Determining the Receptor Proteins AdipoR1, Leptin and Lipid Status in Serum; Mitigating its impact on Obese and Healthy Individuals

2021 ◽  
Vol 15 (6) ◽  
pp. 1164-1168
Author(s):  
M. A. Talat ◽  
I. Liaqat ◽  
T. Usman ◽  
M. K. Ashraf ◽  
A. Malik ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Cross Sectional Study ◽  
Lipid Lowering ◽  
Healthy Individuals ◽  
Cross Sectional ◽  
Receptor Proteins ◽  
Lipid Status ◽  
History Of ◽  
Obese Subjects

Aim: To investigate role of AdipoR1 concentrations and leptin levels in obese and healthy subjects along with their lipid status Methods: This cross sectional study was conducted in residents of Sialkot city and included 132 subjects. Each group had 66 participants. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while healthy group BMI was 20.5±0.2. Individuals with known history of diabetes, hypertension, chronic kidney disease, any malignancy and history of lipid lowering, antihypertensive, antipsychotics and antiepileptic were excluded. Fasting blood samples were taken after informed and written consent. Samples were centrifuged to extract serum and stored for analysis by ELISA method for AdiopR1 and leptin while lipid profile was determined by kits by Randox Diagnostics using micro lab. Data was analyzed by SPSS v. 26. Comparison between groups was carried out by Mann-Whitney U test. Results: Our study revealed higher levels of serum AdipoR1 (28.9±22.86 ng/mL), leptin (320.7±59.38 pg/mL), cholesterol (216±5.31 mg/dl), triglyceride (177.8±4.93 mg/dl) and LDL (139.3±4.56 mg/dl) in obese when compared with healthy individuals, AdiopoR1 (17.8±1.96ng/mL), leptin (219±20.76 pg/mL), cholesterol (179.8±3.25 mg/dl), triglyceride (149.8±3.17mg/dl), LDL (108.5±25.7 mg/dl) respectively. No statistical difference was found for HDL between groups. Conclusion: Our Study concludes that rising levels of AdipoR1 and leptin in addition to lipid profile are associated with obesity. Keywords: Obesity, Receptor Proteins AdipoR1, Leptin, lipid status, adipose tissue

Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor

2021 ◽  
Vol 15 (10) ◽  
pp. 2550-2553
Author(s):  
Muhammad Ali Talat ◽  
Muhammad Shoaib ◽  
Sana Sabir ◽  
Uzair Mumtaz ◽  
Ambreen Tauseef ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Elisa Method ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Lipid Status ◽  
History Of ◽  
Obese Subjects ◽  
Suitable Marker

Aim: To determine Leptin/Adiponectin ratio, LDL/HDL ratio and AdipoR1 in obese and healthy subjects along with their respective lipid status. Methods: This cross-sectional comparative study was conducted in Sialkot city. One hundred and thirty-two participants took part in this research. Participants were equally divided into two groups containing non-obese and obese subjects. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while non-obese group BMI was 20.5±0.2. Individuals with conditions and history of drugs were excluded. Informed and written consent was obtained prior to fasting blood sampling. Serum extraction and proper storage for later testing was carried out. ELISA method used for Adiponectin, AdiopR1 and leptin estimations while lipid profile was determined by Randox Diagnostics kits, using micro lab. SPSS v. 26. was used for comparison between by Mann-Whitney U tes. Results: Higher levels of Leptin/Adiponectin ratio(0.85±0.1) and LDL/HDL ratio (3.39 ± 0.1), serum Adiponectin (545± 73.3 ug/L), leptin (320.7±50.3 pg/mL) and AdipoR1 (28.9± 2.8 ng/mL) in obese when compared with healthy individuals, Leptin/Adiponectin ratio (0.44 ± 0.07 ) and LDL/HDL ratio (2.56 ± 0.08) Adiponectin (834± 70.6 ug/L), AdiopoR1 (17.8± 1.97 ng/mL), leptin (224.4±168.7 pg/mL). Correlation of adiponectin found positive for AdipoR1(r=0.336,p<0.05) and Leptin(r=0263,p<0.05) in obese subjects. L/A ratio correlated positive with leptin (r=0.644,p<0.05) in obese while in healthy subjects (leptin r=0.409,p<0.05,adiponectin r=-0.408,p<0.05 and HDL r=0.266,p<0.05).. Conclusion: The Leptin/Adiponectin ratio was found higher in obese subjects 0.85 as compared to healthy ones 0.44. Also the LDL/HDL ratio was found higher (3.39) when compared to non-obese (2.56), suggesting these ratios as a suitable marker to estimate metabolic disturbances and underlying dyslipidemia in the obese subjects. Key Words: Adiponectin, LDL/HDL ratio, Leptin, Leptin/Adiponectin ratio, Obesity

scholarly journals Role of Psychosocial Factors In Vicarious Traumatization: A Comparative Study

2022 ◽  
Vol 9 (1) ◽  
pp. 53-57
Author(s):  
Nazia Mustafa ◽  
Hina Iqbal
Keyword(s):  
Psychosocial Factors ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Vicarious Traumatization ◽  
Cross Sectional Study ◽  
Personal History ◽  
Vulnerable Group ◽  
Cross Sectional ◽  
History Of

OBJECTIVES: The present study aimed at investigating the role of psychosocial factors such as, gender, marital status, profession, and personal history of trauma in vicarious traumatization (VT). METHODOLOGY: Cross sectional study was conducted at various hospitals in Rawalpindi and Islamabad over the period of 6 months from January 2018 to June 2018. A sample of 170 healthcare professionals (doctors=39, psychiatrists=27, psychologists=36, nurses=30 and others=38) (men=67, women=103) was taken from various hospitals in Rawalpindi and Islamabad. Data were collected by using the Secondary Traumatic Stress Scale. RESULTS: Results revealed significant differences have been found among various groups of healthcare professionals (doctors, psychiatrist, psychologists, nurses and others) in whom psychiatrists are the most vulnerable group for vicarious traumatization and psychologists are the least vulnerable group. Moreover, healthcare professionals who are married and have personal history of trauma are more vulnerable for vicarious traumatization as compared to those who are unmarried and without personal history of trauma. No significant gender differences have been found among health care professionals on vicarious traumatization. CONCLUSION: The findings of present research have emphasized that vicarious traumatization must be addressed and identified in a health setting.

Frequency of Dyslipidemia in Obese

2021 ◽  
Vol 15 (10) ◽  
pp. 2831-2832
Author(s):  
Ambreen Asif ◽  
Kashif Aziz Ahmad ◽  
Sohaib Akbar ◽  
Talha Munir
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Obese Subjects

Objective: frequency of dyslipidemia in obese subjects Methodology: In this was a cross sectional study, we included a total of 100 cases, between 30 and 70 years of age of either gender having body mass index >30 whereas we excluded all those cases who were already taking treatment of dyslipidemia. A fasting blood sample was followed for lipid profile from the hospital lab and results were followed for presence/absence of dyslipidemia. Results: In this trial, mean age was 44.57+8.52 years. Mean lipid profile was recorded as 210.17+36.73 total cholesterol, 178.83+12.10 triglycerides, 133.55+9.74 LDL and 34.42+6.58 HDL. Mean Body mass index was calculated as 34.11+7.25. Frequency of dyslipidemia in obese subjects was recorded as 51%(n=51) Conclusion: We concluded that frequency of dyslipidemia is higher in obese subjects coming to a tertiary care hospital Lahore. So, it is recommended that every patient who present with obesity, should be sort out for dyslipidemia. However, it is also required that every setup should have their surveillance in order to know the frequency of the problem Keywords: Obese, dyslipidemia, frequency

scholarly journals Hypertension and Pre-Hypertension with Associated Risk Factors Among MBBS Students of Shalamar Medical and Dental College, Lahore

2018 ◽  
Vol 23 (4) ◽  
pp. 477-482
Author(s):  
Rana Hanan ◽  
Muhammad Waqar Shafi ◽  
Sumair Anwar ◽  
Numrah Nawaz
Keyword(s):  
Risk Factors ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Male Students ◽  
Junk Food ◽  
Cross Sectional ◽  
History Of ◽  
Obese Subjects ◽  
Family History Of Hypertension ◽  
Associated Risk Factors

Hypertension is a multifactorial chronic disease and a silent cause of high causalities around the globe. Both hyper and pre-hypertension affect all ages and professions, and are as common as flu infections by affecting 1 in every 5 persons. In order to determine frequency of hypertension and pre-hypertensionamong medical students and their association with various variable and fixed risk factors, this study was designed. The cross sectional study of 4 months was carried out on the students of Shalamar Medical and Dental College. Students were aged from 18-25 years and a sample of 100 students was enrolled by stratified random sampling after written consent. We recorded blood pressure at three different time points, one minute apart in sitting position after ten minutes of rest. The average of three measurements was considered as final reading. Data regarding related variables was entered and analysed using SPSS version 21. Out of 100 (43 males and 57 females), three students were hypertensive, 55 pre-hypertensive and 42 normotensive; among pre-hypertensive female students were more in number as compared to male students. Mean age was 21.6 years with increased frequency of pre hypertensive and hypertensive individuals in the first, second and final year class. A total of 64% pre-obese subjects were pre-hypertensive or hypertensive and 75% obese were also pre hypertensive or hypertensive. Frequency of intake of fast/junk food was higher among pre-hypertensive and hypertensive individual than normotensive and same among both genders. Median value of average sleep (hours) among pre-hypertensive subjects was lesser than of hypertensive subjects. Students expressed their concerns related to college timings and hectic routine and increased frequency of teaching sessions including assessments. Frequency of pre-hypertension was higher in the students especially in the first, second and final years of graduation (MBBS). Pre-hypertensive and hypertensive students were pre-obese or obese and had positive family history of hypertension, consumed fast/junk food in both genders. College timing and intensive routines were primary cause of irritation and aggression, which may result in hypertension.

scholarly journals Role of Contact with Tuberculous Patients in Cases of Tuberculous Cervical Lymphadenitis.

2004 ◽  
Vol 43 (152) ◽  
pp. 79-82
Author(s):  
D K Baskota ◽  
RCM Amatya ◽  
RP Shrivastav ◽  
BK Sinha
Keyword(s):  
Communicable Disease ◽  
Disease Process ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Cervical Lymphadenitis ◽  
Cross Sectional ◽  
History Of ◽  
One Year

A prospective, analytical and cross-sectional study to find out the role of contact with tuberculous patientsduring the process of development of Tuberculous Cervical Lymphadenitis was currently carried out in theDepartment of ENT- Head & Neck Surgery of Tribhuvan University Teaching Hospital Kathmandu, Nepal.Altogether 103 cases of histopathologically confirmed cases of Tuberculous Cervical Lymphadenitis of morethan six weeks of duration were included in the study during the period of one year from March, 2000 toFebruary, 2001.History of contact with tuberculous patients in the past during the development of the disease process wasfound to be positive in 19(18.4%) of the 103 cases. In rest of the 84 cases history of contact with tuberculouspatients was found to be negative (81.6%).The result of this study so far indicates that there is a minimal role of contact with tuberculous patients forthe development of tuberculous cervical lymphadenitis. Although tuberculosis is known as a chroniccommunicable disease, in our study majority cases of Tuberculous Cervical Lymphadenitis did not give anyhistory of contact with tuberculous patients in the past.Key Words: Tuberculous cervical lymphadenitis, tuberculous patients, communicable disease.

scholarly journals Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases

2021 ◽  
Author(s):  
Sofia Beghi ◽  
Francesca Cavaliere ◽  
Matteo Manfredini ◽  
Sandro Ferrarese ◽  
Claudio Corazzari ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Previous History ◽  
Kinase Domain ◽  
Cross Sectional Study ◽  
Calcium Signal ◽  
Cross Sectional ◽  
Gene Coding ◽  
History Of ◽  
Dependent Protein

Cardiovascular diseases (CVDs) are leading cause of death worldwide. CVDs have a complex etiology due to the several factors underlying its development including environment, lifestyle, and genetics. Given the role of calcium signal transduction in several CVDs, we investigated via PCR-RFLP the single nucleotide polymorphism (SNP) rs7214723 within the CAMKK1 gene coding for the Ca2 + / calmodulin dependent protein kinase kinase I. The variant rs7214723 causes a E375G substitution within the kinase domain of CAMKK1. A cross-sectional study was conducted on 300 cardiac patients. RFLP-PCR technique was applied, and statistical analysis was performed to evaluate genotypic and allelic frequencies and to identify an association between SNP and risk of developing specific CVD. Genotype and allele frequencies for rs7214723 were statistically different between cardiopathic and several European reference populations. A logistic regression analysis adjusted for gender, age, diabetes, hypertension, BMI and previous history of malignancy was applied on cardiopathic genotypic data and no association was found between rs7214723 polymorphism and a risk of developing specific CAD. These results suggest the potential role of rs7214723 in CVD susceptibility as a possible genetic biomarker.

scholarly journals The role of blood pressures in patients with a headache

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mehrdokht Mazdeh ◽  
Mojtaba Khazaei ◽  
Arezou Sayad ◽  
Javad Zebarjadi Bagherpour ◽  
Mohammad Taheri
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
History Of ◽  
Daily Headache ◽  
Blood Pressures ◽  
Stage 1

Background: A headache is the most common cause of patients referred to the doctor. About 40 percent of people are suffering from a headache for at least once a year. Due to it's the high prevalence and its association with cardiovascular diseases, hypertension was considered as a  health problem in industrialized and developing countries. The aim of this study was to investigate the role of blood pressure in patients with a headache referred to the neurological clinic during  2014-2015 in Hamadan.Method: This cross-sectional study was performed to evaluate patients with a headache referred to the neurological clinic. Exclusion criteria included: a headache with a specific cause (a migraine, stroke, chronic daily headache, kidney disease, Diabetes Mellitus, history of heart disease or use of cigarette. The data were entered into the list and then were analyzed by SPSS software through paired T-test and chi-square test.Results: In this study, the 100 patients with a headache (78% females and 22% males) were investigated. The average age of patients was 60.07±13.175 years. The prevalence of stage 1 & 2 hypertension was 85%, and prehypertension prevalence of 7% was reported. Most of the headaches were in the frontal (33 %). Furthermore, the most headaches occur in varied time (70%). There wasn’t a significant correlation between age (P-value=0.698), gender (P-value=0.952), headache and blood pressure.Conclusion: The results obtained from the present study indicated that there was not any significant correlation between a headache and blood pressure, and the prevalence of blood pressure in the patients with a headache was similar to those who do not have headaches.Keywords: Blood Pressure, Hypertension, Headache

scholarly journals LIPID ALTERATION

2011 ◽  
Vol 18 (04) ◽  
pp. 663-666
Author(s):  
KAMAL ELDIN AHMED ABDELSALAM ◽  
MANAHIL ALI SHARWANI ◽  
SHAZA SALIH TAHA
Keyword(s):  
Lipid Profile ◽  
Cross Sectional Study ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
Obese Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Obese Subjects ◽  
Males And Females

Objective: determine serum lipid profile in diabetic and obese non-diabetic patients. Materials: 300 subjects comprising three groups, the first group included 100 diabetic patients (non-obese) with duration of diabetes over 5 years, the second group (obese) included 100 obese subjects (non-diabetic) with duration of obesity over 5 years, and the third group (control) included 100 healthy subjects. Methods: Lipid profile on the serum was performed with an auto analyzer using standard methods. Study design and period: Prospective Analytical Cross Sectional Study conducted in period from September 2006 to January 2008. Results: A significant (p value<0.05) increase in lipid profile results of diabetic and obese patients comparing to control while HDL-C showed significant decreasing. The cholesterol is significantly increased in females than males in diabetic patients, while the triglycerides are significantly decreased in diabetic females. The parameters showed insignificant variations between males and females in obese patients. Conclusions: In comparison to control group, DM & obese groups showed significantly increase in TG, TC, and LDL-C, but significantly decrease in HDL-C. Females showed significant increasing in TC and significant decreasing in DM group, while in obese group females showed insignificant decreasing in TG and TC. 

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