Indian medicinal plants with antidiabetic potential: An overview

2021 ◽  
pp. 2328-2335
Author(s):  
Monika Sahu ◽  
Vinod Kumar ◽  
Veenu Joshi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
The Body ◽  
Therapeutic Drug ◽  
Major Health ◽  
Synthetic Drugs ◽  
Comprehensive Information ◽  
Chronic Disorders ◽  
The Rich ◽  
Indian Medicinal Plants

Diabetes Mellitus is the most prevalent metabolic disorder which has made it a major health threat worldwide. The available synthetic drugs for the cure of Diabetes mellitus are associated with high cost, various side effects and several limitations. Medicinal plants are the rich depots of the phytochemicals which can be useful for the treatment of chronic disorders. These plants are the better alternative to chemical drugs causing less or no harm to the body. Several plants are traditionally known for their antidiabetic properties but the detail investigation of their active molecules is required in order to be developed as therapeutic drug. Therefore, the present review aims to provide comprehensive information on various Indian medicinal plants, their constituents and mechanism of action for the cure of diabetes mellitus.

scholarly journals Bioactive Phenolic Compounds from Indian Medicinal Plants for Pharmaceutical and Medical Aspects

2021 ◽  
Author(s):  
Bhanu Kumar ◽  
Ankita Misra ◽  
Sharad Srivastava
Keyword(s):  
Phenolic Compounds ◽  
Medicinal Plants ◽  
Modern Medicine ◽  
The Body ◽  
Human Welfare ◽  
Therapeutic Benefits ◽  
Plant Constituents ◽  
Health And Disease ◽  
Tools And Techniques ◽  
Indian Medicinal Plants

Ayurveda is an age old system of medicine which utilizes thousands of medicinal plants, rich in secondary metabolites for their therapeutic benefits and phenolic compounds are important one. Plant phenolic compounds are one of the major group of phytomolecules having tremendous therapeutic and nutraceutical potential. Indian medicinal plants like Emblica, Terminalia spp., Withania, Tinospora etc. are some of the potential source of bioactive phenolics and had been used from ages in various Ayurvedic formulations and were scientifically validated too. In this contribution, a brief account of some common Indian medicinal plants rich in bioactive phenolics are summarized along with their therapeutic action on human health and disease. The vast array of phenolics in these plants makes them a suitable candidate for modern medicine, nutraceutical supplements, immuno-modulatory formulations etc. With the advent of modern separation tools and techniques, it is now possible to identify, isolate and purify desired phytoconstituents from plant extracts. This further opens the avenues of utilizing medicinal plants or plant constituents/metabolites as super food for strengthening the body and maintaining the healthy work-life balance. The need of the hour is to identify therapeutically potential phenolics rich plants and development of herbal formulations for human welfare.

scholarly journals MEDICINAL PLANTS FOR DIABETES MELLITUS: A REVIEW

2021 ◽  
pp. 45-48
Author(s):  
DIPALI P SHELKE ◽  
VIJAYENDRA SWAMY SM
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Causes Of Death ◽  
Well Being ◽  
Metabolic Abnormalities ◽  
Major Health ◽  
Industrialized Nations ◽  
The World ◽  
Diabetic Treatment

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Fourth leading causes of death in the most advanced countries and there, in other emerging and recently industrialized nations, still controlled the epidemic. Inadequate control of blood sugar has significant consequences for well-being. Ayurveda and other Indian writing referenced the utilized of plants in the treatment of different diseases. Medicinal plant with antidiabetic potential has been recent area of research. The efficiency of these medicinal plants may regulate the diabetic metabolic abnormalities. This work would help researchers to choose potential herbal for diabetic treatment.

scholarly journals ANTI-DIABETIC EFFECT OF ETHANOL EXTRACT OF Copaifera salikounda (HECKEL) AGAINST ALLOXAN-INDUCED DIABETES IN RATS

2021 ◽  
Vol 58 (2) ◽  
Author(s):  
Chinyere Aloke ◽  
Emmanuel Igwe ◽  
Nwogo Obasi ◽  
Pascal Amu ◽  
Egwu Ogbonnia
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
The Body ◽  
Albino Rats ◽  
Dependent Manner

Accumulating evidences have reinforced the use of medicinal plants in the treatment of various ailments as a result of negative side effects associated with conventional drugs. Plant components such as phenols and flavonoids with antioxidant potential have confirmed protective roles against oxidative stress-induced degenerative diseases like diabetes mellitus (DM). The current study was carried out to investigate the effect of seed pod ethanol extract from Copaifera salikounda (SPEECS) in alloxan-induced diabetic rats. SPEECS was obtained by maceration of seed pod powder in absolute ethanol for 72 h, filtered, concentrated and dried in-vacuo. Gas chromatography-mass spectrometry (GC–MS) technique was used to quantitatively elucidate the chemical constituents of SPEECS. Twenty-four male albino rats were randomly allocated into four groups (n=6): normal control, DM control, DM + 200 mg/kg SPEECS and DM + 400 mg/kg SPEECS groups. DM was induced in the Wistar albino rats through intraperitoneal injection of 200 mg/kg body weight of alloxan. After 14 days of treatment, the body weight changes and the fasting blood glucose level were determined in the different groups. Also, serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), total protein (TP), malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were estimated. The GC-MS results confirm nine bioactive compounds with 9-octadecenoic acid (55.75%) being most abundant. SPEECS (200 and 400 mg/kg) administration significantly (P 0.05) caused gain in weight, decreased fasting blood glucose and reversed the elevated liver function enzymes (ALT, AST, ALP) while total TP and ALB were markedly elevated relative to DM control group. Furthermore, SPEECS attenuated the activities of SOD and CAT while the level of MDA was significantly (P 0.05) decreased in dose dependent manner in comparison to the DM control. This study indicated that SPEECS can alleviate hyperglyceamia of DM. Key words: Copaifera salikounda; oxidative stress; medicinal plants; diabetes mellitus; phytochemicals; orthodox ANTIDIABETIČNI UČINEK EKSTRAKTA ETANOLA Copaifera salikounda (HECKEL) NA SLADKORNO BOLEZEN, SPROŽENO Z ALLOXAN-om, PRI PODGANAHIzvleček: Obstaja vedno več dokazov, ki poudarjajo uporabnost zdravilnih rastlin pri zdravljenju različnih bolezni, tudi zaradi različnih negativnih stranskih učinkov, povezanih s konvencionalnimi zdravili. Rastlinske sestavine kot so fenoli in flavonoidi z antioksidativnim potencialom, imajo po nekaterih raziskavah zaščitno vlogo pred degenerativnimi boleznimi, ki jih povzroča oksidativni stres, kot je sladkorna bolezen diabetes mellitus (DM). Študija je bila izvedena z namenom raziskovanja učinka etanolnega semenskega ekstrakta iz rastline Copaifera salikounda (SPEECS) pri podganah s sladkorno boleznijo, ki jo je povzročil alloxan. SPEECS je bil pridobljen z maceracijo praška semen v prahu v absolutnem etanolu 72 ur ter nadaljnjo filtracijo, koncentracijo in sušenjem v vakuumu. Za kvantitativno ugotavljanje kemijskih sestavin SPEECS je bila uporabljena tehnika plinske kromatografije in masne spektrometrije (GC-MS). Štiriindvajset samcev podgan Wistar je bilo naključno razporejenih v štiri skupine (n=6): normalna kontrola, kontrola DM, DM + 200 mg/kg SPEECS in DM + 400 mg/kg SPEECS. DM je bil pri podganah sprožen z intraperitonealno injekcijo 200 mg/kg telesne mase alloxana. Po 14 dneh zdravljenja so bile pri različnih skupinah določene spremembe telesne teže in nivo glukoze v krvi (na tešče). Poleg tega so avtorji raziskave izmerili še nekatere serumske biokemične parametre kot so ravni alaninske aminotransferaze (ALT), aspartatne aminotransferaze (AST), alkalne fosfataze (ALP), albumina (ALB), skupnih proteinov (TP), malondialdehida (MDA), superoksiddismutaze (SOD) in katalaze (CAT). Rezultati GC-MS so v izvlečku SPEECS pokazali devet bioaktivnih spojin, v katerih je največ 9-oktadecenojske kisline (55,75%). SPEECS (200 in 400 mg/kg) je povzročil znatno (P 0,05) povečanje telesne mase, znižanje glukoze v krvi na tešče in znižal raven encimov pokazateljev jetrne funkcije (ALT, AST, ALP), medtem ko je bila raven TP in ALB pri podganah, ki so prejemale SPEECS izrazito povišana v primerjavi z DM kontrolno skupino. Zdravljenje s  SPEECS je tudi oslabilo aktivnosti SOD in CAT, medtem ko se je raven MDA znatno zmanjšala (P 0,05) v primerjavi s kontrolno skupino DM. Ta študija je pokazala, da lahko SPEECS ublaži hiperglikemijo pri sladkorni bolezni pri podganah.Ključne besede: Copaifera salikounda; oksidativni stres; zdravilne rastline; sladkorna bolezen; fitokemikalije; ortodoksni

Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants

2020 ◽  
pp. 25-48
Author(s):  
Manish Singh Sansi ◽  
Daraksha Iram ◽  
Kapil Singh Narayan ◽  
Sandeep Kumar ◽  
Om Prakash ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Medicinal Plants ◽  
Insulin Receptor ◽  
Antidiabetic Activity ◽  
Insulin Deficiency ◽  
Receptor Function ◽  
Synthetic Drugs ◽  
Treatment Of Diabetes ◽  
Insulin Receptor Kinase

Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insulin receptor function by activating insulin receptor kinase and inhibiting insulin receptor phosphatase, which lead to an increase in insulin sensitivity. Morinda lucida also had the highest antioxidant activity, and it also inhibited the α-glucosidase. Many plants have also been shown to antihyperlipedemic effects. Finally, it can be concluded that medicinal plants have that ability to treat or prevent DM.

scholarly journals A Review on the Antidiabetic Potential of Medicinal Plants

2021 ◽  
pp. 172-189
Author(s):  
Razan Bushnak ◽  
Mohamad El Hajj ◽  
Ali Jaber
Keyword(s):  
Medicinal Plants ◽  
World Health ◽  
Chronic Complications ◽  
Major Health ◽  
Traditional Medicines ◽  
Synthetic Drugs ◽  
Sugar Regulation ◽  
Alternate Source ◽  
Health Organization ◽  
Substantial Economic Burden

Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adverse effects. Medicinal plants, on the other hand, may serve as an alternate source of anti-diabetic agents. According to the World Health Organization, 80 % of the population in underdeveloped nations still relies on traditional medicines or folk medicines, which are largely made from plants, for disease prevention or treatment. For instance, anti- proliferative, anti-viral, anti-inflammatory and anti-hyperglycemic effects. In order to find a natural anti-diabetic source that comes with less side effects, several studies have been conducted. The aim of this work is to review these studies and highlight the potential of plants when it comes to their anti-diabetic effect.

scholarly journals An Overview on Ethnopharmacology of Different Medicinal Plants of Odisha State of India in the Management of Diabetes Mellitus

2021 ◽  
Vol 33 (11) ◽  
pp. 2589-2598
Author(s):  
Deepankar Rath ◽  
Gurudutta Pattnaik ◽  
Biswakanth Kar
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Ricinus Communis ◽  
Cocos Nucifera ◽  
Aloe Vera ◽  
Traditional Healers ◽  
World Health ◽  
Herbal Remedies ◽  
Synthetic Drugs ◽  
Health Organization

Diabetes mellitus, commonly known as diabetes, is a group of metabolic disorder associated with elevated blood glucose level. World health organization recommended the traditional and herbal remedies for the diabetic management. The application of herbal remedies is extremely increased worldwide in the last three decades. Most of the synthetic drugs were discovered from the plant source out of different regions of the world to meet the demand. Several medicinal plants like Gymnema sylvestre, Pterocarpus marsupium, Catharanthus roseus, Trigonella foenum, Annona squamosa, Aegle marmelos, Withania somnifera, Boerhavia diffusa, Boerhavia erecta, Momordica charantia, Cocos nucifera, Ricinus communis, Azadira chtaindica and Aloe vera have been reported to have varying level of hypoglycemic property. One of the factors involved in the evolution of diabetic convolutions is the impairment due to free radicals and hence a compound with antioxidant and antidiabetic potential would be more effective. The present review article was designed to provide an absolute data on these medicinal plant based remedies by using the traditional healers of Odisha state, India.

scholarly journals ANTIBACTERIAL ACTIVITIES OF SOME MEDICINAL PLANTS AND GREEN LEAFY VEGETABLES: A REVIEW

2021 ◽  
Vol 6 (4) ◽  
Author(s):  
C Mahendranathan ◽  
Ahyg Abhayarathne
Keyword(s):  
Medicinal Plants ◽  
Rural Areas ◽  
Antimicrobial Agents ◽  
Antibacterial Activities ◽  
The Body ◽  
Leafy Vegetables ◽  
Bacterial Strains ◽  
Green Leafy Vegetables ◽  
Synthetic Drugs ◽  
Development Of Resistance

Plants are considered not only as dietary supplement to living organisms but also traditionally used for treating many health problems and the medicinal value of many plants still remains unexplored investigations of plants are carried out to find novel drugs or templates for the development of new therapeutic agents. Plants produce a wide variety of phytochemical constituents, which are secondary metabolites and are used either directly or indirectly in the pharmaceutical industry. Majority of the population, especially those living in rural areas depends largely on medicinal plants for treatment of diseases. The resistance of pathogenic bacterial strains to antibiotics is the major burning issue around the world. Pharmacological industries have produced various new antibiotics ever since, but microorganisms have slowly developed resistance to these drugs because bacteria have the genetic capability to transmit and acquire resistance to these drug. Plants and plant products are a better alternative compared to antibiotics and other synthetic drugs which display negative side effects such as sensitization reactions, and disruption of the metabolic processes in the body via interaction with the body system. Hence antimicrobial agents from plants are a more reliable and effective source to fight these microorganisms without the development of resistance.

scholarly journals Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Potensi Tanaman Mimba (Azadirachta indica A. Juss.) sebagai Antidiabetes

2021 ◽  
pp. 422-430
Author(s):  
Putri Rachma Novitasari ◽  
Baiq Maylinda Gemantari ◽  
Syarifatul Mufidah ◽  
Prita Anggraini Kartika Sari
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Azadirachta Indica ◽  
Review Article ◽  
The Body ◽  
Herbal Extracts ◽  
Alternative Medicines ◽  
Herbal Plants ◽  
Good Potential ◽  
Ancient Times

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

scholarly journals Mechanisms of Action of Flavonoids in the Management of Diabetes mellitus

2021 ◽  
Vol 11 (5-S) ◽  
pp. 194-202
Author(s):  
S Chandra Mohan ◽  
Namrata Jain ◽  
S. Sumathi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Mechanisms Of Action ◽  
The Body ◽  
Antidiabetic Activity ◽  
Cost Of Treatment ◽  
Keywords Diabetes ◽  
Microvascular And Macrovascular Complications ◽  
Chronic Use

Management of diabetes mellitus is a challenge for clinicians. Uncontrolled hyperglycemia increases the risk of microvascular and macrovascular complications, damaging the body systems.  Although a number of antidiabetic drugs are available for therapeutic intervention, toxicity, loss of efficacy in chronic use and high cost of treatment have necessitated the search for new molecules to manage diabetes. Safety and cost are the main prerequisite for the new antidiabetic molecules. Medicinal plants and their purified phytochemicals have shown promising antidiabetic potential in the past few years. The flavonoids can be widely classified into different categories like anthocyanins, catechins, flavanols, flavones, flavanones etc. Some flavonoids have hypoglycemic properties. They may improve al-tered glucose and oxidative metabolisms of diabetic states. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes mellitus (T2DM). Some of the important phytoconstituents from the classes of flavonoid have been discussed here. The current review summarizes the  antidiabetic activity of flavonoids, the mechanism-based action of flavonoids that target the various metabolic pathways in humans. Keywords: Diabetes mellitus, Flavonoids, Medicinal plants, mechanisms of action, T2DM

scholarly journals Indian Medicinal Plants with Antidiabetic Potential

2019 ◽  
Vol 9 (1) ◽  
pp. 257-265 ◽  
Author(s):  
Abu Sufiyan Chhipa ◽  
S.S. Sisodia
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
General Population ◽  
Medicinal Plants ◽  
Hypoglycemic Activity ◽  
Herbal Drugs ◽  
Disease Treatment ◽  
Drug Candidates ◽  
Indian Medicinal Plants

Medicinal plants should be evaluated extensively to determine the active principles present in them that are responsible for the hypoglycemic activity of these plants. Herbal drugs have gained popularity among the general population due to their ability to treat ailments with minimum side effects. The multi-target approaches of medicinal plants make them least susceptible to failure during the treatment therapy. Medicinal plants showing prominent anti-diabetic activity during the initial studies should be further explored to identify the active principles present in them that can become the promising drug candidates for the disease treatment in the coming future. Keywords: Anti-diabetic, Diabetes Mellitus, Insulin, hypoglycemic, anti-hyperglycemic, anti-hyperlipidemic  

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