INVESTIGATION OF THE COMPOSITION OF THE ORGANIC AND MINERAL PARTS OF SOLID WASTE FROM THE PRODUCTION OF HUMIC PREPARATIONS

2021 ◽  
pp. 187-197
Author(s):  
Ivan I Lishtvan ◽  
Galina V. Naumova ◽  
Nadezhda A. Zhmakova ◽  
Natalyia L. Makarova ◽  
Tatiyana F. Ovchinnikova ◽  
...  
Keyword(s):  
Solid Waste ◽  
Humic Substances ◽  
Solid Phase ◽  
Fish Farming ◽  
Component Composition ◽  
Biologically Active ◽  
Base Hydrolysis ◽  
Natural Food ◽  
Waste Products ◽  
Wide Range

The composition of the organic and mineral parts of solid residues from the production of humic preparations Hydrohumate, Oxyhumate, peat oxidate and Consil was studied. Significant differences in the component composition of these wastes, depending on the technologies for obtaining drugs, have been established. Redox-hydrolytic processing of peat leads to almost complete (acid-base hydrolysis) or partial (oxidation) destruction of hemicelluloses and the relative accumulation of cellulose and "lignin" in solid waste. The organic parts of the residues contain up to 30 % humic substances, due to the fact that the technologies for the production of humic preparations do not provide for the stage of washing the residues after separation in a centrifuge and some of the humic preparations remain in the solid phase. It is shown that the mineral part of solid residues includes a wide range of biogenic macro-and microelements, since humates of monovalent metals pass into solution, and salts of humic substances with metals of higher valence are insoluble and remain in the solid residue from hydrolysis or oxidation of peat. The study of the chemical composition of solid residues from the production of humic preparations showed possible directions for their effective disposal. Waste products are humate-containing products with a wide range of biogenic macro-and microelements, so they can be effectively used as biologically active additives to soils, compost, fertilizers, as well as in pond fish farming to stimulate the development of components of the natural food base of fish and increase the fish productivity of reservoirs.

Efficiency of using bioflavonoids in production feeds for promising aquaculture facilities

2020 ◽  
pp. 46-54
Author(s):  
S. V. Ponomarev ◽  
Y. V. Fedorovykh ◽  
A. B. Akhmedzhanova ◽  
O. A. Levina ◽  
V. A. Pospelov ◽  
...  
Keyword(s):  
Growth Rate ◽  
Physiological State ◽  
Fish Farming ◽  
Feed Additives ◽  
Biologically Active ◽  
Planting Density ◽  
Natural Food ◽  
Negative Consequences ◽  
Artificial Ecosystem ◽  
Aquaculture Facilities

Modern technologies of industrial fish farming allow getting high-quality products. However, stressful conditions of an artificial ecosystem (high planting density, violation of optimal hydrochemical conditions) can negatively affect food activity, growth rate, lead to the development of alimentary diseases and depletion of the antioxidant potential In conditions when fish is deprived of natural food, and the metabolism is completely under human control, the use of balanced feeds enriched with macro — and microelements, as well as biologically active substances, maximizes metabolic processes and helps to increase the growth rate and obtain physiologically complete juveniles. The use of antioxidant feed additives allows not only to carry out timely therapy, but also to provide a preventive effect to prevent the negative consequences of an artificial ecosystem. Currently, there are a number of antioxidant feed additives, among which are of particular interest to natural bioantioxidant of flavonoid nature, such as catechins, dihydrochalcones, flavonols, leukocyanins, dihydroquercetin. The article discusses the experience of using a new generation antioxidant — dihydroquercetin and an immunostimulator — arabinogalactan in feeding a tilapia hybrid (Oreochromis mossambicus × Oreochromis niloticus). It was found that the addition of dihydroquercetin (25,0– 50,0 mg/kg) and arabinogalactan (50,0 mg/kg) to the production feed allowed to increase productivity by 26,0%, as well as to show a positive effect on the physiological state of fish. The results obtained complement the existing ideas about the fields of application of antioxidants, and also prove the prospects of using plant-based products as antioxidant feed additives.

Hetero-Diels-Alder Reactions in the Synthesis of Biologically Active Nitrogen Compounds: A Review

2018 ◽  
Vol 15 (1) ◽  
pp. 84-104 ◽  
Author(s):  
Andre F. Constantino ◽  
Carla S. Francisco ◽  
Diana C. Cubides-Roman ◽  
Valdemar Lacerda
Keyword(s):  
Organic Chemistry ◽  
Solid Phase ◽  
Biological Properties ◽  
Alder Reaction ◽  
Diels Alder ◽  
Biologically Active ◽  
Nitrogen Compounds ◽  
Active Nitrogen ◽  
Polycyclic Compounds ◽  
Wide Range

Background: The Hetero-Diels-Alder reaction (HDAR) is a method extensively used in organic chemistry as a tool in the synthesis of innumerous polycyclic compounds in particular nitrogen compounds, presents in many natural products, medicinally relevant substances and organic materials. The literature describes innumerable studies of HDAR using classic methods and modern developments such as reactions on the solid phase, the use of catalysts, transformations in aqueous solution and under microwaves. Objective: This review describes a variety of HDAR focused on obtaining nitrogen-containing compounds of considerable chemical and biological interest, and highlighting reported biological activity. Conclusion: This review has shown the importance of the HDA reaction as a tool of organic chemistry in the synthesis of nitrogen compounds. This type of reaction presents important properties including bond-forming economy, high regio- and stereoselectivities and thus provides highly efficient routes to access a wide range of polycyclic compounds. In addition to the variety of nitrogen compounds synthetized successfully by this method, they present relevant biological properties.

scholarly journals Secondary Metabolites-Derived Polymers: A Potential Approach to Diminish Microbial Infection

2018 ◽  
Author(s):  
Ahmed Al-Jumaili ◽  
Avishek Kumar ◽  
Kateryna Bazaka ◽  
Mohan V. Jacob
Keyword(s):  
Renewable Resources ◽  
Solid Phase ◽  
Biologically Active ◽  
Fungal Colonization ◽  
Attractive Alternative ◽  
Microbial Infection ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Wide Range ◽  
Secondary Plant

The persistent issue of bacterial and fungal colonization of artificial implantable materials and decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. This article reviews one such strategy where inherently biologically active renewable resources, i.e. secondary plant metabolites (SPMs) and their naturally occurring combinations (i.e. essential oils) are used for surface functionalization and synthesis of polymer thin films. With a distinct mode of antibacterial activity, broad spectrum of action and diversity of available chemistries, secondary plant metabolites present an attractive alternative to conventional antibiotics. However, their conversion from liquid to solid phase without significant loss of activity is not trivial. Using select examples, this article shows how plasma techniques provide a sufficiently flexible and chemically reactive environment to enable the synthesis of biologically-active polymer-coatings from volatile renewable resources.

Molecular composition - inhibition activity relationships for humic substances narrow fractions sets obtained by solid-phase extraction

2021 ◽  
Keyword(s):  
High Resolution ◽  
Solid Phase Extraction ◽  
Humic Substances ◽  
Inhibitory Activity ◽  
Solid Phase ◽  
Molecular Composition ◽  
Biologically Active ◽  
Molecular Heterogeneity ◽  
Phase Extraction ◽  
Molecular Components

Humic substances (HS) have a wide spectrum of biological activity including inhibitory activity against β-lactamases.1 The latter are capable of hydrolyzing beta-lactam antibiotics and represent one of the main pathways of bacterial antibiotic resistance. HS are characterized by low toxicity and good solubility in water. A use of HS for therapeutic purposes is hindered by extreme molecular heterogeneity and high level of isomeric complexity. Solid-phase extraction (SPE) fractionation in combination with ultra-high resolution mass spectrometry (FTICR MS) is a promising method to simplify this molecular system and isolate the most active components of HS. The aim of this work was to test various SPE fractionation schemes as an approach to directed isolation of the components with the given activity from HS. The sample of coal humic acids (CHA-G) was isolated from the commercial sodium humate “Genesis” and separated using SPE cartridge according to gradients in polarity1 and acidity2 inherent within the molecular components of HS. Inhibitory activity against β- lactamase TEM-1 and its mutants was measured using chromogenic substrate CENTA. Molecular composition of fractions was determined using FTICR mass spectrometer 15 T solariX (Bruker Daltonics) located at the Collective Use Center of Zelinsky Institute of Organic Chemistry of RAS. Molecular assignments were plotted into van Krevelen diagrams. The diagrams were binned into 20 cells are assigned to seven chemotypes, and occupational densities for each chemotype were calculated after Perminova.3 For the fractions separated by polarity, a substantial difference in the molecular composition was observed. Inhibitory activity grew along with an increase in hydrophobicity. The HS activity increased along with an increase in contribution of condensed tannins and phenylisopropanoids (O/C <0.5, H/C <1.4) and decreased along with contribution of hydrolyzed tannins (O/C> 0.5, H/C <1.4). The similar analysis was conducted for the fractions separated with regard to pKa value of the dominating functional groups. The most isomeric complex molecular components were defined, which can be found in different HS fractions, but they are identical in elemental composition. The data obtained make it possible to choose the most efficient fractionation method that effectively lowers the molecular complexity of HS and makes it possible to isolate the most active HS fractions. SPE-fractionation in combination with 2D chromatography is going to be used in our future studies to achieve high resolution separation and more reliable “molecular composition-activity” relationships. Further research might bring substantial advance in the field of directed design of biologically active humic-based materials and compositions. Acknowledgements. This work was supported by the grant of the Russian Science Foundation no 21-73-20202. The center of collective use of the Zelinsky IOC RAS is appreciated. The research was conducted in the framework of the Scientific-Educational School of the Lomonosov MSU “Future of the plant and global environmental change”. References 1. Mikhnevich et al., ACS Omega, 2021, https://doi.org/10.1021/acsomega.1c02841 2. Zherebker et al., Environ. Sci. Technol. 2020, 54, 2667−2677 3. Perminova, I. V. PAC, 2019, 91(5), 851

scholarly journals Influence of a Feed Additive in the Carp Diet on its Exterior Parameters

2021 ◽  
Author(s):  
Roman Rudenko ◽  
Irina Tkacheva ◽  
Vyacheslav Karatunov ◽  
Arthur Tazayan
Keyword(s):  
Aquatic Organisms ◽  
Fish Farming ◽  
Essential Amino Acids ◽  
Biologically Active ◽  
Adaptive Plasticity ◽  
Feed Additive ◽  
Fish Nutrition ◽  
Natural Food ◽  
Active Components ◽  
Farmed Fish

During fish farming, significant attention should be paid not only to the quantity, but also to the quality of marketable carp, primarily its physiological condition and high adaptive plasticity. Recently, increasing importance is attached to fish farming by industrial methods using various types of feed. A characteristic feature is the almost complete absence of natural food organisms. Significant success has been achieved in the creation of various starter compound feeds that can replace live feed when the larvae switch to exogenous nutrition [1]. During the development of artificial rations, attention was paid to the balance of basic structural elements of nutrition and, to a lesser extent, to various biologically active substances. For the majority of farmed fish, the need for protein and essential amino acids, fat and certain fatty acids, carbon and minerals has been established, on the basis of which, starter and production feeds, as well as various vitamin and mineral premixes, were developed [2]. However, natural food contains a wider range of biologically active components that are the regulators of many metabolic processes of body. Therefore, live food in fish nutrition, even in small proportion, can supplement the energy components of artificial feed and thereby significantly increase the balance of the diet [3]. Keywords: aquaculture, probiotic, exterior, aquatic organisms, bacteria, fatness ratio, diet

scholarly journals Technologies of carp growing and their features

2021 ◽  
Vol 23 (95) ◽  
pp. 54-59
Author(s):  
Yu. V. Loboiko ◽  
Ye. O. Barylo ◽  
Yu. R. Vachko ◽  
B. S. Barylo ◽  
I. R. Rachkivska
Keyword(s):  
Fish Farming ◽  
Distinct Type ◽  
Bottom Fauna ◽  
Natural Food ◽  
Fish Farms ◽  
Energy Needs ◽  
Wide Range ◽  
The Cost ◽  
Genetically Determined ◽  
Fish Productivity

Carp is one of the few fish farms for which a wide range of technologies has been developed: from extensive, with minimal human intervention in the formation of fish productivity of the reservoir, to intensive, with the most controlled production conditions. Carp has many biological features, enhanced by centuries of breeding work, making this fish extremely “technological”, able to more or less fully realize the genetically determined bioproductive properties of different breeding technologies. Technologies for growing commercial carp according to the level of intensification of the production process can be divided into extensive (grazing), semi-intensive, intensive, and continuous, as a distinct type of intensive technology for growing carp in ponds and pools. Extensive technology assumes that the fish will feed exclusively on natural food, zooplankton, and bottom fauna. In this case, the cost of growing carp will be the lowest; the fish will be called “ecological”, but the growth of individuals will be insignificant. Semi-intensive technology assumes that carp feed on natural feeds, and their energy needs are met by providing carbohydrate additives to feed. Intensive technology believes that carp feeding with compound feeds with high protein content is used, which allows achieving productivity of 3–20 tons/ha. This system requires the highest costs, although it gives the highest performance. The pond must provide additional aeration and water flow to prevent contamination of the reservoir and the development of fish diseases. The main disadvantage of popular carp growing technologies is their staging. All operations are carried out strictly one after another in specialized ponds. Moreover, each stage ends with the descent of the tanks, and the fish are transplanted several times from one to another (from spawning to juvenile, from them to nursery). During this, the carp is injured, which negatively affects its productivity and inevitably leads to waste. To remedy this, fish farming is now using continuous rearing technology. The choice of technology for growing carp is a responsible task on which the profitability of fisheries depends.

Aspergillus sydowii Strain SCAU066 and Aspergillus versicolor Isolate BAB-6580: Potential Source of Xylanolytic, Cellulolytic and Amylolytic Enzymes

2020 ◽  
Vol 14 (2) ◽  
pp. 15
Author(s):  
Zaidah Zainal ariffin
Keyword(s):  
Extracellular Enzymes ◽  
Biologically Active ◽  
Aspergillus Versicolor ◽  
Aspergillus Sydowii ◽  
Aspergillus Tamarii ◽  
Alternative Source ◽  
Amylolytic Enzymes ◽  
Potato Dextrose Broth ◽  
Wide Range ◽  
Pharmaceutical Industries

Fungi is known to produce a wide range of biologically active metabolites and enzymes. Enzymes produced by fungi are utilized in food and pharmaceutical industries because of their rich enzymatic profile. Filamentous fungi are particularly interesting due to their high production of extracellular enzymes which has a large industrial potential. The aim of this study is to isolate potential soil fungi species that are able to produce functional enzymes for industries. Five Aspergillus species were successfully isolated from antibiotic overexposed soil (GPS coordinate of N3.093219 E101.40269) by standard microbiological method. The isolated fungi were identified via morphological observations and molecular tools; polymerase chain reactions, ITS 1 (5’- TCC GTA GGT GAA CCT GCG G3’) forward primer and ITS 4 (5’-TCC TCC GCT TAT TGA TAT GC-3’) reverse primer. The isolated fungi were identified as Aspergillus sydowii strain SCAU066, Aspergillus tamarii isolate TN-7, Aspergillus candidus strain KUFA 0062, Aspergillus versicolor isolate BAB-6580, and Aspergillus protuberus strain KAS 6024. Supernatant obtained via submerged fermentation of the isolated fungi in potato dextrose broth (PDB) and extracted via centrifugation was loaded onto specific media to screen for the production of xylanolytic, cellulolytic and amylolytic enzymes. The present findings indicate that Aspergillus sydowii strain SCAU066 and Aspergillus versicolor isolate BAB-6580 have great potential as an alternative source of xylanolytic, cellulolytic and amylolytic enzymes.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

Analysis of Aromatic Amines in Industrial Wastewater by Capillary Gas Chromatography-Mass Spectrometry

2000 ◽  
Vol 35 (2) ◽  
pp. 245-262 ◽  
Author(s):  
Francis I. Onuska ◽  
Ken A. Terry ◽  
R. James Maguire
Keyword(s):  
Gas Chromatography ◽  
Aromatic Amines ◽  
Methylene Chloride ◽  
Solid Phase ◽  
Stationary Phases ◽  
Gas Chromatography Mass Spectrometry ◽  
Substituted Anilines ◽  
Environmental Media ◽  
Solid Phase Extraction Cartridge ◽  
Wide Range

Abstract The analysis of aromatic amines, particularly benzidines, at trace levels in environmental media has been difficult because of the lack of suitable deactivated capillary column stationary phases for gas chromatography. This report describes the use of an improved type of column as well as a method for the analysis of anilines and benzidines in water, wastewater and sewage samples. Extraction procedures are applicable to a wide range of compounds that are effectively partitioned from an aqueous matrix into methylene chloride, or onto a solid-phase extraction cartridge. The extracted analytes are also amenable to separation on a capillary gas chromatographic column and transferable to the mass spectrometer. These contaminants are converted to their N-trifluoroacetyl derivatives. Aniline and some substituted anilines, and 3,3’-dichlorobenzidine and benzidine were determined in 24-h composite industrial water, wastewater, primary sludge and final effluent samples at concentrations from 0.03 up to 2760 µg/L.

Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

2019 ◽  
Vol 26 (23) ◽  
pp. 4323-4354 ◽  
Author(s):  
Ana Cristina Lima Leite ◽  
José Wanderlan Pontes Espíndola ◽  
Marcos Veríssimo de Oliveira Cardoso ◽  
Gevanio Bezerra de Oliveira Filho
Keyword(s):  
Biologically Active ◽  
Neglected Diseases ◽  
Financial Return ◽  
Drug Candidates ◽  
Lead Compounds ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Current Therapies ◽  
Resistant Strains ◽  
Privileged Structures

Background: Privileged motifs are recurring in a wide range of biologically active compounds that reach different pharmaceutical targets and pathways and could represent a suitable start point to access potential candidates in the neglected diseases field. The current therapies to treat these diseases are based in drugs that lack of the desired effectiveness, affordable methods of synthesis and allow a way to emergence of resistant strains. Due the lack of financial return, only few pharmaceutical companies have been investing in research for new therapeutics for neglected diseases (ND). Methods: Based on the literature search from 2002 to 2016, we discuss how six privileged motifs, focusing phthalimide, isatin, indole, thiosemicarbazone, thiazole, and thiazolidinone are particularly recurrent in compounds active against some of neglected diseases. Results: It was observed that attention was paid particularly for Chagas disease, malaria, tuberculosis, schistosomiasis, leishmaniasis, dengue, African sleeping sickness (Human African Trypanosomiasis - HAT) and toxoplasmosis. It was possible to verify that, among the ND, antitrypanosomal and antiplasmodial activities were between the most searched. Besides, thiosemicarbazone moiety seems to be the most versatile and frequently explored scaffold. As well, phthalimide, isatin, thiazole, and thiazolidone nucleus have been also explored in the ND field. Conclusion: Some described compounds, appear to be promising drug candidates, while others could represent a valuable inspiration in the research for new lead compounds.

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