scholarly journals Entamoeba gingivalis and Evaluation of its Effectiveness in Periodontal Diseases

Author(s):  
Fatma Esenkaya Taşbent ◽  
Ceren Ceran Boran

Periodontitis is one of the most common and public health problems worldwide. It is a multifactorial chronic inflammatory disease involving a complex interaction between various etiological factors, host responses, and environmental factors. Risk factors have still been under investigation. Many studies emphasize the possible bacterial etiology and host responses. Entamoeba gingivalis, is a protozoon that resides in the oral cavity of individuals. Many studies have reported that infection rates of this protozoa was higher in patients with periodontitis compared to healthy controls. However, the role of this protozoon in the development of periodontal disease remains controversial. Therefore, in this review, it is aimed to compile the literature data on E. gingivalis whose pathogenicity is yet to be determined.

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
◽  

Abstract Autism is a set of heterogeneous neurodevelopmental conditions, characterised by early-onset difficulties in social communication and restricted, repetitive behaviour and interests. The worldwide population prevalence is about 1% with an increasing incidence and prevalence rates. Autism affects more male than female individuals, and comorbidity is common (>70% have concurrent conditions). Determinants of these changes in incidence and prevalence rates may also be related to exposure to environmental factors and to modifications in diagnostic concepts and criteria. In spite of the uncertainty in determinants of incidence of autisms, there is evidence that environmental characteristics play a significant role both as autism risk factors and as potential obstacles that influence the capabilities of autonomously and fully “using” everyday spaces. The workshop aims to provide a framework on risk factors of autism and explore the relationship with the built environment, focusing on the quality of the everyday spaces and projecting the effects that it could have in the long term on achieving a desirable level of quality of life. The 11th Sustainable Development Goals of United Nations “Make cities inclusive, safe, resilient and sustainable” underlines the necessity of designing policies and projects acting to enhance and promote healthy cities and communities by addressing the needs of the most vulnerable groups of inhabitants. Herewith we bring together the discipline of Public Health and Urban Design to promote an interdisciplinary debate on a little explored topic investigating how the approaches adopted during childhood to promote the wellbeing of people with ASD can be related or strengthen by focusing also on built environment design intervention to pursue and reach the same objectives even during adulthood. The workshop will consist of four presentations. The first focuses on giving an overview on current knowledge of intervention for people with autism, presenting also criteria for evidence-based interventions. The second explores the relationship between autism and built environment by providing an exhaustive framework of the available research literature in order to identify a first set of spatial requirements for autism friendly cities. The third examines the impact of built environment on ASD users with the aim of developing a specific evaluation tool for healthcare spaces and best practices formulation according to the specific sensorial hypo- or hyper-activation of people with autism. Finally, the fourth reports the results of a two years Research & Development project called “GAP REDUCE” finalized at developing an Assistive Technology tool to support people with ASD, adult and high-functioning, to plan urban itineraries towards daily destinations. Key messages World's incidence of autism is about 1% with an increasing incidence whose determining rates may also be related to environmental factors and to modifications in diagnostic concepts and criteria. Environmental characteristics play a significant role also as potential obstacles that influence the capabilities of people with autism of autonomously and fully “using” everyday spaces.


Author(s):  
Asli Aykac ◽  
Rasime Kalkan

AbstractPosttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic–pituitary–adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and catecholaminergic systems; and a variety of environmental factors, such as war, accident, natural disaster, pandemic, physical, or sexual abuse, that cause stress or trauma in individuals. To be able to understand the molecular background of PTSD, rodent animal models are widely used by researchers. When looking for a solution for PTSD, it is important to consider preexisting genetic risk factors and physiological, molecular, and biochemical processes caused by trauma that may cause susceptibility to this disorder. In studies, it is reported that epigenetic mechanisms play important roles in the biological response affected by environmental factors, as well as the task of programming cell identity. In this article, we provided an overview of the role of epigenetic modifications in understanding the biology of PTSD. We also summarized the data from animal studies and their importance during the investigation of PTSD. This study shed light on the epigenetic background of stress and PTSD.


Author(s):  
Sarah Bronwen Horton

The only survey of migrant farmworkers’ health in California that used clinical exams to collect data found this occupational group had “startlingly” high rates of hypertension and risk factors for cardiovascular disease. Drawing upon the narratives of two migrant farmworking women who were both hospitalized for hypertension, this chapter explores the role of “immigration stress” and “work stress” in producing their chronic disease. While public health researchers have recently pointed to racial minorities’ physiological response to chronic discrimination as an explanation for their higher rates of hypertension, this chapter makes an analogous argument for legal minorities. It suggests that the recent trend towards heightened interior immigration enforcement subjects all noncitizens to forms of “everyday violence,” only increasing their chronic worry and “perseverative stress.” This chapter explores how the stress of being a legal minority gets under migrants’ skin, helping account for migrant farmworkers’ higher rates of chronic morbidity and mortality.


2021 ◽  
pp. 17-42
Author(s):  
Paolo Boffetta ◽  
Zuo-Feng Zhang ◽  
Carlo La Vecchia

Neoplasms continue to dominate globally as one of the major sources of human disease and death. There are multiple modifiable causes of cancer and understanding their attributable risk factors for each cancer is of importance. This chapter covers the role of cellular and molecular mechanisms as well as the experimental and epidemiological approaches as determinants of the main cancers. Even if major discoveries in the clinical management of cancer patients will be accomplished in the near future, the changes will mainly affect the affluent part of the world population. Promising approaches focused on prevention of the known causes, reducing its consequences, notably in resource-constrained settings are highlighted.


Author(s):  
Karyn Morrissey

Knowledge of the important role that the environment plays in determining human health predates the modern public health era. However, the tendency to see health, disease, and their determinants as attributes of individuals rather than characteristics of communities meant that the role of the environment in human health was seldom accorded sufficient importance during much of the 20th century. Instead, research began to focus on specific risk factors that correlated with diseases of greatest concern, i.e., the non-communicable diseases such as cardiovascular disease, asthma, and diabetes. Many of these risk factors (e.g., smoking, alcohol consumption, and diet) were aspects of individual lifestyle and behaviors, freely chosen by the individual. Within this individual-centric framework of human health, the standard economic model for human health became primarily the Grossman model of health and health care demand. In this model, an individual’s health stock may be increased by investing in health (by consuming health services, for example) or decreased by endogenous (age) or exogenous (smoking) individual factors. Within this model, individuals used their available resources, their budget, to purchase goods and services that either increased or decreased their health stock. Grossman’s model provides a consumption-based approach to human health, where individuals purchase goods and services required to improve their individual health in the marketplace. Grossman’s model of health assumes that the goods and services required to optimize good health can be purchased through market-based interactions and that these goods and services are optimally priced—that the value of the goods and services are reflected in their price. In reality, many types of goods and services that are good for human health are not available to purchase, or if they are available they are undervalued in the free market. Across the environmental and health literature, these goods and services are, today, broadly referred to as “ecosystem services for human health.” However, the quasi-public good nature of ecosystem services for human health means that the private market will generate a suboptimal environment for both individual and public health outcomes. In the face of continued austerity and scarce public resources, understanding the role of the environment in human health may help to alleviate future health care demand by decreasing (or increasing) environmental risk (or benefits) associated with health outcomes. However, to take advantage of the role that the environment plays in human health requires a fundamental reorientation of public health policy and spending to include environmental considerations.


Author(s):  
Margaret J. Snowling

Dyslexia: A Very Short Introduction provides an accessible overview of the innovative research surrounding dyslexia, beginning with its history, and drawing on the experiences of children and adults with dyslexia today. Considering the skills involved in learning to read, and looking at the role of genetic and environmental factors including the language of learning, this VSI discusses the causes of dyslexia and its associated risk factors. Discussing the various brain-scanning techniques that have been used to find out if the brains of people with dyslexia differ in structure or function from those of typical readers, it moves on to weigh up various strategies and interventions that can help people living with dyslexia today.


Neurology ◽  
2019 ◽  
Vol 93 (4) ◽  
pp. e381-e387 ◽  
Author(s):  
Karman Tandon ◽  
David Tirschwell ◽  
W.T. Longstreth ◽  
Bryn Smith ◽  
Nazem Akoum

ObjectiveTo examine the hypothesis that atrial fibrosis and associated atrial cardiopathy may be in the causal pathway of cardioembolic stroke independently of atrial fibrillation (AF) by comparing atrial fibrosis burden between patients with embolic stroke of undetermined source (ESUS), patients with AF, and healthy controls.MethodsWe used late-gadolinium-enhancement MRI to compare atrial fibrosis in 10 patients with ESUS against 10 controls (no stroke, no AF) and 10 patients with AF. Fibrosis was compared between groups, controlling for stroke risk factors.ResultsMean age was 51 ± 15 years, and 43% of participants were female. Patients with ESUS had more atrial fibrosis than controls (16.8 ± 5.7% vs 10.6 ± 5.7%, p = 0.019) and similar fibrosis compared to patients with AF (17.8 ± 4.8%, p = 0.65). Odds ratios of ESUS per quartile of fibrosis were 3.22 (95% CI [CI] 1.11–9.32, p = 0.031, unadjusted) and 3.17 (95% CI 1.05–9.52, p = 0.041, CHA2DVASc score adjusted). Patients with >12% fibrosis had a higher percentage of ESUS (77.8% vs 27.3%, p = 0.02), and patients with >20% fibrosis had the highest proportion of ESUS (4 of 5).ConclusionsPatients with ESUS exhibit similar atrial fibrosis compared to patients with AF and more fibrosis than healthy controls. Fibrosis is associated with ESUS after controlling for stroke risk factors, supporting the hypothesis that fibrosis is in the causal pathway of cardioembolic stroke independently of AF. Prospective studies are needed to assess the role of anticoagulation in primary and secondary stroke prevention in patients with high atrial fibrosis.


2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Valeria Coviltir ◽  
Miruna Burcel ◽  
Alina Popa Cherecheanu ◽  
Catalina Ionescu ◽  
Dana Dascalescu ◽  
...  

The focus of this update is to emphasize the recent advances in the pathogenesis and various molecular key approaches associated with myopia in order to reveal new potential therapeutic targets. We review the current evidence for its complex genetics and evaluate the known or candidate genes and loci. In addition, we discuss recent investigations regarding the role of environmental factors. This paper also covers current research aimed at elucidating the signaling pathways involved in the pathogenesis of myopia.


2021 ◽  
Vol 129 (s1) ◽  
pp. 100-109
Author(s):  
Karla Patricia Valdés-García ◽  
Luis Miguel Sánchez-Loyo ◽  
Iris Rubí Monroy Velasco ◽  
Claudia Jocabed Carreón Márquez

Due to the number of deaths by suicide, it’s classified as a public health problem, and it is a multifactorial and dynamic problem, influenced by biological, psychological, social, cultural, and environmental factors. The study aimed to identify risk factors based on the proposal of the biopsychosocial model of suicide risk of Turecki by applying the psychological autopsy in three suicide cases in young people. Debido al número de muertes por suicidio se le ha clasificado como un problema de salud pública, es una problemática multifactorial y dinámica, influenciada por factores biológicos, psicológicos, sociales,culturales y ambientales.


2019 ◽  
Vol 51 (4) ◽  
pp. 603-620 ◽  
Author(s):  
Isacar A. Bolaños

AbstractThe cholera and plague pandemics of the 19th and early 20h centuries shaped Ottoman state-building and expansionist efforts in Iraq and the Gulf in significant ways. For Ottoman officials, these pandemics brought attention to the possible role of Qajar and British subjects in spreading cholera and plague, as well as the relationship between Iraq's ecology and recurring outbreaks. These developments paved the way for the expansion of Ottoman health institutions, such as quarantines, and the emergence of new conceptions of public health in the region. Specifically, quarantines proved instrumental not only to the delineation of the Ottoman–Qajar border, but also to defining an emerging Ottoman role in shaping Gulf affairs. Moreover, the Ottomans’ use of quarantines and simultaneous efforts to develop sanitary policies informed by local ecological realities signal a localized and ad hoc approach to disease prevention that has been overlooked. Ultimately, this study demonstrates that environmental factors operating on global and regional scales were just as important as geopolitical factors in shaping Ottoman rule in Iraq and the Gulf during the late Ottoman period.


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