scholarly journals Investigation of the Relationship between Parental Mental Disorders and Autism among the Children of West Azerbaijan -Iran

2020 ◽  
Vol 10 (1) ◽  
pp. 59
Author(s):  
Arezou Kiani Equal ◽  
Javad Rasouli ◽  
Sahar Kiani
Keyword(s):  
Mental Disorders ◽  
Communication Disorders ◽  
Repetitive Behaviors ◽  
Control Group ◽  
Healthy Children ◽  
Control Groups ◽  
Mental Diseases ◽  
West Azerbaijan ◽  
And Control ◽  
The Relationship

Background: Autism disorders have increased over the last years. Autism is a neurological growth disorder associated with social communication disorders, growth retardation, and repetitive behaviors, along with serious consequences for children and families. The purpose of this research was to evaluate the relationship between parental mental disorders and autism among the children of West Azerbaijan Province. Methods: This research was a case-control study in which the case group subjects were selected among the parents with autistic children and control group subjects were selected among the relative parents with healthy children and non-relative parents with healthy children. Both case and control groups were matched in terms of gender, living place, and age of children. Finally, the data were analyzed using SPSS-16 (Chicago, IL, USA) software. Results: The current research results revealed that the frequency of mental diseases, including obsessive-compulsive, inter personality sensitivity, depression, anxiety, hostility, phobia, paranoid ideation, and psychotic disorder are different in fathers and mothers of the case and control groups. As Pvalue was lower than 0.05 in all scales, there was a significant relationship between the mental diseases of parents and the history of mental disorders in relatives and autism. Conclusion: The prevalence of mental disorders in relatives and having a medical history can be a warning sign of autism in children.

Thyroid Functions in Children on Levetiracetam or Valproic Acid Therapy

2020 ◽  
Author(s):  
Elif Karatoprak ◽  
Samet Paksoy
Keyword(s):  
Valproic Acid ◽  
Subclinical Hypothyroidism ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Healthy Children ◽  
Control Groups ◽  
Acid Therapy ◽  
Significant Difference ◽  
And Control ◽  
Tsh Levels

AbstractThe aim of this study was to investigate the thyroid functions in children receiving levetiracetam or valproate monotherapy. We retrospectively reviewed the records of children with controlled epilepsy receiving valproic acid (VPA group) or levetiracetam monotherapy (LEV group) for at least 6 months. Free thyroxine 4 levels (fT4) and thyroid stimulating hormone (TSH) levels were compared between VPA group, LEV group, and age- and gender-matched healthy children (control group). A total of 190 children were included in the study: 63 were in the VPA, 60 in the LEV, and 67 in the control group. Although there was no significant difference regarding average fT4 levels, higher TSH levels were found in the VPA group when compared with the LEV and control groups (p < 0.001 and p < 0.001, respectively). There was no significant difference in terms of fT4 and TSH values in the LEV group when compared with the control group (p = 0.56 and p = 0.61, respectively). Subclinical hypothyroidism (defined as a TSH level above 5 uIU/mL with a normal fT4 level was detected in 16% of patients in the VPA group, none in the LEV and control groups. Our study found that VPA therapy is associated with an increased risk of subclinical hypothyroidism while LEV had no effect on thyroid function tests.

scholarly journals Echocardiographic evaluation of ventricular septal defect haemodynamics

2007 ◽  
Vol 135 (9-10) ◽  
pp. 541-546
Author(s):  
Vesna Miranovic
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Artery ◽  
Body Surface ◽  
Septal Defect ◽  
Left Ventricular ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
And Control ◽  
The Relationship

Introduction Ventricular septal defect (VSD) is an opening in the interventricular septum. 30-50% of patients with congenital heart disease have VSD. Objective The aim of the study was to determine the dependence of the left ventricular diastolic dimension (LVD), left ventricular systolic dimension (LVS), shortening fraction (SF), left atrium (LA), pulmonary artery truncus (TPA) on the body surface and compare their values among experimental, control and a group of healthy children. Values of maximal systolic gradient pressure (Pvsd) of VSD were compared with children from one experimental and control group. Method Children were divided into three groups: experimental (32 children with VSD that were to go to surgery), control (20 children with VSD who did not require surgery) and 40 healthy children. Measurements of LVD, LVS, SF, LA, TPA were performed in accordance to recommendations of the American Echocardiographic Association. The value of Pvsd was calculated from the maximal flow velocity (V) in VSD using the following formula: Pvsd=4xV? (mm Hg). Results For children from the experimental group, the relationship between the body surface and the variability of the LVD was explained with 56.85%, LVS with 66.15%, SF with 4.9%, TPA with 58.92%. For children from the control group, the relationship between the body surface and the variability of LVD was explained with 88.8%, LVS with 72.5%, SF with 0.42%, PA with 58.92%. For healthy children, the relationship between the body surface and the variabilitiy of the LVD was explained with 88.8%, LVS with 88.78%, SF with 5.25% and PA with 84.75%. There was a significant statistical difference between average values of Pvsd in the experimental and control group (p<0.02). Conclusion The presence of the large VSD has an influence on the enlargement of LVD, LVS, SF, TPA. The enlargement of the size of the pulmonary artery depends on the presence of VSD and there is a direct variation in the magnitude of the shunt. There is a relationship and significant dependence of the LVS and LVD on the body surface. There is no statistically significant dependence between SF and body surface.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

scholarly journals The Prevalence and Characteristic of Sleep Problems among Children with Fetal Alcohol Spectrum Disorders (FASD).

2020 ◽  
Author(s):  
Katarzyna Anna Dyląg ◽  
Bożena Bańdo ◽  
Zbigniew Baran ◽  
Paulina Dumnicka ◽  
Katarzyna Kowalska ◽  
...  
Keyword(s):  
Sleep Problems ◽  
Alcohol Exposure ◽  
Control Group ◽  
Published Data ◽  
Healthy Children ◽  
Control Groups ◽  
Diagnostic Center ◽  
Left And Right ◽  
Spectrum Disorders ◽  
And Control

Abstract BackgroundFetal alcohol spectrum disorders (FASD) is a group of conditions resulting from prenatal alcohol exposure (PAE). Patients with FASD experience a variety of neuropsychological symptoms resulting from central nervous system impairment. Little is known about sleep disorders associated with PAE. The objective of this study was to investigate the prevalence and characterize sleep problems among individuals with FASD.Methods40 patients from FASD diagnostic center (median age 8 years (6; 11)) diagnosed with one of the FASD diagnosis and 40 patients from the control group (median age 10 years (8; 13)) participated in the study. In the 1st phase, the screening of sleep problems was performed with Child Sleep Habit Questionnaire (CSHQ) filled in by a caregiver. Those who scored above 41 points were qualified to the 2nd phase of the study in which in-lab attended polysomnography (PSG) was performed. The measurements consisted of electroencephalographic channels, left and right electrooculograms, chin electromyogram, left and right tibialis electromyogram, electrocardiogram, ventilatory monitoring, breathing effort, pulse oximetry, snoring and body position.ResultsThe number of participants with sleep disturbances was markedly higher in the study group as compared to controls (55% vs. 20%). The age-adjusted odds ratio for a positive result in CSHQ was 4.31 (95% CI: 1.54-12.11; p=0.005) for FASD patients as compared to the control group. Significant differences between the study and control groups were observed in the following subscales: sleep onset delay, night wakings , parasomnias , sleep disordered breathing, and daytime sleepiness. In PSG children from the FASD group and children from the control group experienced more arousals during the sleep than the children from the laboratory control group. ). There were no significant differences in comparison of respiratory indexes between FASD and control groups although indices in both groups were higher than previously published data for a normal population.ConclusionSleep disorders are more common among individuals with FASD than among healthy children. As distorted sleep can affect daily performance and worsen neurodevelopmental issues, it is vital for the pediatricians and other FASD specialists to include the question about sleep in the anamnesis.

scholarly journals Prognostic Importance of Thrombospondin-1, VEGF, PDGFR- β in Diffuse Large B-Cell Lymphoma Cases

2021 ◽  
Author(s):  
adnan batman ◽  
Rafiye Çiftçiler ◽  
Elif Birtas Atesoglu ◽  
Abdullah Hacihanefiogullari
Keyword(s):  
Negative Correlation ◽  
B Cell Lymphoma ◽  
Response To Treatment ◽  
Control Group ◽  
Control Groups ◽  
Large B Cell Lymphoma ◽  
Thrombospondin 1 ◽  
Prognostic Importance ◽  
And Control ◽  
The Relationship

Purpose: We aimed to investigate the relationship between the staining rates of thrombospondin-1, VEGF and PDGFR-in tissue preparations in patients diagnosed with DLBCL as a result of lymphadenopathy biopsy and their clinical features at the time of diagnosis, response to treatment and prognosis. Materials and Methods: For this purpose, a total of 44 patients with a diagnosis of DLBCL, 24 male and 20 female, and 13 patients diagnosed with control reactive lymphadenopathy, 6 male and 7 female were enrolled. After the pathology preparations of the patient and control groups were stained immunohistochemically with VEGF, PDGFR-β, thrombospondin-1 stains, the clinical characteristics of the patients and the relationship between survival analysis and staining rates were analyzed statistically. Results: When the patients were compared with the control group in terms of VEGF, PDGFR-β, thrombospondin-1 staining rates, we found that staining with PDGFR-β was lower in patients (p = 0.009). Although it was not statistically significant for PDGFR-β, it was observed that 5-year OS and PFS values were low in patients with high levels of expression, on the contrary, 5-year OS was low in patients with high thrombospondin staining rate. A negative correlation was seen between thrombospondin-1 and PDGFR-β (p=0.003, r=-0.440). Conclusion: As a result, although no relationship was found between VEGF and survival in our study, it was observed that PDGFR-β and thrombospondin-1 were effective in prognosis. A negative correlation was seen between thrombospondin-1 and PDGFR-β.

scholarly journals LIPID PROFILE AND ITS SIGNIFICANCE IN BREAST CANCER

2020 ◽  
Vol 8 (10) ◽  
pp. 1241-1248
Author(s):  
Sharmin Arif ◽  
◽  
Fauzia Abdus Samad ◽  
Syed Abdus Samad ◽  
Asif Riaz Khan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Morbidity And Mortality ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Control Groups ◽  
Common Cancer ◽  
And Control ◽  
The Relationship

Background: According to WHO, breast cancer is the most common cancer in the women worldwide, soearly diagnosis is the best way to reduce its morbidity and mortality. Among various risk factors, the relationship between serum lipid profile and breast cancer is still unclear. Therefore, this study was conducted to evaluate this relationship. Methodology: Prospective, descriptive observational study with a comparative study designconducted at Fauji Foundation Hospital, Rawalpindi between November 2018 to April 2019. Results: 140 patients were divided into two groups i.e. cases and controls. Both groups were equally sub divided based on menstrual status. Independent student t-test was applied for comparison between the groups. BMI was significantly higher in the study group as compared to control group (p=0.002). Serum TG and LDL levels were higher in breast cancer patients (p= 0.032 and p=0.07 respectively). Cholesterol level was not statistically different in any group (p= >0.05). Higher HDL levels were seen in pre-menopausal cases (p=0.004) but there was no statistical difference when studied across cases and control groups. Conclusion: As breast cancer is the most common tumor in females, so early diagnosis is the key to reduce its morbidity and mortality. In this study, higher BMI, TG and LDL levels were seen in breast cancer patients as compared to controls. So, it may be concluded that BMI and dyslipidemia have some role in the etiology of breast cancer.

scholarly journals Susceptibility to injury during a fall among blind children

2012 ◽  
Vol 26 (2) ◽  
pp. 63-70 ◽  
Author(s):  
Dariusz Boguszewski ◽  
Martyna Zabłocka ◽  
Jakub Adamczyk
Keyword(s):  
Physical Activity ◽  
Research Group ◽  
Risk Groups ◽  
Control Group ◽  
Blind People ◽  
Control Groups ◽  
Blind Children ◽  
And Control ◽  
The Relationship ◽  
Positive Effect

Abstract Introduction: The aim of this study was examine the relationship between ability of safe falls and occurrence injuries from the effect of falls, among blind children. Material and methods: More than one hundred children (10-16 years old) was in research and control groups. In the research group was 51 blind people, in control group 66 sighted in a proper manner. Test of Susceptibility to Injury During the Falls (TSIDF) by Kalina and interview directed to determine the number and frequency of falls and their consequences (number and type of injuries) and selected lifestyle factors were used as a research tools. Results: Blind children made more mistakes in test (TSIDF) than their non-disabled peers (although they are trained to safe falls). This may prove that a high susceptibility to injury of the children from the research group. However blind people had more injuries after the falls. Study confirmed positive effect of physical activity on the level of safe falls skills. Conclusion: Physical fitness, physical activity and especially exercises of safe falls skills can be important element of prevention of falls. This concern to high-risk groups, such as blind people.

The Bipolarity of Adolescents' Feelings toward Their Parents with Various Illnesses and Disabilities

2007 ◽  
Vol 15 (4) ◽  
pp. 315-332 ◽  
Author(s):  
Ilana Duvdevany ◽  
Victor Moin ◽  
Rivka Yahav
Keyword(s):  
Research Group ◽  
Control Group ◽  
Control Groups ◽  
Moderator Effect ◽  
Critical Dimensions ◽  
Chronic Heart Disease ◽  
Positive Feelings ◽  
Negative Feelings ◽  
And Control ◽  
The Relationship

The study examined feelings toward parents among Israeli Jewish adolescents with disabled parents (research group, n = 182) and non-disabled parents (control group, n = 285). It also studied the relationship between the types of parental disability (chronic heart disease, multiple sclerosis, and blindness) and the adolescents' feelings toward their parents. Bipolarity, i.e., coexistence of positive and negative feelings toward parents, was found among all participants. Nevertheless, the intensity of these feelings and a predominance of the positive feelings over the negative were higher in the research group than in the control group. The type of parental disability was significantly correlated with intensity of adolescents' feeling toward their parents. The moderator effect of adolescents' anxiety on the intensity and balance of positive and negative feelings toward parents was found in both the research and control groups. The results of this study underline the importance of examining critical dimensions of family life in cases where the parents have a disability or chronic illness.

scholarly journals Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kyoko Ito ◽  
Keitaro Yokoyama ◽  
Masaaki Nakayama ◽  
Masafumi Fukagawa ◽  
Hideki Hirakata
Keyword(s):  
Phosphate Binder ◽  
Fibroblast Growth Factor 23 ◽  
Control Group ◽  
Control Groups ◽  
Post Hoc Analysis ◽  
The Mean ◽  
Iron Based ◽  
Post Hoc ◽  
And Control ◽  
The Relationship

Abstract Background Fibroblast growth factor-23 (FGF23) and α-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc analysis of the ASTRIO study (UMIN000019176), we investigated the relationship between FGF23 and α-klotho during treatment with an iron-based phosphate binder, ferric citrate hydrate (FC), compared with non-iron-based phosphate binders in hemodialysis (HD) patients. We examined the effect of iron absorption by FC on the relationship between FGF23 and α-klotho. There have been few clinical studies evaluating these biomarkers simultaneously in HD patients. Methods The ASTRIO study was a 24-week, randomized, open-label, multicenter trial. HD patients taking non-iron-based phosphate binder(s) were randomized at a 1:1 ratio to continue other binder(s) (control group) or switch to FC (FC group). Serum phosphate (P) and hemoglobin (Hb) were maintained within 3.5–6.0 mg/dL and 10–12 g/dL, respectively. Plasma levels of intact FGF23 (i-FGF23), C-terminal FGF23 (c-FGF23), and α-klotho were measured, as were iron-related parameters. Association analyses of FGF23 and α-klotho were conducted. Results Patients were randomized to FC (n = 48) and control (n = 45) groups. Serum ferritin significantly increased from baseline to end-of-treatment (EOT) in the FC group, compared with the control group (adjusted mean difference [95% confidence interval]: 79.5 [44.7, 114.4] ng/mL; p <  0.001). The mean change from baseline to EOT in c-FGF23 was significantly different between the FC and control groups (mean ± standard deviation (SD): − 0.2 ± 0.8 loge pg/mL vs. 0.2 ± 0.8 loge pg/mL, respectively; p = 0.04). The mean change from baseline to EOT in i-FGF23 and α-klotho were not significantly different between the FC and control groups (mean ± SD: − 0.1 ± 0.8 loge pg/mL vs. 0.1 ± 0.9 loge pg/mL; p = 0.33, and 2.0 ± 91.5 pg/mL vs. − 8.9 ± 145.3; p = 0.58, respectively). However, both forms of FGF23 and α-klotho were not significantly associated with each other in both groups. Conclusions Iron absorbed via FC administration in HD patients did not influence the correlation relationship between plasma levels of FGF23 and α-klotho under the condition of serum P and Hb were maintained. Trial registration ASTRIO study (UMIN000019176, registered at UMIN Clinical Trials Registry on October 1, 2015).

scholarly journals Increased mast cells in endocervical smears of women with dysmenorrhea

CytoJournal ◽  
2018 ◽  
Vol 15 ◽  
pp. 27
Author(s):  
Shunichiro Tsuji ◽  
Kiyoshi Tsuji ◽  
Hirokuni Otsuka ◽  
Takashi Murakami
Keyword(s):  
Methylene Blue ◽  
Mast Cells ◽  
Median Number ◽  
Interquartile Range ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Peritoneal Endometriosis ◽  
And Control ◽  
The Relationship

Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears. Materials and Methods: Between January 2016 and June 2016, patients filled out a questionnaire regarding dysmenorrhea and were classified into the dysmenorrhea or the control group (without dysmenorrhea). Patients underwent endocervical brushing and endocervical smears were obtained. The smears were stained with methylene blue to detect mast cells. The number of mast cells per slide was counted by microscopy and recorded. Results: Eighty-nine patients were enrolled in this study (dysmenorrhea group, 34; control group, 55). The median number of mast cells present in the endocervical one slides was 35 (interquartile range, 17–58) and 2 (interquartile range, 0–6) in the dysmenorrhea and control groups, respectively. There was a significant difference in the number of mast cells between the two groups (P < 0.0001). Conclusion: More mast cells were observed in the endocervical smears of women with dysmenorrhea than in those of women without dysmenorrhea.

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