scholarly journals Aluminium Induced Neurodegeneration in Rat Cerebrum in Presence of Ethanol Co-exposure

2021 ◽  
Author(s):  
Buddhadeb Ghosh ◽  
Suman Yadav ◽  
Ravi Kant Sharma
Keyword(s):  
Body Weight ◽  
Vehicle Control ◽  
The Body ◽  
World Health ◽  
Control Group ◽  
Government Medical College ◽  
Vehicle Control Group ◽  
Medical College ◽  
Group I ◽  
Experimental Group

Introduction: Aluminium (AL) exposure leads to neurotoxicity and many problems in the body. AL role in Alzheimer's Disease (AD) is unknown and controversial to the scientists. According to World Health Organisation (WHO) provisional tolerable weekly intake of AL is 2 mg/kg body weight. Moderate intake of alcohol may favour body in coronary heart disease and diabetes mellitus, etc. Aluminium being cheaper along with increased consumption of alcohol, mixed with each other may induce neurotoxicity. Aim: The study was designed to identify the effects of AL in cerebrum of rats in presence of ethanol co-exposure. Materials and Methods: An experimental study was carried out at Dr. RP Government Medical College, Kangra and Government Medical College, Amritsar, India after due approval from the Institute Animal Ethics Committee. Thirty-two wistar rats were divided into one vehicle control and three experimental groups. Group I received the normal saline water as vehicle control group. Group II received AL chloride 4.2 mg/kg body weight as experimental group. Group III received ethanol 1 gm/kg body weight as experimental group. Group IV received both AL chloride 4.2 mg/kg body weight and ethanol 1 gm/kg body weight as experimental group. After treatment, brain cortex was processed for histopathological observation under microscope. Results: Cerebral cortex showed normal architecture of the brain with haematoxylin and eosin staining and cresyl violet staining and modified Bielchowsky silver staining in low and high magnification in vehicle control group. Experimental group treated with AL and ethanol separately showed reduction in the count of pyramidal cells with moderate neuronal degeneration with pyknotic nuclei. Vacuolar changes and pericellular spaces around the necrotic neurons were also seen. Combined AL and ethanol treated group showed acute neurodegeneration and necrosis of cortex indicating chromatolysis and loss of substances and Neurofibrillary Tangle (NFT) and plaque. Conclusion: It has been concluded that the ethanol induced the effects of AL on the cerebrum and plays a significant role in AD pathogenesis.

scholarly journals The Influence of Highly Dispersed Metal Forms on Calcium and Phosphorus Metabolism in Polygastric Animals

2022 ◽  
Author(s):  
Makaeva Ayna Maratovna ◽  
Sizova Elena Anatolevna ◽  
Atlanderova Ksenya Nikolaevna
Keyword(s):  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Utilization Rate ◽  
Control Group ◽  
Ruminal Fluid ◽  
Group I ◽  
Calcium And Phosphorus ◽  
Group Ii ◽  
Experimental Group

Determining which forms of mineral feed additives can increase farm animal productivity is a key area of research. This study assessed the mineral composition of ruminal fluid and the effectiveness of calcium and phosphorus used by animals after the introduction of finely dispersed particles (FDP) of SiO2 (group I) and FeCo (group II) with a hydrodynamic radius of 109.6 ± 16.6 and 265 ± 25 nm, respectively. The deposition and use of calcium and phosphorus in the body of the experimental animals exceeded the control values. In group I, 30.8% more calcium was deposited (p ≥ 0.05), and in group II, the value was 30.3% (p ≥ 0.01). In the experimental groups, the calcium utilization rate was 27.3% higher in group I (p ≥ 0.05), and 28.2% higher in group II (p ≥ 0.01) compared to in the control. Phosphorus deposition was 34% higher (p ≤ 0.01) in experimental group I and 6% higher in experimental group II, compared with the control. Group I had a high utilization rate of phosphorus from the feed (with a 29% difference compared to the control). Comparison of the experimental groups revealed that the introduction of SiO2 FDP promoted an increase in the concentration of silicon, phosphorus, and calcium in the ruminal fluid. The introduction of FeCo FDP was accompanied by a decrease in the concentration of iron and cobalt in the ruminal fluid. Thus, the use of feed additive in finely dispersed form in the diet of animals was accompanied by an increase in the use of calcium and phosphorus by the animal’s body, which is advisable when intensifying milk and meat productivity. The obtained results require further research. Keywords: finely dispersed forms of microelements, ruminants, calcium and phosphorus exchange, feeding

Effect of Clomiphene Citrate and Letrozole on Body Weight of female Albino Rat for Consecutive 1-4 Estrous Cycles

2021 ◽  
Vol 15 (11) ◽  
pp. 2938-2941
Author(s):  
Fauzia Qureshi ◽  
Syeda Rizwana Jafri ◽  
Hafiza Sadia Ahmad ◽  
Uzma Waseem ◽  
Ursula Akif ◽  
...  
Keyword(s):  
Body Weight ◽  
Estrous Cycle ◽  
Ovulation Induction ◽  
Clomiphene Citrate ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Albino Rat ◽  
Estrous Cycles ◽  
Experimental Group

Background: Ovulation induction with clomiphene citrate in women with infertility has been practiced more than 40% years but in infertile patients this treatment plan proved to be ineffective with multiple complication. Body weight plays an important role modulating reproductive development and functioning. Aim: To observe the effects on body weight of female albino rat after use of clomiphene citrate and letrozole for consecutive 1-4 estrous cycles Method: Eighty four adult female Albino rats were equally divided into three groups for this research. Body weight of each rat was measured before and after the experiment. Vaginal smear cytology of each rat was performed to study different phases of estrous cycle. Control group A was given normal saline orally , In Experimental group B rats were given letrozole (Femara) at dose 5mg/kg orally and in Experimental group C rats were given clomiphene citrate at dose 100ug/kg orally. Results: Significant weight gain is observed in rats taking clomiphene citrate as compared to letrozole Conclusion : Comiphene citrate directly affects the body weight which indirectly reduces the ovulation induction and pregnancy rate. Letrozole is good alternate for ovulation induction and for CC resistant patients. Keywords: Estrous cycle, body weight, citrate and letrozole

scholarly journals The Influence of the Mineral-Microbial Preparation on Ammonia Concentration and Productivity in Laying Hens Houses

Atmosphere ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 751 ◽  
Author(s):  
Remigiusz Gałęcki ◽  
Michał Dąbrowski ◽  
Tadeusz Bakuła ◽  
Kazimierz Obremski ◽  
Adriana Nowak ◽  
...  
Keyword(s):  
Body Weight ◽  
Linear Correlation ◽  
Egg Production ◽  
Laying Hens ◽  
Animal Health ◽  
The Body ◽  
Control Group ◽  
Microbial Composition ◽  
Experimental Group ◽  
Campylobacter Spp

The aim of this study was to evaluate the influence of the biopreparation Deodoric® on ammonia (NH3) concentration, performance, and hygiene standards in laying hen (ROSS-308) production. Statistically significant differences in NH3 concentration and the body weight of laying hens were observed between the control group (C) and the experimental group (E) where Deodoric® was applied at the set dose. In the control group, an increase in NH3 concentration could have contributed to the decrease in the body weight of laying hens, egg production, and % hen day egg production, whereas no such correlations were observed in the experimental group. A moderate linear correlation between NH3 concentration vs. humidity (r = 0.68), air flow (r = 0.48) and weakly linear correlation between NH3 concentration and age of birds (r = 0.27) was noted in group C. In group E, NH3 concentration vs. temperature (r = 0.27) and humidity (r = 0.14) were weakly correlated. Statistical analysis of changes in the microbial counts isolated from manure revealed a significant decrease of mesophilic microorganisms on day 28 decrease of Campylobacter spp. days 14 and 84 in group E. However, for the entire experimental model no statistically significant changes in the number of Campylobacter spp. and mesophilic bacteria were found. The tested preparation did not cause changes in the microbial composition of tissue swabs. Deodoric® contributes to animal welfare by reducing the ammonia concentrations in poultry houses. It is also recommended for use in poultry farms to improve animal health and performance and to generate benefits for producers.

A Teratological Evaluation and Postnatal Behavioral Screen of KF-868 In Rats

1985 ◽  
Vol 4 (1) ◽  
pp. 91-110 ◽  
Author(s):  
A. M. Hoberman ◽  
W. M. Weatherholtz ◽  
R. S. Durloo
Keyword(s):  
Body Weight ◽  
Vehicle Control ◽  
Female Rats ◽  
Reproductive Capacity ◽  
Control Group ◽  
Dosage Group ◽  
Vehicle Control Group ◽  
High Dosage Group ◽  
Significant Difference ◽  
Body Weights

The effects of a new experimental drug, KF-868, were investigated after administration to pregnant Sprague-Dawley rats at 0(vehicle), 0.1, 2.0, and 40.0 mg/kg per day during Days 7 through 17 of gestation by examination of term fetuses and naturally delivered offspring. Pregnant rats administered 0.1, 2.0, and 40.0 mg/kg per day gained significantly more weight during the dosage period than did the vehicle control group. Treatment-related physical signs, bloody crust on nose and stains on fur, were observed in the high dosage group. Fetal viability was significantly increased, and resorptions were significantly decreased for the mid and high dosage groups, when compared with the control group. Average fetal body weights for cesarean-delivered fetuses were less for the 40.0 mg/kg per day dosage groups than for the vehicle control group. Visceral and skeletal evaluations of fetuses revealed no difference between the control and test groups. Percent survival of pups was significantly less for the high dosage group than for the control group. Average rat body weights prior to mating for the high dosage group were generally less than for the control group. All physical and functional developmental values were comparable among the control and test groups. Evaluation of postweaning parameters of pups revealed no significant difference in sex maturation, behavior (open-field and water maze), and reproductive capacity. Average body weight gains during the 9-week growth period before mating were significantly less for the 40.0 mg/kg per day dosage group F1 generation female rats. Toxicity in fetuses and offspring was observed only at the highest dosage level. Dosage-dependent, significant increases in maternal body weight gain, as compared with control values, occurred for doses in the 3 KF-868-administered groups. These results indicate that 0.1 and 2.0 mg/kg per day dosages of KF-868 were not lethal and did not produce any adverse effects on the morphological or functional development of offspring. Toxicity was evident in offspring and fetuses of dams administered 40.0 mg/kg per day KF-868, 40,000 times as high as the daily therapeutic dose.

DYNAMICS OF PROTEIN METABOLISM AND ACTIVITY OF AMINOTRANSFERASES OF DOGS BY ADDING DIHYDROQUERCETIN

2016 ◽  
Vol 1 (1) ◽  
pp. 6-8
Author(s):  
Полищук ◽  
Sergey Polishchuk ◽  
Молянова ◽  
Galina Molyanova
Keyword(s):  
Body Weight ◽  
The Body ◽  
Control Group ◽  
German Shepherd ◽  
Formalin Edema ◽  
Working Dogs ◽  
Healthy Dogs ◽  
Biochemical Indices ◽  
Experimental Group ◽  
Operational Capacity

The purpose of research is to improve business and operational capacity of the body through the use of dogs dihydroquercetin. The article presents the results of experiment by the effect of dihydroquercetin dynamics of biochemical indices of the dogs blood. Dihydroquercetin – it is an active antioxidant, natural scavenger of oxygen free radicals, hepatoprotector, having anti-inflammatory action due to limitations of the formalin edema and histamine, and inhibits the formation of serous fluid, painkillers, immunocorrelation properties. Due to the high complexing properties it displays the body of heavy metals, including radionuclides, helps to restore the blood vessels tone, normalizing the lipid levels and slows the progression of atherosclerotic plaques. Investigations were carried out in zonal center of the dog expert service GU MVD of Russia in Samara region with clinically healthy dogs, German shepherd breed, age 2-4 years with an average body weight of 30 kg in the background conditions and feeding, adopted by the enterprise. The dogs of the experimental group received dose dihydroquercetin 0.001 g/kg for body weight once a day during meals. When added to the basic diet, dihydroquercetined dogs of the experimental group shown the increase in indicators such as: total protein – by 11.5% (p<0.01), albumin – to 12.8% (p<0.01), AST 13.6% (p <0.001), ALT – by 11% (p<0.05), alkaline phosphatase in the – 12% (p<0.01) relative to the control group. Based on the results, obtained during the experiment, we can conclude that the use of dietary supplements in the diet of dogs, dihydroquercetin allows biocorrection level of protein and enzymatic metabolism in the body, which improves service and working dogs potential.

Effect of vitamin E on reproductive function in the mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin*

2008 ◽  
Vol 24 (9) ◽  
pp. 595-601 ◽  
Author(s):  
JP Xu ◽  
YP Yin ◽  
XQ Zhou
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Survival Rate ◽  
Sex Ratio ◽  
Pregnancy Rate ◽  
Reproductive Performance ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Experimental Group

The study was conducted to determine the effects of vitamin E on reproductive performance in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The 75 female and 40 male mice were randomly assigned into five groups. The levels of both TCDD and vitamin E given by gavage were 0 and 0 (Control group), 100 and 0 (experimental group I), 100 and 20 (experimental group II), 100 and 100 (experimental group III), and 100 ng/kg/day and 500 mg/kg/day (experimental group IV), respectively. Males and females were mixed to mate at the ratio of 1:2 after 4-week experiment. The gavage treatments were continued until the end of gestation in female mice after mating. The results showed that the litter number, survival rate, and body weight at birth of offspring in experimental group I had significantly decreased, and the females’ pregnancy rate and pup sex ratio in experimental group I had the decreasing tendencies when compared with the control group. The litter number in experimental group III, survival rate in experimental group II and III, body weight at birth in experimental group III and IV exhibited significant increase compared with experimental group I. The female pregnancy rate in both experimental group III and IV recovered to 100%, but there were no significant differences when compared with experimental group I. The pups’ sex ratio had a gradually increasing tendency with increase of vitamin E level, but there was no significant difference among experimental group I–IV. The results suggest that TCDD could induce reproductive toxicity in mice, whereas vitamin E alleviated adverse effects on reproductive performance in mice caused by TCDD.

scholarly journals Influence of the probiotic preparation “Plantarum” in the diets of pregnant animals on the growth and development of young animals

2021 ◽  
Vol 37 ◽  
pp. 00143
Author(s):  
Irina Funk ◽  
Nikolay Vladimirov ◽  
Alexander Yashkin ◽  
Lyudmila Pautova ◽  
Vitaly Gorshkov
Keyword(s):  
Body Weight ◽  
Growth And Development ◽  
The Body ◽  
Control Group ◽  
Standard Diet ◽  
Absolute Increase ◽  
Probiotic Preparation ◽  
Positive Effect ◽  
Experimental Group ◽  
Different Doses

The work aims to study the effect of different doses of the experimental probiotic preparation “Plantarum” when fed to pregnant animals on their reproductive qualities, as well as on the growth and development of young animals. To obtain young animals, four groups of goats were formed in the type of the Saanen breed, 20 heads each. In the first (control) group, the animals received a standard diet, in the diet of the animals of the second, third and fourth groups in the second half of pregnancy, the probiotic preparation “Plantarum” was additionally introduced, containing Lactobacillus Plantarum, Propiobacterium freudenreihii, in dosages from 0.4 to 0.8 ml/kg of body weight per day. From the offspring of the goats of the experimental groups, four groups of 12 goats were formed. The highest percentage of preservation (94%) and the highest business output of kids per 100 queens (150%) were observed in the fourth experimental group (0.8 ml). The goats of the second, third and fourth groups exceeded the body weight of their contemporaries from the control group by 3%, 6.3%, and 8.8%. The highest indices of the absolute increase in body weight by age periods were noted in the fourth group of goats. There were no significant differences in body build indices during the experiment between the goats of the control and experimental groups. Thus, the maximum positive effect was observed with the introduction of a probiotic preparation into the diet of pregnant goats at a dose of 0.8 ml/kg of body weight per day.

scholarly journals «Energosil» in the diets of replacement gilts

2019 ◽  
Vol 20 (2) ◽  
pp. 153-162
Author(s):  
A. A. Suvorov ◽  
в Sh. Gayirbegov ◽  
A. S. Fedin ◽  
A. M. Guryanov
Keyword(s):  
Body Weight ◽  
Live Weight ◽  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Practical Training ◽  
Optimal Dosage ◽  
Growth Energy ◽  
Experimental Group

The article gives scientific substantiation of using silicon-containing new feed additive “Energosil” for replacement gilts. The studies were conducted in pig-breeding complex of the Center for Practical Training of Agricultural Specialists in Mordovia Republic. There were three experimental groups of replacement gilts (10 animals each). The effect of various dosages of Energosil (5.0, 7.5, and 10 mg per kg of body weight) on digestibility, nutrient utilization, and animal growth energy was studied. The most optimal dosage of a new feed additive in their rations was revealed, which constituted 5 mg / kg of the animal live weight. It was established that the animals from the first experimental group, who received silicon-containing feed additives of this amount digested the nutrients of the diet better than their counterparts from the other groups. Compared to the control group, the digestibility of dry matter increased by 3.62% (p<0.05), organic matter by 3.29% (p<0.01), crude protein by 4.09% (p<0.001), fat by 4.30% (p<0.01), cellulose by 3.79% (p<0.01) and nitrogen-free extractives by 2.03% (p>0.05).Replacement gilts of the first experimental group, who were given Energosil in the amount of 5 mg / kg body weight in addition to the basic ration, retained nitrogen in their bodies by 17.1%, calcium by 55.9% and phosphorus by 69.7% more than their counterparts from the control group. It contributed to an increase in body weight of gilts from the first group compared to control counterparts by 10.8%. Increased dosages of Energosil (7.5 and 10 mg / kg body weight) also had a better effect on the growth energy of gilts compared with the control group. The feed additive in the amount of 7.5 mg kg of animal  live weight contributed to an increase in animal weight compared with control counterparts by 6.21 kg or 4.8% (p<0.05), with a third experimental group by 4.4 kg or by 3.4% (p<0.05). When given Energosil in the dosage of 10 mg/kg, the body weight of gilts from the third experimental group was higher by 1.81 kg or 1.4% (p> 0.05) compared with the control counterparts.

scholarly journals THE EFFECT OF BISOLBI ON BIOCHEMICAL AND PRODUCTIVE PROCESSES OF THE HOLSTEIN-FRIESIAN CALVES

2021 ◽  
Vol 6 (1) ◽  
pp. 57-63
Author(s):  
Galina Molyanova ◽  
Maksim Nogotkov
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Average Daily Gain ◽  
The Body ◽  
Daily Weight Gain ◽  
Control Group ◽  
Average Daily Weight Gain ◽  
Glucose Content ◽  
Holstein Friesian ◽  
Experimental Group

The purpose of the research is increasing the average daily gain of animals due to the use of the Bisolbi drug. The effect of Bisolbi preparation based on Bacillus subtilis H-13 1.5×108 (LLC «Bisolbi-Inter») on the biochemical and productive life of calves was studied. The scientific and production experiment was carried out on the basis of a dairy farm of the State «Kupinskoe» Unitary Enterprise of the Samara region involving 30 Holstein-Friesian calves. The biological effect of the drug is provided due to its adsorption properties, the ability to enhance the activity of a number of enzyme systems and increase the digestive and systemic immunity of the body. The drug use increases the integration intensity of animals: the amount of total protein in the blood serum of calves of the experimental group at 120 days of age was higher by 8.9% (p<0.05), albumin – by 9.2% (p<0.01), compared with the animal data of con-trolled group. The Bisolbi indication contributed to an increase in the intensity of carbohydrate-lipoid metabolism: the cholesterol amount was higher by 23% (p<0.01), the glucose content – by 0.4 mmol/l (p<0.05) in the blood of 120 day old calves of the experimental group, compared with the data of controlled animals. It was found that the body weight of calves in the control group of 100 days age was 105.23±2.11 kg, in the experimental group – 108.6±2.19 kg, which is 3.37 kg higher. The average daily weight gain of animals in experimental group was signif-icantly higher by 0.075 kg (p<0.01). At 120 days of age, the body weight of the experimental calves was higher by 4.19 kg (p<0.05), the average daily weight gain by 0.080 kg (p<0.05), compared with the data of the controlled ani-mals. The indication of Bisolbi 5-10 ml (LLC «Bisolbi-Inter») to calves daily for 2 months resulted in an additional profit constructively of 137 rubles from each head.

scholarly journals Effect of green tea on obesity and serum lipid profiles in both normo- and hyper-cholesterolemic rabbits

2019 ◽  
Vol 10 (2) ◽  
pp. 1035-1041
Author(s):  
Dlawer Abdulhammed Ahmad AL-Jaff
Keyword(s):  
Body Weight ◽  
Green Tea ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
The Body ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Obesity has been linked with several comorbidities like cardiovascular disorders, diabetes, and hypertension. Weight reduction is directly associated with the consumption of green tea. So, with this premise of background, we evaluated the potential of green tea consumption on obesity and serum lipid profiles in both normo- and hyper-cholesterol emic rabbits. Sixty New Zealand white rabbits (age: 6-8 months; weight 1.5-2 kg) were used for this experiment. Rabbits were randomized and equally divided into three different groups. Group I (control group) received 10 ml/kg of distilled water twice daily, Group II received high cholesterol diet twice daily, and Group III received high cholesterol diet along with green tea solution 10 ml/kg, twice daily for 90 days. Weight measurements and serum analysis were conducted on Day 0 and day 90. For the obtained data, SPSS analysis was performed (SPSS 21). A significant increment of body weight was observed in control (1.97 ± 0.12 vs 2.87 ± 0.21, p<0.0001) and high cholesterol groups (1.91 ± 0.23 vs 3.13 ± 0.31, p<0.0001) at Day 90 when compared with Day 0. Though the results were not significant, there was a reduction in the body weight in the green tea group (2.20 ± 1.47 vs 1.72 ± 0.22) at Day 90 when compared with Day 0. Consumption of green tea for 90 days resulted in weight loss and inhibition of the increase in the levels of TC, LDL, and VLDL. So, green tea can act as a natural food supplement for the management of obesity and dyslipidemia.

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