scholarly journals Evaluation of efficacy and safety of platelet rich plasma (PRP) and microneedling (radiofrequency) in the treatment of atrophic acne scars

2019 ◽  
Vol 2 (2) ◽  
pp. 118-122
Author(s):  
Burooj Mohammed Razooqi Al-aajem ◽  
Khudhair Khalaf Alkayally ◽  
Aya Khudhair Khalaf Alkayally
Keyword(s):  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Poor Response ◽  
Surgical Excision ◽  
Response To Therapy ◽  
Inadequate Response ◽  
Acne Scars ◽  
Atrophic Scar ◽  
Chemical Peeling ◽  
Chronic Skin

Background: Acne Vulgaris is a self-limiting, chronic skin lesion, which may heal with squally of different types of scars (ice pitted, boxcar, rolling, and keloid). Different options used to deal with scars such as laser dermabrasion, surgical excision, and chemical peeling. This study aims to assess the safety and effectiveness of using a combination of radiofrequency (RF) microneedling and platelet-rich plasma (PRP) in managing the atrophic acne scars among a sample of Iraqi patients. Method: An interventional study conducted from January 2017 to December 2018 at a private dermatological clinic in Kalar City, Al-Sulaymmania Province, Iraq. Patients with the atrophic scar and willing to participate are adequately assessed and treated by RF and PRP. A different number of sessions of therapy used, and patients followed for three months after the last meeting. Results: Thirty-one patients were involved in the study. The majority of them (27, 87.0%) were females with a mean age of 26.41±8 years. Twenty patients (64.5%) had opened mouth (boxcar and rolling) scars, and eleven (35.5%) had ice pitted scars. Ten patients (32.25%) showed an excellent response to RF and PRP therapy with two grades improvement, fifteen patients (48.38%) showed good response with one-grade improvement and six patients (19.6%) showed poor response without improvement in grades, (all of them of ice pitted scars). There was a direct relationship between the number of sessions and the response to therapy. Three patients developed folliculitis at sits of puncturing with the isolation of staphylococcus auras bacteria, which cleared by topical and systemic antibiotics. Conclusions: Although ice pitted scars showed an inadequate response to therapy, however, the reaction of the boxcar and rolling scars to RF and PRP was excellent, indicating that combination procedure is a safe, efficient and satisfactory option for the treatment of atrophic acne scars.

scholarly journals EFFICACY OF FRACTIONAL CO2 LASER WITH TOPICAL PLATELET RICH PLASMA IN TREATMENT OF ACNE SCARS

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Kiran Puram ◽  
Rachana Laul ◽  
Anand Asia
Keyword(s):  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Tertiary Care ◽  
Acne Scar ◽  
Tertiary Care Centre ◽  
Self Assessment ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Quantitative Score

Background: Acne scars are most distressing sequelae of acne vulgaris having a major impact on psychosocial aspect and quality of life of an individual. In spite of various therapeutic modalities available treatment of acne scars is challenging. Resurfacing techniques such as Fractional Co2 Laser is a well-established treatment option for acne scar. Platelet-Rich Plasma (PRP), an autologous preparation of growth factors helps in wound healing and tissue regeneration. Aim: To study the efficacy of Fractional CO2 Laser with Topical Platelet-Rich Plasma in Acne scars. Materials and Methods: A total of 15 patients with atrophic facial acne scar, aged 18-40 years attending Outpatient Department of Dermatology, Venereology and Leprosy at tertiary care centre during January 2019 to December 2019 were included for this interventional study after written informed consent. The patients underwent six sessions of Fractional CO2 Laser with Topical application of Platelet-Rich Plasma at monthly intervals. Pre and post treatment comparative Goodman and Baron’s quantitative global scarring grading and patients self-assessment score were used for assessment. Results: At the end of study mild reduction in Goodman and Baron’s quantitative score for acne scar was noted in 13 patients (86.6%). Mean Goodman and Baron’s quantitative score att 4 weeks after sixth sitting was 13.13 ± 4.60. On patients self-assessment moderate resolution of acne scar was noted in 8 patients (53.3%). Conclusion: Fractional CO2 Laser with Topical Platelet-Rich Plasma application has mild to moderate improvement of acne scars and shorter down time of Fractional CO2 Laser. Keywords: Acne scar, Fractional Co2 Laser, Topical Platelet-Rich Plasma

scholarly journals The Efficacy of Autologous Nanofat Versus Enhanced Nanofat with Adipose-Derived Stem Cells Transfers in the Treatment of Atrophic Post Acne Scars

2020 ◽  
pp. 17-31
Author(s):  
Marwa Elsamongy ◽  
Hashem Ayad ◽  
Manal Eid ◽  
Shereen Gheida ◽  
Amany Abdel- Latif
Keyword(s):  
Stem Cells ◽  
Histopathological Examination ◽  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Cost Effective ◽  
Elastic Fibers ◽  
Adipose Derived Stem Cells ◽  
Acne Scars ◽  
Significant Difference ◽  
Group B

Background: Acne scarring is a visible reminder of acne vulgaris resulting from inappropriate healing of active lesions. Yet, no golden standard is present. Nanofat is an emulsified homogenous suspension of adipose tissue rich in adipose derived stem cells (ADSCs). Its application serves regenerative purposes. Objective: To evaluate efficacy of nanofat versus enhanced nanofat with adipose-derived stem cells transfer in treating atrophic acne scars. Methods and Materials: This study was carried on 40 patients with atrophic acne scars; grouped into two groups. Group A: 20 patients; treated with nanofat with platelet-rich plasma (PRP) and group B: 20 patients; treated with enhanced nanofat with ADSCs and PRP. Histopathological examination was done before and 6-months after treatment, specimens were stained by haematoxylin and eosin, Mallory trichrome and Verhoeff-Van Gieson. Results: In both groups; 70% showed excellent and very good improvement and patients’ satisfaction was 60% for both groups. Histopathological examination revealed increase in epidermal thickness, formation of new collagen and elastic fibers without significant difference between both groups. Conclusion: Nanofat transfer is easy, cost-effective, and safe for treating acne scars, compared to enhanced nanofat with ADSCs transfer which is costly and time consuming

scholarly journals Effectiveness of Injection of Trigger Points with Platelet Rich Plasma as A Pain Management Method in Rotator Cuff Syndrome: إدارة الآلام المزمنة في متلازمة الكفة المدورة بواسطة زرق نقاط التوتر بالبلازما الغنية بالصفائح الدموية

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Hayder Ghali Algawwam, Abdullah Ahmed Mohammad
Keyword(s):  
Chronic Pain ◽  
Pain Management ◽  
Rotator Cuff ◽  
Platelet Rich Plasma ◽  
Poor Response ◽  
Trigger Points ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Significant Difference ◽  
Management Method

Objective The aim of the current study is to evaluate the effectiveness of the injection of trigger points with platelet-rich plasma as a pain management method in chronic pain resulting from rotator cuff syndrome. Methodology A retrospective study was designed for the period from August 1, 2016, until July 31, 2019, 36 patients (21 females and 15 males) visited our private clinic in Kirkuk, Iraq because of chronic shoulder pain, they received trigger points PRP injections. The PRP was prepared by centrifuging the patient's own blood. The response to therapy was graded: excellent, good, fair and poor. Results The mean age was 52.3± 1.9 years. Most of the patients (n: 33, 92%) had either overweight or obesity and (n: 16, 44.6%) had hypertension either alone or in combination with diabetes mellitus. Most of the patients (n: 30, 83.3%) received three sessions while (n: 6, 16.7%) received one session of PRP injections. Most of the patients (n: 28, 77.8%) yielded either good or excellent response to treatment, while (n: 8, 22.2%) from the patient had an either fair or poor response to treatment, there was a statistically significant difference (p˂0.01) between the 2 groups. Conclusion PRP injections of trigger points in patients complaining from chronic pain as a result of rotator cuff syndrome seem to be an effective, safe and cheap pain management method.

scholarly journals Fractional erbium-YAG laser vs platelet rich plasma in acne scar: a comparative study

2021 ◽  
Vol 7 (2) ◽  
pp. 223
Author(s):  
Neeti Kumari ◽  
Arun Kumar ◽  
Jitendra S. Bist ◽  
Anil K. Mehta
Keyword(s):  
Yttrium Aluminum Garnet ◽  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Treatment Session ◽  
Treatment Modalities ◽  
Acne Scar ◽  
Yag Laser ◽  
Multiple Treatment ◽  
Acne Scars ◽  
Moderate Response

<p><strong>Background</strong>: Facial acne scar is a common complication of acne vulgaris leading to social isolation, lack of self-confidence and depression that warrants multiple treatment approach. In recent years, fractional erbium-yttrium aluminum garnet (er-YAG) 2940 nm laser and platelet-rich plasma (PRP) have been used independently or in combination with other resurfacing modalities in treating acne scars with variable outcomes.  The objective of this study is to compare the therapeutic responses and safety of fractional erbium-YAG 2940 nm laser and platelet-rich plasma in atrophic post acne scars.</p><p><strong>Methods</strong>: Patients were randomly divided into two groups (30 each), receiving six sittings of fractional er-YAG laser and PRP every month. Response was evaluated 4 weeks after each treatment session using Goodman and Baron qualitative acne scar grading system, photographic assessment by 2 blinded dermatologist and patients own satisfaction.</p><p><strong>Results</strong>: Both treatment modalities showed improvement of acne scars, but the improvement with fractional er-YAG laser (27% marked and 70% moderate response) treatment was higher in comparison to PRP (10% marked and 67% moderate response) in terms of acne scar grade severity (p=0.33). Similar results were obtained on photographic assessment (p=0.015 and 0.021), and patient’s own satisfaction (p=0.011), respectively. Pain and stinging score were lower in er-YAG group while down time for same was shorter in PRP.</p><p><strong>Conclusions</strong>: Both er-YAG laser and PRP showed significant improvement in atrophic acne scar while former showing slightly superior response with lesser adverse effects.</p>

scholarly journals Bleomycin: A worthy alternative

2011 ◽  
Vol 44 (01) ◽  
pp. 050-053
Author(s):  
Gursev Sandlas ◽  
Paras Kothari ◽  
Parag Karkera ◽  
Abhaya Gupta
Keyword(s):  
Poor Response ◽  
Surgical Excision ◽  
Response To Therapy ◽  
Long Term Effects ◽  
Lymphatic Malformations ◽  
Long Term Follow Up ◽  
Nonrandomized Trial ◽  
Total Disappearance

ABSTRACT Context: Lymphangiomas are developmental anomalies presenting mainly in the first two years of life. Surgical excision has been the mainstay of treatment; however a potentially disfiguring surgery along with presence of important structures in the vicinity and infiltration into surrounding structures makes the dissection difficult. Aims: To study the safety and efficacy of Bleomycin as a sclerosing agent for lymphatic malformations in children. Settings and Design: Prospective non comparative nonrandomized trial. Materials and Methods: The study was carried out in 15 children between Day 5 of life to 12 years of age who presented between May2008 to May 2009. Bleomycin aqueous solution was injected intralesionally at a dose not exceeding 0.6 to 0.8 mg. /kg Body wt. The response to therapy was monitored clinically by measuring the length, breadth and area as well as by measuring the two largest perpendicular dimensions. The response was graded as excellent [total disappearance], good [>50% reduction] and poor [<50% decrease]. Those patients with diffuse lymphangiomas associated predominantly with hemangiomatous malformations, mediastinal, spinal or retroperitoneal extensions, visceral lymphangiomas, those with infections were excluded from the study. Statistical analysis used: None applicable. Results: The reduction in the size of the mass usually took between two weeks to ten months. The average duration of follow up has been ten months. A significant response was seen in 8 out of the fifteen [53.33%] patients. 5 patients [33.33%] patients showed a good response to therapy and achieved >50% reduction in the size of their swellings. 2 patients [13.33%] showed a poor response to therapy and achieved less than 50% reduction in the size of the swelling. Complications of the therapy were few and far between. 2 patients developed fever after injection, one patients reported a transient increase in size of swelling, 2 patients have developed discoloration of the overlying skin and are currently being followed up for final outcome. None of the patients developed leucopenia or leukocytosis. All of the complications were managed with conservatively. Patients are on long term follow up to evaluate long term effects, if any.

scholarly journals Management of Acne Scars with Platelet-Rich-Plasma (PRP) Therapy as a Tvaka Rasayanam

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Tissue Repair ◽  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Acne Scar ◽  
Tissue Remodelling ◽  
Exclusion Criteria ◽  
Double Spin ◽  
Acne Scars ◽  
Scar Management

Introduction: Acne vulgaris can lead to lifelong sequel in the form of atrophic or hypertrophic scars, depending on the degree of inflammation. Acne scar management remains a challenge to dermatologists. Platelet rich plasma (PRP), in which the platelets are in a highly concentrated form, has shown its effect in accelerating tissue repair and wound healing. The platelet releases a variety of growth factors which bring about tissue remodelling. Aim: To study the efficacy and safety of PRP in managing acne vulgaris as tvak rasayanam at Skin Care Unit, R.G.G.P.G. Ayurvedic College, Paprola, Kangra (H.P). Materials and Methods: Based on inclusion and exclusion criteria twenty patients were included in the study. PRP was made by double spin method. The area to be treated was cleaned with spirit and betadine, the skin was stretched and activated PRP loaded in an insulin syringe was injected into and around the scars by multiple punctures. Results: Out of 20 patients, 20% patients (4) showed marked improvement in the grading of acne scars, i.e. They improved up to grade 1 or there was an improvement by 2 grades. 50% patients (10) showed moderate improvement. In these patients grading of acne scars improved by 1. In 15% patients (3) although the grading did not changed but there was visible improvement in the appearance of the scars. In only 15% patients (3), here was no significant improvement was seen even after 4 sittings but texture of skin is mildly improved. Conclusion: Platelet- Rich-Plasma (PRP) therapy is easy to perform. Done as an outpatient procedure. It doesn’t hamper the daily activities quality of the patient. It works well for superficial acne scars, providing good results with minimal side effects like erythema and edema which subside within 2-4 hrs. PRP is thus an effective modality for treating acne scars.

Efficacy and safety of oral dapsone in acne vulgaris – experience of a tertiary care teaching hospital in central Lahore

2020 ◽  
Vol 14 (2) ◽  
pp. 87-90
Author(s):  
Sadaf Amin Chaudhry ◽  
Nadia Ali Zafar ◽  
Rabia Hayat ◽  
Ayesha Noreen ◽  
Gulnaz Ali ◽  
...  
Keyword(s):  
Side Effects ◽  
Therapeutic Option ◽  
Acne Vulgaris ◽  
Treatment Options ◽  
Tertiary Care ◽  
Poor Response ◽  
Global Assessment Scale ◽  
Severe Acne ◽  
Hematologic Profile

Background: Acne is the eighth most prevalent disease affecting 9.4% of the population worldwide and its prevalence in our country is estimated to be around 5%. Severe inflammatory acne is most likely to leave scars and in order to prevent facial disfigurement due to acne scarring, early treatment is desirable. Various treatment options have been formulated for acne, and are tailored according to the severity of the disease. Numerous clinical trials have been conducted till now, to determine the usefulness and side effect profile of such therapies, making acne treatment a highly studied area in dermatology. Objective of this study is to highlight the fact that oral Dapsone could be used as a cheaper alternate to isotretinoin in recalcitrant severe acne, especially in females where retinoids are sometimes contraindicated. Patients and methods: 51 patients, suffering from severe nodulocystic acne, fulfilling the criteria, were enrolled from the Department of Dermatology, Sir Ganga Ram Hospital, Lahore. All the study patients were given oral Dapsone 50mg for initial two weeks and then 100mg daily for the next 10 weeks along with oral cimetidine and topical clindamycin application twice daily. Investigator Global Assessment Scale (IGAS) was employed to measure effectiveness. The treatment was considered ʽeffectiveʹ if the patient achieves 2 or more than 2-grade improvement or almost clear or clear skin at the end of 12 weeks according to IGAS scale. The lesion counts were also done before the start of therapy (day 1) and at every two weeks follow up for 12 weeks. The change in lesion count observed between the baseline number and that seen at follow up visits was also used to evaluate the effectiveness of oral Dapsone. Safety was analyzed by fortnightly visits of the patients to look for any undesirable side effects and monitoring of the hematologic profile of the patients. Final follow up was done at the end of 16 weeks. Results: The study was conducted on 51 patients, with a ratio of 1:3 for males and females and a mean age of 25.2 years (SD ±5.81). At 12th week, patients had significant reduction in their acne lesions; with 7 patients (13.7%) showing completely clear skin, 17 patients (33.3%) had almost clear skin, 5 patients (9.8%) had 3-grade improvement. Twelve patients (23.5%) had 2-grade improvement from baseline score and only 2 patients (3.9%) had 1-grade improvement from baseline. Based on percentage reduction of lesions, excellent response was seen in 32 patients (62.7%), good response in 9 patients (17.6%), moderate response in 2 patients (3.9%), while no patient showed poor response. Dapsone was discontinued in 8 patients due to derangement of hematologic profile. Conclusion: Oral Dapsone, when given carefully, is a very effective therapeutic option in severe recalcitrant acne, with limited side effects.

Sidharthakadi Lepa in Mukhadushika - A Clinical Study

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Ravindra Angadi ◽  
Rekha J.
Keyword(s):  
Skin Disorder ◽  
Acne Vulgaris ◽  
Response To Therapy ◽  
Inclusion Criteria ◽  
Pilosebaceous Unit ◽  
External Application ◽  
Acne Lesion ◽  
Common Skin ◽  
The Face ◽  
Inflammatory Component

Background: Acne vulgaris is a very common malady of adolescents. It is common enough to be called as a physiological process but is better regarded as a disease due to its inflammatory component and the disfigurement. Acne vulgaris is a common skin disorder of pilosebaceous unit that primarily affects the face which if not treated leads to pigmentation. Mukhadushika is a Kshudra Roga which mainly involves Kapha and Vatadosa with Raktha. This is a common illness affecting 80 % of adolescents. Lepa is one of the external therapies explained in Ayurvedic classics. Objectives: To evaluate the efficacy of Sidharthakadilepa in the management of mukhadushikaw.s.r. to acne vulgaris. Methods: 30 patients fulfilling the inclusion criteria were selected. They were given Sidharthakadi Lepa for external application over face for one month. Patients were observed for changes on 7th, 14th, 21st and 28th day. The response to therapy was evaluated at the end of 28 days by calculating acne lesion score and the efficacy was determined by the percentage reduction in ALS. Results: The analysis revealed that 40% of patients had complete remission, 30% patients showed marked improvement and 30% showed moderate improvement.

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

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