scholarly journals Myeloid Sarcoma: Evaluation of Histopathology, Immunoprofile and Cytogenetics

2021 ◽  
Author(s):  
Sanjiban Patra ◽  
Biren P Parikh ◽  
Kanwalpreet Kaur
Keyword(s):  
Myeloid Leukaemia ◽  
De Novo ◽  
Myeloproliferative Neoplasm ◽  
Molecular Data ◽  
Cross Sectional Study ◽  
Myeloid Sarcoma ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Cross Sectional ◽  
Present Cross Sectional Study ◽  
Wrong Diagnosis

Introduction: Myeloid Sarcoma (MS), an uncommon tumour of immature myeloid blasts at extramedullary sites can be diagnostically challenging, if it is present de novo, precedes Acute Myeloid Leukaemia (AML) or Myeloproliferative Neoplasm (MPN). There are a few studies in literature with a substantial number of cases on clinicopathological, Immunophenotypic (IPT) and Immunohistochemical (IHC) characteristics of MS. Aim: This study was aimed to analyse myeloid sarcoma in Indian population according to the age, gender, site of involvement, differential diagnoses, IHC, IPT and cytogenetics and to add some to the existing knowledge. Materials and Methods: The present cross-sectional study was conducted at Gujarat Cancer Research Institute, Ahmedabad, with a total of 38 patients, diagnosed over past three years (January 2017 to December 2019). Clinical, morphological, IHC, IPT and molecular data of those 38 patients were retrieved and analysed. Results: Out of 38 cases, 16 (42.1%) and 13 (34.2%) cases were previously diagnosed cases of AML and Chronic Myeloid Leukaemia (CML) respectively. Nine patients (23.7%) presented as de novo. Most common site was lymph node (12/38, 31%), followed by breast, vertebra and other unusual sites. Myeloperoxidase (MPO) (31/38, 81.5%), CD117(25/35, 71.4%), CD45 (21/23, 91.3%), CD43 (14/22, 63.6%), CD68 (12/28, 42.8%), CD34 (15/37, 40.5%), CD33 (14/14, 100%), CD13 (15/16, 93.7%), HLA-DR (11/12, 91.6%), CD99 (3/29, 10.3%) and Terminal deoxynucleotidyl Transferase (TdT) (1/9, 11.1%) were expressed by tumour cells. However, epithelial mesenchymal, B and T lymphoid markers were negative. The present study found inv(16) and t(8;21) in MS in known AML patients. Among the known CML patients, two had variant positive for t (9;22) {t (2;9;22) (p23;q34;q11.2)}. Conclusion: Results of present study depicts that considering MS in differential diagnosis in its de novo presentation is necessary to prevent wrong diagnosis and help early treatment of these patients.

Etiologies, Clinical Manifestations, and Factors Associated with Severe Symptomatic Hyponatremia among Hospitalized Hyponatremia Patients

2020 ◽  
Vol 103 (5) ◽  
pp. 465-471
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Sectional Study ◽  
Close Attention ◽  
Cross Sectional ◽  
Factors Associated ◽  
Present Cross Sectional Study ◽  
Important Health ◽  
Baseline Characteristics

Background: Hyponatremia is associated with unfavorable outcomes in many cases. The mainstay of hyponatremia treatment depends on its symptoms and etiology. However, etiologies, clinical manifestations, and factors associated with severe symptomatic hyponatremia have been rarely reported. Objective: To analyze and report etiologies, clinical manifestations, and factors associated with severe symptomatic hyponatremia. Materials and Methods: In the present cross-sectional study, the authors enrolled hospitalized patients with hyponatremia who had consulted a nephrologist between October 1, 2017, and October 31, 2018. Their baseline characteristics and clinical manifestations were recorded. Etiologies were confirmed by the attending nephrology staff. Factors associated with severe symptomatic hyponatremia were evaluated using logistic regression analysis. Results: One hundred patients were included in this study. The syndrome of inappropriate antidiuresis (SIAD), hypovolemia, and hydrochlorothiazide use were the leading hyponatremia etiologies. Hyponatremia etiologies differed between patients with community-acquired hyponatremia (n=50) and those with hospital-associated hyponatremia (n=50). Patients with communityacquired hyponatremia were older, presented with a higher frequency of severe symptomatic hyponatremia, and showed lower SNa-levels. Low SNa-levels were significantly associated with severe symptomatic hyponatremia (p=0.014). Conclusion: Hyponatremia remains an important health problem. SIAD, hypovolemia, and hydrochlorothiazide use are among the leading etiologies of hyponatremia. Low SNa-levels are associated with severe symptomatic hyponatremia; thus, physicians should pay close attention to low SNa-levels in hospitalized patients. Keywords: Hyponatremia, Symptomatic Hyponatremia, Community-acquired hyponatremia, Hospital-associated hyponatremia

The Relationship of Mode and Intensity of Training on Resting Metabolic Rate in Women

2001 ◽  
Vol 11 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Heidi K. Byrne ◽  
Jack H. Wilmore
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Women Subjects ◽  
Present Cross Sectional Study ◽  
Significant Difference ◽  
Level Of Training ◽  
The Relationship ◽  
Aerobically Trained

The present cross-sectional study was designed to investigate the relationship between exercise training and resting metabolic rate (RMR). The focus of this investigation was to compare RMR in aerobically trained (AT), resistance trained (RT), and untrained (UNT) women. Subjects were also classified as highly trained (HT), moderately trained (MT), or untrained (UNT) in order to examine the relationship between RMR and level of training. Sixty-one women between the ages of 18 and 46 years volunteered to serve as subjects in this study. Each subject completed measurements of body composition, maximal oxygen uptake (V̇O2max), and two consecutive measurements of RMR. The data presented show that there was no significant difference in resting metabolic rate between resistance-trained, aerobically trained, and control subjects. However, when grouped by intensity of training, there was a trend for an increased resting metabolic rate (kcal/day) in the highly trained subjects, regardless of mode of training.

scholarly journals Student dropout at university: a phase-orientated view on quitting studies and changing majors

2021 ◽  
Author(s):  
Lisa Bäulke ◽  
Carola Grunschel ◽  
Markus Dresel
Keyword(s):  
Decision Making ◽  
Information Search ◽  
Structural Equation ◽  
Cross Sectional Study ◽  
Final Decision ◽  
Cross Sectional ◽  
Confirmatory Factor Analyses ◽  
Student Dropout ◽  
Regulatory Processes ◽  
Present Cross Sectional Study

AbstractStudent dropout can be conceptualized as a decision-making process, consisting of different phases. Based on previous literature on student dropout, decision-making, and action-phases, we proposed that the process of developing dropout intentions includes the following phases: non-fit perception, thoughts of quitting/changing, deliberation, information search, and a final decision. In the present cross-sectional study, we empirically investigated if the assumed phases can be distinguished from each other, if the phases follow the presumed order, and whether each phase is associated with certain characteristics. Furthermore, we considered a strict separation between quitting studies completely and changing a major. For this purpose, we analyzed data of N = 1005 students (average age of 23.0 years; 53% female; 47% male) from a German University. By using confirmatory factor analyses, we found the supposed factor structure for the different phases concerning both kinds of dropout, quitting studies, and changing majors. In each process, structural equation modelling indicated positive relations between adjoining phases. The factor values correlated to a substantial amount with an assortment of variables associated with student dropout. On a theoretical level, the conception of different phases of student dropout helps to get a better understanding of regulatory processes in the context of student dropout.

A Comparative Study between Conventional and Modified Leishman Stain

2021 ◽  
Vol 8 (2) ◽  
pp. 5-12
Author(s):  
Rizwana Abdul Hye ◽  
Bindiya Gisuthan ◽  
Indira Kariveettil
Keyword(s):  
Conventional Method ◽  
Peripheral Blood ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Health Care Centre ◽  
Cross Sectional ◽  
Modified Method ◽  
Present Cross Sectional Study ◽  
Short Period

Introduction: Leishman stain has been used as the stain of choice for peripheral blood films since many decades .But it has a disadvantage of consuming 15 minutes for the procedure alone thereby increasing the turn around time of peripheral smear reporting. In this study modified Leishman stain was made by adding phenol to conventional Leishman to reduce the staining time to 3 minutes without interfering with the quality of stain. Aim: To study the quality of modified Leishman stain in comparison with conventional preparation on peripheral blood smears. Materials and Methods: The present cross-sectional study was carried out in Central Haematology laboratory of a tertiary health care centre in Southern India. A pilot study was done to determine the ideal ratio of phenol to Leishman powder in preparing modified stain without compromising the staining quality. After obtaining consent, the blood sample was collected in anticoagulated vials. Sample size was calculated to be 85.Two thin wedge smears were prepared from each sample and one was stained with conventional Leishman stain and other with modified Leishman stain. The staining characteristics were assessed and scored by an experienced pathologist in terms of 6 parameters- RBC pattern, nuclear pattern, neutrophil granules, eosinophil granules, platelets and background staining. The grades were 1, 2, 3 & 4 (poor, satisfied, good and excellent). Smears each with grades 2, 3 and 4 were selected for study. The results were analysed by Statistical Package for the Social Sciences (SPSS) software version 16.0. Result: The mean value for the staining quality using conventional method was 4.73 and for modified method was 5.39, and the total score possible is 6. Photomicrograph showed excellent results with modified Leishman stain. Thus from these values we can interpret that modified method gave much more acceptable results than that of conventional method. Conclusion: Unlike the conventional method which requires a total of 15 minutes, to complete the staining process, modified Leishman staining techniques takes only 3 minutes. Blood films can be stained within a short period of time thus aiding in rapid diagnosis and treatment of patients. Keywords: Leishman stain, Modified Leishman stain, Phenol.

scholarly journals Nutritional status of 1-5 years children in the urban slum area of Jagdalpur city, Bastar region, Chhattisgarh

2018 ◽  
Vol 5 (3) ◽  
pp. 1172
Author(s):  
Q. H. Khan ◽  
Garima Arora ◽  
Susheel Kumar Nalli
Keyword(s):  
Nutritional Status ◽  
Immunization Coverage ◽  
Urban Slum ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Present Cross Sectional Study ◽  
Chi Square Test ◽  
Nutritional Status Of Children ◽  
High Level

Background: Nutritional status is the best indicator of the child health. Malnutrition has both short and long term adverse ramifications. As per NFHS III 47% children are stunted in the state of Chhattisgarh. However still many communities in the tribal dominated and naxal affected state may remain affected, hence the study was planned to identify the nutritional status of children and find out its determinant.Methods: Present cross-sectional study was conducted among 12-59 months children in the urban slum of Jagdalpur city, Bastar region of Chhattisgarh. Predesigned and pretested questionnaire was administered to the caregiver of the child, information on socio-demographic characteristics was obtained and anthropometric measurements were taken. Statistical Analysis: all frequencies were derived for completeness of data. WHO Anthro Software version 3.1.0 was used to classify the malnutrition status. Chi-square test was applied to find association between dependent variables.Results: Out of 225 children 53.3% were boys and 46.7% were girls. The overall prevalence of underweight stunting and wasting was 28.4%, 41.3%, and 19.1% respectively.Conclusions: Prevalence of underweight has reduced in the district over a period of years. However high level of stunting, a sign of chronic hunger points towards the pivotal role of socio-demographic and behavioral practices prevalent in the district. Interaction with health system in the form of ANC, institutional delivery and safeguarding effective 100% immunization coverage has shown preventive effect.

scholarly journals Hypertension and its Relation with Waist to Hip Ratio in Women Referred to Bojnurd Urban Health Centers in 2014

2019 ◽  
Vol 11 (1) ◽  
pp. 1-5
Author(s):  
Hossein Lashkardoost ◽  
Fateme Hoseyni ◽  
Elham Rabbani ◽  
Farzane Q Moqadam ◽  
Leila Hosseini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Health Centers ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Significant Relationships ◽  
Present Cross Sectional Study

Introduction: North Khorasan province has one of the highest rates of hypertension. One of the main causes of hypertension is obesity. Obesity is one of the most important public health problems around the world as a risk factor for non-communicable diseases. Since a similar study was not conducted in Bojnurd, we examined the relationship between waist to hip ratio with hypertension. Methods: The present cross-sectional study was conducted on women referring to Bojnurd health centers. To analyze the data, we used t-test, chi-square, multiple logistic regression and Pearson correlation in Stata 12 software. Results: In this cross-sectional study, the prevalence of systolic blood pressure was 14.78% and diastolic blood pressure was 15.65%. So waist to the hips showed the highest correlation with the changes in hypertension. Conclusion: There are significant relationships between the age and the number of pregnancies with the risk of hypertension. Since a significant percentage of people are unaware of the existence of hypertension, changing diet and having regular physical activity along with social support is an important strategy.

scholarly journals Maternal co-relates of anaemia among children aged 1-3 years of age in a rural area of Meerut

2018 ◽  
Vol 5 (8) ◽  
pp. 3532
Author(s):  
Tanveer Bano ◽  
Abhishek Agarwal ◽  
Sunil Kumar Garg ◽  
Harivansh Chopra ◽  
Seema Jain ◽  
...  
Keyword(s):  
Maternal Education ◽  
Demographic Factors ◽  
Cross Sectional Study ◽  
Severe Anaemia ◽  
Maternal Factors ◽  
Cross Sectional ◽  
Present Cross Sectional Study ◽  
History Of ◽  
Iron Folic Acid ◽  
Socio Demographic Factors

Background: Iron deficiency anaemia constitutes more than half of the anaemia burden among the under 5 children. In addition to socio-demographic factors, the maternal factors plays an important role in determining childhood anaemia. The objective of the study was to determine the prevalence of anaemia among 1-3 year old children and to find their association with maternal factors.Methods: The present cross sectional study was conducted in a sub centre village under Machhra CHC. Sample size was calculated as 182 by taking the prevalence of anaemia as 79% with 7.5% relative precision and 95% confidence interval. From the list of 404 children obtained from MCTS data, 200 children were selected randomly. Detailed information regarding socio demographic factors and maternal factors was obtained on a pre tested and pre designed questionnaire. Hemoglobin levels were estimated using haemo check rapid diagnostic kit. The data was collected and analyzed on epi info 3.7.2 using appropriate statistical tests.Results: Out of 200 children 77.5% of them were suffering from mild to severe anaemia. Among all the maternal factors studied maternal education, iron folic acid consumption during pregnancy, birth order of the index case and history of exclusive breast feeding were found to be significantly associated with prevalence of anaemia among the children.Conclusions: The present study revealed a high prevalence of anaemia in children and maternal factors plays an important role in determining the disease. 

scholarly journals Analgesic Effect of Apotel Versus Pethidine After Hemilaminectomy

2019 ◽  
Vol 5 (4) ◽  
pp. 185-189
Author(s):  
Mohammadreza Emamhadi ◽  
◽  
Hamid Behzadnia ◽  
Seifollah Jafari ◽  
Mohammadreza Zamanidoust ◽  
...  
Keyword(s):  
Recovery Process ◽  
Cross Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Vas Score ◽  
Relieve Pain ◽  
Present Cross Sectional Study ◽  
Significant Difference ◽  
Vas Scores ◽  
The Difference

Background: Postoperative pain is a common phenomenon, and its management affects considerably on the recovery process, and patients’ satisfaction. Apotel and pethidine are two conventional medicines used to relieve pain after operation. Objectives: The present study aimed to compare the effect of intravenous injection of Apotel and intramuscular injection of pethidine in relieving pain after hemilaminectomy. Materials & Methods: In the present cross-sectional study, 150 patients who underwent hemilaminectomy were recruited between May 2015 and November 2015. They were taking either Apotel (n=75) or pethidine (n=75) after the operation, which was done at Poursina Hospital affiliated to Guilan University of Medical Sciences, Rasht City, Iran. The patients’ pain levels were measured using visual analog scale (VAS), and the results were compared between the 2 groups. Results: There was no significant difference in the total VAS score between the Apotel and pethidine groups (P=0.189). However, there was a significant reduction in VAS score hours 2 (P=0.03) and 4 (P=0.004) hours after the injection of Apotel in this group, compared with those scores in the pethidine group. Also, VAS scores at other times (8, 12, 20, 28 hours after the injection) were lower than those in the pethidine group, but the difference was not significant. Conclusion: Apotel was better pain-killer in the early hours after the first injection compared to pethidine. But its effect was similar to pethidine at the late hours after the first injection. Therefore it seems that Apotel is better painkiller after laminectomy, especially in the early hours after the operation.

Prevalence and Multidrug-Resistance Salmonella in Swine Production Chain in a Central Province, Thailand

2021 ◽  
Author(s):  
Kaknokrat Chonsin ◽  
Ruchirada Changkwanyeun ◽  
Achiraya Siriphap ◽  
Apiradee Intarapuk ◽  
Watsawan Prapasawat ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Disease Outbreaks ◽  
Cross Sectional Study ◽  
Single Type ◽  
Economic Losses ◽  
Cross Sectional ◽  
Production Chain ◽  
Extended Spectrum Beta Lactamase ◽  
Present Cross Sectional Study ◽  
Cutting Boards

Salmonella causes foodborne disease outbreaks worldwide and raises considerable concerns about public health and economic losses. To determine prevalence, serovar, antimicrobial resistance (AMR) patterns, and extended-spectrum beta-lactamase (ESBL) genes, the present cross-sectional study collected a total of 418 fecal, carcass (three slaughterhouses), pork and cutting board (four markets) samples from a province in central Thailand in 2017 and 2018. Results showed that 65.1% (272/418) of samples were positive for Salmonella. The percentage of Salmonella positive samples from markets (88.8%; 158/178) was significantly higher than those from slaughterhouses (47.5%; 114/240) ( P<0.05 ). In total, 1,030 isolates were identified; of these, 409 were assigned to 45 serovars with S. Rissen (20%; 82/409) being the most common. New serovars of Thai isolates, S. Cannstatt and S. Braubach, were identified in market and slaughterhouse samples, respectively. AMR of Salmonella isolates showed that 73.9% (133/180) of 19 different serovars exhibited multidrug resistance (MDR). Screening for ESBL production showed that 10.3% (41/399) of isolates were ESBL positive. ESBL-producing Salmonella isolates in market samples (75.6%; 31/41) were significantly higher than those in slaughterhouse samples (24.4%; 10/41) ( P<0.05 ). In market samples, 77.4% (24/31) were isolated from pork and 22.6% (7/31) from cutting boards. Nine ESBL-producing isolates carried single type ESBL genes bla TEM (9.8%; 4/41) or bla CTX-M (12.2%; 5/41), while 11 (26.8%) carried both bla TEM and bla CTX-M . No ESBL-producing Salmonella isolate carried the gene bla SHV . Results suggest that pigs, their flesh, and cutting boards could be reservoirs for widespread MDR, ESBL-producing Salmonella outbreak across the food chain.

ASSOCIATION OF SERUM MAGNESIUM LEVEL WITH RESISTANT HYPERLIPIDEMIA IN DIABETIC AND HYPERTENSIVE PATIENTS

2021 ◽  
pp. 33-35
Author(s):  
Manish Kumar ◽  
Syed Yousuf Faisal ◽  
Sudhir Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Level ◽  
Lipid Lowering ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Present Cross Sectional Study ◽  
Lipid Lowering Agents

Introduction: Both diabetes mellitus and hypertension are aspects of metabolic syndrome. Objectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients. Patients And Methods: The present cross- sectional study was carried out on 90 hypertensive and diabetic patients in Medicine Department of DMCH, Laheriasarai, Bihar, (45 hypertensive and 45 diabetic patients). Included patients had high triglyceride levels despite 8 weeks of treatment with lipid-lowering agents. Results: There was an inverse signicant relationship between serum magnesium and triglyceride levels in diabetic patients (P=0.002, r=-0.458), however, this correlation was not signicant in hypertensive patients (P=0.754, r=0.048). Conclusion: This study showed, serum magnesium may affect triglycerides levels in diabetic patients, however, our nding requires further investigation with larger population

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