scholarly journals Neural network of social interaction observation in marmosets

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Justine C Cléry ◽  
Yuki Hori ◽  
David J Schaeffer ◽  
Ravi S Menon ◽  
Stefan Everling
Keyword(s):  
Social Cognition ◽  
Social Interaction ◽  
Common Marmoset ◽  
Neural Basis ◽  
Primate Model ◽  
Old World ◽  
Crucial Component ◽  
The Social ◽  
The Common ◽  
The Brain

A crucial component of social cognition is to observe and understand the social interactions of other individuals. A promising nonhuman primate model for investigating the neural basis of social interaction observation is the common marmoset (Callithrix jacchus), a small New World primate that shares a rich social repertoire with humans. Here, we used functional magnetic resonance imaging acquired at 9.4 T to map the brain areas activated by social interaction observation in awake marmosets. We discovered a network of subcortical and cortical areas, predominately in the anterior lateral frontal and medial frontal cortex, that was specifically activated by social interaction observation. This network resembled that recently identified in Old World macaque monkeys. Our findings suggest that this network is largely conserved between New and Old World primates and support the use of marmosets for studying the neural basis of social cognition.

scholarly journals The Influence of the Social Situation of Development on the Social Cognition in the Children-Orphans

2019 ◽  
Vol 8 (1) ◽  
pp. 19-32
Author(s):  
T.V. Avakyan ◽  
S.V. Volikova ◽  
M.G. Sorokova
Keyword(s):  
Social Cognition ◽  
Social Interaction ◽  
Social Anxiety ◽  
Social Development ◽  
Theoretical Basis ◽  
Social Situation ◽  
Multifactor Model ◽  
The Social

The influence of a specific social development situation on the operational and motivational components of social cognition in orphan adolescents investigated. The theoretical basis of the study was the provisions of the "social situation of development" L.S. Vygotsky, theories of attachment by J. Bowlby, the multifactor model of social cognition A.B. Kholmogorova, O.V. Rychkova. 68 orphans aged from 10 to 17 years old living in the orphanage examined. It shown that orphaned teenagers with an insecure type of attachment have more difficulty in understanding their own feelings, regardless of the length of their stay in the institution. Orphans living in institutions for more than 5 years have a higher level of social anxiety and distress during social interaction.

scholarly journals What does the interactive brain hypothesis mean for social neuroscience? A dialogue

2016 ◽  
Vol 371 (1693) ◽  
pp. 20150379 ◽  
Author(s):  
Hanne De Jaegher ◽  
Ezequiel Di Paolo ◽  
Ralph Adolphs
Keyword(s):  
Social Cognition ◽  
Dynamical Systems ◽  
Social Environment ◽  
Cognitive Neuroscience ◽  
Social Neuroscience ◽  
Phenomenological Philosophy ◽  
The Social ◽  
New Directions ◽  
The Brain ◽  
And Robotics

A recent framework inspired by phenomenological philosophy, dynamical systems theory, embodied cognition and robotics has proposed the interactive brain hypothesis (IBH). Whereas mainstream social neuroscience views social cognition as arising solely from events in the brain, the IBH argues that social cognition requires, in addition, causal relations between the brain and the social environment. We discuss, in turn, the foundational claims for the IBH in its strongest form; classical views of cognition that can be raised against the IBH; a defence of the IBH in the light of these arguments; and a response to this. Our goal is to initiate a dialogue between cognitive neuroscience and enactive views of social cognition. We conclude by suggesting some new directions and emphases that social neuroscience might take.

The Common Marmoset (Callithrix jacchus) as a Model in Toxicology

2003 ◽  
Vol 31 (1_suppl) ◽  
pp. 123-127 ◽  
Author(s):  
U. Zühlke ◽  
G. Weinbauer
Keyword(s):  
Animal Model ◽  
Current Knowledge ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Human Reproduction ◽  
Background Information ◽  
Reproductive Toxicology ◽  
Primate Model ◽  
Wide Range ◽  
The Common

The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This paper provides a general overview of the marmoset with special emphasis on the benefits and disadvantages of this species as a model for inclusion in preclinical drug development programmes. In view of its small size in comparison with other nonrodent species marmosets have become of value for toxicology studies with biotechnology products where compound supply is limited. In general toxicology studies, marmosets have been successfully used to meet regulatory endpoints also for specific investigatory purposes. The widespread use of this species has allowed extensive background information to become available and a summary of the most frequently measured parameters are presented. Marmosets apparently represent an interesting animal model for comparative research on primate reproductive physiology. However, several basic aspects of reproductive processes exhibit cardinal discrepancies to those described for macaques and human. Thus, from the viewpoint of reproductive toxicology, the relevance of the marmoset primate model for human reproduction remains unclear to date and further research is obviously needed. Given our current knowledge of marmoset reproductive features, the use of this animal model cannot be recommended for reproductive toxicology assessment.

scholarly journals The social brain: allowing humans to boldly go where no other species has been

2010 ◽  
Vol 365 (1537) ◽  
pp. 165-176 ◽  
Author(s):  
Uta Frith ◽  
Chris Frith
Keyword(s):  
Social Cognition ◽  
Social Interaction ◽  
Comparative Studies ◽  
Computational Models ◽  
Developmental Psychology ◽  
Critical Factor ◽  
Social Signals ◽  
Social Brain ◽  
The Social ◽  
Closing The Loop

The biological basis of complex human social interaction and communication has been illuminated through a coming together of various methods and disciplines. Among these are comparative studies of other species, studies of disorders of social cognition and developmental psychology. The use of neuroimaging and computational models has given weight to speculations about the evolution of social behaviour and culture in human societies. We highlight some networks of the social brain relevant to two-person interactions and consider the social signals between interacting partners that activate these networks. We make a case for distinguishing between signals that automatically trigger interaction and cooperation and ostensive signals that are used deliberately. We suggest that this ostensive signalling is needed for ‘closing the loop’ in two-person interactions, where the partners each know that they have the intention to communicate. The use of deliberate social signals can serve to increase reputation and trust and facilitates teaching. This is likely to be a critical factor in the steep cultural ascent of mankind.

scholarly journals Common Marmosets (Callithrix jacchus) as a Nonhuman Primate Model To Assess the Virulence of Eastern Equine Encephalitis Virus Strains

2008 ◽  
Vol 82 (18) ◽  
pp. 9035-9042 ◽  
Author(s):  
A. Paige Adams ◽  
Judith F. Aronson ◽  
Suzette D. Tardif ◽  
Jean L. Patterson ◽  
Kathleen M. Brasky ◽  
...  
Keyword(s):  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Encephalitis Virus ◽  
Eastern Equine Encephalitis Virus ◽  
Primate Model ◽  
Common Marmosets ◽  
Eastern Equine Encephalitis ◽  
Equine Encephalitis Virus ◽  
The Brain ◽  
Arboviral Disease

ABSTRACT Eastern equine encephalitis virus (EEEV) produces the most severe human arboviral disease in North America (NA) and is a potential biological weapon. However, genetically and antigenically distinct strains from South America (SA) have seldom been associated with human disease or mortality despite serological evidence of infection. Because mice and other small rodents do not respond differently to the NA versus SA viruses like humans, we tested common marmosets (Callithrix jacchus) by using intranasal infection and monitoring for weight loss, fever, anorexia, depression, and neurologic signs. The NA EEEV-infected animals either died or were euthanized on day 4 or 5 after infection due to anorexia and neurologic signs, but the SA EEEV-infected animals remained healthy and survived. The SA EEEV-infected animals developed peak viremia titers of 2.8 to 3.1 log10 PFU/ml on day 2 or 4 after infection, but there was no detectable viremia in the NA EEEV-infected animals. In contrast, virus was detected in the brain, liver, and muscle of the NA EEEV-infected animals at the time of euthanasia or death. Similar to the brain lesions described for human EEE, the NA EEEV-infected animals developed meningoencephalitis in the cerebral cortex with some perivascular hemorrhages. The findings of this study identify the common marmoset as a useful model of human EEE for testing antiviral drugs and vaccine candidates and highlight their potential for corroborating epidemiological evidence that some, if not all, SA EEEV strains are attenuated for humans.

scholarly journals Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus)

2013 ◽  
Vol 81 (8) ◽  
pp. 2909-2919 ◽  
Author(s):  
Laura E. Via ◽  
Danielle M. Weiner ◽  
Daniel Schimel ◽  
Philana Ling Lin ◽  
Emmanuel Dayao ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Human Disease ◽  
Small Animal ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Primate Model ◽  
Content Type ◽  
Positron Emission ◽  
The Common ◽  
Fdg Pet Ct

ABSTRACTExisting small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. To develop a smaller primate model with pathology similar to that seen in humans, we experimentally infected the common marmoset (Callithrix jacchus) with diverse strains ofMycobacterium tuberculosisof various pathogenic potentials. These included recent isolates of the modern Beijing lineage, the Euro-American X lineage, andM. africanum. All three strains produced fulminant disease in this animal with a spectrum of progression rates and clinical sequelae that could be monitored in real time using 2-deoxy-2-[18F]fluoro-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT). Lesion pathology at sacrifice revealed the entire spectrum of lesions observed in human TB patients. The three strains produced different rates of progression to disease, various extents of extrapulmonary dissemination, and various degrees of cavitation. The majority of live births in this species are twins, and comparison of results from siblings with different infecting strains allowed us to establish that the infection was highly reproducible and that the differential virulence of strains was not simply host variation. Quantitative assessment of disease burden by FDG-PET/CT provided an accurate reflection of the pathology findings at necropsy. These results suggest that the marmoset offers an attractive small-animal model of human disease that recapitulates both the complex pathology and spectrum of disease observed in humans infected with variousM. tuberculosisstrain clades.

The mirror neuron system in social interactions and schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 2111-2111
Author(s):  
T. Kicher
Keyword(s):  
Social Cognition ◽  
Social Interaction ◽  
Social Interactions ◽  
Cognitive Processing ◽  
Mirror Neuron System ◽  
Mirror Neuron ◽  
Neural Correlates ◽  
Body Language ◽  
Neuron System ◽  
The Social

The term social cognition comprises of the perception and cognitive processing of stimuli of the social environment that is necessary to understand one's own behaviour and that of others. Social cognition is important for conscious and unconscious behaviour in social interactions and is composed of the recognition and interpretation of emotions in faces, body language and speech, reflection of one's own mental state and intentions as well as the realization of others’ intentions, thoughts and feelings. The mirror neuron system is involved in empathetic processes. Several aspects of the neural correlates of social interaction, embodiment and the mirror neuron system in schizophrenia and autism will be reported.

scholarly journals Functional localization of the frontal eye fields in the common marmoset using microstimulation

2019 ◽  
Author(s):  
Janahan Selvanayagam ◽  
Kevin D. Johnston ◽  
David J. Schaeffer ◽  
Lauren K. Hayrynen ◽  
Stefan Everling
Keyword(s):  
Spatial Attention ◽  
Common Marmoset ◽  
Frontal Eye Field ◽  
Cortical Region ◽  
Compelling Evidence ◽  
Primate Model ◽  
Promising Alternative ◽  
Cortical Areas ◽  
Eye Field ◽  
The Common

AbstractThe frontal eye field (FEF) is a critical region for the deployment of overt and covert spatial attention. While investigations in the macaque continue to provide insight into the neural underpinnings of the FEF, due to its location within a sulcus the macaque FEF is virtually inaccessible to electrophysiological techniques such as high-density and laminar recordings. With a largely lissencephalic cortex, the common marmoset (Callithrix jacchus) is a promising alternative primate model for studying FEF microcircuitry. Putative homologies have been established with the macaque FEF on the basis of cytoarchitecture and connectivity, however physiological investigation in awake, behaving marmosets is necessary to physiologically locate this area. Here we addressed this gap using intracortical microstimulation in a broad range of frontal cortical areas in marmosets. We implanted marmosets with 96-channel Utah arrays and applied microstimulation trains while they freely viewed video clips. We evoked short-latency fixed vector saccades at low currents (<50 μA) in areas 45, 8aV, 8C and 6DR. We observed a topography of saccade direction and amplitude consistent with findings in macaques and humans; we observed small saccades in ventrolateral FEF and large saccades combined with contralateral neck and shoulder movements encoded in dorsomedial FEF. Our data provide compelling evidence supporting homology between marmoset and macaque FEF and suggest the marmoset is a useful primate model for investigating FEF microcircuitry and its contributions to oculomotor and cognitive functions.Significance StatementThe frontal eye field (FEF) is a critical cortical region for overt and covert spatial attention. The microcircuitry of this area remains poorly understood, as in the macaque, the most commonly used model, it is embedded within a sulcus and is inaccessible to modern electrophysiological and optical imaging techniques. The common marmoset is a promising alternative primate model due to its lissencephalic cortex and potential for genetic manipulation. However, evidence for homologous cortical areas in this model remains limited and unclear. Here we applied microstimulation in frontal cortical areas in marmosets to physiologically identify the FEF. Our results provide compelling evidence for a frontal eye field in the marmoset, and suggest that the marmoset is a useful model for FEF microcircuitry.

scholarly journals Is left-behind a real reason for children’s social cognition deficit? An fNIRS study on the effect of social interaction on left-behind preschooler’s prefrontal activation

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0254010
Author(s):  
Keya Ding ◽  
Chuanjiang Li ◽  
Huibin Jia ◽  
Mingming Zhang ◽  
Dongchuan Yu
Keyword(s):  
Social Cognition ◽  
Social Interaction ◽  
Joint Attention ◽  
Rural Areas ◽  
Near Infrared ◽  
Brain Activation ◽  
Neural Basis ◽  
Functional Near Infrared Spectroscopy ◽  
Left Behind ◽  
Initiating Joint Attention

The left-behind phenomenon, caused by parent out-migration, has become a common social issue and might lead to long-term and potential risks for children in rural areas of China. It is important to investigate the effect of social interaction on prefrontal activation of left-behind children in China because of possible effects of parent out-migration on children’s social cognition. We recruited 81 rural Chinese preschoolers aged 52–76 months (mean = 64.98 ± 6.321 months) preschoolers with three different statuses of parental out-migration (including non-, partially, and completely left-behind children). Using functional Near-Infrared Spectroscopy (fNIRS), we compared behavior and brain activation and in three groups (non-, partially-, completely-left-behind children) under two different social interaction conditions (child-teacher and child-stranger situation). Results revealed that initiating joint attention (IJA) may evoke higher brain activation than responding to joint attention (RJA) in the prefrontal cortex (PFC), especially in the case of initiating joint attention with the stranger. In addition, the activation of joint attention was positively correlated with children’s language score, cognitive flexibility, and facial expression recognition. More importantly, partially-left-behind children evoked higher brain activation in the IJA condition and presented a higher language level than completely/non-left-behind children. The current study provides insight into the neural basis of left-behind children’s development and revealed for the first time that family economic level and left-behind status may contribute to the lower social cognition.

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