Medication prescribing pattern and potential teratogenicity risk among pregnant women at Hidar 11 General Hospital, south Wollo, northeast Ethiopia

2020 ◽  
Vol 35 (1) ◽  
pp. 67-72
Author(s):  
Oumer Sada Muhammed ◽  
Kemal Ahmed Seid ◽  
Beshir Bedru Nasir

Drugs given to pregnant mothers for therapeutic purposes may cause serious structural and functional adverse effects in the developing child. However, the fact that drugs are needed to mitigate complications during pregnancy cannot be totally avoided. Hence, the current study is aimed to evaluate the pattern of medication prescribing practice during pregnancy at Hidar 11 General Hospital, Ethiopia. Institution based cross sectional study was conducted on 310 pregnant women whose medical charts were selected using systematic random sampling from antenatal care (ANC) attendants at Hidar 11 General Hospital. Data was collected through medical chart review by using data abstraction tool and analyzed by statistical package for social sciences (SPSS) Version 24 software. Among the study participants, 263 (84.8%) had a prescription at least for one drug during their pregnancy. Majority of the drugs prescribed for the pregnant women were vitamins and minerals (60.6%), antibacterial agents (30.6%) and central nervous system drugs (28.4%). A high proportion of drugs were prescribed from US Food and Drug Administration (US FDA) category C (57.7%) followed by category B (50.6%) and category A (22.9%). Only 6.8% of the prescribed drugs were with positive evidence of risk (US FDA category D) during all trimesters and no drugs were prescribed from proven fetal risk category (US FDA X category). Even though, drugs from category X were not prescribed, a significant number of pregnant women consumed drugs with potential fetal risk that should be addressed by informing the prescribers to stick to the treatment guidelines and seek safer options.  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Niguse Meles Alema ◽  
Getachew Semagn ◽  
Shetey Melesse ◽  
Ephrem Mebrahtu Araya ◽  
Hagazi Gebremedhin ◽  
...  

Abstract Background A vigilant prescription of drugs during pregnancy can potentially safeguard the growing fetus from the deleterious effect of the drug while attempting to manage the mother’s health problems. There is a paucity of information about the drug utilization pattern in the area of investigation. Hence, this study was implemented to investigate the pattern of drug utilization and its associated factors among pregnant women in Adigrat general hospital, Northern Ethiopia. Methods An institution-based cross-sectional study was conducted among randomly selected 314 pregnant women who attended obstetrics-gynecology and antenatal care units of the hospital. Relevant data were retrieved from the pregnant women’s medical records and registration logbook. The drugs prescribed were categorized based on the United States Food and Drug Administration (US-FDA) fetal harm classification system. Data analysis was done using SPSS version 20 statistical software. Multivariate logistic regression was employed to analyze the association of the explanatory variables with the medication use, and p < 0.05 was declared statistically significant. Results The overall prescribed drug use in this study was found to be 87.7%. A considerable percentage of the study participants (41.4%) were prescribed with supplemental drugs (iron folate being the most prescribed drug) followed by antibiotics (23.4%) and analgesics (9.2%). According to the US-FDA drug’s risk classification, 42.5, 37, 13, and 7% of the drugs prescribed were from categories A, B, C, and D or X respectively. Prescribed drug use was more likely among pregnant women who completed primary [AOR = 5.34, 95% CI (1.53–18.6)] and secondary education [AOR = 4.1, 95% CI (1.16–14)], who had a history of chronic illness [AOR = 7.9, 95% CI (3.14–19.94)] and among multigravida women [AOR = 2.9, 95% CI (1.57 5.45)]. Conclusions The finding of this study revealed that a substantial proportion of pregnant women received drugs with potential harm to the mother and fetus. Reasonably, notifying health practitioners to rely on up-to-date treatment guidelines strictly is highly demanded. Moreover, counseling and educating pregnant women on the safe and appropriate use of medications during pregnancy are crucial to mitigate the burden that the mother and the growing fetus could face.


2019 ◽  
Vol 3 (3) ◽  
Author(s):  
David Franli ◽  
Makmur Sitepu ◽  
Hotma Partogi Pasaribu ◽  
Sake Juli Martina

Introduction. Chronic energy deficieny (CED) is a condition of a body characterized by low body weight and low energy stores, possibly limited physical capacity due to deprivation of food over a long period time. Ministry of Health ( Kemenkes) showed that in 2015, 305 out of 100.000 death of pregnant women is realated to malnutriotion and CED. Objective. The aim of this study is to determine the overview of pregnant women nutritional status based on mid-upper arm circumference (MUAC) in Sundari Medan General Hospital. Method. The study was an observational descriptive study with a cross sectional design. The samples of this study consists of pregnant women from Sundari Medan Genaral Hospital, who had fulilled the inclusion and esclusion criteria by total sampling. Results.. Among 60 samples, the prevalance of Non-CED woman (85%) was found higher than the mild malnutrition (15%). Conclusion. Prevalance of CED pregnant women was found higher in risky age, middle educated and high income family.  


Author(s):  
Yuhemy Zurizah Yuhemy Zurizah

ABSTRACT   Hyperemesis Gravidarum is nausea and vomiting that occurs in a pregnant woman causing the imbalance electrolyte levels, weight loss (more than 5% of initial body weight), dehydration, ketosis, and nutritional deficienies. In Indonesia in 2010 the percentage of high risk pregnant women with hyperemesis gravidarum who were referred and health services further by 20.44%. Provinces with the highest percentage is the province of Central Sulawesi (96.53%) and Yogyakarta (76.60%) while the lowest is the province of North Maluku (3.66%). At the General Hospital Dr. Mohammad Hoesin in Palembang, the incidence of women who experience Hyperemesis Gravidarum in 2011 there were 183 people (71.4%) of 256 pregnant women. The purpose of this study are known factors associated with the incidence of hyperemesis gravidarum in pregnant women at the General Hospital Dr. Mohammad Hoesin in Palembang  2011. This study uses the approach of Analytical Surveys Cross Sectional. The population in this study were all pregnant women who had been treated at General Hospital Dr. Mohammad Hoesin in Palembang in 2011. Sampling in this study with the method of random sampling with simple random sampling technique. Data analysis carried out univariate and bivariate statistics with Chi-Square test with significance level α = 0.05. The results showed that of 252 respondents had hyperemesis gravidarum with high-risk age (70.0%) were low risk (1.9%), the status of a primigravida (75.0%) were multigravida (3.6%), and the work (83.3%) who did not work (5.3%). The results of this study showed no significant association between maternal age, parity, and work on General Hospital Dr. Mohammad Hoesin in Palembang,  in 2011. From the results of this study, researchers hope to improve the health care workers care service delivery and more attention to maternal risk hypermesis gravidarum.   ABSTRAK   Hyperemesis Gravidarum adalah mual dan muntah yang terjadi pada wanita hamil sehingga menyebabkan terjadinya ketidakseimbangan kadar elektrolit, penurunan berat badan (lebih dari 5% berat badan awal), dehidrasi, ketosis, dan kekurangan nutrisi. Di Indonesia pada tahun 2010 presentase ibu hamil resiko tinggi dengan hyperemesis gravidarum yang dirujuk dan mendapatkan pelayanan kesehatan lebih lanjut sebesar 20,44%. Provinsi dengan presentase tertinggi adalah provinsi Sulawesi Tengah (96,53%) dan di Yogyakarta (76,60%) sedangkan yang terendah adalah provinsi Maluku Utara (3,66%). Di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang, angka kejadian ibu yang mengalami Hyperemesis Gravidarum pada tahun 2011 terdapat 183 orang (71,4%) dari 256 ibu hamil. Tujuan penelitian ini adalah diketahuinya faktor-faktor yang berhubungan dengan kejadian hyperemesis gravidarum pada ibu hamil di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang tahun 2011. Penelitian ini menggunakan metode Survey Analitik dengan pendekatan Cross Sectional. Populasi pada penelitian ini adalah seluruh ibu hamil yang pernah dirawat di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang tahun 2011. Pengambilan sampel pada penelitian ini dengan metode random sampling dengan teknik simple random sampling. Analisa data dilakukan secara univariat dan bivariat dengan uji statistik Chi-Square dengan tingkat kemaknaan α = 0,05. Hasil penelitian menunjukkan dari 252 responden yang mengalami hyperemesis gravidarum dengan umur resiko tinggi (70,0%) yang resiko rendah (1,9%),  status yang primigravida (75,0%) yang multigravida (3,6%), dan yang bekerja (83,3%) yang tidak bekerja (5,3%). Hasil penelitian ini menunjukkan ada hubungan yang bermakna antara umur ibu, paritas, dan pekerjaan di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2011. Dari hasil penelitian ini, peneliti berharap petugas pelayanan kesehatan dapat meningkatkan pelayanan asuhan persalinan dan lebih memperhatikan kehamilan ibu yang berisiko hypermesis gravidarum.


2020 ◽  
Author(s):  
Godana Arero ◽  
Kinde Asssefa

Abstract Objective: The purpose of the study is to assess magnitude of anemia and associated factors among pregnant women attending antennal care follow-up at Yabello General Hospital in Pastoralist Borena Zone from July-August, 2019.Method: A hospital based cross-sectional study design was employed among 265 pregnant women attending antenatal care at Yabello General Hospital from June 17-August 16 2019. A systematic random sampling technique was used to select two hundreds sixty five study subjects. The first study subject was chosen randomly by simple random sampling method blindly picking one of two using pieces of papers named for the first two visitors. The sampling interval (K) calculated to be 2, and then, every second pregnant woman who attending antenatal care was recruited.Socio-demographic, maternal nutrition, information and obstetric and medical characteristics were assessed. Hemoglobin value, stool examination, HIV and syphilis test results were collected from their regular laboratory tests. Blood film was conducted for pregnant women who had signs and symptoms and whose hemoglobin value less than the established cut of values and data were analyzed using SPSS version 20.0 softwareResults: Magnitude of anemia with median hemoglobin value were (11.10g/dl ± 1.66); majority 46(63.9%) had mildly anemia, 24(33.3%) moderate and 2(2.8%) were severe anemia. Urban dwellers women (AOR, 95% CI: .18(.05-.64)), for those who had abortion before current pregnancy (AOR, 95% CI: 3.08(1.17-8.13)); coffee/tea drinking immediately after meal (AOR, 95% CI: 4.39(1.82-10.59), & who had excessive menstrual bleeding before current pregnancy were (AOR, 95% CI: 3.39(1.47-7.84)) & mid-upper arm circumference less than 23cm (AOR, 95% CI: 6.27(1.15-14.30)) were found to be independent predictors of anemia among pregnant women.Conclusion: Anemia in study area among pregnant women in Ethiopia was higher as compare with similar study elsewhere. Malnutrition, abortion, excessive bleeding & nutrition interaction with other inhibitors like coca cola, tea and coffee immediately after meals were independent predictors for anemia.


2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Kemal Jemal ◽  
Mukemil Awol

Background. Consumption of diversified food during pregnancy found very important and critical to determine healthy pregnancy outcome. Low dietary diversity has a major adverse effect on mothers, fetus, and life of new born. Dietary diversity is still low in low-resourced countries. Therefore, this study aims to determine prevalence of minimum dietary diversity score (MDDS) and associated factors among pregnant women. Methods. Facility-based cross-sectional study was conducted from April to May, 2017, in Alamata General Hospital (AGH). Data were collected using a pretested and structured self-interview questionnaire. A systematic sampling technique was used to select study participants. Binary logistic regression and odds ratio with 95% confidence interval (CI) were carried out to see the association between variables and the outcomes. Results. From a survey of 412 participants, 61.2% had high MDDS and 38.8% had low MDDS. Multivariate analysis revealed that being government employees (AOR = 4.87, CI: 1.70–13.95), merchant (AOR = 4.67, CI: 1.81–12.05), secured food (AOR = 3.85, CI: 2.12–6.97), and eating three meals and above (AOR = 2.66, CI: 1.47–4.82) were significantly associated with high MDDS among pregnant women. Conclusions. In our study, minimum dietary diversity shows small increment from previous study. Screening and special emphases should be given by a health-care provider on women diet during antenatal follow-up at health-care settings.


2017 ◽  
Vol 59 (4) ◽  
pp. 39
Author(s):  
Adeyinka Abiodun Alabi ◽  
Oladele Vincent Adeniyi ◽  
Olukayode Ademola Adeleke ◽  
Pamela Pilla ◽  
Mohamed Rashid Haffajee

Background: The use of spinal anaesthesia has increased in the last three decades, given that it is the recommended anaesthetic of choice for better foetal and maternal outcomes in Caesarean section. Failed spinal anaesthesia (FSA) exposes patients to unfavourable experience of pain and the potential complications of general anaesthesia that are being avoided in the first instance. This study determines the incidence and the predictors of failed spinal anaesthesia in pregnant women presenting for Caesarean section at Mthatha General Hospital, Eastern Cape. Methods: This descriptive cross-sectional study included 197 pregnant women scheduled for Caesarean section under spinal anaesthesia at Mthatha General Hospital from May 1 to August 30, 2013. A standard proforma was utilised for data collection on items of demographic, surgical and anaesthetic records of each parturient. The main outcome measure was the incidence of failed spinal anaesthesia (defined as partial or incomplete spinal block requiring conversion to general anaesthesia). Results: The incidence of failed spinal anaesthesia was 11.7%, which was slightly higher in emergency Caesarean sections. In univariate analysis, previous anaesthesia, obesity, dry tap of cerebrospinal fluid (CSF), bloody CSF and duration of work experience less than one year were significantly associated with FSA in the cohort. Conclusion: The study found a high incidence of failed spinal anaesthesia during Caesarean section in this setting. Upskilling of doctors in spinal anaesthesia is urgently needed in the study setting. (Full text of the research articles are available online at www.medpharm.tandfonline.com/ojfp) S Afr Fam Pract 2017; DOI: 10.1080/20786190.2017.1292696


2020 ◽  
Vol 4 (3) ◽  
pp. 343-350
Author(s):  
HOSEA YAYOCK ◽  
N. O. Osageide ◽  
H. Mande ◽  
H. Habib ◽  
I. Zamani

A cross sectional study designed to assess the difference in level of Awareness, Access and Use of Long Lasting Insecticidal Nets (LLINs) from consenting pregnant women aged between 15 to 40 years attending routine ante-natal clinic sessions at Kaduna State University (Barau Dikko) Teaching Hospital, General Hospital Kawo, Primary Health Care Badarawa, Primary Health Care Angwan Romi and General Hospital Sabon Tasha. A total of 360 questionnaires were distributed, but only 308 returned completed. Also, mosquito samples were collected in 30 randomly selected households of the consenting pregnant women that were within three kilometer radius range of the antenatal clinic for 12 weeks’ period. A one-way ANOVA was conducted using SPSS statistical package version 22. The result revealed that there was no significant difference (P> 0.05) in level of Awareness (92.53%), Access (75.32%) and Use (67.86%) of Long Lasting Insecticidal Nets (LLINs) among the pregnant women attending the various ante-natal hospitals/primary health care facilities. A total of 344 larvae samples were encountered and identified as Culex species 259(75.29%) and Aedes species 85(24.71%). Awareness, Access and Use of LLINs is relatively similar; while the mosquito species are vectors of Filariasis, Yellow fever, Dengue fever and can be prevented by the use of LLINs. ______________________________________________________________________________ Key word: Kaduna Metropolis, LLINs Awareness, Access and Use, Mosquito Preventive


2019 ◽  
pp. 128-136
Author(s):  
Yuliana Nelcy ◽  
Sri Vitayani ◽  
Hasriwiyani Habo Abbas

Sexual relations are a primary need for married couples. However, many couples who disagree about sex during pregnancy are caused by anxiety from each partner. The general purpose of this research is to analyze the factors that influence anxiety in pregnant women against sexual relations in RSIA Sitti Khadijah 1 Makassar City.This research approach is observational, with a cross sectional approach. The population in this study were all pregnant women in RSIA Sitti Khadijah 1, Makassar City. The sample in this study was conducted by accidental sampling.The results showed the majority of respondents had the age in the risk category as many as 65.7%. The results of statistical tests obtained X2 count (7.672)> X table (5.991) and the value of p value = 0.024 <value of α = 0.05, most respondents have gestational age in the risk category as many as 53.7%. The results of statistical tests obtained X2 count (13,449)> X table (5,991) and p value = 0,001 <value α = 0,05, most respondents have parity in the risk category as many as 58,2%. Statistical test results obtained X2 count (9.217)> X table (5.991) and p value = 0.007 <value α = 0.05, most respondents have economic status in the category <UMK as many as 50.7%. The results of statistical tests obtained X2 count (8.941)> X table (5.991) and the value of p value = 0.009 <value of α = 0.05, most of the respondents did not work as many as 55.2%. Statistical test results obtained compute X2 (7,783)> X table (5,991) and p value = 0,019 <value α = 0,05, most respondents have education in the low category as many as 59,7%. The results of statistical tests obtained X2 count (4.353) <X table (5.991) and the value of p value = 0.117> the value of α = 0.05, the variables that most influence the anxiety in pregnant women on sexual relations are socio-economic.It is expected that health workers can be included in KIE (Information and Education Communication) regarding sexual activity so that it is expected that all pregnant women who have their pregnancies will not experience anxiety.Keywords: Age, Age of Pregnancy, Parity, Socio-Economic, Job, Education, Anxiety, Sexual RelationshipBibliography: 50 (1990 - 2017)  


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