scholarly journals Clinical, Laboratory, and Short-Term Outcomes in Neonatal Nonketotic Hyperglycinemia

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Muhittin Celik ◽  
Osman Akdeniz
Keyword(s):  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Newborn Infants ◽  
Clinical Findings ◽  
Resonance Spectroscopy ◽  
Short Term ◽  
Laboratory Findings ◽  
Respiratory Problems ◽  
Metabolism Disorder ◽  
Nonketotic Hyperglycinemia

Background: Nonketotic hyperglycinemia (NKH) is a rare metabolism disorder with autosomal recessive transmission. Newborn infants characteristically present with hypotonia, lethargy, convulsions, and apnea and are generally lost within the first year of life. Objectives: The aim of this study was to evaluate the clinical characteristics, laboratory findings, and short-term results of infants diagnosed with NKH. Methods: The retrospective study included 10 infants diagnosed with NKH between August 2013 and July 2020. The clinical characteristics, laboratory findings, treatment methods, and short-term outcomes of the patients were evaluated. Results: The age range of patients (50% males vs. 50% females) was 2 - 8 days on presentation. The complaints on presentation were decreased breastfeeding, lethargy, convulsions, hiccups, apnea, and respiratory problems. In the physical examination, significant hypotonia and reduced or absence of newborn reflexes were predominant. Mechanical ventilation (MV) was required for nine patients. The cerebral spinal fluid/serum glycine ratio was > 0.08 in all patients, with median value of 0.19 (range: 0.12 - 0.30). The presence of a burst suppression pattern on electroencephalography and an increase in the glycine peak in magnetic resonance spectroscopy were the supportive diagnostic findings. Mutation analysis was performed on one patient. Seizures resistant to treatment were controlled with levetiracetam in three patients and dextromethorphan in one patient. Conclusions: According to the results, the most common clinical findings in NKH were severe hypotonia, seizure, and encephalopathy. In some cases, with resistant seizures, levetiracetam was found to be effective.

scholarly journals Clinical Characteristics and Outcomes of Diabetic COVID-19 patients in Kuwait

2020 ◽  
Author(s):  
Abdullah Alshukry ◽  
Mohammad Bu Abbas ◽  
Yaseen Ali ◽  
Barrak Alahmad ◽  
Abdullah A. Al-Shammari ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Fasting Blood Glucose ◽  
List Type ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Patients With Diabetes ◽  
Laboratory Investigations ◽  
Insight Into ◽  
Variable Clinical Presentation

AbstractBackgroundCOVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome.ObjectiveIn here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients.MethodsIn this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients.ResultsCOVID-19 patients with diabetes had more severe outcomes and higher mortality than non-diabetic COVID-19 patients. Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications.ConclusionDiabetes could be a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases.Highlights of the StudyA significantly higher proportion of Diabetic COVID-19 patients required admission to the ICU.Higher fasting blood glucose was associated with higher risk of COVID-19 associated mortality.Diabetic COVID-19 patients had significantly higher incidence of complications including sepsis, ARDS, cardiac failure and renal failure.

scholarly journals Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 474
Author(s):  
Sojung Yoon ◽  
Han Li ◽  
Keum Hwa Lee ◽  
Sung Hwi Hong ◽  
Dohoon Kim ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Case Reports ◽  
Meta Analysis ◽  
Clinical Findings ◽  
Chest Ct ◽  
Therapeutic Interventions ◽  
Symptomatic Infection ◽  
Abnormal Chest ◽  
Study Designs

Background and objectives: Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. Materials and Methods: We searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web of Science) for articles from January 2020. This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: Eligible study designs included case reports and series, while we excluded comments/letters, reviews, and literature not written in English. Initially, 817 articles were identified. Forty-three articles encompassing 158 confirmed pediatric COVID-19 cases were included in the final analyses. Lymphocytosis and high CRP were associated with symptomatic infection. Abnormal chest CT more accurately detected asymptomatic COVID-19 in older patients than in younger ones, but clinical characteristics were similar between older and younger patients. Conclusions: Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. Further studies evaluating pediatric COVID-19 could contribute to potential therapeutic interventions and preventive strategies to limit spreading.

scholarly journals Diagnostic Tests and Clinical, Laboratory and Radiological Charactersitics of COVID-19 in Pregnant Women: A Review

2020 ◽  
Vol 24 (2) ◽  
pp. 146-157
Author(s):  
Sedigheh Hasani Moghadam ◽  
◽  
Abbas Alipour ◽  
Saeid Abedian Kenari ◽  
Soghra Khani ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Laboratory ◽  
Ground Glass Opacity ◽  
Clinical Findings ◽  
Diagnostic Methods ◽  
Laboratory Findings ◽  
Radiographic Findings ◽  
Controllable Factors ◽  
Second Category ◽  
Do So

The emerging Coronavirus (COVID-19) is a new infectious disease and the definitive gold standard for its diagnosis in pregnancy has not yet been established. Therefore, this study was conducted with the aim of reviewing the diagnostic methods and clinical, laboratory and radiological symptoms of COVID-19 disease in pregnant women. The present study is a Narrative review. To do so, the keywords were searched in the Scopus, Google scholar, PubMed, Embase, Science Direct, WHO databases from April 1, 2020 to May 9, 2020. 34 articles were obtained and finally 6 articles were used to write this study. Evidence related to the purpose of this study was identified in three categories. The first category examines clinical findings (fever and cough), the second category examines laboratory findings (leukocytosis and lymphopenia), and a third category examines chest radiographic findings (Pure ground-glass opacity). Since infection is one of the most important causes of death in pregnant women and is one of the preventable and controllable factors, so by identifying the correct diagnostic methods of this infection, at-risk pregnant women will be identified and Prevent the consequences of this infection.

scholarly journals Clinical findings of 35 cases with novel coronavirus pneumonia outside of Wuhan

2020 ◽  
Author(s):  
Wen Luo ◽  
Yihua Lin ◽  
Xiangyang Yao ◽  
Yonghong Shi ◽  
Fang Lu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Findings ◽  
General Ward ◽  
Invasive Ventilation ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Novel Coronavirus ◽  
Maximum Body ◽  
Admission Group

Abstract Objective: We sought to investigate the clinical characteristics of patients with novel coronavirus pneumonia in Xiamen, which is a city in Fujian Province, China. Methods: From January 20, 2020, to March 4, 2020, the clinical characteristics of all patients confirmed with novel coronavirus pneumonia admitted to the First Affiliated Hospital of Xiamen University, which was the only designated hospital for cases of novel coronavirus pneumonia in Xiamen, were analyzed. Results: A total of 35 cases of novel coronavirus pneumonia were confirmed. Patients were divided into the general-ward admission group and the intensive-care-unit (ICU) admission group. The most commonly observed symptoms were fever (80%), cough (51%), expectoration (28%), and fatigue (23%). Compared with patients in the general-ward group, patients in the ICU group had a higher maximum body temperature, a longer duration of fever after admission, and more symptoms of systemic pain. Considering the laboratory findings, patients in the ICU group exhibited lower peripheral blood lymphocyte ratios and lymphocyte counts but higher C-reactive protein and lactate dehydrogenase levels. All patients were discharged without death, and no patients required invasive ventilation, continuous renal replacement therapy, or extracorporeal membrane oxygenation. Conclusion: Relative to patients with novel coronavirus pneumonia in Wuhan, the cases in Xiamen were less severe.

scholarly journals Clinical, laboratory and ultrasonographic findings in 38 calves with type-4 abomasal ulcer

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Ueli Braun ◽  
Christina Widmer ◽  
Karl Nuss ◽  
Monika Hilbe ◽  
Christian Gerspach
Keyword(s):  
Clinical Laboratory ◽  
Clinical Findings ◽  
Pathological Examination ◽  
Severe Illness ◽  
Diffuse Peritonitis ◽  
Laboratory Findings ◽  
Poor General Health ◽  
Abdominal Examination ◽  
The Right ◽  
Tentative Diagnosis

Abstract Background Type-4 abomasal ulcers (U4) are perforated ulcers causing diffuse peritonitis. This retrospective study describes the clinical, laboratory and ultrasonographic findings in 38 calves with U4. The medical records of 38 calves aged three days to 20 weeks with U4 were scrutinised. Results The most common clinical findings were poor general health (95%), reduced skin elasticity (95%), rumen atony (91%), abdominal guarding (76%) and positive percussion auscultation and/or swinging auscultation on the right side of the abdomen (75%). The most frequent laboratory findings were increased numbers of segmented neutrophils (87%), eosinopenia (87%), acidosis (84%), azotaemia (79%) and hyponatraemia (79%). The most frequent abdominal ultrasonographic findings were intestinal atony (68%), fluid (67%) and fibrin deposits (58%) in the abdomen. Thirty-five calves were euthanased and three calves died spontaneously. All calves underwent pathological examination. Diffuse peritonitis caused by a transmural abomasal ulcer was the principal diagnosis in all calves. Conclusions Perforated abomasal ulcers cause severe illness, and a thorough clinical examination combined with ultrasonographic abdominal examination should lead to a tentative diagnosis.

scholarly journals Evaluation of clinical, laboratory and treatment modalities of pituitary adenomas: Single center experience

2021 ◽  
Vol 38 (4) ◽  
pp. 404-409
Author(s):  
Ayşe ÖZDEMİR YAVUZ ◽  
Elif KILIÇ KAN ◽  
Ramis ÇOLAK
Keyword(s):  
Pituitary Adenomas ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Treatment Options ◽  
Treatment Modalities ◽  
Single Center ◽  
Laboratory Findings ◽  
Single Center Experience ◽  
Operative Complications ◽  
Pituitary Macroadenomas

Pituitary adenomas are a group of disease with broad different clinical characteristics and complications. We aimed to present the data of patients being followed in a single center and discuss the pituitary adenomas based on the literature. Two hundred and twenty patients followed at Department of Endocrinology and Metabolism, Medical School of Ondokuz Mayis University, were included into study. Clinical characteristics, laboratory findings and treatment modalities were examined retrospectively. 59% of patients were female and 41% were male. Mean age during the diagnosis was 43.7 years. Pituitary macroadenomas were 62% of all adenomas and 73% of pituitary adenomas were functional. Among the functional adenomas, the most frequently seen types were prolactin-secreting adenoma and growth-hormone secreting adenoma. Treatment options were surgical treatment (67%), medical treatment (20%) and radiotherapy (7%). Post-operative complications were developed in 27 (13.2%) of patients. In patients with non-functional adenoma, the cure after surgery was detected as 19.6% and the remission after the surgery was detected as 8.9%. In this study, the characteristics of the pituitary adenomas were found similar to the literature in general. The early diagnosis of the disease has a significant importance in terms of treatment and the response to the treatment.

scholarly journals Clinical, Laboratory, and Imaging Features of 148 Patients with COVID-19 in Bushehr: A Report from the South of Iran

2020 ◽  
Author(s):  
Mohsen Keshavarz ◽  
Ahmad Tavakoli ◽  
Sareh Zanganeh ◽  
Mohammad Javad Mousavi ◽  
Katayoun Vahdat ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Patients ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Imaging Features ◽  
Ministry Of Health ◽  
Laboratory Findings ◽  
Southern Province ◽  
Increased Risk

Aim: To investigate clinical characteristics, laboratory findings, and imaging features of patients confirmed with COVID-19 in Bushehr, a southern province of Iran. Method: During April 29th to May 30th 2020, a total of 148 patients confirmed with COVID-19 infection were admitted to three hospitals in Bushehr province, assigned by the Iranian Ministry of Health. Results: The most common coexisting disease was type 2 diabetes. Levels of ESR, CRP, LDH, and AST among inpatients were higher than the outpatients (P<0.05). There were significant differences in the levels of creatinine and BUN between elderly and non-elderly patients (P<0.05). Conclusion: Patients with comorbidities and elderly patients are at increased risk of severe progression of COVID-19.

scholarly journals Clinical characteristics and laboratory biomarkers changes in COVID-19 patients requiring or not intensive or sub-intensive care: a comparative study

2020 ◽  
Author(s):  
Anna Maria Cattelan ◽  
Eugenia Di Meco ◽  
Marco Trevenzoli ◽  
Alessia Frater ◽  
Anna Ferrari ◽  
...  
Keyword(s):  
Intensive Care ◽  
Neutrophil Count ◽  
Clinical Characteristics ◽  
Primary Outcome ◽  
Clinical Laboratory ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Group 2 ◽  
Group 1

Abstract Background Identifying risk factors for severe novel-coronavirus disease (COVID-19) is useful to ascertain which patients may benefit from advanced supportive care. The study aims to offer a comparative description of the COVID-19 patients, admitted to a general ward for a non-critical clinical picture, who required or not to be transferred to the intensive (ICU) and/or sub-intensive care (SICU) units. Methods This observational retrospective study included all COVID-19 patients admitted to the Infectious Diseases Unit. Clinical, laboratory, radiological and treatment data were collected. The primary outcome was a composite of need of transfer to the ICU and/or SICU during the hospitalization. Patients who did not require to be transferred are defined Group 1; patients who were transferred to the ICU and/or SICU are defined Group 2. Demographic and clinical characteristics were compared between the two groups. Results 303 patients were included. Median age was 62 years. 69 patients (22,8%) met the primary outcome and were defined Group 2. The overall mortality rate was 6.8%. Group 2 were more likely to be men, had a higher mortality (14,5% vs. 3,8%, p<0,01), had more hypertension (72,4% vs. 44%, p<0,01) and diabetes (31,9% vs. 21%, p=0,04) and were more likely to present dry cough (49,3% vs. 25,2%, p<0.01). Overall, chest X-ray at admission showed findings suggestive of pneumonia in 63,2%, and Group 2 were more likely to develop pathological findings during the hospitalization (72,7%vs. 17,2%, p<0,01). At admission, Group 2 presented significantly higher neutrophil count, aspartate-transaminase and C-reactive-protein. At the 3rd measurement, Group 2 presented persistently higher neutrophil count, liver function tests and C-reactive-protein. Group 1 presented a shorter duration from admission to negativization of follow-up swabs (20 vs. 35 days, p<0,01). Conclusions The presence of comorbidities and the persistent observation of abnormal laboratory findings should be regarded as predisposing factors for clinical worsening.

scholarly journals Clinicoepidemiological Profile and Short term Outcome of Abdominal Tuberculosis in Western Region of Bangladesh

2018 ◽  
Vol 37 (1) ◽  
pp. 25-29
Author(s):  
Madhusudan Saha ◽  
SAHM Mesbahul Islam ◽  
Irin Perveen ◽  
Nasrin Aktar ◽  
Kabir Ahmed ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Intestinal Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Clinical Findings ◽  
Response To Therapy ◽  
Laboratory Findings ◽  
Term Outcome ◽  
Gold Standard Method

Introduction: Abdominal tuberculosis is not uncommon in daily medical practice. This study was done focusing variable presentations of abdominal tuberculosis Material and methods: Data of consecutive patients diagnosed as abdominal tuberculosis were analyzed. Their epidemiological features, presentations, laboratory findings, and response to therapy were analysed. Result: Total 69 cases (male 43, 62.3%,and female 26, 37.7%), age ranging from 15 to 85 years (mean 36.23) were enrolled. Rural (55, 79.7%), poor (49,71%) and housewives (24, 34.8%) and people of 21-30 years age group (27, 39.1%) were more affected. Diagnosis was based on combinations of clinical, laboratory findings and therapeutic response. In this series 30 (43.5%), 23 (33.4%) and 12 (17.3%) were diagnosed as intestinal, peritoneal and disseminated tuberculosis respectively. Of them68 patients recovered with treatment. Five patients developed intestinal obstruction and one developed hepatitis and lost from follow up. Conclusion: Diagnosis of abdominal tuberculosis is by combinations of clinical findings, without gold standard method. In our series intestinal tuberculosis and peritoneal tuberculosis were common clinical types with weight loss and abdominal pain as common clinical symptoms. And outcome of Treatment of TB was excellent J Bangladesh Coll Phys Surg 2019; 37(1): 25-29  

Advances in methods for surveillance of rejection

2004 ◽  
Vol 14 (S1) ◽  
pp. 93-96 ◽  
Author(s):  
Robert J. Boucek Jr ◽  
Mark M. Boucek ◽  
Alfred Asante-Korang
Keyword(s):  
Acute Rejection ◽  
Newborn Infants ◽  
Major Complication ◽  
High Specificity ◽  
Clinical Findings ◽  
Short Term ◽  
Effective Treatment Modality ◽  
High Negative Predictive Value ◽  
End Stage ◽  
The Ideal

Transplantation is an effective treatment modality for infants1 and children2 with end-stage cardiac diseases. Rejection remains a major complication (Figure 1), even in newborn infants.3 Acute rejection can best be operationally defined by clinical findings, histopathology, and/or abnormalities of ventricular function of new origin that require, and respond to, intensified immunosuppression. Mechanistically, the ability to detect acute rejection is critically dependent on the detection of significant new myocytic injury, damage, and/or death. Surveillance for rejection is critically important in determining both long and short-term outcomes following cardiac transplantation. The ideal strategy for surveillance should have a high negative predictive value, correctly identifying the absence of myocytic injury, with high specificity, such that it does not falsely predict such injury.4

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