Hepatic and Renal Safety of Remdesivir in COVID-19 Patients Observational prospective study

Background: SARS-CoV-2 has been demonstrated to be inhibited by Remdesivir, a broad-spectrum antiviral medication. Remdesivir has been tried for a compassionate use in severe COVID-19 in the absence of any viable treatment for SARS-CoV-2 infection (COVID-19). Methods: In 50 patients with SARSCoV-2 infection who were given Remdesivir as part of their institutional treatment plan, we conducted an observational prospective analysis. Remdesivir 100 mg was given daily for7 days during the therapy period. The results of liver and kidney function tests were compared before and after Remdesivir administration. Results: With the administration of Re%) exhibited an improvement in their oxygen needs. Patients reported only a few minor side effects. Serious side effects, on the other hand, were rare. Conclusion: Remdesivir seems to have an excellent safety profile, while its efficacy in the treatment of COVID-19 is currently inconclusive. Remdesivir use in patients was shown to be safe, with no serious side effects or significant changes in normal test results for liver and kidney functions. Keywords: Adverse events, Covid-19, liver function, remdesivir, renal function

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The oil of garlic, Allium sativum L. (Amaryllidaceae), as a potential protectant against Anisakis spp. Type II (L3) (Nematoda) infection in Wistar rats

Revista Brasileira de Parasitologia Veterinária ◽

10.1590/s1984-296120201086 ◽

2021 ◽

Vol 30 (1) ◽

Author(s):

Kareem Morsy ◽

Ali AL Ghamdi ◽

Saad Bin Dajem ◽

Mashael Bin-Meferij ◽

Ali Alshehri ◽

...

Keyword(s):

Normal Structure ◽

Infected Fish ◽

Type Ii ◽

Oral Inoculation ◽

Before And After ◽

Liver And Kidney ◽

Kidney Functions ◽

Anisakis Spp ◽

Normal Architecture ◽

Thermally Treated

Abstract The consumption of inadequately thermally treated fish is a public health risk due to the possible propagation of Anisakis larvae. The present study demonstrated the physiological and histopathological changes that accompanied an oral inoculation of crude extracts from fresh and thermally treated Anisakis Type II (L3) in rats. Worms were isolated from a marine fish and examined and identified using light and scanning electron microscopy. The study was performed in 6 rat groups: control (I), garlic oil (GO) inoculated (II), fresh L3 inoculated (III), thermally treated L3 inoculated (IV), fresh L3 + GO inoculated (V), and a thermally treated L3 + GO inoculated (VI) groups. Rats inoculated with fresh and thermally treated L3 showed abnormal liver and kidney functions associated with the destruction of normal architecture. GO produced a protective effect in rat groups inoculated with L3 extracts + GO via the amelioration of liver and kidney functions, which was confirmed by the marked normal structure on histology. Cooking of L3-infected fish induced severe alterations compared to uncooked fish. The administration of garlic before and after fish eating is recommended to avoid the dangerous effect of anisakids, even if they are cooked.

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Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

10.21203/rs.3.rs-448267/v1 ◽

2021 ◽

Author(s):

Emin Sengul ◽

Volkan Gelen ◽

Serkan Yildirim ◽

Esra Senturk ◽

Yusuf Dag ◽

...

Keyword(s):

Dna Damage ◽

Side Effects ◽

Total Bilirubin ◽

Control Group ◽

High Dose ◽

Liver And Kidney ◽

Group 5 ◽

High Doses ◽

Kidney Functions ◽

Liver And Kidney Damage

Abstract Hepatotoxicity and nephrotoxicity are common side effects of 5-Fluorouracil (5-FU). The present study aimed to investigate the effects of Silymarin (SLY) on 5-FU induced hepatotoxicity and nephrotoxicity in mice. In our study, 10 mice in each group were randomly divided into four groups as the control group, 5-FU, SLY50+5-FU, and SLY100+5-FU group. SLY50+5-FU and SLY100+5-FU groups were administered at a dose of 50 and 100 mg/kg for seven days, respectively. 5-FU was administered at a dose of 400 mg/kg intraperitoneally on the fourth day. After the applications, the mice were decapitated under anesthesia. The liver and kidney functions which urea, creatinine, AST, ALT, and total bilirubin levels were analyzed in serum. In liver and renal tissues, MDA and GSH levels, SOD, CAT, and GR activity were determined. Also, histopathological and immunohistochemical changes were examined in liver and kidney sections. Urea, creatinine, ALT, AST, and total bilirubin levels increased 5-FU group according to control and prevented to this increases the especially high dose of SLY. 5-FU also causes histopathological and immunohistochemical changes such as degeneration, necrosis, hyperemia, DNA damage, and IL-6 increase in kidney and liver tissue. High doses of SLY prevented these changes caused by 5-FU. As a result of this study, it was determined that SLY has hepatoprotective and nephroprotective effects on 5-FU-induced liver and kidney damage in mice.

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Changes in treatment plan for carpal tunnel syndrome based on electrodiagnostic test results

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193413497903 ◽

2013 ◽

Vol 39 (2) ◽

pp. 187-193 ◽

Cited By ~ 9

Author(s):

S. J. E. Becker ◽

H. S. Makanji ◽

D. Ring

Keyword(s):

Carpal Tunnel Syndrome ◽

Carpal Tunnel ◽

Treatment Plan ◽

Test Results ◽

Electrodiagnostic Testing ◽

Recommended Treatment ◽

Before And After ◽

Tunnel Syndrome ◽

English Speaking ◽

Sensory Latency

This study evaluated how often the treatment plan for carpal tunnel syndrome (CTS) changed based on electrodiagnostic test results. Secondly, we assessed factors associated with a change in the treatment plan for CTS. One-hundred-and-thirty English-speaking adult patients underwent electrodiagnostic testing in a prospective cohort study. Treatment plan was recorded before and after testing. Treatment plan changed in 25 patients (19%) based on electrodiagnostic test results. The plan for operative treatment before testing decreased significantly after testing (83% versus 72%). The best logistic regression model for no change in treatment plan included a prolonged or non-recordable median distal sensory latency (normal, prolonged, or non-recordable), and explained 24% of the variation. For surgeons that manage CTS on the basis of objective pathophysiology rather than symptoms, electrodiagnostic test results often lead to changes in recommended treatment.

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Local Treatment of Recent Arterial Thromboembolic Occlusions with Brinase

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651408 ◽

1975 ◽

Vol 34 (02) ◽

pp. 498-503 ◽

Cited By ~ 1

Author(s):

D Nyman ◽

M. A da Silva ◽

L. K Widmer ◽

F Duckert

Keyword(s):

Side Effects ◽

Local Treatment ◽

Before And After ◽

Local Side

SummaryBrinase was administered intra-arterially in 16 patients with thrombotic or embolic arterial occlusions. Angiography could be performed before and after treatment in 13 patients. Thrombolysis was obtained in 3 of 9 patients with thrombotic and in 3 of 4 patients with embolic occlusions. In 3 patients severe local side effects occurred.

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EVALUATION OF THE EFECTS OF ELECTRONIC ACUPUNCTURE COMBINED WITH “TAM TY THANG” REMEDY IN THE TREATMENT OF RHEUMATOID ARTHRITIS BY WIND-COLD-DAMP

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.6.17 ◽

2017 ◽

pp. 122-127

Author(s):

Thi Luu Nguyen ◽

Thi Tan Nguyen

Keyword(s):

Rheumatoid Arthritis ◽

Side Effects ◽

Prospective Study ◽

Key Words Rheumatoid Arthritis ◽

Good Effect ◽

Good Level ◽

Relieve Pain ◽

Level Of Activity ◽

Before And After ◽

The Moment

Objectives: To assess the effect of electronic acupuncture combined with “Tam ty thang” remedy in the treatment of rheumatoid arthritis by wind-cold-damp. Materials and methods: prospective study, comparing before and after treatment, including 43 patients who were diagnosed with rheumatoid arthritis by wind-cold-damp according to traditional medicine. Results: good level occupied 69,8%, and fair good level occupied 30,2%.The improved motor function accounted for 95.3%, to relieve pain up to 95,3%, reducing inflammation of VSS in 1 hour at the moment No 31,65, N28 17,88. The improvement in the level of activity of the hand reached 48,8% for good level. Conclusions: The method of electronic acupuncture combined with “Tam ty thang” remedy have a good effect in the treatment of rheumatoid arthritis by wind-cold-damp and it didn’t cause significantly side effects in clinic. Key words: rheumatoid arthritis, electronic acupuncture, “Tam ty thang” remedy

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Sunlight exposure: the effects on the performance of paragliding fabric

Industria Textila ◽

10.35530/it.069.05.1406 ◽

2018 ◽

Vol 69 (05) ◽

pp. 381-389

Author(s):

MENGÜÇ GAMZE SÜPÜREN ◽

TEMEL EMRAH ◽

BOZDOĞAN FARUK

Keyword(s):

Mechanical Properties ◽

Aging Process ◽

Air Permeability ◽

Sunlight Exposure ◽

Test Results ◽

Coating Materials ◽

Strength Tests ◽

Before And After ◽

The Relationship ◽

Dark Blue

This study was designed to explore the relationship between sunlight exposure and the mechanical properties of paragliding fabrics which have different colors, densities, yarn counts, and coating materials. This study exposed 5 different colors of paragliding fabrics (red, turquoise, dark blue, orange, and white) to intense sunlight for 150 hours during the summer from 9:00 a.m. to 3:00 p.m. for 5 days a week for 5 weeks. Before and after the UV radiation aging process, the air permeability, tensile strength, tear strength, and bursting strength tests were performed. Test results were also evaluated using statistical methods. According to the results, the fading of the turquoise fabric was found to be the highest among the studied fabrics. It was determined that there is a significant decrease in the mechanical properties of the fabrics after sunlight exposure. After aging, the fabrics become considerably weaker in the case of mechanical properties due to the degradation in both the dyestuff and macromolecular structure of the fiber

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EDUKASI TERHADAP REMAJA DALAM PENINGKATAN PENGETAHUAN TENTANG PENGGUNAAN GAME DENGAN BIJAK

Jurnal Pemberdayaan Masyarakat Universitas Al Azhar Indonesia ◽

10.36722/jpm.v2i1.361 ◽

2020 ◽

Vol 2 (1) ◽

pp. 11

Author(s):

Ikhsan Fuady ◽

Rangga Saptya MP

Keyword(s):

Side Effects ◽

Violent Behavior ◽

Daily Lives ◽

Before And After ◽

Improper Use ◽

Effective Role ◽

Education And Outreach ◽

The Right ◽

Dedicated Team ◽

User Ratings

AbstrakPemanfaatan game dikalangan remaja memiliki peran yang efektif sebagai wadah untuk hiburan. Tetapi pemanfaatan game tidak tepat memiliki efek samping game terhadap kehidupan sehari hari remaja, mulai dari kurang bersosialIsasi hingga perilaku kekerasan dikalangan remaja. Penyuluhan terhadap remaja bertujuan untuk memberikan pemahaman kepada remaja tentang variasi game berdasarkan rating pengguna, maupun cerdas dalam manajemen penggunaan game dalam kehidupan remaja sehari hari. Pengetahuan remaja tentang varian/ragam game berdasarkan rating relatif rendah sebagaian besar pemengetahuannya tersebar pada kategori sangat rendah dan rendah yaitu sebesar 65 persen. Metode edukasi dan sosialisasi ini adalah dengan beberapa tahapan. Tahap pertaman tim pengabdian memberikan edukasi dan diskusi tentang beragam bentuk game, karakteristik, serta karakteristik pengguna game yang tepat. Selanjutnya beberapa permainan dan kuis untuk meingkatkan literasi remaja tentang pemanfaatan game secara bijak. Kegiatan penyuluhan ini mampu meningkatkan pemahaman para remaja dalam mengenali game yang baik digunakan, hal ini dapat dilihat dari peningkatan pengetahuan remaja relatif signifikan sebelum dan sesudah penyuluhan.Kata kunci: Edukasi, Game, Penyuluhan Abstract The use of games among teenagers has an effective role as a forum for entertainment. But the improper use of games has the side effects of games on the daily lives of adolescents, ranging from lack of socialization to violent behavior in adolescents. Counseling against adolescents aims to provide understanding to adolescents about the variety/variance of games based on user ratings, as well as being smart in managing game use in daily teenage life. Teenagers' knowledge about game variants/based on the rating is relatively low, most of the knowledge is spread in the very low and low categories, which is 65 percent. The method of education and outreach is by several stages. The first stage of the dedicated team provided education and discussion about various forms of games, characteristics, and characteristics of the right game user. Furthermore, some games and quizzes to improve teen literacy about game use wisely. This counseling activity can increase the understanding of teenagers in recognizing games that are well used, this can be seen from the relatively significant increase in adolescent knowledge before and after counseling.Keywords: Education, Games, Counseling

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Clinical manifestations of Liver and Renal impairments in asymptomatic, moderate and severe COVID-19 patients of Madinah city of Saudi Arabia: a retrospective analysis (Preprint)

10.2196/preprints.23629 ◽

2020 ◽

Author(s):

Firdous Beigh ◽

Nidda Syeed ◽

Walaa Saeed ◽

Ziab Alahmadey ◽

Ibrahim Seedi

Keyword(s):

Saudi Arabia ◽

Clinical Status ◽

Clinical Manifestations ◽

Normal Liver ◽

Significant Percentage ◽

Renal Functions ◽

Moderate Disease ◽

Novel Association ◽

Liver And Kidney ◽

Kidney Functions

BACKGROUND Coronavirus disease (COVID-19) is a budding infectious disease that has affected various countries globally. OBJECTIVE The aim of this study was to analyze the effect of COVID-19 disease on liver and kidney functions and to determine their association with the severity and mortality of disease METHODS A total of 100 confirmed COVID-19 adult patients from Madinah city of Saudi Arabia hospitalized between April 28, and June 30, 2020 were included,and categorized into asymptomatic,mild to moderate and severely ill patients.We analyzed the clinical status of liver and renal functioning in all of the three groups. RESULTS The majority of patients (51%) were diagnosed with mild to moderate disease, 27% of patients were severely ill and 22% of patients were asymptomatic.The liver and renal functional analysis showed that the severity of the COVID-19 patients were significantly associated with the kidney and renal impairments exhibiting higher levels of ALT, AST, Creatinine, Urea levels (P < 0.05). Furthermore, in this study, a novel association is found between high Na and Cl levels with the severely ill COVID-19 patients. CONCLUSIONS We concluded from the present study that a significant percentage of COVID-19 patients continued to have a normal liver and renal function during the course of their disease. Nevertheless, severely ill COVID-19 patients were more prone to have abnormal liver and renal functions. During the course of treatment, the patients had a gradual normalization of their liver and kidney parameters and subsequently achieved a complete normal liver and renal functions upon discharge with no mortality.

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Effectiveness of paranasal air suction on acute migraine using portable air sucker – a randomized, double blind study

BMC Neurology ◽

10.1186/s12883-021-02203-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

S. M. R. Bandara ◽

S. Samita ◽

A. M. Kiridana ◽

H. M. M. T. B. Herath

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Sri Lanka ◽

Primary Headache ◽

Headache Disorder ◽

Low Pressure ◽

Outcome Variable ◽

Double Blind ◽

Primary Headache Disorder ◽

Before And After

Abstract Background Migraine is a primary headache disorder and is the most common disabling primary headache disorder that occurs in children and adolescents. A recent study showed that paranasal air suction can provide relief to migraine headache. However, in order to get the maximum benefit out of it, an easy to use effective air sucker should be available. Aiming to fulfil the above requirement, a randomized, double blind control clinical trial was conducted to investigate the efficacy of a recently developed low–pressure portable air sucker. Methods Eighty-six Sri Lankan school children of age 16–19 years with migraine were enrolled for the study. They were randomly allocated into two groups, and one group was subjected to six intermittent ten-second paranasal air suctions using the portable air sucker for 120 s. The other group was subjected to placebo air suction (no paranasal air suction). The effect of suction using portable air sucker was the primary objective but side of headache, type of headache, and gender were also studied as source variables. The primary response studied was severity of headache. In addition, left and right supraorbital tenderness, photophobia, phonophobia, numbness over the face and scalp, nausea and generalized tiredness/weakness of the body were studied. The measurements on all those variables were made before and after suction, and the statistical analysis was performed based on before and after differences. As a follow–up, patients were monitored for 24-h period. Results There was a significant reduction in the severity of headache pain (OR = 25.98, P < 0.0001), which was the primary outcome variable, and other migraine symptoms studied, tenderness (left) (OR = 289.69, P < 0.0001), tenderness (right) (OR > 267.17, P < 0.0001), photophobia (OR = 2115.6, P < 0.0001), phonophobia (OR > 12.62, P < 0.0001) nausea (OR > 515.59, P < 0.0001) and weakness (OR = 549.06, P < 0.0001) except for numbness (OR = 0.747, P = 0.67) in the treatment group compared to the control group 2 min after the suction. These symptoms did not recur within 24-h period and there were no significant side effects recorded during the 24-h observation period. Conclusion This pilot study showed that low–pressure portable air sucker is effective in paranasal air suction, and suction for 120 s using the sucker can provide an immediate relief which can last for more than 24-h period without any side effects. Trail registration Clinical Trial Government Identification Number – 1548/2016. Ethical Clearance Granted Institute – Medical Research Institute, Colombo, Sri Lanka (No 38/2016). Sri Lanka Clinical Trial Registration No: SLCTR/2017/018. Date of registration = 29/ 06/2017. Approval Granting Organization to use the device in the clinical trial– National Medicines Regulatory Authority Sri Lanka (16 Jan 2018), The device won award at Geneva international inventers exhibition in 2016 and President award in 2018 in Sri Lanka. It is a patented device in Sri Lanka and patent number was SLKP/1/18295. All methods were carried out in accordance with CONSORT 2010 guidelines.

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