scholarly journals Data framework for efficient management of sequence and microsatellite data in biodiversity studies

2013 ◽  
Vol 56 (1) ◽  
pp. 50-64 ◽  
Author(s):  
C. V. C. Truong ◽  
Z. Duchev ◽  
E. Groeneveld

Abstract. In recent years, software packages for the management of biological data have rapidly been developing. However, currently, there is no general information system available for managing molecular data derived from both Sanger sequencing and microsatellite genotyping projects. A prerequisite to implementing such a system is to design a general data model which can be deployed to a wide range of labs without modification or customization. Thus, this paper aims to (1) suggest a uniform solution to efficiently store data items required in different labs, (2) describe procedures for representing data streams and data items (3) and construct a formalized data framework. As a result, the data framework has been used to develop an integrated information system for small labs conducting biodiversity studies.

2014 ◽  
Vol 20 (1) ◽  
pp. 142-158 ◽  
Author(s):  
Ayhan Ceylan ◽  
Ilke Ekizoglu

In order to adopt measures for storing more water in reservoirs, lakes and ponds; to prevent water pollution, protect water sources and extend the service life of these facilities, it is important for manager (Municipalities, Directorates of the State Hydraulic Works (DSHW), Irrigation Unions etc.) to know the current topographic conditions and any changes in the storage capacities of these facilities. This study aimed to identify the updated topographic and bathymetric data required for the efficient management and usage of Altınapa reservoir, changes in surface area and volume of the facility, and to form a Reservoir Information System (RIS). Two digital elevation models, from 2009 and 1984, were used to determine changes in the storage capacity of the reservoir. The calculations indicated that, within this 25-year period, the storage capacity of the reservoir decreased by 12.7% due to sedimentation. A Dam Information System (RIS) was developed from a wide range of data sources, including topographic and bathymetric data of the reservoir and its surrounding area, data on specific features such as plant cover, water quality characteristics (Temperature, Dissolved Oxygen (DO), Secchi Disk Depth (SDD) and pH), geological structure, average water level, water supplied from springs, evaporation value of the reservoir, and precipitation.


Fault Tolerant Reliable Protocol (FTRP) is proposed as a novel routing protocol designed for Wireless Sensor Networks (WSNs). FTRP offers fault tolerance reliability for packet exchange and support for dynamic network changes. The key concept used is the use of node logical clustering. The protocol delegates the routing ownership to the cluster heads where fault tolerance functionality is implemented. FTRP utilizes cluster head nodes along with cluster head groups to store packets in transient. In addition, FTRP utilizes broadcast, which reduces the message overhead as compared to classical flooding mechanisms. FTRP manipulates Time to Live values for the various routing messages to control message broadcast. FTRP utilizes jitter in messages transmission to reduce the effect of synchronized node states, which in turn reduces collisions. FTRP performance has been extensively through simulations against Ad-hoc On-demand Distance Vector (AODV) and Optimized Link State (OLSR) routing protocols. Packet Delivery Ratio (PDR), Aggregate Throughput and End-to-End delay (E-2-E) had been used as performance metrics. In terms of PDR and aggregate throughput, it is found that FTRP is an excellent performer in all mobility scenarios whether the network is sparse or dense. In stationary scenarios, FTRP performed well in sparse network; however, in dense network FTRP’s performance had degraded yet in an acceptable range. This degradation is attributed to synchronized nodes states. Reliably delivering a message comes to a cost, as in terms of E-2-E. results show that FTRP is considered a good performer in all mobility scenarios where the network is sparse. In sparse stationary scenario, FTRP is considered good performer, however in dense stationary scenarios FTRP’s E-2-E is not acceptable. There are times when receiving a network message is more important than other costs such as energy or delay. That makes FTRP suitable for wide range of WSNs applications, such as military applications by monitoring soldiers’ biological data and supplies while in battlefield and battle damage assessment. FTRP can also be used in health applications in addition to wide range of geo-fencing, environmental monitoring, resource monitoring, production lines monitoring, agriculture and animals tracking. FTRP should be avoided in dense stationary deployments such as, but not limited to, scenarios where high application response is critical and life endangering such as biohazards detection or within intensive care units.


Author(s):  
S. Voronkova

The article discusses ways to obtain information about risk factors and the health status of the population. The article describes a new information system «labor Medicine», which allows to organize the collection of a wide range of data for further analysis and application in the activities of various Executive authorities, public organizations, foundations, legal entities and citizens. It is proposed to improve this system by expanding the types of information collected, creating a passport for health promotion organizations, as well as integration with systems that are being implemented in the Russian Federation for managing the health of the working-age population in the context of state policy in the field of Informatization.


2020 ◽  
Vol 5 ◽  
pp. 59-66
Author(s):  
Y.M. Iskanderov ◽  

Aim. The use of intelligent agents in modeling an integrated information system of transport logistics makes it possible to achieve a qualitatively new level of design of control systems in supply chains. Materials and methods. The article presents an original approach that implements the possibilities of using multi-agent technologies in the interests of modeling the processes of functioning of an integrated information system of transport logistics. It is shown that the multi-agent infrastructure is actually a semantic shell of the information system, refl ecting the rules of doing business and the interaction of its participants in the supply chains. The characteristic of the model of the class of an intelligent agent, which is basic for solving problems of management of transport and technological processes, is given. Results. The procedures of functioning of the model of integration of information resources of the participants of the transport services market on the basis of intelligent agents are considered. The presented procedures provide a wide range of network interaction operations in supply chains, including traffi c and network structure “fl exible” control, mutual exchange of content and service information, as well as their distributed processing, and information security. Conclusions. The proposed approach showed that the use of intelligent agents in modeling the functioning of an integrated information system makes it possible to take into account the peculiarities of transport and technological processes in supply chains, such as the integration of heterogeneous enterprises, their distributed organization, an open dynamic structure, standardization of products, interfaces and protocols.


Author(s):  
N.A. Mironov ◽  
E.A. Maryshev ◽  
N.A. Divueva

The article discusses the issues of improving the examination system of competitive applications for state support in the form of grants of the President of the Russian Federation on the basis of an integrated information system that includes the information support system of the Grants Council of the President of the Russian Federation and the information system of the Federal Roster of Scientific and Technological Experts and containing information about experts, applications and expert examination results. In order to improve the principles of transparency and openness of support programs and competition winners, to ensure the objectivity of the competitive selection of projects, a number of organizational and technical solutions are proposed in the application examination system based on an integrated information system. The new and proposed new approaches to the organizational and technical support of the examination of competitive applications for state support in the form of grants of the President of the Russian Federation to young Russian scientists made it possible, by attracting a wide range of scientific and technological communities, to conduct examination of more than five thousand applications with high quality and deadlines set by the Ministry of Education and Science of Russia.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ranju Ravindran Santhakumari Manoj ◽  
Maria Stefania Latrofa ◽  
Sara Epis ◽  
Domenico Otranto

Abstract Background Wolbachia is an obligate intracellular maternally transmitted, gram-negative bacterium which forms a spectrum of endosymbiotic relationships from parasitism to obligatory mutualism in a wide range of arthropods and onchocercid nematodes, respectively. In arthropods Wolbachia produces reproductive manipulations such as male killing, feminization, parthenogenesis and cytoplasmic incompatibility for its propagation and provides an additional fitness benefit for the host to protect against pathogens, whilst in onchocercid nematodes, apart from the mutual metabolic dependence, this bacterium is involved in moulting, embryogenesis, growth and survival of the host. Methods This review details the molecular data of Wolbachia and its effect on host biology, immunity, ecology and evolution, reproduction, endosymbiont-based treatment and control strategies exploited for filariasis. Relevant peer-reviewed scientic papers available in various authenticated scientific data bases were considered while writing the review. Conclusions The information presented provides an overview on Wolbachia biology and its use in the control and/or treatment of vectors, onchocercid nematodes and viral diseases of medical and veterinary importance. This offers the development of new approaches for the control of a variety of vector-borne diseases. Graphic Abstract


2021 ◽  
Vol 11 (5) ◽  
pp. 62
Author(s):  
Jialin Fan ◽  
Andrew P Smith

(1) Psychology must play an important role in the prevention and management of the COVID-19 pandemic. The aim of the present study was to examine associations between the perceptions of information overload and wellbeing in China during the initial phase of COVID-19. (2) Methods: The present research involved a cross-sectional online survey, which controlled for established predictors of wellbeing and the perception of general (not COVID-19-specific) information overload. The setting of the research was China, February 2020. A total of 1349 participants completed an online survey, and the results from 1240 members of the general public who stated that they were uninfected are reported here (55.6% female; 49.4% single; age distribution: 17–25 years: 26%; 26–30 years: 24.3%; 31–40 years: 23.9%; 41–50 years: 16.2%; 51 years+: 9.6%; the most frequent occupations were: 21.5% students; 19.5% teachers; 25.9% office workers; 10.8% managers, plus a few in a wide range of jobs). The outcomes were positive wellbeing (positive affect and life satisfaction) and negative wellbeing (stress, negative affect, anxiety and depression). (3) Results: Regressions were carried out, controlling for established predictors of wellbeing (psychological capital, general information overload, positive and negative coping). Spending time getting information about COVID-19 was associated with more positive wellbeing. In contrast, perceptions of COVID-19 information overload and feeling panic due to COVID-19 were associated with more negative wellbeing. (4) Conclusions: These results have implications for the communication of information about COVID-19 to the general public and form the basis for further research on the topic.


Author(s):  
Zahra Zakeri Khatir ◽  
Hamid Irannejad

: 1, 2, 4-Triazine derivatives have received much attention due to their multifunctional nature, especially in diverse pharmacological properties as well as a key fragment in many drug candidates. Introduction of a vicinal 5, 6-diaryl/heteroaryl moiety on the 1, 2, 4-triazine ring has attracted plentiful attention in the field of medicinal chemistry. 5, 6-Diaryl/heteroaryl-3-substituted-1, 2, 4-triazine is as a prominent scaffold in many drug candidates which has shown a wide range of pharmacological activities such as anti-diabetic, antifungal, anti-inflammatory, anticancer, anti-HIV, neuroprotective, anticonvulsant, anti- Alzheimer, anti-Parkinson and antioxidant. In this review, we have discussed synthesis, various pharmacological activities of 5, 6-diaryl/heteroaryl-3-substituted-1, 2, 4-triazines, their structure-activity relationship (SAR), pharmacophoric elements and their mechanism of action reported in the published articles during 2000-2019. Evaluation of compounds by PAINS filtering tool was accomplished and showed that this versatile structure could be considered as a privileged structure. Compilation of the biological data confirmed that the position 3 of the 1,2,4-triazine is a key location to determine the affinity and selectivity of the 5,6-diaryl/heteroaryl-3-substituted-1, 2, 4-triazines towards different biologic targets. Specific geometrical and thermodynamic characters of this motif have prompted it as a frequent hitter.


2020 ◽  
Vol 1 (1) ◽  
pp. 61-74
Author(s):  
Mohamad Siraji ◽  
Heri Kuswara

Medical record is a file that contains records and documents about patient identity, examination, treatment, actions and other services that have been provided to patients in health care facilities. Problems that occur in the Clinic PT. Nippon Paint Jakarta is an ineffective and efficient management of medical data. This information system aims to manage medical data quickly and accurately. This system development method uses SDLC by making UML diagrams such as use case diagrams, class diagrams, activity diagrams, entity relationship diagrams as stages of system design. This information system is based on WEB using the PHP programming language supported by SQL database. The results of the design of this system are expected to be one of the solutions to the problems that have occurred so far.   Keywords: Clinic, Medical Records, Informations Systems     Abstrak   Rekam medis adalah berkas yang berisi catatan dan dokumen tentang identitas pasien, pemeriksaan, pengobatan, tindakan dan pelayanan lain yang telah diberikan kepada pasien pada sarana pelayanan kesehatan. Permasalahan yang terjadi di Klinik PT. Nippon Paint Jakarta yaitu pengelolaan data medis yang kurang efektif dan efisien. Sistem informasi ini bertujuan supaya pengelolaan data medis dapat berjalan dengan cepat dan tepat. Metode pengembangan sistem ini menggunakan SDLC dengan membuat diagram-diagram UML seperti use case diagram, class diagram, activity diagram, entity relationship diagram sebagai tahapan perancangan sistem. Sistem informasi ini dibuat dengan berbasis WEB menggunakan bahasa pemrograman PHP yang didukung basis data SQL. Hasil rancang bangun sistem ini diharapkan dapat menjadi salah satu solusi dari permasalahan yang terjadi selama ini.   Kata kunci: Klinik, Rekam Medis, Sistem Informasi


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