scholarly journals Association of PPARG rs3856806 C>T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents

2021 ◽  
Vol 52 (1) ◽  
pp. 15-21
Author(s):  
Vanja Vidović ◽  
Nela Maksimović ◽  
Stojko Vidović ◽  
Tatjana Damnjanović ◽  
Ivana Novaković

Background/Aim: Peroxisome proliferator-activated receptor gamma (PPARg) belongs to a family of nuclear hormone receptors and ligand-activated transcription factors. PPARG gene is expressed in many tissues including adipose tissue where it plays a crucial role in differentiation of adipocyte, insulin resistance, blood glucose levels and lipid metabolism. The aim of the study was to examine the association of rs3856806 polymorphism with the body mass index (BMI), fasting glucose levels and lipid parameters in Serbian adolescents. Methods: This research included 287 adolescents of both genders (143 boys and 144 girls), 14-15 years of age. Genotype detection was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay. Results: Results showed statistically significant difference in terms of fasting glucose levels among girls (p = 0.013) depending on their genotype. Female carriers of CC genotype had significantly higher level of fasting glucose levels. Also, results showed that in the group of overweight and obese girls, carriers of CT or TT genotype had statistically significant lower values of HDL cholesterol compared to girls - carriers of CC genotype (p = 0.000). However, this result was not confirmed by multiple regression analysis. Statistically significant association of rs3856806 polymorphism was not observed with BMI nor with other lipid parameters. Conclusion: This polymorphism is associated with fasting glucose level and HDL cholesterol among girls. To draw definite conclusions, further research should be conducted including non-genetic factors and other polymorphisms among this gene.

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.


Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1638
Author(s):  
Antonio Viñuela ◽  
Juan José Criado-Álvarez ◽  
Javier Aceituno-Gómez ◽  
Carlos Durantez-Fernández ◽  
José Luis Martín-Conty ◽  
...  

(1) Objective: This study analyzes the evolution of the body mass index (BMI) throughout the academic year associated with changes in the lifestyle associated with the place where students live during the course, lifestyle design, and health strategies for the university community. (2) Methods: A total of 93 first-year nursing students participated in this study. Data were collected throughout the course by administering self-reported questionnaires about eating habits and lifestyles, weight, and height to calculate their BMI and place of residence throughout the course. Data were analyzed using statistical analysis (Mann–Whitney, chi-square, Student’s t-test, repeated-measures analysis of variance, and least significant difference tests). (3) Results: We found that the mean BMI increases significantly throughout the course among all students regardless of sex, age, eating habits, or where they live during the course. At the beginning of the course, the mean BMI was 22.10 ± 3.64. The mean difference between the beginning of the course and the middle has a value of p-value < 0.015 and between the middle of the course and the end a p-value < 0.009. The group that increased the most is found among students who continue to live in the family nucleus rather than those who live alone or in residence. Students significantly changed their eating and health habits, especially those who live alone or in residence. (4) Conclusions: There is an increase in BMI among students. It is necessary to carry out seminars or talks that can help students understand the importance of good eating practices and healthy habits to maintain their weight and, therefore, their health, in the short, medium, and long term and acquire a good quality of life.


2021 ◽  
Vol 11 (9) ◽  
pp. 137-147
Author(s):  
Lorik Ramaj ◽  
Sadete Hasani

The purpose of this study was to investigate and analyze the problems of underweight, overweight and obesity in young people of high school in Drenas, respectively a sample of 150 adolescents (73 males and 77 females aged 17 years). The research was conducted in the physical education class, initially was performed measurement of weight and height then the questionnaire with 26 questions. Data were collected with the statistical program SPSS version 21.0, descriptive analysis was performed with (Mean and standard deviation), all variables were tested for normality, significant level (significant level p <0.05). Results of anthropometric characteristics, the average age was 17.2 years. Weight / kg for men was 59.4 kg for women 57.3kg the average for both genders was 58.3 (± 6.2) kg. Height / cm  males 1.68cm,  females 1.61cm the average of both genders was 1.64 (± 6.6) cm. BMI body mass index kg / m² in men 21.0, women 22.1, the average of both sexes 21.55 kg / m5. The results show that men have lower BMI (p> 0.05) 21.55 kg / m² than girls with 22.1 kg / m². Data showed underweight males are 12%, and females 10%. BMI Normal male 74%, and female 69%. Overweight males 11%, females 13% while a significant difference was observed between obese boys and girls (obese) males 3% and females 8%. The analysis of the questionnaire showed that small percentages are involved in collective or individual sports, the most pronounced participation in sports was identified: football, volleyball and basketball, and relatively satisfactory were physical activity in household activities. It is recommended to build outdoor fitness and sports gyms, as well as the opening of various sports clubs in this area, and to have more research in this area, to prove the institucions how important are places for sport and physical activities.


2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Genna A. Jerrard ◽  
Jing Liu ◽  
Rosemary C. Case ◽  
Mahnaz Motevalli ◽  
Stephen G. Bolton ◽  
...  

This study determined the percentage of potential plasma donors who could donate plasma in the 3 allowable plasma volume limit categories as specified by the Food and Drug Administration (FDA), as well as the association of the body mass index (BMI) of these individuals with age, blood pressure, oral temperature, and pulse. Of 315 plasma donors analyzed, 107 (34.0%) weighed between 110 and 149 lbs (50.0–67.7 kg), 89 (28.2%) weighed between 150 and174 lbs (68.2–79.1 kg), and 119 (37.8%) weighed >175 lbs (79.5 kg), theoretically allowing collection of an additional 101.4 liters (16% more plasma) from both heavier categories based on FDA standards for plasma donor quantities. BMI was positively associated with age, mean arterial pressure (MAP), and pulse (Pearson’s r=0.36, 0.24, and 0.18, resp., P values <0.05), but not with oral temperature. Average BMI for females was higher than for males (+1.8, P=0.01), and BMI for African Americans was higher than for White and Asian participants (+2.2 and +5.1, resp., Ps <0.05). A significant association was also found in the sex by race interaction with BMI (P=0.0004). Follow-up analyses suggested a significant difference in BMI by sex among African Americans, higher BMI among African American females than Asian and White males, and higher BMI among White females than African American males (Ps <0.05).


2016 ◽  
Vol 7 (10) ◽  
pp. 4379-4387 ◽  
Author(s):  
Celia Bañuls ◽  
Susana Rovira-Llopis ◽  
Sandra López-Doménech ◽  
Silvia Veses ◽  
Víctor M. Víctor ◽  
...  

This study assessed the effects of an inositol-enriched beverage (IEB) on blood glucose levels and inflammation status in subjects with an impaired fasting glucose (IFG) state according to body mass index (BMI).


2018 ◽  
Vol 57 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Safet Kapo ◽  
Izet Rađo ◽  
Nusret Smajlović ◽  
Siniša Kovač ◽  
Munir Talović ◽  
...  

Abstract Introduction The aim of the study was to analyse the deviations of the body posture and to assess the occurrence of spine deformities. Additionally, Body Mass Index in school children was related to the trend in postural deformities for different age groups (5-8 years old, n=112; 9-11 years old, n=205; 12-14 years old, n=212) as part of the project “Spine Lab”, granted from the European Commission IPA founds, investigating the importance of public health issues. Methods Body posture was measured using Contemplas 3D software analyser, based on video image trajectory and BIA weight scale (Tanita BC 420). Overall, 17 variables were assessed, and differences were confirmed using MANOVA analysis. Results The results showed that there is a significant difference between age groups for the measured variables (F=9.27; p<0.01; η2=0.26), suggesting a moderate difference across the age span. Conclusion The study results showed that there is a negative trend of increasing Body Mass Index within the first and youngest age group. The fact is that the trend of increasing deformity of the shoulder belt has been noted, often inclining towards the formation of milder forms of kyphotic posture. Other forms of deformity that are accentuated in the survey results are the negative trend of increasing pelvic rotation and pelvis rotation which inclines towards the formation of lordotic posture for all three age groups.


2018 ◽  
Vol 128 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Kelsey Alabaster ◽  
M. Fred Bugg ◽  
Bruno Splavski ◽  
Frederick A. Boop ◽  
Kenan I. Arnautovic

OBJECTIVEA fibrous structure located dorsal to the dura at the posterior craniocervical junction stretches horizontally between the bilateral occipital condyles and the upper borders of the C-1 laminae. Partially covered by the occipital bone, this structure is always encountered when the bone is removed from the foramen magnum rim during approaches to the posterior cranial fossa. Although known to surgeons, this structure has not been defined, studied, or named. The most appropriate name for this structure is “the suboccipital ligament,” and a detailed rationale for this name is provided.METHODSThis 3-year-long study included 10 cadaveric specimens and 39 clinical patients: 31 consecutive surgically treated patients with Chiari Type I malformations (CM-I subgroup) and 8 other patients with posterior fossa pathologies (non–CM-I subgroup). The dimensions were defined, the function of this ligament was hypothesized, size and histological composition were compared between patient subgroups, and its origin and relationship to the surrounding structures were analyzed. Possible statistical differences in the parameters between the 2 groups were also evaluated.RESULTSThe suboccipital ligament consists of horizontally oriented hyaline fibers and has a median length of 35 mm, height of 10 mm, and thickness of 0.5 mm. These dimensions are not significantly different between the CM-I and non–CM-I patients. The median age of the patients was 43 years, with CM-I patients being significantly younger (median 35 years) than non–CM-I patients (median 57 years). There was no statistically significant difference in weight, height, and body mass index between patient subgroups. There was no significant correlation between the body mass index or height of the patients and the dimensions of the ligament. No statistically significant differences existed between the subgroups in terms of smoking history, alcohol consumption, and the presence of diabetes mellitus, hypertension, hydrocephalus, or headaches. The ligament tissue in the CM-I patients was disorganized with poorly arranged collagen bands and interspersed adipose tissue. These patients also had more hyalinized fibrosis and showed changes in the direction of fibers, with hyaline nodules ranging from 0 to 2+. The result of the histological evaluation of the suboccipital ligament for hyaline nodules, calcification, and ossification was graded as 2+ if present in 3 or more medium-power magnification fields (MPFs); 1+ if present in 1–2 MPFs; and 0, if present in less than 1 MPF. Histological examination of the ligaments showed structural differences between CM-I and non–CM-I patients, most notably the presence of hyaline nodules and an altered fiber orientation in CM-I patients.CONCLUSIONSThe suboccipital ligament extends between the occipital condyle and the superior edge of the C-1 lamina, connecting the contralateral sides, and appears to function as a real ligament. It is ventral to the occipital bone, which covers approximately two-thirds of the height of the ligament and is loosely attached to the dura medially and more firmly laterally. Because of its distinctive anatomy, characteristics, and function, the suboccipital ligament deserves its own uniform designation and name.


Author(s):  
Nazlı Yanar ◽  
Melek Güler

This study aims to determine whether the number of daily steps is effective in the body composition and mental well-being of university students during the COVID-19 pandemic. The research group of the study consisted of 40 volunteer students studying at the Faculty of Sport Sciences by being randomly assigned to the experimental (n:20) and control (n:20) groups. The research is in the experimental model with a pre-test/post-test control group. As a data collection tool in the study, the 'Warwick-Edinburgh Mental Well-Being Scale' was used to determine the personal information form and mental well-being. The obtained data were analysed in the Jamovi 1.8.2 statistical software program with a 95% reliability interval and 5% margin of error. In the analysis of the data, percentage (%), frequency (f), and mean (x̄) values were used in the descriptive data, Paired Samples t-test was used in the pre-test/post-test comparison, and Multinomial Regression analysis was used in the relational analysis. According to the findings of the study, 75% of the students in the experimental group and 70% of the students in the control group were in the normal weight class according to the body mass index classification. According to waist-hip ratio classification, 85% of the experimental group and 70% of the control group were in the group that did not have cardiovascular disease risk. After two months of application, the daily average number of steps of the experimental group (12.5751898.1) and the daily average number of steps of the control group were determined as (5381.272026.2). While there was a statistically significant difference in the pre-test/post-test body mass index averages of the experimental group who were asked to take at least 10,000 steps per day (p0.05), although there was an increase in the mean waist-hip ratio and mental well-being, there was no statistically significant difference (p0.05). It was determined that the step average had a statistically significant effect on the experimental group according to the body mass index classification (p0.05). As a result, while taking at least 10,000 steps per day was effective in the body mass index of the students, it was not so in the waist-hip ratio and mental well-being. In this context, physical activity, and especially walking, can be recommended at the point of protecting health. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0881/a.php" alt="Hit counter" /></p>


2019 ◽  
Vol 65 (3) ◽  
pp. 111-115
Author(s):  
Irina-Bianca Kosovski ◽  
Dana-Valentina Ghiga ◽  
Monica Tarcea ◽  
Cristina Nicoleta Ciurea ◽  
Ana Ioana Savin ◽  
...  

AbstractObjective: The study aims to analyze obesogenic behavioral patterns of adolescents living in Mureş County, Romania, as well as to establish a relationship between these behaviors and their Body Mass Index (BMI), in an attempt to provide effective prevention strategies for obesity.Material and Methods: 153 students between 9th to 12th grade, aged between 14 and 19 years old, from the Vocational and Art Highschool of Târgu Mureş were included in the study. All the candidates filled out an evaluation questionnaire of lifestyle and risky behaviors. The analyzed data were sex, age, residence, BMI and risky eating behavior defined as the consumption of carbohydrates (bread, potatoes, sweets), sodas, junk food, alcohol (wine, distilled beverages, beer), beer separately, level of physical activity (school and extra-school sports activities), sedentary behaviors (≥2 hours/day in front of a screen: personal computer-PC and television-TV), and spending ≥2 hours/day separately on the PC and on the TV.Results: A statistically significant association was observed between BMI and consumption of fast-food, tobacco, beer, sedentary behavior and spending ≥2 hours/day in front of the PC. Moreover, there was a statistically significant difference between the BMI values of adolescents presenting all studied risk behaviors compared to those who did not.Conclusions: Obesity among adolescents from Mureş County is influenced by lifestyle choices like fast-food, tobacco, beer, sedentary behavior and spending ≥2 hours/day in front of the PC.


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