scholarly journals Prognostic Importance of Thrombospondin-1, VEGF, PDGFR- β in Diffuse Large B-Cell Lymphoma Cases

2021 ◽  
Author(s):  
adnan batman ◽  
Rafiye Çiftçiler ◽  
Elif Birtas Atesoglu ◽  
Abdullah Hacihanefiogullari
Keyword(s):  
Negative Correlation ◽  
B Cell Lymphoma ◽  
Response To Treatment ◽  
Control Group ◽  
Control Groups ◽  
Large B Cell Lymphoma ◽  
Thrombospondin 1 ◽  
Prognostic Importance ◽  
And Control ◽  
The Relationship

Purpose: We aimed to investigate the relationship between the staining rates of thrombospondin-1, VEGF and PDGFR-in tissue preparations in patients diagnosed with DLBCL as a result of lymphadenopathy biopsy and their clinical features at the time of diagnosis, response to treatment and prognosis. Materials and Methods: For this purpose, a total of 44 patients with a diagnosis of DLBCL, 24 male and 20 female, and 13 patients diagnosed with control reactive lymphadenopathy, 6 male and 7 female were enrolled. After the pathology preparations of the patient and control groups were stained immunohistochemically with VEGF, PDGFR-β, thrombospondin-1 stains, the clinical characteristics of the patients and the relationship between survival analysis and staining rates were analyzed statistically. Results: When the patients were compared with the control group in terms of VEGF, PDGFR-β, thrombospondin-1 staining rates, we found that staining with PDGFR-β was lower in patients (p = 0.009). Although it was not statistically significant for PDGFR-β, it was observed that 5-year OS and PFS values were low in patients with high levels of expression, on the contrary, 5-year OS was low in patients with high thrombospondin staining rate. A negative correlation was seen between thrombospondin-1 and PDGFR-β (p=0.003, r=-0.440). Conclusion: As a result, although no relationship was found between VEGF and survival in our study, it was observed that PDGFR-β and thrombospondin-1 were effective in prognosis. A negative correlation was seen between thrombospondin-1 and PDGFR-β.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

scholarly journals LIPID PROFILE AND ITS SIGNIFICANCE IN BREAST CANCER

2020 ◽  
Vol 8 (10) ◽  
pp. 1241-1248
Author(s):  
Sharmin Arif ◽  
◽  
Fauzia Abdus Samad ◽  
Syed Abdus Samad ◽  
Asif Riaz Khan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Morbidity And Mortality ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Control Groups ◽  
Common Cancer ◽  
And Control ◽  
The Relationship

Background: According to WHO, breast cancer is the most common cancer in the women worldwide, soearly diagnosis is the best way to reduce its morbidity and mortality. Among various risk factors, the relationship between serum lipid profile and breast cancer is still unclear. Therefore, this study was conducted to evaluate this relationship. Methodology: Prospective, descriptive observational study with a comparative study designconducted at Fauji Foundation Hospital, Rawalpindi between November 2018 to April 2019. Results: 140 patients were divided into two groups i.e. cases and controls. Both groups were equally sub divided based on menstrual status. Independent student t-test was applied for comparison between the groups. BMI was significantly higher in the study group as compared to control group (p=0.002). Serum TG and LDL levels were higher in breast cancer patients (p= 0.032 and p=0.07 respectively). Cholesterol level was not statistically different in any group (p= >0.05). Higher HDL levels were seen in pre-menopausal cases (p=0.004) but there was no statistical difference when studied across cases and control groups. Conclusion: As breast cancer is the most common tumor in females, so early diagnosis is the key to reduce its morbidity and mortality. In this study, higher BMI, TG and LDL levels were seen in breast cancer patients as compared to controls. So, it may be concluded that BMI and dyslipidemia have some role in the etiology of breast cancer.

scholarly journals Susceptibility to injury during a fall among blind children

2012 ◽  
Vol 26 (2) ◽  
pp. 63-70 ◽  
Author(s):  
Dariusz Boguszewski ◽  
Martyna Zabłocka ◽  
Jakub Adamczyk
Keyword(s):  
Physical Activity ◽  
Research Group ◽  
Risk Groups ◽  
Control Group ◽  
Blind People ◽  
Control Groups ◽  
Blind Children ◽  
And Control ◽  
The Relationship ◽  
Positive Effect

Abstract Introduction: The aim of this study was examine the relationship between ability of safe falls and occurrence injuries from the effect of falls, among blind children. Material and methods: More than one hundred children (10-16 years old) was in research and control groups. In the research group was 51 blind people, in control group 66 sighted in a proper manner. Test of Susceptibility to Injury During the Falls (TSIDF) by Kalina and interview directed to determine the number and frequency of falls and their consequences (number and type of injuries) and selected lifestyle factors were used as a research tools. Results: Blind children made more mistakes in test (TSIDF) than their non-disabled peers (although they are trained to safe falls). This may prove that a high susceptibility to injury of the children from the research group. However blind people had more injuries after the falls. Study confirmed positive effect of physical activity on the level of safe falls skills. Conclusion: Physical fitness, physical activity and especially exercises of safe falls skills can be important element of prevention of falls. This concern to high-risk groups, such as blind people.

The Bipolarity of Adolescents' Feelings toward Their Parents with Various Illnesses and Disabilities

2007 ◽  
Vol 15 (4) ◽  
pp. 315-332 ◽  
Author(s):  
Ilana Duvdevany ◽  
Victor Moin ◽  
Rivka Yahav
Keyword(s):  
Research Group ◽  
Control Group ◽  
Control Groups ◽  
Moderator Effect ◽  
Critical Dimensions ◽  
Chronic Heart Disease ◽  
Positive Feelings ◽  
Negative Feelings ◽  
And Control ◽  
The Relationship

The study examined feelings toward parents among Israeli Jewish adolescents with disabled parents (research group, n = 182) and non-disabled parents (control group, n = 285). It also studied the relationship between the types of parental disability (chronic heart disease, multiple sclerosis, and blindness) and the adolescents' feelings toward their parents. Bipolarity, i.e., coexistence of positive and negative feelings toward parents, was found among all participants. Nevertheless, the intensity of these feelings and a predominance of the positive feelings over the negative were higher in the research group than in the control group. The type of parental disability was significantly correlated with intensity of adolescents' feeling toward their parents. The moderator effect of adolescents' anxiety on the intensity and balance of positive and negative feelings toward parents was found in both the research and control groups. The results of this study underline the importance of examining critical dimensions of family life in cases where the parents have a disability or chronic illness.

scholarly journals Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kyoko Ito ◽  
Keitaro Yokoyama ◽  
Masaaki Nakayama ◽  
Masafumi Fukagawa ◽  
Hideki Hirakata
Keyword(s):  
Phosphate Binder ◽  
Fibroblast Growth Factor 23 ◽  
Control Group ◽  
Control Groups ◽  
Post Hoc Analysis ◽  
The Mean ◽  
Iron Based ◽  
Post Hoc ◽  
And Control ◽  
The Relationship

Abstract Background Fibroblast growth factor-23 (FGF23) and α-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc analysis of the ASTRIO study (UMIN000019176), we investigated the relationship between FGF23 and α-klotho during treatment with an iron-based phosphate binder, ferric citrate hydrate (FC), compared with non-iron-based phosphate binders in hemodialysis (HD) patients. We examined the effect of iron absorption by FC on the relationship between FGF23 and α-klotho. There have been few clinical studies evaluating these biomarkers simultaneously in HD patients. Methods The ASTRIO study was a 24-week, randomized, open-label, multicenter trial. HD patients taking non-iron-based phosphate binder(s) were randomized at a 1:1 ratio to continue other binder(s) (control group) or switch to FC (FC group). Serum phosphate (P) and hemoglobin (Hb) were maintained within 3.5–6.0 mg/dL and 10–12 g/dL, respectively. Plasma levels of intact FGF23 (i-FGF23), C-terminal FGF23 (c-FGF23), and α-klotho were measured, as were iron-related parameters. Association analyses of FGF23 and α-klotho were conducted. Results Patients were randomized to FC (n = 48) and control (n = 45) groups. Serum ferritin significantly increased from baseline to end-of-treatment (EOT) in the FC group, compared with the control group (adjusted mean difference [95% confidence interval]: 79.5 [44.7, 114.4] ng/mL; p <  0.001). The mean change from baseline to EOT in c-FGF23 was significantly different between the FC and control groups (mean ± standard deviation (SD): − 0.2 ± 0.8 loge pg/mL vs. 0.2 ± 0.8 loge pg/mL, respectively; p = 0.04). The mean change from baseline to EOT in i-FGF23 and α-klotho were not significantly different between the FC and control groups (mean ± SD: − 0.1 ± 0.8 loge pg/mL vs. 0.1 ± 0.9 loge pg/mL; p = 0.33, and 2.0 ± 91.5 pg/mL vs. − 8.9 ± 145.3; p = 0.58, respectively). However, both forms of FGF23 and α-klotho were not significantly associated with each other in both groups. Conclusions Iron absorbed via FC administration in HD patients did not influence the correlation relationship between plasma levels of FGF23 and α-klotho under the condition of serum P and Hb were maintained. Trial registration ASTRIO study (UMIN000019176, registered at UMIN Clinical Trials Registry on October 1, 2015).

scholarly journals Investigation of the Relationship between Parental Mental Disorders and Autism among the Children of West Azerbaijan -Iran

2020 ◽  
Vol 10 (1) ◽  
pp. 59
Author(s):  
Arezou Kiani Equal ◽  
Javad Rasouli ◽  
Sahar Kiani
Keyword(s):  
Mental Disorders ◽  
Communication Disorders ◽  
Repetitive Behaviors ◽  
Control Group ◽  
Healthy Children ◽  
Control Groups ◽  
Mental Diseases ◽  
West Azerbaijan ◽  
And Control ◽  
The Relationship

Background: Autism disorders have increased over the last years. Autism is a neurological growth disorder associated with social communication disorders, growth retardation, and repetitive behaviors, along with serious consequences for children and families. The purpose of this research was to evaluate the relationship between parental mental disorders and autism among the children of West Azerbaijan Province. Methods: This research was a case-control study in which the case group subjects were selected among the parents with autistic children and control group subjects were selected among the relative parents with healthy children and non-relative parents with healthy children. Both case and control groups were matched in terms of gender, living place, and age of children. Finally, the data were analyzed using SPSS-16 (Chicago, IL, USA) software. Results: The current research results revealed that the frequency of mental diseases, including obsessive-compulsive, inter personality sensitivity, depression, anxiety, hostility, phobia, paranoid ideation, and psychotic disorder are different in fathers and mothers of the case and control groups. As Pvalue was lower than 0.05 in all scales, there was a significant relationship between the mental diseases of parents and the history of mental disorders in relatives and autism. Conclusion: The prevalence of mental disorders in relatives and having a medical history can be a warning sign of autism in children.

scholarly journals Increased mast cells in endocervical smears of women with dysmenorrhea

CytoJournal ◽  
2018 ◽  
Vol 15 ◽  
pp. 27
Author(s):  
Shunichiro Tsuji ◽  
Kiyoshi Tsuji ◽  
Hirokuni Otsuka ◽  
Takashi Murakami
Keyword(s):  
Methylene Blue ◽  
Mast Cells ◽  
Median Number ◽  
Interquartile Range ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Peritoneal Endometriosis ◽  
And Control ◽  
The Relationship

Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears. Materials and Methods: Between January 2016 and June 2016, patients filled out a questionnaire regarding dysmenorrhea and were classified into the dysmenorrhea or the control group (without dysmenorrhea). Patients underwent endocervical brushing and endocervical smears were obtained. The smears were stained with methylene blue to detect mast cells. The number of mast cells per slide was counted by microscopy and recorded. Results: Eighty-nine patients were enrolled in this study (dysmenorrhea group, 34; control group, 55). The median number of mast cells present in the endocervical one slides was 35 (interquartile range, 17–58) and 2 (interquartile range, 0–6) in the dysmenorrhea and control groups, respectively. There was a significant difference in the number of mast cells between the two groups (P < 0.0001). Conclusion: More mast cells were observed in the endocervical smears of women with dysmenorrhea than in those of women without dysmenorrhea.

scholarly journals Correlation Between Craniovertebral Angle and Thickness of Longus Colli in Women with and Without Forward Head Posture

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Fatemeh Bokaee ◽  
Ehsan Ghasemi ◽  
Fateme Etemadi ◽  
Sedighe Sadat Naimi
Keyword(s):  
Case Control ◽  
Control Group ◽  
Control Groups ◽  
Forward Head Posture ◽  
Head Posture ◽  
Longus Colli ◽  
Control Research ◽  
Craniovertebral Angle ◽  
And Control ◽  
The Relationship

Background: Forward head posture (FHP) of the craniocervical region is one of the most common poor postures. The craniovertebral angle (CVA) is one of the most common methods to evaluate this posture. The longus colli (LCo) muscle is an important muscle to control head posture. Objectives: This study aimed to evaluate the relationship between CVA and thickness of LCo in women with FHP. Methods: This case-control research included 35 women with FHP and a control group. Sagittal view photography of the cervical spine was used for measurement of CVA. An ultrasonography device measured the thickness of the LCo. Correlation between CVA and thickness of LCo was determined using correlation coefficient in both groups. Results: Our findings showed a non-significant correlation between the CVA and thickness of LCo in case and control groups. Conclusions: According to the results of this study, there was no significant correlation between a lower CVA and smaller thickness of LCo.

The Study of G/T Polymorphism in COLIA1 Gene and Osteoporosis in b-Thalassemia Patients.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4078-4078
Author(s):  
Amal M. El-Beshlawy ◽  
Mona Mohamed Hamdy ◽  
Ibtesam Ramzy Hussein ◽  
Hala Fathy Sheba ◽  
Mona Abdel Gawad
Keyword(s):  
Negative Correlation ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Control Group ◽  
Type I ◽  
Control Groups ◽  
Significant Difference ◽  
High Prevalence ◽  
S Allele ◽  
And Control

Abstract Abstract 4078 Poster Board III-1013 Introduction Osteoporosis is an important cause of morbidity in patients with β thalassemia major. Several genes are thought to be involved in the pathogenesis of osteoporosis. Collagen type I alpha 1 (COLIA1) is one of the most prominent candidate genes, which has been consistently associated with osteoporosis in different populations. Polymorphism at the Sp1 binding site within a key regulatory region of COLIA 1 has been reported to be associated with susceptibility to osteoprotic fractures. Our objective was to detect the allelic distribution of COLIA1 gene in beta thalassemia patients and its relation to bone mineral density (BMD). Patients and methods The study included 25 beta thalassemia major patients (12-28 years, mean = 18.12±5.077 years) and 20 controls (mean age = 23.05±2.3 years) with no family history of thalassemia. Anthropometric measurements were done to all patients .Femoral and lumbar BMD was measured in all patients and control groups using dual energy absorbiometry (DXA). Assessment of the COLIA1 genotypes (SS, Ss, ss) and G/T polymorphism were done using PCR amplification and restriction enzyme digestion (Bal1) of DNA amplified products to thalassemic patients and control groups. Results High prevalence of growth retardation was observed in β thalassemia major patients in the form of short stature (36%), truncal shortening (48%) and under weight (8%). Osteopenia and osteoporosis were detected in 68% of the thalassemia patients with a highly significant lower lumbar and femoral BMD compared to controls (P<0.01) (Table 1). There was a non significant difference between genders regarding BMD, significant negative correlation was observed between long duration of desferroxamine (DFO) intake and low femoral and lumbar BMD (R=-0.571& P<0.01,R=-0.571&P<0.05) in β thalassemia patients. A negative correlation was observed between ferritin level and fat free mass% (FFM%) in thalassemic patients (R=-0.48& P<0.05) and low lumbar BMD in female patients (R=-0.55& P<0.05). There was a positive correlation between age of starting DFO and decreased sitting height in male patients (R=0.74&P<0.01). In the thalassemic group, frequency of COLIA1 alleles was S (94%), s (6%), 12% showed the G/T polymorphism while 88% had the G/G polymorphism (Table 2). Non significant difference was observed in most of the parameters between the 2 different groups of polymorphism. In the control group allele frequencies were S (87.5%) and s (12.5%), G/T polymorphism was present in 25%.and G/G in 75%. No association was detected between COLIA1 gene polymorphism and BMD in the lumbar spine or in femur bone in the thalassemia patients (P>0.05) while the s allele was associated with femoral and lumbar BMD in the control group (P<0.05, P<0.01) (Table 3). Conclusion High prevalence of growth impairment, osteopenia and osteoporosis in our β thalassemia major patients. Desferroxamine duration therapy was related to osteoporosis in our patients. The absence of association between BMD and COLIA 1 polymorphism and the low frequency of s allele in our thalassemic group may be due to the small sample size of the thalassemia patients together with the fact that BMD is determined by a variety of genetic and environmental factors. Further studies including larger number of patients are needed to evaluate these findings. Disclosures: No relevant conflicts of interest to declare.

The ACTN3 XX Genotype’s Underrepresentation in Japanese Elite Wrestlers

2013 ◽  
Vol 8 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Naoki Kikuchi ◽  
Dai Ueda ◽  
Seok-ki Min ◽  
Koichi Nakazato ◽  
Shoji Igawa
Keyword(s):  
Athletic Performance ◽  
Olympic Games ◽  
National Level ◽  
Control Group ◽  
International Level ◽  
Control Groups ◽  
Athletic Status ◽  
Significant Difference ◽  
And Control ◽  
The Relationship

Purpose:To examine the relationship between ACTN3 polymorphisms and level of athletic performance in Japanese wrestlers.Methods:The control group consisted of 243 healthy Japanese individuals. The authors divided 135 wrestlers into 3 groups based on their results in national or international competitions. They classified as elite 24 wrestlers who had placed in the top 8 in a world championship or participated in Olympic games, 28 wrestlers who had participated in world championships or become champions in Japan’s national championships were classified as subelite, and 83 wrestlers were classified as national (N-W, ie, national-level wrestler). In addition, the authors combined the elite and subelite to form the classification international-level wrestlers (I-W).Results:The frequency of the null X allele and the XX genotype were significantly lower in the I-W group than in the control group. However, there was no significant difference in ACTN3 genotype or allele frequency between the N-W and control groups. The frequency of the ACTN3 XX genotype in the elite groups was lower than that of all groups, and a linear tendency was observed between ACTN3 XX genotype and athletic status.Conclusions:In conclusion, the data indicated that ACTN3 polymorphisms were related to athletic performance in Japanese wrestlers.

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