scholarly journals A Review on the Neuroendocrine Regulation of the Endothelial Cells

2021 ◽  
pp. 1-4
Author(s):  
Paolo Lissoni ◽  
◽  
Franco Rovelli ◽  
Giusy Messina ◽  
◽  
...  
Keyword(s):  
Neuroendocrine System ◽  
Neuroendocrine Regulation ◽  
Common Mechanism ◽  
Systemic Diseases ◽  
Cytokine Network ◽  
Pathological Conditions ◽  
Inflammatory Processes ◽  
The Common ◽  
Endothelial Functions ◽  
Inflammatory Action

Today, it is known that inflammation represents the common mechanism of human systemic diseases, including cancer and autoimmunity. Obviously, the endothelial system is involved in all inflammatory processes. Then, the control of the endothelial functions could constitute a new medical strategy to treat several pathological conditions, including ischemic and thrombotic events. Moreover, in addition to the action of angiogenic and anti-angiogenic factors, the endothelial system has been proven to be physiologically under a double control, represent by the cytokine network and the neuroendocrine system. Most cytokines have appeared to exert angiogenic and inflammatory effects, which are balanced by an anti-angiogenic and an anti-inflammatory action exerted by the pineal hormone melatonin (MLT), cannabinoid agents, and the product of ACE2, the angiotensin 1-7 (Ang 1-7). Then, a neuroendocrine approach with MLT, cannabinoids and Ang 1-7 could constitute a new way in the treatment of endothelial alterations and angiogenesis.

scholarly journals A Review on the Neuroendocrine Regulation of the Endothelial Cells

2020 ◽  
pp. 1-4
Author(s):  
Paolo Lissoni ◽  
◽  
Franco Rovelli ◽  
Keyword(s):  
Neuroendocrine System ◽  
Neuroendocrine Regulation ◽  
Common Mechanism ◽  
Systemic Diseases ◽  
Cytokine Network ◽  
Pathological Conditions ◽  
Inflammatory Processes ◽  
The Common ◽  
Endothelial Functions ◽  
Inflammatory Action

Today, it is known that inflammation represents the common mechanism of human systemic diseases, including cancer and autoimmunity. Obviously, the endothelial system is involved in all inflammatory processes. Then, the control of the endothelial functions could constitute a new medical strategy to treat several pathological conditions, including ischemic and thrombotic events. Moreover, in addition to the action of angiogenic and anti-angiogenic factors, the endothelial system has been proven to be physiologically under a double control, represent by the cytokine network and the neuroendocrine system. Most cytokines have appeared to exert angiogenic and inflammatory effects, which are balanced by an anti-angiogenic and an anti-inflammatory action exerted by the pineal hormone melatonin (MLT), cannabinoid agents, and the product of ACE2, the angiotensin 1-7 (Ang 1-7). Then, a neuroendocrine approach with MLT, cannabinoids and Ang 1-7 could constitute a new way in the treatment of endothelial alterations and angiogenesis.

scholarly journals The Occurrence of Tongue Lesions among Dental Outpatients Attending Khanzad Dental Polyclinics Center in Erbil City

2020 ◽  
Vol 19 (2) ◽  
pp. 41-51
Author(s):  
Rawa hameed Mirkhan Abdulla ◽  
◽  
Ali Fakhree Alzubaidee
Keyword(s):  
Risk Factors ◽  
Allergic Reactions ◽  
Systemic Diseases ◽  
Pathological Conditions ◽  
Wide Range ◽  
History Of ◽  
Common Risk Factors ◽  
The Common ◽  
Age Range ◽  
Fissured Tongue

Background: The tongue can be targeted by a wide range of pathological conditions; the recognition of tongue lesions may be helpful in the early diagnosis of some systemic disorders. Objective: To determine the frequency and relation of the tongue conditions with risk factors among a group of dental outpatients attending a specialized dental polyclinics center in Erbil city, for individuals who are aware of their tongue lesion when to exist, and to estimate the possible coincidence between some of the tongue lesions with age, gender, smoking, alcohol drinking habit, allergic reactions, and systemic diseases. Patients and Methods: 1100 patients were examined for a period of 3 months from October 1st , 2019 – December 31st , 2019. Results: The frequency of tongue conditions was 52.8%, the study sample consists of 520 males 47.3%, and 580 females 52.7%. The age range was from 0.58 to 85 years, and 112 patients had one or more systemic diseases 92 of them were on regular medications. The most common frequent condition was fissured tongue diagnosed in 420 patients 38.2%. Conclusion: The common risk factors for tongue conditions in this study were old age, male gender, smoking, alcohol consumption, and medication intake, around one quarter (25.6%) of the sample has a family history of tongue condition. Keywords: Tongue conditions, fissured tongue, clinical study, coated tongue

STUDY OF PEDIATRIC INJURIES: PATTERNS AND OUTCOME

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Yasir. B. Elshambaty
Keyword(s):  
School Level ◽  
Common Mechanism ◽  
Injury Patterns ◽  
Severe Injuries ◽  
Injured Child ◽  
Cross Sectional ◽  
Pediatric Injuries ◽  
Pediatric Injury ◽  
The Common ◽  
Structured Questionnaire

Purpose this study aims to show the patterns and outcome of pediatric injury among those living in Albaha region in Saudi Arabia Methods this is a cross-sectional descriptive household-based study, included children between 0-17 years old both male and female. The data were collected with structured questionnaire between 20 Nov – 20 Dec 2018 and  analyzed with SPSS version 25 Results the total of participants was 257 injured child. 199(77.4%) are male and 58(22.6%) are female. About 44%of them were injured at pre-school level and 56% were traumatized at school age. The least incidence of injury occurred in those less than 2 yrs and higher incidence in those between 3-10 yrs old. The most common mechanism of injury was falling from height. The most affected group age by RTA accidents was 11-17 yrs old. Approximately 83% of the injured children required hospital management. Only one third of the injuries were  associated complications. The most common injured anatomic part was the upper limb and the least affected part was the spine. Only 5% of the injuries were associated with a disability and the common was loss of organ or part of it. Paralysis occurred in less than 1% and head injury resulted in disabilities more than 1%. Conclusion the vast majority of the injuries in our participants are not serious. The severe injuries were associated with RTA-related trauma. Most of injuries due to falling from height are not serious. We recommend not to allow the children to drive cars. Keywords: pediatric injuries; injury patterns; household.

scholarly journals Roles of Microglial Ion Channel in Neurodegenerative Diseases

2021 ◽  
Vol 10 (6) ◽  
pp. 1239
Author(s):  
Alexandru Cojocaru ◽  
Emilia Burada ◽  
Adrian-Tudor Bălșeanu ◽  
Alexandru-Florian Deftu ◽  
Bogdan Cătălin ◽  
...  
Keyword(s):  
Ion Channels ◽  
Neurodegenerative Diseases ◽  
Excitable Cells ◽  
Proton Channels ◽  
Voltage Gated ◽  
Cellular Processes ◽  
Pathological Conditions ◽  
The Common ◽  
Transient Receptor ◽  
The Impact

As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases.

scholarly journals Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage

Atmosphere ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 116
Author(s):  
Mascia Benedusi ◽  
Elena Frigato ◽  
Cristiano Bertolucci ◽  
Giuseppe Valacchi
Keyword(s):  
Cardiovascular Diseases ◽  
Air Pollutants ◽  
Environmental Stressors ◽  
Common Mechanism ◽  
Particulate Matters ◽  
Circadian Misalignment ◽  
Pathological Conditions ◽  
Peripheral Clocks ◽  
Living Organisms ◽  
Almost All

Circadian rhythms are 24-h oscillations driven by a hypothalamic master oscillator that entrains peripheral clocks in almost all cells, tissues and organs. Circadian misalignment, triggered by industrialization and modern lifestyles, has been linked to several pathological conditions, with possible impairment of the quality or even the very existence of life. Living organisms are continuously exposed to air pollutants, and among them, ozone or particulate matters (PMs) are considered to be among the most toxic to human health. In particular, exposure to environmental stressors may result not only in pulmonary and cardiovascular diseases, but, as it has been demonstrated in the last two decades, the skin can also be affected by pollution. In this context, we hypothesize that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and we suggest a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions.

scholarly journals Evidence for biological shaping of hair ice

2015 ◽  
Vol 12 (14) ◽  
pp. 4261-4273 ◽  
Author(s):  
D. Hofmann ◽  
G. Preuss ◽  
C. Mätzler
Keyword(s):  
Organic Matter ◽  
Dead Wood ◽  
Complex Mixture ◽  
Fulvic Acids ◽  
Common Mechanism ◽  
Ice Growth ◽  
Physical Chemical ◽  
Broad Leaf ◽  
The Common

Abstract. An unusual ice type, called hair ice, grows on the surface of dead wood of broad-leaf trees at temperatures slightly below 0 °C. We describe this phenomenon and present physical, chemical, and biological investigations to gain insight in the properties and processes related to hair ice. Tests revealed that the biological activity of a winter-active fungus is required in the wood for enabling the growth of hair ice. We confirmed the fungus hypothesis originally suggested by Wegener (1918) by reproducing hair ice on wood samples. Treatment by heat and fungicide suppresses the formation of hair ice. Fruiting bodies of Asco- and Basidiomycota are identified on hair-ice-carrying wood. One species, Exidiopsis effusa (Ee), was present on all investigated samples. Both hair-ice-producing wood samples and those with killed fungus show essentially the same temperature variation, indicating that the heat produced by fungal metabolism is very small, that the freezing rate is not influenced by the fungus activity, and that ice segregation is the common mechanism of ice growth on the wood surface. The fungus plays the role of shaping the ice hairs and preventing them from recrystallisation. Melted hair ice indicates the presence of organic matter. Chemical analyses show a complex mixture of several thousand CHO(N,S) compounds similar to fulvic acids in dissolved organic matter (DOM). The evaluation reveals decomposed lignin as being the main constituent. Further work is needed to clarify its role in hair-ice growth and to identify the recrystallisation inhibitor.

scholarly journals A Review on the Neuroendocrine Regulation of Cytokine Secretion: Possible Modulation of the Cytokine Network by the Pineal Hormone Melatonin and Cannabidiol

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Paolo Lissoni ◽  
Franco Rovelli ◽  
Giusy Messina ◽  
Alejandra Monzon ◽  
Sonja Pensato ◽  
...  
Keyword(s):  
Cytokine Secretion ◽  
Neuroendocrine Regulation ◽  
Cytokine Network

scholarly journals PHYTONCIDES IN THE COMPOSITION OF COMMON BIRD CHERRY

2021 ◽  
Vol 447 (3) ◽  
pp. 70-75
Author(s):  
P.N. Naguman ◽  
A.A. Zhorabek ◽  
A.S. Amanzholova ◽  
I.V. Kulakov ◽  
A.N. Rakhimbaeva
Keyword(s):  
Plant Protection ◽  
Folk Medicine ◽  
Antimicrobial Properties ◽  
Biologically Active ◽  
Natural Immunity ◽  
Prussic Acid ◽  
Destructive Effect ◽  
Inflammatory Processes ◽  
The Common ◽  
Anti Inflammatory

Everyone knows that forest air is very good for health, and one of the most important reasons for this is the presence of phytoncides in it, which kill or suppress pathogens and have a healing effect. Also, phytoncides are one of the factors of the natural immunity of plants (plants sterilize themselves with the products of their vital activity). Their large number is allocated by plants. One of them is the common bird cherry. Cherry-a representative of the genus of plums of the Rosaceae family. The view includes low trees and shrubs. Cheremukha-forest orderly. Its flowers and leaves are rich in phytoncides, thanks to which they exude an alluring aroma. However, when they break down, they release prussic acid, which is dangerous for all living things. This gave them the opportunity to attract and destroy pests. Phytoncides are volatile biologically active substances formed by plants that kill or inhibit the growth and development of bacteria, microscopic fungi, and protozoa. In addition to all of the above, bird cherry has exceptional properties. The strong, somewhat intoxicating scent of flowers and leaves cleanses the air of germs. Antimicrobial properties of phytoncides have led to a large number of studies on their use in medicine, veterinary medicine, plant protection, storage of fruit and vegetable products, in the food industry and other areas of practice. Almost all parts of the plant have bactericidal, fungicidal and insecticidal properties. In folk medicine, bird cherry has long been used as an astringent, fixing, anti-inflammatory and anti-scurvy agent. Bird cherry produces the most powerful phytoncides containing prussic acid. Protozoa die under the influence of bird cherry phytoncides in 5 minutes. On the basis of numerous studies, the time of death of protozoa after noncontact exposure to phytoncidal plants has been established. Especially a lot of phytoncides are released by young leaves in spring and summer, in autumn phytoncides are released much less. The presence of tannins and essential oil in the fruit has an anti-inflammatory effect, which is used to treat inflammatory processes in the gastrointestinal tract and dysentery. The infusion of cherry fruits has a destructive effect on microorganisms. Preparations of the fruits of the common cherry have an antiseptic effect. They are used in dental practice in the treatment of inflammatory processes of the oral mucosa, paradontosis, toothache and hypovitaminosis.

scholarly journals Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Yong Tan ◽  
Qiu Qi ◽  
Cheng Lu ◽  
Xuyan Niu ◽  
Yanping Bai ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Molecular Mechanism ◽  
Mononuclear Cells ◽  
Mitogen Activated Protein Kinase ◽  
Common Mechanism ◽  
New Paradigm ◽  
Peripheral Blood Mononuclear ◽  
The Common ◽  
Common Pathogenesis ◽  
Cytokine Imbalance

Psoriasis (PS) and rheumatoid arthritis (RA) are immune-mediated inflammatory diseases. Previous studies showed that these two diseases had a common pathogenesis, but the precise molecular mechanism remains unclear. In this study, RNA sequencing of peripheral blood mononuclear cells was employed to explore both the differentially expressed genes (DEGs) of 10 PS and 10 RA patients compared with those of 10 healthy volunteers and the shared DEGs between these two diseases. Bioinformatics network analysis was used to reveal the connections among the shared DEGs and the corresponding molecular mechanism. In total, 120 and 212 DEGs were identified in PS and RA, respectively, and 31 shared DEGs were identified. Bioinformatics analysis indicated that the cytokine imbalance relevant to key molecules (such as extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF), colony-stimulating factor 3 (CSF3), interleukin- (IL-) 6, and interferon gene (IFNG)) and canonical signaling pathways (such as the complement system, antigen presentation, macropinocytosis signaling, nuclear factor-kappa B (NF-κB) signaling, and IL-17 signaling) was responsible for the common comprehensive mechanism of PS and RA. Our findings provide a better understanding of the pathogenesis of PS and RA, suggesting potential strategies for treating and preventing both diseases. This study may also provide a new paradigm for illuminating the common pathogenesis of different diseases.

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