scholarly journals A CRITICAL REVIEW ON STAMBHANA AND GRAHI KARMA: CONCEPT BASED TREATMENT MODALITIES

2020 ◽  
pp. 41-48
Author(s):  
Daneshwari Kanashetti ◽  
Kamal Nayan Dwivedi
Keyword(s):  
Present Article ◽  
Mechanism Of Action ◽  
Critical Review ◽  
Good Practice ◽  
Body Fluids ◽  
Treatment Modalities ◽  
Treatment Approaches ◽  
Clinical Applicability ◽  
Basic Concepts

In Ayurveda it is necessary to reveal basic concepts, without which one cannot achieve good practice because many treatment approaches are hidden in basic concepts. In this aspect, Rasa, Guna, Veerya, Vipaka, Prabhava and Karma constitute basic concepts of Dravyaguna. Stambhana and Grahi comes under heading of karma, both do the same function of checking the excess flow but applicable in different conditions, having different mechanism of action. Grahi karma is different from Stambhana karma in performing Deepana and Pachana. Stambhana karma is applicable in excess flow of all the Srotas and Grahi karma is restricted to Purishavaha, Udakavaha, Annavaha srotas. Many drugs and formulations are explained in classics which perform Stambhana and Grahi action by their Rasadi Panchaka and Panchabhautik composition. Most of the Stambhana and Grahi drugs contain tannins, which help in ceasing excess flow of body fluids. Present article reveals the Stambhana, Grahi and Sangrahi karma along with its clinical applicability.

IS tRNA DRIVING BREAST CANCER PROGRESSION?

2019 ◽  
Author(s):  
Zil-e- Rubab
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Developing Countries ◽  
Molecular Mechanism ◽  
Cancer Progression ◽  
Critical Review ◽  
Driving Forces ◽  
Treatment Modalities ◽  
Critical Research ◽  
Research Article

This critical research periodical is mainly based on critical review of research article titled ‘Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression published in Cell by Goodarzi et al1. According to Globocan, 2008 report2, breast is among the leading site of new cancer cases and deaths (691,300/268,900) in females of developing countries and second leading site in USA (Globocan, 2012)3. The extensive research is in progress on different aspects of molecular mechanism of driving forces and different treatment modalities to ease this burden. The above mentioned research article is also part of this effort.

Vitiligo: An Updated Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Alexander K. C. Leung ◽  
Joseph M. Lam ◽  
Kin Fon Leong ◽  
Kam Lun Hon
Keyword(s):  
Present Article ◽  
English Literature ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Calcineurin Inhibitors ◽  
Ultraviolet B ◽  
Lower Limbs ◽  
Treatment Modalities ◽  
Topical Corticosteroids ◽  
Topical Calcineurin Inhibitors

Background: Vitiligo is a relatively common acquired pigmentation disorder that can cause significant psychological stress and stigmatism. Objective: This article aims to familiarize physicians with the clinical manifestations, evaluation, diagnosis, and management of vitiligo. Methods: A Pubmed search was conducted in Clinical Queries using the key term "vitiligo". The search included metaanalyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to the English literature. The information retrieved from the above search was used in the compilation of the present article. The information retrieved from the above search was used in the compilation of the present article. Results: Approximately one quarter of patients with vitiligo have the onset before 10 years of age. Genetic, immunological, neurogenic and environmental factors may have a role to play in the pathogenesis. Vitiligo typically presents as acquired depigmented, well-demarcated macules/patches that appear milk- or chalk-white in color. Lesions tend to increase in number and enlarge centrifugally in size with time. Sites of predilection include the face, followed by the neck, lower limbs, trunk, and upper limbs. The clinical course is generally unpredictable. In children with fair skin, no active treatment is usually necessary other than the use of sunscreens and camouflage cosmetics. If treatment is preferred for cosmesis, topical corticosteroids, topical calcineurin inhibitors, and narrowband ultraviolet B phototherapy are the mainstays of treatment. Conclusion: The therapeutic effect of all the treatment modalities varies considerably from individual to individual. As such, treatment must be individualized. In general, the best treatment response is seen in younger patients, recent disease onset, darker skin types, and head and neck lesions. Topical corticosteroids and calcineurin inhibitors are the treatment of choice for those with localized disease. Topical calcineurin inhibitors are generally preferred for lesions on genitalia, intertriginous areas, face, and neck. Narrowband ultraviolet B phototherapy should be considered in patients who have widespread vitiligo or those with localized vitiligo associated with a significant impact on the quality of life who do not respond to treatment with topical corticosteroids and calcineurin inhibitors.

scholarly journals The Tale of the Dueling Neurosurgeons. A Contribution to the Neurosciences and Neurosurgery

2019 ◽  
Vol 38 (03) ◽  
pp. 250-252
Author(s):  
Gilvan Aguiar da Silva ◽  
Elton Gomes da Silva ◽  
Seidel Guerra López
Keyword(s):  
Human Brain ◽  
Present Article ◽  
Critical Review ◽  
Current Issue ◽  
Lower Number ◽  
Neuroscience Research ◽  
History Of ◽  
Lay Public

AbstractIn the present article, we elaborate a critical review of the book “The Tale of the Dueling Neurosurgeons: The History of the Human Brain as Revealed by True Stories of Trauma, Madness, and Recovery”, written by Sam Kean. In our opinion, this book can contribute to the dissemination of neurosciences to the lay public, but it can also have an important role: to increase the interest of medicine students in neurosciences and research, since an increasingly lower number of students declare they have this interest. Thus, this book can be an important tool to deal with a pertinent and current issue under debate in the neuroscience research and neurosurgery communities.

scholarly journals Management of Grahani Roga by Ayurveda principles and life style modification

2018 ◽  
Vol 8 (6) ◽  
pp. 393-396
Author(s):  
Sapan Jain ◽  
Seema G Chawardol ◽  
Jinesh Jain ◽  
O.P Dwivedi
Keyword(s):  
Present Article ◽  
Developing Country ◽  
Life Style ◽  
Food Habits ◽  
Pathological Condition ◽  
Large Population ◽  
Treatment Modalities ◽  
Ancient Text ◽  
Digestive Function

Grahani is an ayurveda terms related to the seat of agni (digestive fire), which help in the metabolism and digestion of food. The ancient text of ayurveda described that ingestion, digestion, absorption and assimilation of Aahaar is regulated by Grahani. When this Agni becomes; mandagni then improper digestion of ingested food leads pathological condition termed as Grahani roga. Similarly Trividh anomalies of the Jatharagni also termed as Grahanidosha. Grahani is a disease which affects large population globally especially in developing country and associated with improper food habits along with stressful lifestyle. The pathogenesis of Grahani roga works around Agnidosha which associated with impaired digestive function of digestive fire. Ayurveda described various treatment modalities for the management of Grahani roga such as; use of herbs & formulation, yoga and life style modification. Present article summarized ayurveda perspective of Grahani roga and its management by ayurveda principles and life style modification. Keywords: Ayurveda, Grahani, Agnidosha, Yoga, Life style

scholarly journals LA FORMACIÓN DIDÁCTICO-MATEMÁTICA DE DOCENTES: RESULTADOS TEÓRICOS

PARADIGMA ◽  
2020 ◽  
pp. 271-288
Author(s):  
Nancy Montes de Oca Recio
Keyword(s):  
Human Development ◽  
Present Article ◽  
Learning Process ◽  
Theoretical Perspective ◽  
Mathematical Education ◽  
School Teachers ◽  
Mathematical Communication ◽  
Basic Concepts ◽  
Teaching Learning ◽  
Theoretical Results

El objetivo del presente artículo es comunicar el proceso y los resultados teóricos de unainvestigación relacionada con la formación didáctico matemática de docentes, generada a partirde las insuficiencias detectadas en el desempeño de docentes de Matemática en el ejercicio dela profesión. La investigación aborda aspectos relacionados con: la comprensión de los objetosde la Geometría Plana; la gestión didáctica de las demostraciones matemáticas, la promoción deuna valoración positiva hacia la Matemática, la producción de problemas, el dominio deconceptos básicos del Álgebra Lineal y la expresión al comunicarse en matemática, desde unaperspectiva teórica que integra el enfoque histórico cultural del desarrollo humano y losenfoques ontosemiótico, comunicativo y contextualizado de la enseñanza-aprendizaje de laMatemática. Los resultados responden a la labor realizada por un equipo de trabajo constituidopor profesores que imparten docencia en carreras de formación de docentes de Matemática,maestrías y doctorados de la Universidad de Camagüey y la Universidad Autónoma de SantoDomingo.Palabras clave: Formación Didáctico-Matemática, Educación Matemática, Docentes deMatemática, Gestión DidácticaA Formação Didático-Matemática de Pedagogos: implicações teóricasAbstractO objetivo deste artigo presente é comunicar o processo e os resultados teóricos de umainvestigação relacionados com o processo de aprendizagem didático-matemático de pedagogos;este estudo começou a levar em conta as insuficiências descobriu no processo de ensinoaprendizagemde Matemática administrado por professores escolares. Esta investigação chegaaspectos relacionados com: a compreensão de objetos de Geometria Planos; a administraçãodidática de demonstrações de Matemáticas, a promoção de uma estimação positiva paraMatemática, a geração de problemas didáticos, o dominando de conceitos básicos de ÁlgebraLinear e comunicação matemática, de uma perspectiva teórica que integra a aproximaçãohistórica cultural de desenvolvimento humano e o ontosemiotico, comunicativo e contextualfocaliza do ensino-aprendizagem de Matemática. Os resultados apresentados são um resultadodo trabalho levado a cabo por um time constituiu por professores que ensinam Matemática empre-serviço, mestres e cursos de doutorado em Universidade de Camaguey e a UniversidadeAutônoma de Santo Domingo.Palavras chave: Formação Didático-Matemática, Educação Matemática, Educação deMatemática, Administração didática.The Didactic and Mathematical Formation of Teachers: theoric resultsAbstractThe objective of this present article is to communicate the process and the theoretical results of an investigation related with the didactic-mathematical learning process of educators; this study began taking into account the inadequacies detected in the teaching-learning process of Mathematics managed by school teachers. This investigation approaches aspects related with: the understanding of Plane Geometry objects; the didactic management of Maths demonstrations, the promotion of a positive valuation towards Mathematics, the generation of didactic problems, the mastering of basic concepts of Lineal Algebra and mathematical communication, from a theoretical perspective that integrates the cultural historical approach of human development and the ontosemiotic, communicative and contextual focuses of the teaching-learning of Mathematics. The results presented is a result of the work carried out by a team constituted by professors that teach Mathematics in pre-service, masters and doctorates courses at Camaguey University and the Autonomous University of Santo Domingo.Key words: Didactic-Mathematical Formation, Mathematical Education, Education of Mathematics, Didactic Management.

scholarly journals Critical response to the article «The crisis of natural science and humanitarian approaches in psychiatry»

2021 ◽  
pp. 25-28
Author(s):  
Y. M. Zislin
Keyword(s):  
Natural Science ◽  
Critical Review ◽  
Critical Response ◽  
Basic Concepts

The letter is devoted to the critical review of the basic concepts of the methodological article of Neznanov N.G., Kotsyubinsky A.P., Kotsyubinsky D.A. «Crisis of natural-scientific and human approaches in psychiatry».

scholarly journals Multimodality treatment of malignant pleural mesothelioma

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1681 ◽  
Author(s):  
Lawek Berzenji ◽  
Paul Van Schil
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Asbestos Exposure ◽  
Multimodality Treatment ◽  
Treatment Modalities ◽  
Surgical Approaches ◽  
Extrapleural Pneumonectomy ◽  
Pleural Mesothelioma ◽  
Treatment Approaches ◽  
Definitive Answer ◽  
Platinum Based Chemotherapy

Malignant pleural mesothelioma (MPM) is a rare disease of the pleura and is largely related to asbestos exposure. Despite recent advancements in technologies and a greater understanding of the disease, the prognosis of MPM remains poor; the median overall survival rate is about 6 to 9 months in untreated patients. The main therapeutic strategies for MPM are surgery, chemotherapy, and radiation therapy (RT). The two main surgical approaches for MPM are extrapleural pneumonectomy (EPP), in which the lung is removed en bloc, and pleurectomy/decortication, in which the lung stays in situ. Chemotherapy usually consists of a platinum-based chemotherapy, such as cisplatin, often combined with a folate antimetabolite, such as pemetrexed. More recently, immunotherapy has emerged as a possible therapeutic strategy for MPM. Evidence suggests that single-modality treatments are not an effective therapeutic approach for MPM. Therefore, researchers have started to explore different multimodality treatment approaches, in which often combinations of surgery, chemotherapy, immunotherapy, and RT are investigated. There is still no definitive answer to the question of which multimodality treatment combinations are most effective in improving the poor prognosis of MPM. Research into the effects of trimodality treatment approaches have found that radical approaches such as EPP and hemithoracic RT post-EPP are less effective than was previously assumed. In general, there are still a great number of unanswered questions and unknown factors regarding the ideal treatment approach for MPM. Hopefully, more research into multimodality therapy will provide insight into which combination of treatment modalities is most effective.

scholarly journals Knowledge and Attitude of Nursing Students toward Electroconvulsive Therapy

2017 ◽  
Vol 08 (S 01) ◽  
pp. S007-S012 ◽  
Author(s):  
Nitasha Sharma ◽  
Sandhya Ghai ◽  
Sandeep Grover
Keyword(s):  
Nursing Students ◽  
Side Effects ◽  
Electroconvulsive Therapy ◽  
Mechanism Of Action ◽  
Significant Proportion ◽  
Negative Attitude ◽  
Treatment Modalities ◽  
Attitude Score ◽  
Negative Attitudes ◽  
Knowledge And Attitude

ABSTRACT Background: Electroconvulsive therapy (ECT) is one of the commonly used treatment modalities for patients with severe mental disorders. However, acceptance of ECT by the patient and relatives often depends on how the health-care professionals themselves present the treatment modality to the patients and their relatives. There is a lack of information about the knowledge and attitude toward ECT among health professionals. Aim: This study aimed to evaluate the knowledge about and attitude toward ECT among nursing students. Methodology: Knowledge of and attitudes toward ECT among nursing students were assessed using ECT knowledge and attitude questionnaires. Results: The study included 183 nursing students. Majority (n = 62; 60.8%) of the participants obtained information about ECT from media (movies, television, print media, etc.). None of the students had full knowledge about ECT. Although a significant proportion of students had knowledge about the ECT procedure and consent procedure, majority of them had poor knowledge about the effectiveness, mechanism of action, indications, and side effects of ECT. Negative attitudes were also highly prevalent, with more than two-thirds of the participants having negative attitudes toward ECT on more than half of the attitude items of the scale. Total knowledge score positively correlated with total attitude score, suggesting that higher knowledge was associated with more positive attitude. Conclusions: Although nursing students have knowledge about basic ECT procedure and consent, they lack knowledge about the effectiveness, mechanism of action, indications, and side effects of ECT. Negative attitude toward ECT is also highly prevalent among nursing students. Accordingly, there is a need to improve the knowledge and address the negative attitude of nursing students, which may ultimately lead to better acceptance of the treatment.

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