inflammation of the pleural cavities, scleritis and other lesions that are usually seen in the cutaneous, subcutaneous tissue. Overall, it is a problem in the immune system of the body. The researchers now had concentrated on the utilization of the herbs and medicinal plants to treat arthritis effectively. They are found to be safe and effective compared to the synthetic immune suppressant drugs. They are also the cheapest sources of drugs. So the herbs had been investigated for the production of the newer molecules that treat arthritis effectively and relatively safer with that of the existing drugs. The plant extract of the stem bark of the plant Berberis orthobotrys was collected and extracted using ethanol. This was used to prepare oil formulation, and this was investigated for the anti-arthritic activity. The oil formulation showed a better activity compared to the extract and compared to the standard.

Phytochemical screening and evaluation of antioxidant activity of the stem bark of Anacardium occidentale L. and Vitellaria paradoxa C.F. Gaertn, two medicinal plants from Poro region (Northern of Côte d'Ivoire)

2021 ◽  
Vol 1 (2) ◽  
pp. 022-028
Author(s):  
Gboko Abiba Ouattara ◽  
Tiekpa Wawa Justine ◽  
Kamagaté Tidiane ◽  
Boni Ahoussi Pascal ◽  
Kabran Aka Faustin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Stem Bark ◽  
Anacardium Occidentale ◽  
Phytochemical Screening ◽  
Vitellaria Paradoxa ◽  
Dpph Method ◽  
Treatment Of Diabetes ◽  
Major Chemical ◽  
Chemical Groups

Anacardium occidentale and Vitellaria paradoxa are two medicinal plants traditionally used by Ivorian, particularly in the treatment of diabetes, arterial hypertension and diarrhea. The objective of this work was to evaluate the phytochemical constituents and the antioxidant activity of the stem barks of A. occidentale L. and V. paradoxa. The stem bark of both plants was used for the aqueous extraction. Major chemical groups were identified using the tube staining method followed by confirmation by thin layer chromatography (TLC). The antioxidant activity of the extracts was evaluated by DPPH method. The results of phytochemical screening of plant extracts revealed the presence of polyphenols, anthraquinones, tannins, sterols, terpenes and saponins. In addition, the evaluation of the antioxidant activity by spectrophotometry using the DPPH method showed that all extracts had significant and different antioxydant activity compared to the reference molecule (Vitamin C, IC50 = 0.80 ± 0.70 µg/mL) with respective IC50 of 0.42 ± 0.32 µg/mL for V. paradoxa and 0.87 ± 0.77 µg/mL for A. occidentale. V. paradoxa therefore has the best antioxydant activity. These results could explain the therapeutic virtues of A. occidentale and V. paradoxa in the treatment of various pathologies.

Hydrotherapy in the evaluation of enzymatic antioxidants in an elderly population

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
A Valado ◽  
S Fortes ◽  
M Morais ◽  
J Rosado ◽  
JP Figueiredo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Glutathione Reductase ◽  
Venous Blood ◽  
The Body ◽  
Cell Aging ◽  
Enzymatic Antioxidants ◽  
Sod Activity ◽  
Antioxidant Agents

Abstract Introduction Oxidative stress is the imbalance between reactive species produced in the body during metabolic reactions and antioxidant agents that have the ability to neutralize or prevent the formation of these species. One of the effects of oxidative stress is the normal and physiological process of cell aging that arises from the accumulation of tissue damage caused by free radicals. Objectives To assess whether the activity of enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) are influenced by the hydrotherapy sessions. Methodology 37 subjects aged 60 years old and above, of both genders, were divided into two groups (experimental and control). The experimental group underwent 15 hydrotherapy sessions supervised by a physical therapist. Two peripheral venous blood samples were collected at two different times: T0, instant before the intervention and T1, instant after the last session. The activity of SOD, GPx and GR enzymes were determined, respectively, with the Ransod superoxide dismutase, Ransel glutathione peroxidase and glutathione reductase commercial kits, from Randox Laboratories Limited, United Kingdom. The assay was performed as described in the kits and the sample results were obtained by spectrophotometric reading. Results SOD activity at T1 tended to decrease slightly compared to T0 (1437.64 ± 593.46 vs 1421.41 ± 705.39 U/g Hb). At T1, there was a statistically significant increase in GPx activity (48.14 ± 17.22 vs 57.72 ± 19.99 U/g Hb) and in GR activity (78.44 ± 21.26 vs 100.18 ± 30.85 U/L). Regarding gender, both genders tended to have higher values of GPx and GR at T1. Conclusion According to the obtained results, we conclude that the practice of hydrotherapy presents as a positive stimulus in the antioxidant activity of aged individuals suggesting that a regular and moderate practice of exercise induces a higher quality of life.

scholarly journals In vivo Antiplasmodial and Toxicological Effects of Goniothalamus lanceolatus Crude Extracts

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Rozaini Mohd Zohdi ◽  
Shahida Muhamad Mukhtar ◽  
Nur Vicky Bihud ◽  
Nurulfazlina Edayah Rasol ◽  
Fasihuddin Badruddin Ahmad ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Crude Extract ◽  
Stem Bark ◽  
Antiplasmodial Activity ◽  
Bark Extract ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Crude Extracts ◽  
Leaves And Roots

This study is aimed at investigating the antiplasmodial activity and acute toxicity of the methanol (MeOH) extracts of the leaves and roots, and the dichloromethane (DCM) extracts of the stem bark, leaves, and roots of Goniothalamus lanceolatus. Phytochemical analysis was then carried out on the most active extract. In vivo antiplasmodial activity was assessed using the 4-day suppressive test against Plasmodium berghei ANKA (PbANKA) in mice. The plant extracts were administered intraperitoneally (i.p.) as a single dose (30 mg/kg) starting 4 h after infection. At a dose level of 30 mg/kg (i.p.), the DCM extracts of the stem bark and leaves, and the MeOH root extracts, prolonged the survival period of infected mice compared to that of the negative control. In addition, all crude extracts, except for the DCM root extract, exhibited parasitemia suppressive activity. The highest level of parasitemia suppression was recorded in mice treated with the DCM stem bark extract at 66.3%. No mortality was observed in mice treated with the DCM extracts of the stem bark and leaves, and the MeOH extract of the leaves, indicating that the LD50 is greater than 300 mg/kg. On the other hand, both the MeOH and DCM extracts of the roots showed toxic effects at a dose of 300 mg/kg (i.p) with an 83.3% mortality rate. The results obtained indicate that the stem bark of G. lanceolatus (DCM crude extract) possesses good antiplasmodial activity against PbANKA infected mice without causing acute toxicity. Five known styrylpyrone derivatives namely goniodiol 1, 8-epi-9-deoxygoniopypyrone 2, 9-deoxygoniopypyrone 3, digoniodiol 4 and goniothalamin 5 have been isolated from the bark of Goniothalamus lanceolatus (DCM crude extract). The structures and stereochemistry of all compounds were elucidated by interpretation of spectroscopic data. This study provides a scientific basis to support the traditional use of the plant as a remedy for malaria.

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