scholarly journals THEATROTHERAPY AS AN INDEPENDENT THERAPEUTIC-INTEGRATIVE SYSTEM

Author(s):  
Martin Dominik Polinek
Keyword(s):  
2021 ◽  
pp. 1-14
Author(s):  
Debo Dong ◽  
Dezhong Yao ◽  
Yulin Wang ◽  
Seok-Jun Hong ◽  
Sarah Genon ◽  
...  

Abstract Background Schizophrenia has been primarily conceptualized as a disorder of high-order cognitive functions with deficits in executive brain regions. Yet due to the increasing reports of early sensory processing deficit, recent models focus more on the developmental effects of impaired sensory process on high-order functions. The present study examined whether this pathological interaction relates to an overarching system-level imbalance, specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Methods We applied a novel combination of connectome gradient and stepwise connectivity analysis to resting-state fMRI to characterize the sensorimotor-to-transmodal cortical hierarchy organization (96 patients v. 122 controls). Results We demonstrated compression of the cortical hierarchy organization in schizophrenia, with a prominent compression from the sensorimotor region and a less prominent compression from the frontal−parietal region, resulting in a diminished separation between sensory and fronto-parietal cognitive systems. Further analyses suggested reduced differentiation related to atypical functional connectome transition from unimodal to transmodal brain areas. Specifically, we found hypo-connectivity within unimodal regions and hyper-connectivity between unimodal regions and fronto-parietal and ventral attention regions along the classical sensation-to-cognition continuum (voxel-level corrected, p < 0.05). Conclusions The compression of cortical hierarchy organization represents a novel and integrative system-level substrate underlying the pathological interaction of early sensory and cognitive function in schizophrenia. This abnormal cortical hierarchy organization suggests cascading impairments from the disruption of the somatosensory−motor system and inefficient integration of bottom-up sensory information with attentional demands and executive control processes partially account for high-level cognitive deficits characteristic of schizophrenia.


2006 ◽  
Vol 3 (2) ◽  
pp. 109-122 ◽  
Author(s):  
◽  
Christopher H. Bryant ◽  
Graham J.L. Kemp ◽  
Marija Cvijovic

Summary We have taken a first step towards learning which upstream Open Reading Frames (uORFs) regulate gene expression (i.e., which uORFs are functional) in the yeast Saccharomyces cerevisiae. We do this by integrating data from several resources and combining a bioinformatics tool, ORF Finder, with a machine learning technique, inductive logic programming (ILP). Here, we report the challenge of using ILP as part of this integrative system, in order to automatically generate a model that identifies functional uORFs. Our method makes searching for novel functional uORFs more efficient than random sampling. An attempt has been made to predict novel functional uORFs using our method. Some preliminary evidence that our model may be biologically meaningful is presented.


2019 ◽  
Vol 169 ◽  
pp. 756-763 ◽  
Author(s):  
Haoxiang Cheng ◽  
Liping Wang ◽  
Dongbin Wang ◽  
Jushan Zhang ◽  
Long Cheng ◽  
...  

2019 ◽  
Author(s):  
Md. Jakaria ◽  
Kowshika Sarker ◽  
Mostofa Rafid Uddin ◽  
Md. Mohaiminul Islam ◽  
Trisha Das ◽  
...  

AbstractThe propitious developments in molecular biology and next generation sequencing have enabled the possibility for DNA storage technologies. However, the full application and power of our genomic revolution have not been fully utilized in clinical medicine given a lack of transition from research to real world clinical practice. This has identified an increasing need for an operating system which allows for the transition from research to clinical use. We present eMED-DNA, an in silico operating system for archiving and managing all forms of electronic health records (EHRs) within one’s own copy of the sequenced genome to aid in the application and integration of genomic medicine within real world clinical practice. We incorporated an efficient and sophisticated in-DNA file management system for the lossless management of EHRs within a genome. This represents the first in silico integrative system which would bring closer the utopian ideal for integrating genotypic data with phenotypic clinical data for future medical practice.


Author(s):  
S. V. Volkov

The complexity and importance of the study of the U.S. – Japan relations in world politics requires continuous improvement of scientific methods. However, works which would analyze the U.S. – Japan relations as a single organism are practically nonexistent. The article analyzes the U.S. – Japan relations as a whole integrative system with a specific structure. The institutionalization of the American- Japanese system, its interaction with world politics are considered especially. The author determines structure of the system, detects leading interactions between its elements, examines the integrity of the American-Japanese system, its levels and hierarchy, dynamics of functioning. The study attempts to prove the author’s methodology which considers bilateral U.S. – Japan institutions as the basis of the American – Japanese system. As part of this methodology the conjugation between the system of bilateral American- Japanese institutions and world politics is analyzed. The dependence of the system on world politics and the dependence of world politics on changes in the U.S. – Japan relations are also revealed. As a result of the study an integral picture of the U.S. – Japan relations is demonstrated. The logic and patterns of their development are determined. It is shown that globalization, changes in balance of power, emergence of a vast number of non-state actors on a world stage changed and continue to change U.S. – Japan relations. What is more, the transformation of the U.S. – Japan relations is the transformation of world politics itself.


2017 ◽  
Vol 22 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Wayne Gulliver ◽  
Ian D. R. Landells ◽  
David Morgan ◽  
Syed Pirzada

Unnecessary investigations, inappropriate treatment, worsening disease, and frustration for both patients and health care professionals are the hallmarks of hidradenitis suppurativa (HS) management. In light of a new treatment algorithm and biologic therapies made available to patients, an HS model of care is outlined in this article. The recommendations and management strategy presented here have been developed to help address the currently unmet needs of this patient population. The patient-centred model of care and disease management strategies were developed through the guidance and recommendations of HS medical experts in Newfoundland and Labrador. This article lays the foundation for the resources and steps required to change the status of this orphan disease and firmly embed patients with HS within a coordinated and integrative system of care.


2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Diksha Yadav ◽  
Rajdeep Dey ◽  
Piyush Gupta

The literature on the limitations on the current archaic education system is limitless, the consequences of which have only been exacerbated in the current lockdown scenario. The timed evaluations have not only failed as an assessment tool during these times but research has shown there are increased rates of using unfair means and proctoring as a result. Not only was the system faulty to begin with, it is failing miserably under current lockdown situations. Simultaneously the current literature keeps positing that since technology has become an integral part of our life already, it would not be long before technology integrates with education and assessments. Taking into consideration the need and potential of an integrative system, this paper aims to explore how artificial intelligence can be effectively introduced into education and improve learning outcomes. The paper performs a Comprehensive Literature Review (CLR), and analyses data based on the framework developed by Onwuegbuzie and Frels (2015). The paper thus reviews literature with the aim to explore current models of AIEd and relevant psychological concepts relating to learning and career outcomes. 


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