scholarly journals A COMPARATIVE PHARMACEUTICO ANALYTICAL STUDY OF BHAGANDHARAHARA LEPA WITH ITS MODIFIED FORM AS A HYDROGEL

2020 ◽  
Vol 04 (04) ◽  
pp. 2309-2318
Author(s):  
Hari Anand Tripathi ◽  
J. Dinesh Nayak ◽  
Sathyanarayana B
Keyword(s):  
Shelf Life ◽  
Physicochemical Parameters ◽  
Analytical Study ◽  
Analytical Techniques ◽  
Stability Evaluation ◽  
Foul Smell ◽  
The Stability ◽  
Physical And Chemical ◽  
Instrumental Methods ◽  
Form Stability

ABSTRACT Objective of the study: To the develop standard operative procedures of Bhagandharahara lepa and change the form of Bhagandharahara lepa into the form of the Hydrogel. To comparatively analysis Bhagandharahara lepa and its pharmaceutically modified form of Hydrogel with classical and advanced analytical techniques. Methods: Pharmaceutical study: Bhagandharahara lepa and its modified form as a Hydrogel is prepared with standard household parameters. Analytical study: Comparative analysis of both Bhagandharahara lepa and its modified form as a Hydrogel will be comparatively analysed with suitable physicochemical parameters and advanced instrumental methods of analysis. Results: In Stability evaluation of BHL, classically prepared lepa got decomposed next day with foul smell and become darker mustard field in colour, so lepa (wet form) stability remains within 24 hrs. and here physical and chemical stability of dried form of lepa churna is good throughout 3 months of period and in Stability evaluation of BHG prepared hydrogel Light Ochre in colour with easily spreading and physicochemical parameters also like homogeneity and extrudability, viscosity, pH, irritancy test, melting point within limit there is no any major changes throughout the stability period 3 months. So Bhagandharahara Hydrogel is almost remained stable till 3 months. Conclusions: As lepa is having shorter shelf life, it cannot be preserved to longer time, so in this study its modification to Hydrogel form facilitates a longer shelf life. Due to some special features of Hydrogel like extrudability, spreadability, viscosity, pH, homogeneity it is easy to apply to the target site.

Comparative Analytical Study of Dhutturadi Taila prepared in two different media

2017 ◽  
Vol 2 (06) ◽  
Author(s):  
Bibin K. B.
Keyword(s):  
Physicochemical Parameters ◽  
Analytical Study ◽  
Analytical Techniques ◽  
Therapeutic Practice ◽  
Methods Of Analysis ◽  
Instrumental Methods ◽  
Existing Result

Background: Sneha Kalpana is one among the several highly established Kalpana of Ayurvedic system of medicine. Many types of Taila Kalpana are mentioned in Ayurvedic classics and used effectively in therapeutic practice. Tila Taila is the most commonly using Taila. However Narikelataila, Erandataila, Sarshapataila, etc, are also used in special conditions. It is interesting to note that certain preparations are available in the market based on both TilaTaila and Narikela Taila. This is an attempt to comparatively evaluate the formulation Dhutturadi Taila prepared in Tila Taila and Narikela Taila as the bases. Dhutturadi Taila mentioned in Sahasrayogam is taken for the present study. Objectives: To comparatively analyse Dhutturadi Taila samples with classical and advanced analytical techniques. Materials and Methods: Dhutturadi Taila was prepared using two media i.e. Narikela Taila and Tila Taila. Both Taila samples were comparatively analysed with suitable physicochemical parameters and advanced instrumental methods of analysis. Conclusion: As per the existing result it seems that more amount of marker components are extracted into Tila Taila medium when compared with Narikela Taila.

scholarly journals POLYMER GRAFTING AND APPLICATIONS IN PHARMACEUTICAL DRUG DELIVERY SYSTEMS - A BRIEF REVIEW

2017 ◽  
Vol 10 (6) ◽  
pp. 59 ◽  
Author(s):  
Mahesh S Sakhare ◽  
Hrishikesh H Rajput
Keyword(s):  
Dosage Form ◽  
Polymer System ◽  
Analytical Techniques ◽  
Polymer Grafting ◽  
Grafted Polymers ◽  
The Stability ◽  
Form Type ◽  
Physical And Chemical ◽  
Modern Analytical ◽  
Selection Of

  Selection of proper polymer system is a critical step involved in the formulation of dosage form. Type of polymer/s incorporated in pharmaceutical formulation majorly decides the stability of formulation and drug itself, mechanism, and rate of drug release. Pharmaceutical and biological therapeutics are suffered from disadvantages such as short half-lives, poor bioavailability, and physical and chemical instability. Delivery of drugs to target site at a specific concentration for a specific time can be successfully achieved by the use of suitable polymer/s. Thus, it is not necessary that available polymer till the date should have all ideal properties with respect to above. This makes a demand of tailored polymers with desired features and introduces concept of grafting for making new polymers to be used in dosage forms. Grafting can be achieved by various techniques described herein and can be analyzed by various modern analytical techniques including infrared, NMR, X-ray diffractometer, and differential scanning calorimeter. These grafted polymers offer many applications in terms of site drug/biological carrying capacity, tailored physicochemical properties based dosage form modifications and with desired features, and also to deliver therapeutics at specific sites. Considering these advantages, a number of applications of grafted polymers developed and many patents were filed in this area till the date. This review highlights the basic concept of grafting and its various techniques and their significant pharmaceutical applications.

scholarly journals Functional and technological properties of food additive "Magnetofood" in production of shaped jelly marmalade on agar and pectin

2021 ◽  
Vol 15 (3) ◽  
Author(s):  
I. Tsykhanovska ◽  
V. Yevlash ◽  
R. Trishch ◽  
T. Lazarieva ◽  
A. Alexandrov ◽  
...  
Keyword(s):  
Shelf Life ◽  
Food Additives ◽  
Food Additive ◽  
Gelling Agent ◽  
Technological Properties ◽  
Ζ Potential ◽  
Surface Active Properties ◽  
Wide Range ◽  
The Stability ◽  
Physical And Chemical

Jelly and marmalade products are "lyophilic colloids" – lyophilic colloidal-dispersed, ie microheterogeneous (multi- or polyphasic) systems based on high molecular weight compounds (gelatin, pectin, agar, etc.). Therefore, the problem of stabilizing their polyphasic structure is relevant. In addition, the expansion and improvement of the production of jelly and marmalade products requires the search for simplified resource- and energy-saving technology, increasing the stability of the colloidal disperse system, improving the quality and extending the shelf life of finished products. Promising technological applications have food additives in the nanometer range, due to specific and stable physical and chemical parameters, a wide range of functional and technological properties. The paper proposes the solution of the problem of stabilization of the polyphase structure of jelly-marmalade products and the formation of their quality by using the food additive "Magnetofood" (based on double oxide of divalent and trivalent iron: FeO×Fe2O3). "Magnetofood" - highly dispersed powder with a particle size (70–80) nm, which has a fairly diverse functional and technological potential: high ζ-potential and surface activity; clusterophilicity and amphiphilicity; complexing, thickening, structuring, stabilizing, thixotropic properties. This allows us to recommend "Magnetofood" as a food additive of complex action to improve the quality and prolong the shelf life of jelly-marmalade products, in particular jelly-shaped marmalade. The surface-active properties of nanoparticles of the food additive "Magnetofood" are determined: a rather significant value of ζ-potential (34-44) mV, amphiphilicity (marginal wetting angle Q<90o by polar-nonpolar medium) - show signs of stability and stability on polyphasic colloidal-dispersed systems , which increases in acidic environments, in solutions of polysaccharides, proteins on average by (55±)%, which is due to clusterophilicity and self-organization of nanoparticles "Magnetofood" into electrostatic complexes with proteins, polysaccharides and their spatial structuring. It was found that the addition of "Magnetofood" in the mass fraction (0,10–0,20)% to the mass of the structurant increases the viscosity of aqueous solutions of gelling agents in (1,22–1,27) times for agar and in (1,24–1,29) times for pectin and the rate of structuring of gel masses in (1,73±0,01) times for agar and in (1,67±0,01) times for pectin due to the structure-forming action of nanoparticles "Magnetofood". In addition, the ability of the gel structure to thixotropy increases by (1,4–1,5) times and the mechanical strength of the gel well by (1,32–1,80) times for agar and (1,49–1,57) times for pectin due to the stabilizing action of Magnetofood nanoparticles, which allows to reduce the amount of gelling agent by (9.0–11.0)% for agar and by (7.0–9.0)% for pectin.

scholarly journals SHELF LIFE PREDICTION OF DIAGNOSTIC FLUORESCENT TULAREMIA DRY IMMUNOGLOBULINS

2019 ◽  
pp. 56-60
Author(s):  
O.L. Startseva ◽  
S.A. Kurcheva
Keyword(s):  
Shelf Life ◽  
Storage Temperature ◽  
Chemical Properties ◽  
Storage Conditions ◽  
Medical Product ◽  
Shelf Life Prediction ◽  
The Stability ◽  
Physical And Chemical

We described the results of studying the stability of the main indicators of medical product quality for in vitro diagnostics - diagnostic fluorescent tularemia dry immunoglobulins RIF-Tul-StavNIPCHI, developed on the basis of Stavropol Anti-Plague Institute of Rospotrebnadzor to justify the shelf life and recommended storage conditions when used on a real scale time and accelerated research methods. At the same time, one of the main criteria for the study of stability is its study during sample storage not only in the primary packaging of an industrial output, but also after the first opening of the package, during the use period of the reconstituted preparation. On the basis of data obtained in both long-term and accelerated trials, a shelf life of three years is recommended. It was experimentally proved that during this period of time, the quality indicators of the drug remain at a level one that complies with the requirements of technical and operational documentation. In the course of application the recovered product demonstrates stability of its biological and physical-and-chemical properties within 5 days at a storage temperature of 2 to 8°С.

scholarly journals Paper Ageing: The Effect of Paper Chemical Composition on Hydrolysis and Oxidation

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1029
Author(s):  
Edyta Małachowska ◽  
Dominika Pawcenis ◽  
Jacek Dańczak ◽  
Joanna Paczkowska ◽  
Kamila Przybysz
Keyword(s):  
Lignin Content ◽  
Cellulose Degradation ◽  
Chemical Properties ◽  
Analytical Techniques ◽  
Size Exclusion ◽  
Cellulose Structure ◽  
Exclusion Chromatography ◽  
Paper Ageing ◽  
Physical And Chemical ◽  
Instrumental Methods

The degradation of cellulose is an important factor influencing its mechanical, optical, physical, and chemical properties and, hence, the lifetime of paper in libraries and archival collections. Regardless of the complexity of the paper material, the main chemical pathways for its degradation are hydrolysis and oxidation. This study presents an overview of the analytical techniques employed in the evaluation of the hydrolysis and oxidation processes; these techniques include size-exclusion chromatography, Fourier-transform infrared and ultraviolet–visible spectroscopy, and X-ray diffraction. This paper aims to determine the extent to which these instrumental methods are useful for studying the aforementioned processes and for which lignin contents. It also highlights how atmospheric humidity could affect the cellulose structure in paper containing lignin. It was found that humidity causes significant changes in the cellulose chain lengths and that a high lignin content in paper could suppress some cellulose degradation pathways. This knowledge can be applied to developing strategies and selective chemical treatments preventing the consequences of paper ageing.

PENGARUH VIRGIN COCONUT OIL (VCO) TERHADAP KARAKTERISTIK DAN UMUR SIMPAN ROTI MANIS

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Aulia Alfi
Keyword(s):  
Moisture Content ◽  
Shelf Life ◽  
Coconut Oil ◽  
Temperature Treatment ◽  
Ash Content ◽  
Virgin Coconut Oil ◽  
Food Ingredients ◽  
Life Analysis ◽  
Antibacterial And Antifungal ◽  
Physical And Chemical

Virgin Coconut Oil (VCO) adalah bahan alami yang memiliki sifat antimikroba (antivirus, antibakteri, dan antijamur). Sehingga VCO dapat memberikan efek pengawet pada bahan makanan, salah satunya adalah roti manis. Penelitian ini dilakukan untuk mengevaluasi pengaruh VCO terhadap karakteristik (fisik dan kimia) dan umur simpan roti manis. Roti manis dianalisis secara fisik (tekstur dan porositas) dan kimia (kadar air, kadar abu, kadar lemak, kadar protein, dan kandungan karbohidrat), dan analisis umur simpan dengan FFA, uji organoleptik dan jamur setiap dua hari selama delapan hari penyimpanan di suhu ruang. Variasi perlakuan roti manis adalah dari rasio konsentrasi VCO: margarin: mentega, K (0%: 8%: 8%); A (4%: 6%: 6%); B (8%: 4%: 4%), C (12%: 2%: 2%); D (16%: 0%: 0%). Hasil penelitian menunjukkan bahwa VCO tidak memiliki pengaruh yang signifikan terhadap karakteristik fisik dan karakteristik kimia roti manis. Namun, VCO berpengaruh signifikan terhadap kadar air roti manis yang dihasilkan, roti manis K memiliki kadar air tertinggi (22,36%) dan berbeda dengan sampel roti manis lainnya. VCO secara efektif menghambat pertumbuhan jamur di roti manis pada konsentrasi 8%, 12%, dan 16%. Roti manis K dan A memiliki masa simpan 4 hari, sedangkan roti manis B, C, dan D memiliki masa simpan 6 hari.Kata kunci: VCO, roti manis, karakteristik, umur simpanABSTRACTVirgin Coconut Oil (VCO) is a natural ingredient that has antimicrobial (antiviral, antibacterial, and antifungal) properties. So that VCO can provide a preservative effect on food ingredients, one of which is sweet bread. This research was conducted to evaluate the effect of VCO on characteristics (physical and chemical) and shelf life of sweet bread. Sweet bread was analyzed physically (texture and porosity) and chemistry (moisture content, ash content, fat content, protein content, and carbohydrate content), and shelf life analysis with FFA, organoleptic and mold tests every two days for eight days of storage at ambient temperature. Treatment variations of sweet breads is from the ratio of the concentration of VCO: margarine: butter, K (0%: 8%: 8%); A (4%: 6%: 6%); B (8%: 4%: 4%), C (12%: 2%: 2%); D (16%: 0%: 0%). The results showed that VCO did not have a significant effect on the physical characteristics and chemical characteristics of sweet bread. However, the VCO has a significant effect on the water content of the sweet bread produced, sweet bread K has the highest moisture content (22,36%) and it is different from other sweet bread samples. VCO effectively inhibits the growth of sweet bread mold at concentrations of 8%, 12%, and 16%. K and A sweet bread has a shelf life of 4 days, while sweet breads B, C, and D have a shelf life of 6 days.Keywords: VCO, sweet bread, characteristics, shelf life

The stability and shelf-life of food

2000 ◽  
Author(s):  
David Kilcast ◽  
Persis Subramaniam
Keyword(s):  
Shelf Life ◽  
The Stability

scholarly journals 3D sub-nanometer analysis of glucose in an aqueous solution by cryo-atom probe tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
T. M. Schwarz ◽  
C. A. Dietrich ◽  
J. Ott ◽  
E. M. Weikum ◽  
R. Lawitzki ◽  
...  
Keyword(s):  
Atom Probe Tomography ◽  
Density Functional ◽  
Chemical Characterization ◽  
Analytical Techniques ◽  
Atom Probe ◽  
Characterization Methods ◽  
Signal Deconvolution ◽  
The Stability ◽  
Frozen Solutions ◽  
3D Volume

AbstractAtom Probe Tomography (APT) is currently a well-established technique to analyse the composition of solid materials including metals, semiconductors and ceramics with up to near-atomic resolution. Using an aqueous glucose solution, we now extended the technique to frozen solutions. While the mass signals of the common glucose fragments CxHy and CxOyHz overlap with (H2O)nH from water, we achieved stoichiometrically correct values via signal deconvolution. Density functional theory (DFT) calculations were performed to investigate the stability of the detected pyranose fragments. This paper demonstrates APT’s capabilities to achieve sub-nanometre resolution in tracing whole glucose molecules in a frozen solution by using cryogenic workflows. We use a solution of defined concentration to investigate the chemical resolution capabilities as a step toward the measurement of biological molecules. Due to the evaporation of nearly intact glucose molecules, their position within the measured 3D volume of the solution can be determined with sub-nanometre resolution. Our analyses take analytical techniques to a new level, since chemical characterization methods for cryogenically-frozen solutions or biological materials are limited.

scholarly journals Specification and Evaluation of Plasticizer Migration Simulants for Human Blood Products: A Delphi Study

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1081
Author(s):  
Aurélie Thelliez ◽  
Grégory Hénard ◽  
Bruno Delorme ◽  
Sonia Chatellier ◽  
Cécile Danel ◽  
...  
Keyword(s):  
Human Blood ◽  
Delphi Study ◽  
Clinical Situation ◽  
Blood Products ◽  
Laboratory Studies ◽  
Short Supply ◽  
Plasticizer Migration ◽  
Physical And Chemical ◽  
Form Stability ◽  
Qualitative Phase

Potentially toxic plasticizers are commonly added to polyvinyl chloride medical devices for transfusion in order to improve their flexibility and workability. As the plasticizers are not chemically bonded to the PVC, they can be released into labile blood products (LBPs) during storage. Ideally, LBPs would be used in laboratory studies of plasticizer migration from the medical device. However, short supply (i.e., limited stocks of human blood in collection centres) has prompted the development of specific simulants for each type of LBP in the evaluation of new transfusion devices. We performed a Delphi study with a multidisciplinary panel of 24 experts. In the first (qualitative) phase, the panel developed consensus definitions of the specification criteria to be met by each migration simulant. Next, we reviewed the literature on techniques for simulating the migration of plasticizers into LBPs. A questionnaire was elaborated and sent out to the experts, and the replies were synthesized in order to obtain a consensus. The qualitative study established specifications for each biological matrix (whole blood, red blood cell concentrate, plasma, and platelet concentrate) and defined the criteria required for a suitable LBP simulant. Ten criteria were suggested: physical and chemical characteristics, opacity, form, stability, composition, ability to mimic a particular clinical situation, ease and safety of use, a simulant–plastic interaction correlated with blood, and compatibility with analytical methods. The questionnaire data revealed a consensus on the use of natural products (such as pig’s blood) to mimic the four LBPs. Opinions diverged with regard to synthetic products. However, an isotonic solution and a rheological property modifier were considered to be of value in the design of synthetic simulants. Consensus reached by the Delphi group could be used as a database for the development of simulants used to assess the migration of plasticizers from PVC bags into LBPs.

scholarly journals Analytical study of Buddha sculptures in Jingyin temple of Taiyuan, China

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiaojian Bai ◽  
Chen Jia ◽  
Zhigen Chen ◽  
Yuxuan Gong ◽  
Huwei Cheng ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Analytical Study ◽  
Energy Dispersive Spectrometry ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Ancient China ◽  
X Ray ◽  
Unique Style ◽  
Scanning Electron

AbstractWith exquisite design and unique style, the painted sculptures of Tutang Buddha and two attendants Buddha in Jingyin Temple are precious cultural heritages of China. The sculpture of Tutang Buddha, which was carved from a mound and painted by ancient craftsmen, was rarely found in ancient China. However, due to natural and human factors, the sculptures were severely damaged. Obviously, they require urgent and appropriate protection and restoration. In this study, samples taken from the sculptures were analysed through multiple analytical techniques, including scanning electron microscopy with energy dispersive spectrometry (SEM–EDS), Raman spectroscopy, X-ray diffraction (XRD), optical microscopy (OM) and granulometry. The analysis results enable us to infer the techniques used by the craftsmen in making the sculptures and provide a reliable evidence for the conservation and future protection of these and similar sculptures.

Sign in / Sign up

Export Citation Format

Share Document