Evaluation of the psychological and biological changes of patients diagnosed with benign and malignant breast tumors

2012 ◽  
Vol 27 (4) ◽  
pp. 322-330 ◽  
Author(s):  
Lan-Jun Bai ◽  
Qing Liu ◽  
Min Wang ◽  
Wings TY Loo ◽  
Rebecca Wy Cheng ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Malignant Tumors ◽  
Chinese Women ◽  
High Sensitivity ◽  
Psychological Trauma ◽  
Breast Tumors ◽  
Serum Levels ◽  
Control Group ◽  
Low Grade ◽  
Malignant Breast

Purpose Posttraumatic stress disorder (PTSD) is a severe anxiety disorder developed by exposure to any incident or circumstance that results in psychological trauma. In this study we compared the psychological and physiological changes between patients with malignant and benign breast tumors. Methods We selected 150 Chinese women with a breast mass, aged 20 to 45 years, from the Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital between 2009 and 2011 for this study; 30 healthy participants were enrolled into the control group. All subjects were examined and had their tumor mass aspirated for diagnosis. Equal numbers of patients with benign and malignant tumors were recruited. Patients with malignant tumors presented with low grade, minimal tumor invasion and non-involved lymph nodes. Questionnaires regarding anxiety, depression and PTSD were conducted 2 hours before getting the diagnostic result and 1 month after the diagnosis. Serum levels of IL-6, TNF-, cortisol and high-sensitivity C-reactive protein before and after diagnosis were investigated and compared. The number of occurrences of oral ulcerative mucositis was also recorded. Results All patients experienced a certain degree of anxiety and their biomarkers were elevated compared with the normal reference range before the pathological report was disclosed. However, 1 month after the operation, the benign tumor group showed significantly lower levels of biomarkers and anxiety scores than patients with a malignant breast tumor. The results were consistent throughout 12 months of study. Conclusion Study subjects with a benign tumor returned to their normal condition after being diagnosed, while patients with a malignant tumor suffered from a certain degree of PTSD or depression.

HISTOLOGICAL DIAGNOSTICS OF MAMMARY GLAND NEOPLASMS IN CATS

2020 ◽  
Keyword(s):  
Mammary Gland ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Domestic Animals ◽  
Breast Diseases ◽  
Microscopic Studies ◽  
Malignant Breast ◽  
Poorly Differentiated ◽  
Breast Adenocarcinomas

Mammary gland neoplasms in cats are at the top of the list of the most common nosological diseases among domestic animals; more than half of the tumors appear as malignant. Veterinary practitioners have many questions about the prevalence of breast tumors in cats, depending on age, breed and seasons of the year. The article presents the results of diseases prevalence of benign and malignant breast tumors in cats kept in the conditions of Bishkek. The characteristic of macroscopic and microscopic studies of benign and malignant breast tumors in cats at different periods of life and depending on the breed is also described. Studies were conducted in the period from March 2018 to March 2019. Morphological methods were used in the study of breast tumors. As a result of our research, we established the morphological forms of benign and malignant breast tumors in cats. Among benign neoplastic breast diseases in cats, breast lipoma was observed. Also among the malignant tumors of the breast met highly differentiated, moderately differentiated and poorly differentiated breast adenocarcinomas malnutrition and necrosis as well as the rare phylloid (leaf-shaped) fibroadenoma of the mammary gland which makes up only 0.3-0.5 % of all breast tumors.

A COMPARATIVE STUDY OF LEVELS OF HIGH SENSITIVITY CREACTIVE PROTEIN (hs-CRP) IN DIABETIC AND NON- DIABETIC POPULATION OF CENTRAL INDIA

2021 ◽  
pp. 31-32
Author(s):  
Parag Gupta ◽  
Lal Pranay Singh
Keyword(s):  
Diabetes Mellitus ◽  
Central India ◽  
High Sensitivity ◽  
Control Group ◽  
Low Grade ◽  
Medical College ◽  
Diabetic Population ◽  
Hs Crp ◽  
And Control

Background: Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and long term complications. It is characterized by hyperglycemia resulting from defect in insulin secretion and in its action. It has become a leading cause of morbidity and mortality world over. hs- CRP is a marker of low-grade inammation and it is raised in patients with type 2 DM. The present study was undertaken with the objective of studying the relation of High Sensitivity CRP (hs-CRP) in patients of type 2 Diabetes Mellitus and in non-diseased population. Methods: This was a comparative observational study, conducted at Diabetic clinic, Index Medical College, Indore during August 2014 to July 2015. Cases and control were selected as per the inclusion criteria. Statistical analysis was done using SPSS v20. Mean age of the group was 48years. The mean hs CRP in the diabe Results: tic group was 0.45 compared with 0.35, in the control group. hs CRP levels are directly related to insulin resistance and is Conclusion: highly associated with diabetic population.

Neopterin, Catalase and Superoxide Dismutase in Females with Benign and Malignant Breast Tumors

Pteridines ◽  
2007 ◽  
Vol 18 (1) ◽  
pp. 132-138 ◽  
Author(s):  
Osman Yuksel ◽  
Tevfik Tolga Sahin ◽  
Gozde Girgin ◽  
Hande Sipahi ◽  
Kursat Dikmen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
High Performance ◽  
Breast Tumors ◽  
Breast Disease ◽  
Control Group ◽  
Sod Activity ◽  
Neopterin Level ◽  
Malignant Breast ◽  
The Mean ◽  
Urinary Neopterin

Abstract The aim of the present study was to evaluate the relationship between the levels of neopterin among patients with benign and malignant breast disease and the relation with the stage of the malignant process. In this study, neopterin concentrations and enzyme activities of superoxide dismutase (SOD) and catalase (CAT) were determined in malign (n=30) and benign breast tumor patients (n=30) by high performance liquid chromatographic and spectrophotometric methods, respectively. Results were compared with a healthy control group (n=20). The correlations between neopterin, CAT and SOD were also evaluated in controls and patients. Urinary neopterin level of the control group was (mean value ± S.D.) 128.6 ± 64.6 μmol/mol creatinine. Neopterin concentrations in patients with breast malignancy were 153.6 ± 71.2 μmol/mol creatinine and 107.8 ± 32.1 μmol/mol creatinine in benign disorders patients. The mean neopterin level in the benign group was found to be statistically different from the malign tumor group (p = 0.039). SOD and CAT activities in controls were found as 3.57 ± 0.84 U/mg protein and 2.19 ± 0.20 U/mg protein, respectively. In patients with malignancy, the SOD activity was 3.84 ± 0.73 U/mg protein while CAT activity was 1.03 ± 0.13 U/mg protein. Patients with benign breast disorders, SOD activity was 4.09 ± 1.00 U/mg protein and CAT activity was 1.02 ± 0.18 U/mg protein. Whereas SOD activity did not differ between the groups of patients and controls, the mean catalase level in the control group was higher than in the benign and malign tumor groups (both p <0.001). Urinary neopterin concentration seems to be an important and useful biomarker in diagnosis of breast tumors in clinical practice.

scholarly journals Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Vincenzo Sepe ◽  
Marilena Gregorini ◽  
Teresa Rampino ◽  
Pasquale Esposito ◽  
Rosanna Coppo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vitamin E ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Low Grade ◽  
Oxide Formation ◽  
Blood Samples ◽  
Indoleamine 2,3 Dioxygenase ◽  
Nitric Oxide Formation

Abstract Background Inflammaging is a persistent, low−grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system. Such condition downregulates both innate and adaptive immune responses during chronic disorders as type II diabetes, cancer and hemodialysis, accounting for their susceptibility to infections, malignancy and resistance to vaccination. Aim of this study was to investigate hemodialysis inflammaging, by evaluating changes of several hemodialysis treatments on indoleamine 2,3-dioxygenase-1 activity and nitric oxide formation. Methods We conducted a randomized controlled observational crossover trial. Eighteen hemodialysis patients were treated with 3 different hemodialysis procedures respectively: 1) Low−flux bicarbonate hemodialysis, 2) Low−flux bicarbonate hemodialysis with vitamin E − loaded dialyzers, and 3) Hemodialfitration. The control group consisted of 14 hospital staff healthy volunteers. Blood samples were collected from all 18 hemodialysis patients just after the long interdialytic interval, at the end of each hemodialysis treatment period. Results Hemodialysis kynurenine and kynurenine/L − tryptophan blood ratio levels were significantly higher, when compared to the control group, indicating an increased indoleamine 2,3-dioxygenase-1 activity in hemodialysis patients. At the end of the low−flux bicarbonate hemodialysis with vitamin E − loaded dialyzers period, L − tryptophan serum levels remained unchanged vs both low−flux bicarbonate hemodialysis and hemodialfitration. Kynurenine levels instead decreased, resulting in a significant reduction of kynurenine/L − tryptophan blood ratio and indoleamine 2,3-dioxygenase-1 activity, when matched to both low−flux bicarbonate hemodialysis and HDF respectively. Serum nitric oxide control group levels, were significantly lower when compared to all hemodialysis patient groups. Interestingly, low−flux bicarbonate hemodialysis with vitamin E − loaded dialyzers nitric oxide serum levels from venous line blood samples taken 60 min after starting the hemodialysis session were significantly lower vs serum taken simultaneously from the arterial blood line. Conclusions The treatment with more biocompatible hemodialysis procedure as low−flux bicarbonate hemodialysis with vitamin E − loaded dialyzers, reduced indoleamine 2,3-dioxygenase-1 activity and nitric oxide formation when compared to both low−flux bicarbonate hemodialysis and hemodialfitration. These data suggest that low−flux bicarbonate hemodialysis with vitamin E − loaded dialyzers lowering hemodialysis inflammaging, could be associated to changes of proinflammatory signalling a regulated molecular level. Trial registration NCT Number: NCT02981992; Other Study ID Numbers: 20100014090. First submitted: November 26, 2016. First posted: December 5, 2016. Last Update Posted: December 5, 2016.

Chronic Low-Grade Systemic Inflammation in Children with Asthma and Obesity

2018 ◽  
Vol 11 (2) ◽  
pp. 128-134
Author(s):  
Niya A. Krasteva ◽  
Boiko R. Shentov ◽  
Adelaida L. Ruseva ◽  
Chaika K. Petrova ◽  
Simeon P. Petkov
Keyword(s):  
Bronchial Asthma ◽  
Systemic Inflammation ◽  
Inflammatory Markers ◽  
Serum Levels ◽  
Control Group ◽  
Low Grade ◽  
Obese Children ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
Hs Crp

Summary The rising incidence of bronchial asthma and obesity in children raises the question of whether there is a link between them. Chronic low-grade systemic inflammation could be one of the linking mechanisms. We aimed to determine the serum concentrations of high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumour necrosis factor a (TNF-a) in children with asthma and obesity and to seek a relationship between these inflammatory markers and asthma control. We investigated 88 children aged 6 to 17 years - 25 asthmatic obese children (AsOb), 25 asthmatic non-obese children (AsNOb), 19 obese non-asthmatic children (ObNAs), and 19 non-obese non-asthmatic children as controls. Serum levels of IL-6 and hs-CRP were significantly increased in asthmatic obese and ObNAs compared to AsNOb and the control group. Serum TNF-a concentration was similar in the four studied groups. There were no statistically significant differences in serum levels of these inflammatory markers between controlled and partially controlled/uncontrolled asthmatics (obese and non-obese). Knowing the possible mechanisms of interaction between bronchial asthma and obesity would contribute to a more effective therapeutic approach in these patients.

scholarly journals Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Atakan Yesil ◽  
Gul Babacan Abanonu ◽  
Yasar Colak ◽  
Nurcan Paker ◽  
Can Gonen
Keyword(s):  
Prognostic Significance ◽  
Serum Levels ◽  
Colorectal Polyps ◽  
Adenomatous Polyps ◽  
Control Group ◽  
Low Grade ◽  
Colon Polyps ◽  
High Grade ◽  
Polyp Size ◽  
Potential Marker

Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps.Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels.Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001). DR-70 was higher in group 1b as compared to group 1a (P<0.001). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001).Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.

Serum urate is related to subclinical inflammation in asymptomatic hyperuricaemia

Rheumatology ◽  
2020 ◽  
Vol 60 (1) ◽  
pp. 371-379 ◽  
Author(s):  
Desirée Luis-Rodríguez ◽  
Javier Donate-Correa ◽  
Ernesto Martín-Núñez ◽  
Carla Ferri ◽  
Víctor G Tagua ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Mononuclear Cells ◽  
High Sensitivity ◽  
Serum Levels ◽  
Normal Serum ◽  
Control Group ◽  
Subclinical Inflammation ◽  
Peripheral Blood Mononuclear ◽  
Tnf Α ◽  
Inflammatory Profile

Abstract Objective Asymptomatic hyperuricaemia (AHU) is associated with inflammatory disorders, including cardiovascular disease. Uric acid (UA) lowering therapies may reduce the risk of appearance or the progression of these comorbidities. In this work, we investigated the relationship between serum UA levels and inflammation in subjects with AHU. Methods Serum levels of high-sensitivity CRP (hsCRP), TNF-α and IL-6, and mRNA expression of TNFa and IL6 in peripheral blood mononuclear cells were measured in individuals with AHU and without comorbid conditions and in a control group with similar characteristics and normal serum UA levels. Additionally, we determined the variations in the inflammatory profile in a subgroup of subjects after 6 months of treatment with allopurinol. Results Subjects at higher tertiles of serum UA presented higher levels of hsCRP and increased serum and mRNA expression levels of both cytokines (P &lt; 0.001). UA levels constituted an independent predictor of increased levels of inflammatory parameters in multiple regression models (P &lt; 0.001) and a risk factor for the presence of a subclinical inflammation in multivariate logistic regression (P &lt; 0.001). Allopurinol reduced UA and serum and mRNA expression of inflammatory cytokines (P &lt; 0.001). There was a significant correlation between the variations in serum UA and the variations in serum TNF-α (P &lt; 0.01) and IL-6 (P &lt; 0.05), and mRNA expression of these cytokines (P &lt; 0.05). This association remained significant and independent (P &lt; 0.01). Conclusion In subjects with AHU, serum UA may be an inductor of subclinical inflammation. Therapeutic reduction of serum UA was associated with a modulation of the inflammatory profile.

P0161TO EVALUATE THE TH PROFILE (TH1/TH2/TH17 ) AMONG GESTATIONAL DIABETES AND NORMAL PREGNANCY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Anupma Kaul ◽  
Amita Pandey ◽  
Vikas Aggrwal
Keyword(s):  
Gestational Diabetes ◽  
High Sensitivity ◽  
Normal Pregnancy ◽  
Treg Cells ◽  
System Response ◽  
Control Group ◽  
Low Grade ◽  
The Third ◽  
Uncomplicated Pregnancy ◽  
Intracellular Cytokines

Abstract Background and Aims Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by insulin resistance and low-grade systemic inflammation with a pro-inflammatory immune system response. Our objective was to study the peripheral Th1, Th2, Th17 and Treg response in GDM compared to normal pregnancy. Method Th1, Th2, Th17 and Treg subsets was determined by flow cytometry based on staining for specific intracellular cytokines levels and their CRP levels were also assessed.. The health status of all offspring was also assessed 6 months post-delivery. Results Α total of 32 adult pregnant women were enrolled into a GDM (n=18) and Control (n=14) group. At the third trimester of pregnancy, the GDM group had a higher proportion of Th2, Th17 and Treg cells compared to control. Contrary to the control group, the GDM group exhibited no significant change in the Th1/Th2/Th17/Treg profile postpartum. A higher circulating CRP were noted in the GDM group compared to controls. At the 6-month post-delivery assessment, 23.6% of the offspring from the GDM group were found to have developed atopic dermatitis or food allergy compared to none from the control group. Conclusion Compared to an uncomplicated pregnancy, GDM exhibits a significantly different peripheral T-cell profile at the third pregnancy trimester characterized by higher proportion of Th2, Th17 and Treg cells which persist six months post-delivery, while the increased high sensitivity CRP (hsCRP) levels stressed the low-grade inflammatory profile of this disease

scholarly journals Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

2017 ◽  
Vol 10 (1) ◽  
pp. 166
Author(s):  
Naser Sarafan ◽  
Mohammad Fakoor ◽  
Abdolhossein Mehdinasab ◽  
Mohammad Bahadoram ◽  
Damoon Ashtary-Larky ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
High Sensitivity ◽  
Serum Levels ◽  
Control Group ◽  
Interleukin 17 ◽  
Reactive Protein ◽  
Articular Fractures ◽  
Inflammatory Processes ◽  
Hs Crp ◽  
Post Hoc

BACKGROUND & OBJECTIVES: Inflammatory processes play an important role in intra-articular fractures. The present study aimed to examine the relationship between chemerin, high-sensitivity C-reactive protein (hs-CRP), and Interleukin 17 (IL-17) serum and synovial fluid levels of osteoarthritis patients and individuals with intra-articular fractures.METHOD: In this case-control study, all osteoarthritis patients and individuals with intra-articular fractures who visited the Imam Khomeini Orthopedic Clinic of Ahvaz were examined. Blood samples (5 cc) were collected prior to surgery to measure chemerin Interleukin 17, and hs-CRP serum levels. Synovial fluid samples (2 cc) were collected during the surgery.RESULTS: Measuring the levels of IL-17, chemerin and hs-CRP indicated a significant statistical difference between the serum and synovial fluids of osteoarthritis patients, individuals with intra-articular fractures, and the control group (p < .001). Post-hoc analyses showed statistically significant differences in all conditions except for hs-CRP levels between osteoarthritis patients and individuals with intra-articular fractures.CONCLUSION: Discovering ways to stop or slow down osteoarthritis is a matter of great concern. The findings on osteoarthritis indicate diverse, complex, and multidimensional processes involving cytokines. Information on cytokines that effect diseases can help develop efficient therapy methods.

scholarly journals Proinflammatory Cytokines and Leptin Are Increased in Serum of Prepubertal Obese Children

2005 ◽  
Vol 2005 (3) ◽  
pp. 180-183 ◽  
Author(s):  
A. Denizmen Aygun ◽  
Serdal Gungor ◽  
Bilal Ustundag ◽  
Metin K. Gurgoze ◽  
Yasar Sen
Keyword(s):  
Body Mass ◽  
Elevated Serum ◽  
Serum Levels ◽  
Obese Group ◽  
Control Group ◽  
Low Grade ◽  
Obese Children ◽  
Prepubertal Children ◽  
Markers Of Inflammation ◽  
Systemic Inflammatory Disease

It has not yet been shown in prepubertal children how cytokines, leptin, and body mass, as well as parameters of obesity are interrelated. The aim of this study was to explore the relation between circulating levels of some cytokines with leptin and body mass index. A case control study was carried out in obese children of both sexes. An obese group was carried out with 63 school prepubertal children and a control group comprised the same number of nonobese children paired by age and by sex. Mean serum leptin concentration was significantly higher in the obese children at19.9±7.4ng/mL, than the control group (7.9±5.1ng/mL). Serum IL-1β, IL-6, and TNF-αlevels were also significantly higher in the obese group than controls (33.0±8.9,45.2±11.8, and9.2±2.3pg/mL, versus3.6±1.0,13.1±3.9, and3.9±1.0pg/mL, resp). In controversy, serum IL-2 level was diminished in the obese group as0.4±0.1versus0.9±0.1U/L. Obesity may be a low-grade systemic inflammatory disease. Obese prepubertal children have elevated serum levels of IL-1β, IL-6, and TNF-αwhich are known as markers of inflammation.

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