HBA1c and 2 Hours Post-Prandial Blood Sugar Levels in Known Cirrhotic Adult Patients due to HBsAg and/or Anti-HCV Positive, Who are Not Known Diabetics

2021 ◽  
Vol 15 (11) ◽  
pp. 2958-2960
Author(s):  
Ali Hyder Mugheri ◽  
Abdul Hayye Phulpoto ◽  
Sumbul Shaikh ◽  
Abdul Qayoom Memon ◽  
Imdad Ali Ansari ◽  
...  

Background: Liver has a special and unique system of glucose metabolism which keeps its levels under normal ranges. In chronic liver hepatitis and cirrhosis this mechanism is altered. Aim: To evaluate undiagnosed diabetics through HbA1C and 2 hours post prandial blood sugar levels in confirmed hepatitis B and C cirrhotic adult patients. Study design: Descriptive cross-sectional study Place and duration of study: Department of Gastroenterology, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana from 1st July 2020 to 30th June 2021. Methodology: One hundred and twenty four patients >50 years with liver cirrhosis due to hepatitis B and C were enrolled. All clinical, demographic data of patients as well as their blood analysis was performed for testing HbA1C and two hour post prandial blood sugar (as well as liver function test). Results: The mean age was 57.9±5.9 years and majority of patients were males in both hepatitis cases. There were 39.5% of liver cirrhosis patients having undiagnosed diabetes which was confirmed by 2 hours post prandial blood sugar and HbA1c. Within this value 54.8% had hepatitis C and 24.2% had hepatitis B. Conclusion: There is a high prevalence of elevated HbA1c, post prandial blood sugar and consequently diabetic population (undiagnosed) among hepatitis B and C liver cirrhotic adult patients. Keywords: Post-prandial blood sugar, Cirrhotic adult patients, HBsAg, Anti-HCV, Diabetics

2019 ◽  
Author(s):  
Caixia Xia ◽  
Wei Zhu ◽  
Chunhong Huang ◽  
Guohua Lou ◽  
Bingjue Ye ◽  
...  

Abstract Background Interleukin-6 (IL-6) plays an important role in chronic inflammation. Thus, we aimed to investigate the effects of IL-6 polymorphisms in predicting the progression of hepatitis B virus (HBV) -related liver cirrhosis. Methods A cross-sectional study was conducted to analysis IL-6 polymorphisms and serum levels of IL-6 in HBV-infected patients of different clinical phases and in healthy controls. IL-6 polymorphisms were detected by Taqman PCR method and plasma IL-6 levels were assessed by ELISA. Results Our analysis included 182 chronic hepatitis B (CHB) patients, 190 HBV-infected liver cirrhosis cases, 125 inactive HBsAg carriers, and 246 healthy controls. Seven SNPs in IL-6 including rs10499563, rs17147230, rs1800796, rs2069837, rs1524107, rs2066992, rs2069852 were analyzed. In haplotype analysis between HBV-infected liver cirrhosis cases with CHB patients, inactive HBV-carriers or healthy controls, haplotype CT in block 1 and haplotype GGCGG in block 2 were associated with liver cirrhosis (P<0.05). What’s more, the genotype or allele frequencies were significantly different in IL-6 rs10499563 and rs2069837 when HBV-infected liver cirrhosis patients compared with CHB patients, inactive HBV-carriers or healthy controls. A further study found that compared with the controls or CHB patients, plasma IL-6 was elevated in HBV-infected liver cirrhosis patients (P<0.05). Conclusion In conclusion, the polymorphisms of the IL-6 rs10499563 and rs2069837 are associated with the susceptibility of liver cirrhosis may through their effects on IL-6 expressions and these two single nucleotide polymorphisms can be used as potential predicting markers for prognosis of HBV-infected liver cirrhosis.


2019 ◽  
Vol 6 (1) ◽  
pp. 77-80
Author(s):  
Ni Wayan Suniyadewi ◽  
G.N Indraguna Pinatih

Abstract Objective Carbohydrates, proteins, and fats are energy sources needed by the body for performing daily activities and generating primary energy substances. In women who have undergone menopause, the function of thyroid hormone in their body begins to decline and thus affects the ability of the body to produce energy. The purpose of this study was to determine the correlation between the intakes of carbohydrates, proteins, and fats and random blood sugar levels in menopausal women. Methods This study was a correlational analytical research with a cross-sectional design, which was conducted in 72 menopausal women recruited by the purposive sampling technique. In this study, a 24-hour food recall form was used, and randomized blood sugar levels were measured using a glucometer. The analysis of the data was performed using a Pearson product moment and multiple linear regression. Results Carbohydrates and fats together affected random blood sugar levels with an F-value of 25.810 and a p-value of 0.000. Meanwhile, adjusted R2 showed the value of 0.411, indicating that the difference in the intake of carbohydrates and fats together affected random blood sugar levels by 41.1%. Conclusions Intake of carbohydrates and fats affected random blood sugar levels, whereas the rest were influenced by other factors, and protein intake was unrelated to random blood sugar levels in menopausal women.


2021 ◽  
Vol 7 (1) ◽  
pp. 51-58
Author(s):  
Ely Nur Fauziyah ◽  
Sri Dinengsih ◽  
Risza Choirunissa

ABSTRACT UTERI FUNDUS HIGH RELATIONSHIP, BLOOD SUGAR AND CONDITIONSHEMOGLOBIN MOM WITH A NEW BORN WEIGHT  Background : Maternal and infant mortality rates are indicators commonly used to determine the degree of public health, assessment of the success of other health development programs. Low birth weight accounted for 51% of neonatal deaths throughout birth. The size of the birth weight depends on how the intrauterine fetus develops during pregnancy. This birth weight is one of the indicators of newborn health.Purpose: This research to find out the relationship between Uterine Fundus Height, Blood Sugar Levels, Hemoglobin Levels of mothers with weight and newborns at Puskesmas Sindang Jaya Year 2020.Method : This research is an Analytical Survey research with Cross Sectional design. The sample in this study of pregnant women who gave birth from june to August as many as 40 people.Results : In the results that there is a statistically significant relationship between high fundus uteri, blood sugar levels, and hemoglobin levels of mothers with baby weight born in the puskesmas sindang jaya with p value of 0.013 for high fudus ureteri, p value 0.042 for blood sugar levels, and p value of 0.069 for hemoglobin levels. Which means that all three variables have a p value of <0.05). With the variable that most affects the baby's weight is a high variable fundus erteri with a value (OR : 24).Conclusion : There is a link between high uterine fundus, blood sugar levels, and hemoglobin levels of mothers with newborn weight at Puskesmas Sindang Jaya Year 2020Suggestion  It is hoped that the next researcher can conduct further research because there are still many factors that can affect the weight of the newborn. Keywords : Baby Weight Born, Uterine Fundus Height, Blood Sugar Levels, Hemoglobin Levels. ABSTRAK Latar Belakang : Angka kematian ibu dan bayi adalah indikator yang lazim digunakan untuk menentukan derajat kesehatan masyarakat, penilaian terhadap keberhasilan pelayanan kesehatan program pembangunan kesehatan lainnya. Beratbayilahirrendahmenyumbang sebesar51%sebagaipenyebabkematianneonataldiseluruh kelahiran.Besar kecilnyaberatbadanlahirtergantungbagaimana pertumbuhan janinintrauterine selama kehamilan.Beratbadanlahirinilahyang menjadi salahsatuindikator kesehatanbayi baru lahir.Tujuan : Penelitian ini untuk mengetahui hubungan antara tinggi fundus uteri, kadar gula darah, dan kadar hemoglobin ibu dengan berat dan bayi baru lahir di Puskesmas Sindang Jaya Tahun 2020.Metode : Penelitian ini adalah penelitianSurvei AnalitikdenganrancanganCross Sectional. Sampel dalam penelitian ini ibu hamil yang melahirkan dari bulan juni-agustus sebanyak 40 orang.Hasil: Di dapatkan hasil bahwaterdapathubungan secarastatistiksignifikanantaratinggi fundus uteri, kadar gula darah, dan kadar hemoglobin ibu  dengan berat badan bayi lahir di puskesmas sindang jaya dengan p value 0.013 untuk tinggi fudus uteri, p value 0.042 untuk kadar gula darah, dan p value 0.069 untuk kadar hemoglobin. Yang artinya dari ketiga variabel memiliki nilai p value <0,05. Dengan variabel yang paling mempengaruhi berat badan bayi adalah variabel tinggi fundus uteri dengan nilai (OR : 24).Kesimpulan : Ada hubungan antara tinggi fundus uterus, kadar gula darah, dan kadar hemoglobin ibu dengan berat badan bayi baru lahir di Puskesmas Sindang Jaya Tahun 2020Saran: Diharapkan bagi peneliti selanjutnya dapat melakukan penelitian lebih lanjut dikarenakan masih banyak faktor yang dapat mempengaruhi berat badan bayi baru lahir.Kata Kunci : Berat Bayi Lahir, Tinggi Fundus Uteri, Kadar Gula Darah, Kadar Hemoglobin. 


2019 ◽  
Vol 26 (03) ◽  
Author(s):  
Nadia Ijaz ◽  
Tazeen Nazar ◽  
Bilal Aziz

Objectives: To determine the correlation between serum albumin levels and the grades of esophageal varices in patients of liver cirrhosis due to hepatitis B and C. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Unit I, Department of Medicine, Allied Hospital, Faisalabad from 29th June, 2014 to 28th December, 2014. Methodology: 95 patients of either sex between 20-70 years of age, with the diagnosis of liver cirrhosis due to hepatitis B and C were selected using non - probability consecutive sampling. The presence of esophageal varices was confirmed by endoscopy. Results: Out of a total of 95 patients, 59 (62.11%) were between the age group of 20-50 years while 36 (37.89%) were between 51-70 years of age. Mean+SD was calculated as 48.37+11.75 years. Gender distribution showed that 51 (53.68%) patients were males and 44 (46.32%) were females. Correlation between serum albumin level and the grade of esophageal varices in patients of liver cirrhosis due to hepatitis B & C showed that out of 26 cases with serum albumin level <2.8, 10 had Grade I and 16 had Grade II while out of 69 cases with ≥2.8 serum albumin level, 40 had grade I and 29 had grade II EV. r value was recorded to be -0.697 whereas p-value was calculated as 0.000. Conclusion: There is a significant negative correlation between serum albumin level and grade of esophageal varices in patients of liver cirrhosis due to hepatitis B and C.


2020 ◽  
Vol 3 (1) ◽  
pp. 26-31
Author(s):  
Ashish Thapa ◽  
Anugya Amatya ◽  
Roshan Parajuli

Introduction: Nearly half of people with diabetes don’t know they have it. It is often not diagnosed until complications appear. The aim of the study was to determine the prevalence of diabetes mellitus and prediabetes in patients presenting to the Emergency Department with incidental hyperglycemia, because the duration of hyperglycemia is a predictor of adverse outcomes, and there are effective interventions to prevent disease progression and to reduce complications. Methods: It was an observational cross-sectional study, 720 patients from Emergency Department of Kathmandu Medical College, Sinamangal were screened from December 2018 to March 2019 and a total of 128 patients with incidental hyperglycemia (>140mg/dl) were included. Patients with a previous diagnosis of diabetes, unstable patients and pregnant patients were excluded. Incidental hyperglycemia, fasting blood sugar, 2 hours postprandial blood sugar and HbA1c were noted, data entry was done in Microsoft Excel and analysis was done using the SPSS 24. Results: Total of 128 patients were enrolled for the study.10% of the patients had hyperglycemia and 34% among the hyperglycemic had the finding in the absence of history of diabetes. Incidental hyperglycemia ranged from 150-500 mg/dl. Among the incidental hyperglycemic, 29% and 36% had prediabetes and diabetes respectively. Incidental hyperglycemia was divided into four groups; <159, 160-179, 180-199 and >200 mg/dl, and each group was analyzed with the diagnostic criteria and the final outcome. It was found that each group correlated well with the diagnostic criteria and final outcome and was found to be statistically significant with p<0.0001 based on the Chi square test. Conclusions: Following the patients with incidental hyperglycemia in the Emergency Department, a significant number of undiagnosed diabetes or prediabetes can be diagnosed, early intervention can be started that can prevent progression from prediabetes to diabetes and risk of complications can be reduced.


2020 ◽  
Vol 6 (3) ◽  
pp. 85-93
Author(s):  
Rita Irma ◽  
Emi Widianingsih ◽  
Rasmaniar Rasmaniar

Background: In Indonesia, the prevalence of Diabetes Mellitus (DM) has increased. DM can have a significant impact on health that requires serious countermeasures. Moringa leaves have been extensively studied in terms of their efficacy in the treatment and prevention of DM.Objective: To identify the relationship between the habit of consuming Moringa leaves and blood sugar levels of Muna tribe.Method: This study was a cross-sectional study design conducted among local people in the Muna tribe community at Gunung Jati sub-district, Kendari, Southeast Sulawesi, Indonesia. A total of 81 people was participated selected using a proportional random sampling.Results: The average of frequency consumption of Moringa leaves among Muna tribe was one time a day, with consumption as much as 160 grams/day. The average of normal blood sugar was 103.5 mg/dl. There was no relationship between age, gender, education, working status with the frequency and amount of Moringa leaf intake. Similarly, analysis of blood sugar based on characteristics, there was no relationship between gender, education, working status with blood sugar, but there was a significant relationship between age and blood sugar (p=0.00). There was no relationship between the frequency and amount of moringa leaf intake with blood sugar levels.Conclusion: There was no relationship between the habit of consuming Moringa leaves both in terms of characteristics and blood sugar level among Muna people in the Gunung Jati, Kendari, Southeast Sulawesi, Indonesia.


Author(s):  
INDAH ROHMAWATI ◽  
Dora Dayu Rahma Turista

Coronary arteries are blood vessels that carry oxygen and nutrients to the heart muscle. These vessels can experience constriction due to the accumulation of plaque which causes atherosclerosis. Atherosclerosis is characterized by reduced coronary artery elasticity. Blood glucose levels are one of the factors that cause atherosclerosis. The aims of this study was to determine whether there was a correlation of blood sugar levels with the elasticity of coronary arteries. This study is an analytical study with cross sectional design. The population in this study were all patients who visited the Gipateda Tulungagung treatment clinic that was more than 30 years old and female. Through accidental sampling technique, 30 respondents were obtained. The study was conducted from March 1, 2016 to May 1, 2016. Data was collected using a quantum resonance magnetic analyzer (QMRA) to determine the value of blood sugar levels and the value of elasticity of coronary arteries. The data obtained were analyzed statistically by bivariate linear regression tests to determine whether there was a significant correlation of blood sugar levels with the elasticity of coronary arteries. The results showed that the p value is 0.000 < 0.05, which means that there was a significant correlation between blood sugar levels and the elasticity of the coronary arteries. High blood glucose levels can damage the vascular endothelium and also increasing platelet agegrat, so that can resulting atherosclerosis. Every individual should be able to control blood sugar levels with a healthy lifestyle and early detection regularly to prevent the decrease of coronary arteries elasticity because that can lead to coronary heart disease (CHD).


2015 ◽  
Vol 22 (10) ◽  
pp. 1284-1288
Author(s):  
Muhammad Usman Anjum ◽  
Muhammad Safdar Khan ◽  
Nazar Muhamamd Afridi ◽  
Syed Humayun Shah

Patients with end stage renal disease require haemodialysis as a part of theirtreatment. The incidence of hepatitis B and C virus infection is quite high in patients undergoingmaintenance haemodialysis than in general population. This risk is specifically associatedwith use of blood and its products as well as repeated intravascular access in these patients.Objectives: To determine the seropositivity of hepatitis B and C virus infection in patientsreceiving haemodialysis. Design: Descriptive cross sectional study. Setting: NephrologyDepartment, Ayub Teaching Hospital, Abbottabad, Pakistan. Period: From October 2014 toApril 2015. Methods: Five hundred patients were included in the study based on inclusionand exclusion criteria. Demographic data was recorded and detailed history was taken fromeach patient specifically about the no of blood transfusions received, the frequency of dialysisand the dialysis done in other centers. All patients were checked for the presence of hepatitisB surface antigen (HbsAg) and antibodies to HCV using third generation enzyme linkedimmunoassay (ELISA). Results: Mean age of study sample was 46±5 years with 60.8 % males.Incidence of hepatitis positive cases was 164 (32.8 %), out of which 66 (13.2 %) patients wereHBV positive and 98 (19.08 %) patients were HCV positive. The hepatitis B and C infectionswere more common in males than females. Seropositivity of HBV and HCV was higher (HBV18.1 % and HCV 22.2 %) among haemodialysis patients who have received more than threeblood transfusions. The frequency of HBV and HCV infections increases significantly with theincrease in frequency of dialysis, with 49 (17.11 %) patients were HBV positive and 70 (24.5%) patients were HCV positive cases, who have received haemodialysis for more than fivetimes. There were 48 (15.7 %) HBV positive cases as well as 68 (22.3 %) HCV positive cases inpatients who have received their treatment from a single center. Conclusion: Hepatitis B andC infection is quite common in patients undergoing haemodialysis. The risk of these infectionscan be reduced by following infection control guidelines, proper training of the staff and strictscreening of blood and blood products specifically for hepatitis C virus.


Jurnal GIZIDO ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 18-26
Author(s):  
Yessi Alza ◽  
Yuliana Arsil ◽  
Yessi Marlina ◽  
Lidya Novita ◽  
Niken Dwi Agustin

Diabetes mellitus (DM) is a chronic disease caused by the inability of the pancreas to produce enough insulin, or the body cannot effectively use the insulin produced by the pancreas. Regular aerobic physical activity in people with a diagnosis of DM can improve insulin sensitivity. The prevalence of DM in Indonesia based on Basic Health Research (Riskesdas) in 2018 is 10.9% while in Riau province occupies the third-highest rank in Indonesia. This study aims to determine the description of physical activity and blood sugar levels in people with type 2 diabetes mellitus at the Sidomulyo Health Center, Pekanbaru City. This study is descriptive with cross-sectional design. The sampling technique in this study was a total sampling of 24 people with DM type 2. Data collection for physical activity variables was carried out using a questionnaire included in PAL (Physical Activity Level). Measurement of blood sugar levels in patients with DM is done by taking respondent capillary blood then measured using a glucometer (Easy Touch GCU). Univariate analysis was carried out to analyze the variables of physical activity and blood sugar levels which were then presented in the form of frequency distribution tables and narratives. The results showed a description of the level of physical activity in respondents who suffer from DM as many as 16 people (66.7%) with mild physical activity levels, and 8 people (33.3%) with moderate levels of physical activity. Description of fasting blood sugar levels of respondents as many as 19 people (79.2%) had controlled fasting blood sugar levels, and 5 people (20.8%) had uncontrolled fasting blood sugar levels.


2019 ◽  
Vol 2 (2) ◽  
pp. 98-106
Author(s):  
Tarun Paudel ◽  
Bir Rawal ◽  
Keshab Deuba ◽  
Sampurna Kakchapati ◽  
Kapil Amgain ◽  
...  

 Introduction: HIV epidemic has become the major problems among people with injecting drugs (PWIDs) in Nepal. The study was carried out to assess the prevalence of sexually transmitted diseases including HIV/AIDS among PWIDs. Methods: This descriptive cross-sectional survey was conducted in male PWIDs of age more than 16 years residing in Western to Far West Terai Districts of Nepal who had been injecting drugs for three months prior to the date of the survey" March-April 2017. A two-stage cluster sampling was used to recruit 300 PWIDs from seven Districts. HIV was diagnosed by using standard techniques approved by WHO. Similarly, Syphilis was tested using the "Rapid Plasma Reagin" and Hepatitis C as well as Hepatitis B was tested by using rapid test kits. Demographic data were collected by using structured questionnaire and the data obtained were entered in MS excel was transformed into the SPSS version 21 for the descriptive as well as inferential analysis. Results: Prevalence of HIV, HBV, HCV, and STI among PWIDs were 5.3%, 2.7%, 23.7%, and 2.0% respectively. Majority of the PWIDs were literate (93.7%) and their age was below 35 years. Among the married PWIDs, 32.4% had got married before the age of 19. Similarly, 53.7% of them were living with their female sexual partner, and 95.0% were living with their wife. Ninety six percent of the respondents reported to be ever involved in sexual activity, 77.1% of them initiated the sexual intercourse before the age of 20 years and 41.9% of them had more than one female sexual partner. The survey indicated that 36.3% had been injecting drugs for more than 5 years while 27.7% had been injecting for last 2-5 years and 55.0% of the respondents had injected for the first time at the age of 16-24 years. About one in 10 respondents had started injecting drugs recently. Conclusion: There is high prevalence of HIV, HCV, HBV and active syphilis among the PWIDs. Co-infection of HIV and HCV as well as Hepatitis B and C were also prevalent among PWIDs. Comprehensive education and awareness program is required to reduce the prevalence.


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