scholarly journals Nutritional factors in the pathogenesis and treatment of psoriasis in children

2021 ◽  
Vol 24 (5) ◽  
pp. 348-355
Author(s):  
Svetlana G. Makarova ◽  
Irina Yu. Pronina
Keyword(s):  
Specific Effect ◽  
Diet Therapy ◽  
Evidence Base ◽  
Current Data ◽  
Biologically Active ◽  
Dietary Recommendations ◽  
Dietary Interventions ◽  
Nutritional Factors ◽  
Psoriatic Disease ◽  
Paediatric Age

In the pathogenesis of the psoriatic disease, genetic and environmental factors play a significant role, and one of the most critical ecological influences is nutrition. At the same time, the influence of nutrition on the pathogenetic links of psoriasis is currently underestimated. The clinical guidelines for managing children and adults with psoriasis do not mention the need to consult a nutritionist and any dietary recommendations. The purpose of this literature review was to analyze current data on the role of various nutritional factors in the development of psoriatic disease, the pathogenesis of its complicated course, as well as the effectiveness of dietary interventions in the treatment of this category of patients. The analysis of sixty eight sources of literature has shown that dietary changes and the use of biologically active food supplements can have a specific effect on the complex therapy of the disease. The possibilities of diet therapy in patients with psoriasis and metabolic syndrome are also discussed. At the same time, it is evident that further research is needed to improve the evidence base for the effectiveness of nutritional methods in managing this category of patients, especially in paediatric-age patients.

New Insight into Diabetes Management: From Glycemic Index to Dietary Insulin Index

2020 ◽  
Vol 16 (4) ◽  
pp. 293-300 ◽  
Author(s):  
Zahra Yari ◽  
Vahideh Behrouz ◽  
Hamid Zand ◽  
Katayoun Pourvali
Keyword(s):  
Glycemic Index ◽  
Diabetes Management ◽  
Glycemic Load ◽  
Insulin Response ◽  
Diet Therapy ◽  
Current Data ◽  
Diabetic Patients ◽  
Carbohydrate Counting ◽  
Insulin Requirements ◽  
Insight Into

Background: Despite efforts to control hyperglycemia, diabetes management is still challenging. This may be due to focusing on reducing hyperglycemia and neglecting the importance of hyperinsulinemia; while insulin resistance and resultant hyperinsulinemia preceded diabetes onset and may contribute to disease pathogenesis. Objective: The present narrative review attempts to provide a new insight into the management of diabetes by exploring different aspects of glycemic index and dietary insulin index. Results: The current data available on this topic is limited and heterogeneous. Conventional diet therapy for diabetes management is based on reducing postprandial glycemia through carbohydrate counting, choosing foods with low-glycemic index and low-glycemic load. Since these indicators are only reliant on the carbohydrate content of foods and do not consider the effects of protein and fat on the stimulation of insulin secretion, they cannot provide a comprehensive approach to determine the insulin requirements. Conclusion: Selecting foods based on carbohydrate counting, glycemic index or glycemic load are common guides to control glycemia in diabetic patients, but neglect the insulin response, thus leading to failure in diabetes management. Therefore, paying attention to insulinemic response along with glycemic response seems to be more effective in managing diabetes.

scholarly journals Different Expressions of Pericardial Fluid MicroRNAs in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy and Ischemic Heart Disease Undergoing Ventricular Tachycardia Ablation

2021 ◽  
Vol 8 ◽  
Author(s):  
Aleksandr A. Khudiakov ◽  
Daniil D. Panshin ◽  
Yulia V. Fomicheva ◽  
Anastasia A. Knyazeva ◽  
Ksenia A. Simonova ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ventricular Tachycardia ◽  
Right Ventricular ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Pericardial Fluid ◽  
Current Data ◽  
Biologically Active ◽  
Differentially Expressed ◽  
Ventricular Cardiomyopathy ◽  
Ventricular Tachycardia Ablation

Introduction: Pericardial fluid is enriched with biologically active molecules of cardiovascular origin including microRNAs. Investigation of the disease-specific extracellular microRNAs could shed light on the molecular processes underlying disease development. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by life-threatening arrhythmias and progressive heart failure development. The current data about the association between microRNAs and ARVC development are limited.Methods and Results: We performed small RNA sequence analysis of microRNAs of pericardial fluid samples obtained during transcutaneous epicardial access for ventricular tachycardia (VT) ablation of six patients with definite ARVC and three post-infarction VT patients. Disease-associated microRNAs of pericardial fluid were identified. Five microRNAs (hsa-miR-1-3p, hsa-miR-21-5p, hsa-miR-122-5p, hsa-miR-206, and hsa-miR-3679-5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. Enrichment analysis of differentially expressed microRNAs revealed their close linkage to cardiac diseases.Conclusion: Our data extend the knowledge of pericardial fluid microRNA composition and highlight five pericardial fluid microRNAs potentially linked to ARVC pathogenesis. Further studies are required to confirm the use of pericardial fluid RNA sequencing in differential diagnosis of ARVC.

scholarly journals Prospects for Using Amaranth and Native Buckwheat in Dry Gluten-Free Mixes for Children with Gluten Intolerance

2020 ◽  
Vol 50 (2) ◽  
pp. 232-241
Author(s):  
Sergey Urubkov ◽  
Svetlana Khovanskaya ◽  
Stanislav Smirnov
Keyword(s):  
Unsaturated Fatty Acids ◽  
Raw Materials ◽  
Young Patients ◽  
Diet Therapy ◽  
Biologically Active ◽  
Gluten Free ◽  
Free Products ◽  
Gluten Intolerance ◽  
Protein Amino Acids ◽  
Main Components

Introduction. Diet therapy is one of the main approaches to the treatment of various diseases of the digestive system. A strict lifetime diet is the main method of treatment for gluten intolerance. However, young patients, who are particularly sensitive to dietary restrictions, often fail to follow the diet due to the limited menu of recommended foods and dishes. The diet for children with gluten intolerance should include a sufficient amount of gluten-free grain-based products. They provide children with carbohydrates, dietary fibers, vegetable proteins, fats, B vitamins, and minerals, e.g. potassium, magnesium, selenium, etc. In this regard, it is urgent to develop new types of specialized gluten-free products to expand the diet both in terms of nutritional value and taste diversity. Study objects and methods. The research is part of a project on the development of dry gluten-free mixes based on buckwheat and amaranth with fruit, vegetable, and berry raw materials. The new formulations are intended for children older than three years of age with gluten intolerance. The research objective was to study the main nutrients in amaranth and buckwheat flours. The study involved the method of infrared spectroscopy using a SpectraStar 2500 analyzer. The data obtained made it possible to calculate the nutritional and energy value of products based on amaranth and buckwheat flours, as well as fruit, vegetable, and berry powders intended for children older than three years of age with gluten intolerance. Results and discussion. Amaranth flour proved to be rich in protein (13.4%), lipids (5.1%), and ash (2.8%). Native buckwheat flour contained 7.5% of protein, 3.6% of lipids, and 1.4% of ash. The carbohydrate content appeared approximately the same in both samples (56–58%). The dry gluten-free mixes can serve as an important source of vegetable protein (up to 9.44 g per 100 g of the finished product), carbohydrates (up to 40.08 g per 100 g of the finished product, and energy (from 158.12 to 221.85 kcal per 100 g of the finished product). Conclusion. The high nutritional and biological value of amaranth and buckwheat flours, as well as fruit, vegetable, and berry powders, confirmed the prospect of using them as the main components for functional foods. Amaranth and buckwheat contain no gluten but are rich in protein, amino acids, saturated and unsaturated fatty acids, minerals, and biologically active elements, which makes them an important source of nutrition for children with gluten intolerance.

scholarly journals Migraine and Diet

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1658 ◽  
Author(s):  
Parisa Gazerani
Keyword(s):  
Clinical Manifestations ◽  
Dietary Factors ◽  
Current Status ◽  
Future Perspective ◽  
Dietary Recommendations ◽  
Dietary Interventions ◽  
Ketogenic Diets ◽  
Underlying Mechanisms ◽  
Definition Of ◽  
Future Work

Migraine is characterized by recurrent attacks of disabling headaches, often accompanied by sensory and motor disturbances. Clinical manifestations of migraine are influenced by dietary behaviors and dietary elements. Several dietary triggers for migraine have been identified, leading to the definition of strategies such as elimination diets, ketogenic diets, and comprehensive diets, mainly to help prevent migraine. Although inconsistency is present in the literature and no consensus exists, the available data are promising in supporting beneficial dietary interventions for some migraine patients. Several factors influence the net outcome, including age, sex, genetics, and environmental factors. Advancement in understanding the underlying mechanisms of migraine pathogenesis and how dietary factors can interfere with those mechanisms has encouraged investigators to consider diet as a disease-modifying agent, which may also interfere with the gut–brain axis or the epigenetics of migraine. Future work holds potential for phenotyping migraine patients and offering personalized recommendations in line with biopsychosocial models for the management of migraine. Diet, as an important element of lifestyle, is a modifiable aspect that needs further attention. Well-designed, systematic, and mechanism-driven dietary research is needed to provide evidence-based dietary recommendations specific to migraine. This narrative review aims to present the current status and future perspective on diet and migraine, in order to stimulate further research and awareness.

An update on diet and nutritional factors in systemic lupus erythematosus management

2017 ◽  
Vol 30 (1) ◽  
pp. 118-137 ◽  
Author(s):  
Marina Aparicio-Soto ◽  
Marina Sánchez-Hidalgo ◽  
Catalina Alarcón-de-la-Lastra
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Diet Therapy ◽  
Multiple Organ ◽  
Dietary Factors ◽  
Clinical Experiences ◽  
Systemic Lupus ◽  
Nutritional Factors ◽  
Biological Heterogeneity

AbstractSystemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease characterised by multiple organ involvement and a large number of complications. SLE management remains complicated owing to the biological heterogeneity between patients and the lack of safe and specific targeted therapies. There is evidence that dietary factors can contribute to the geoepidemiology of autoimmune diseases such as SLE. Thus, diet therapy could be a promising approach in SLE owing to both its potential prophylactic effects, without the side effects of classical pharmacology, and its contribution to reducing co-morbidities and improving quality of life in patients with SLE. However, the question arises as to whether nutrients could ameliorate or exacerbate SLE and how they could modulate inflammation and immune function at a molecular level. The present review summarises preclinical and clinical experiences to provide the reader with an update of the positive and negative aspects of macro- and micronutrients and other nutritional factors, including dietary phenols, on SLE, focusing on the mechanisms of action involved.

scholarly journals Dietary Care for ADPKD Patients: Current Status and Future Directions

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1576 ◽  
Author(s):  
Sol Carriazo ◽  
Maria Vanessa Perez-Gomez ◽  
Adrian Cordido ◽  
Miguel Angel García-González ◽  
Ana Belen Sanz ◽  
...  
Keyword(s):  
Negative Impact ◽  
Aerobic Glycolysis ◽  
Evidence Base ◽  
Current Status ◽  
Dietary Recommendations ◽  
Preclinical Research ◽  
Ketogenic Diets ◽  
Modifiable Factors ◽  
Autosomal Dominant Polycystic Kidney ◽  
The Impact

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, and tolvaptan is the only therapy available. However, tolvaptan slows but does not stop disease progression, is marred by polyuria, and most patients worldwide lack access. This and recent preclinical research findings on the glucose-dependency of cyst-lining cells have renewed interest in the dietary management of ADPKD. We now review the current dietary recommendations for ADPKD patients according to clinical guidelines, the evidence base for those, and the potential impact of preclinical studies addressing the impact of diet on ADPKD progression. The clinical efficacy of tolvaptan has put the focus on water intake and solute ingestion as modifiable factors that may impact tolvaptan tolerance and ADPKD progression. By contrast, dietary modifications suggested to ADPKD patients, such as avoiding caffeine, are not well supported and their impact is unknown. Recent studies have identified a chronic shift in energy production from mitochondrial oxidative phosphorylation to aerobic glycolysis (Warburg effect) as a contributor to cyst growth, rendering cyst cells exquisitely sensitive to glucose availability. Therefore, low calorie or ketogenic diets have delayed preclinical ADPKD progression. Additional preclinical data warn of potential negative impact of excess dietary phosphate or oxalate in ADPKD progression.

Nutritional intervention for ADHD

2018 ◽  
Author(s):  
Jan K. Buitelaar ◽  
Nanda Rommelse ◽  
Verena Ly ◽  
Julia J. Rucklidge
Keyword(s):  
Fatty Acids ◽  
Clinical Relevance ◽  
Randomized Clinical Trials ◽  
Nutritional Intervention ◽  
Evidence Base ◽  
Small Sample ◽  
Omega 3 ◽  
Dietary Interventions ◽  
Small Sample Sizes ◽  
Sampling Procedures

This chapter discusses four dietary interventions (exclusion of artificial colours and preservatives; restrictive elimination diets/oligoantigenic diets; supplementation with omega-3 fatty acids; and supplementation with micronutrients) and their clinical relevance for ADHD. The evidence base for exclusion of artificial colours and preservatives has many gaps. Effectiveness of the elimination phase of elimination diets has been demonstrated in several randomized clinical trials and about one-third of the children with ADHD show an excellent response. Data on maintenance of effect in the longer term, however, are lacking. Supplementation of free fatty acids was associated with a small but reliable reduction of ADHD symptoms, but the clinical relevance is unclear. The trials using a broad spectrum of micronutrients show promise but suffered from small sample sizes, lack of controls, varied sampling procedures and inclusion criteria, and multiple assessment methods, and need confirmation.

Progress in diagnosis and treatment of bipolar disorder among children and adolescents: an international perspective

2018 ◽  
Vol 21 (4) ◽  
pp. 177-181 ◽  
Author(s):  
Robert L Findling ◽  
Ekaterina Stepanova ◽  
Eric A Youngstrom ◽  
Andrea S Young
Keyword(s):  
Bipolar Disorder ◽  
Children And Adolescents ◽  
Evidence Base ◽  
International Perspective ◽  
Current Data ◽  
Diagnosis And Treatment ◽  
Pharmacological Agents ◽  
Course Of Illness ◽  
History Of ◽  
Made In

Bipolar disorder (BPD) is a potentially lifelong condition characterised by extreme changes in mood that may begin in childhood and cause substantial impairment. Over the past decades, BPD has been the focus of increased attention mainly due to controversies surrounding its prevalence, diagnosis and treatment in children and adolescents. This report addresses these controversies by reviewing the extant evidence base, providing clinicians with a summary of the literature on diagnosis, phenomenology and treatment of paediatric BPD. The debate regarding diagnosing children with BPD based on severe irritability and aggression is mostly resolved. The current data support utilising the diagnostic criteria based on episodic changes of mood polarity. Therefore, longitudinal course of illness should be explored in detail when diagnosing BPD. Given high rates of genetic predisposition for BPD, assessment of youth should focus on obtaining accurate family history of this condition. Additionally, there has been a substantial increase in randomised placebo-controlled clinical trials evaluating pharmacological agents for mood stabilisation in children and adolescents, which we summarise in this review. Despite significant progress being made in the field of paediatric BPD, more research is needed in the areas of phenomenology, pathophysiology, course and treatment of this condition in youth.

scholarly journals Genomics in Personalized Nutrition: Can You “Eat for Your Genes”?

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3118
Author(s):  
Veronica A. Mullins ◽  
William Bresette ◽  
Laurel Johnstone ◽  
Brian Hallmark ◽  
Floyd H. Chilton
Keyword(s):  
Fatty Acid Biosynthesis ◽  
Dietary Exposure ◽  
Specific Gene ◽  
Dietary Recommendations ◽  
Dietary Interventions ◽  
Vitamin D Metabolism ◽  
Alcoholic Fatty Liver ◽  
Practical Applications ◽  
Snp Data ◽  
Dietary Choices

Genome-wide single nucleotide polymorphism (SNP) data are now quickly and inexpensively acquired, raising the prospect of creating personalized dietary recommendations based on an individual’s genetic variability at multiple SNPs. However, relatively little is known about most specific gene–diet interactions, and many molecular and clinical phenotypes of interest (e.g., body mass index [BMI]) involve multiple genes. In this review, we discuss direct to consumer genetic testing (DTC-GT) and the current potential for precision nutrition based on an individual’s genetic data. We review important issues such as dietary exposure and genetic architecture addressing the concepts of penetrance, pleiotropy, epistasis, polygenicity, and epigenetics. More specifically, we discuss how they complicate using genotypic data to predict phenotypes as well as response to dietary interventions. Then, several examples (including caffeine sensitivity, alcohol dependence, non-alcoholic fatty liver disease, obesity/appetite, cardiovascular, Alzheimer’s disease, folate metabolism, long-chain fatty acid biosynthesis, and vitamin D metabolism) are provided illustrating how genotypic information could be used to inform nutritional recommendations. We conclude by examining ethical considerations and practical applications for using genetic information to inform dietary choices and the future role genetics may play in adopting changes beyond population-wide healthy eating guidelines.

Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients (pts) with relapsed/refractory multiple myeloma (MM): A phase I study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 8034-8034 ◽  
Author(s):  
Shaji Kumar ◽  
William Bensinger ◽  
Craig B. Reeder ◽  
Todd M. Zimmerman ◽  
James R. Berenson ◽  
...  
Keyword(s):  
Dose Escalation ◽  
Proteasome Inhibitor ◽  
Phase 1 ◽  
Hydrolysis Product ◽  
Proteasome Inhibition ◽  
Median Number ◽  
Current Data ◽  
Biologically Active ◽  
Multiple Tumor ◽  
Grade 3

8034 Background: Phase 1 studies are evaluating IV and oral dosing of the reversible proteasome inhibitor MLN9708 in multiple tumor types. We report the safety, MTD, pharmacokinetics (PK), pharmacodynamics, and preliminary responses with weekly oral MLN9708 in pts with relapsed/refractory MM (NCT00963820). Methods: Pts aged ≥18 yrs received MLN9708 on d 1, 8, and 15 of 28-d cycles. In the dose-escalation phase, pts required ≥2 prior therapies (including bortezomib, thalidomide/lenalidomide, and corticosteroids). At the MTD, pts were to be enrolled to relapsed and refractory (RR), bortezomib-relapsed (VR), proteasome inhibitor (PI) naïve, and carfilzomib (CZ) expansion cohorts. Results: 36 pts have been enrolled to date (data cut-off: Dec 1, 2011), 32 in the dose-escalation phase (0.24–3.95 mg/m2) and 8 to expansion cohorts (2 RR, 5 VR, 1 PI naïve; RR and VR cohorts each include 2 pts from MTD dose-escalation cohort). Median age was 64.5 yrs (range 40–79), 53% were male, and median number of prior lines of therapy was 3.5 (range 1-13), including 92%, 92%, 56%, and 8% who had prior bortezomib, lenalidomide, thalidomide, and carfilzomib, respectively. Pts have received a median of 2 cycles (range 1–11); 5 pts remain on treatment. Among 24 DLT-evaluable pts, 3 DLTs were seen: 2 at 3.95 mg/m2 (1 grade 3 rash, 1 grade 3 GI AEs) and 1 at 2.97 mg/m2 (grade 3 GI AEs). The MTD was determined as 2.97 mg/m2. Overall, 69% of pts had drug-related AEs, and 28% had related grade ≥3 AEs, including thrombocytopenia (17%), diarrhea (11%), nausea, neutropenia, and fatigue (each 8%). Only 3 (8%) pts had drug-related peripheral neuropathy (PN; no grade ≥3). 2 pts discontinued due to AEs. In 18 response-evaluable pts, 1 had a VGPR at 3.95 mg/m2, 1 had a PR at 2.97 mg/m2, and 8 have achieved SD durable for up to 9.5 mos. PK analyses showed linear plasma PK (0.8–3.95 mg/m2), Tmax of 0.5-2 hr, and terminal half-life of 7 d for MLN2238 (biologically active hydrolysis product). There was a trend for a dose-dependent increase in whole blood 20S proteasome inhibition. Conclusions: Current data suggest weekly oral MLN9708 is generally well tolerated with infrequent PN, and shows early signs of antitumor activity.

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