Hematological Parameters in Pregnant Women with Special Reference to Iron

First Trimester ◽

Control Group ◽

Corpuscular Hemoglobin ◽

Cross Sectional ◽

Hematological Indices ◽

Group I ◽

Several biological factors, particularly haematological, are physiologically altered during normal pregnancy. Biologists and doctors who are aware of these changes in the maternal body can screen for potential abnormalities. The aim of this research is to find healthy pregnant women's reference values. This was a cross-sectional research of pregnant women who attended an antenatal clinic at Sree Balaji Medical College, with anaemic and non-anemic pregnant women. Pregnant women were categorized into three groups -Group I - First Trimester (50 cases); Group II - Second Trimester (50 cases) and Group III - Third Trimester (72 cases) while non pregnant women formed the fourth group (30 cases). A statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. The present study provides additional baseline data for basic hematological parameters in healthy pregnant women and concluded that pregnancy in women has the tendency to alter some hematological indices.

Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

Pan African Medical Journal ◽

10.11604/pamj.2018.29.205.13043 ◽

2018 ◽

Vol 29 ◽

Cited By ~ 2

Author(s):

Saad Bakrim ◽

Youssef Motiaa ◽

Ali Ouarour ◽

Azlarab Masrar

Keyword(s):

Pregnant Women ◽

Reference Values ◽

Blood Count ◽

Complete Blood Count ◽

Control Group ◽

Healthy Population ◽

Corpuscular Hemoglobin ◽

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

EVALUATING SOME OF THE HEMATOLOGICAL PARAMETERS FOR HELICOBACTER PYLORI INFECTED PATIENTS

Periódico Tchê Química ◽

10.52571/ptq.v17.n36.2020.1067_periodico36_pgs_1052_1060.pdf ◽

2020 ◽

Vol 17 (36) ◽

pp. 1052-1060

Author(s):

Nidhal Abdullah HASHIM ◽

Younus Jasim ABDULLAH ◽

Hasan Rahman SHAWI

Keyword(s):

Helicobacter Pylori ◽

Complete Blood Count ◽

Control Group ◽

Healthy Individuals ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Significant Difference ◽

H Pylori

Helicobacter pylori are Gram-negative curved rods that habitats the gastric mucosa and considered as the leading causes of stomach ulcers and duodenal ulcers in humans. The main object of this study was to evaluate the influences of the bacteria on several hematological parameters. A total of 60 patients aged between 15 to 40 years were included in this study (30 male and 30 female) in addition to 30 healthy individuals from the same ages who were considered as a control group. Venous blood (4 ml) was obtained from the study population and investigated for complete blood count (CBC) using an automated hematology analyzer. The results revealed that there is a substantial decrease (p 0.01) in Hemoglobin (Hb), Red cell distribution width (RDW), and mean corpuscular hemoglobin (MCH) in patients compared to control. However, no significant difference in Red blood cells (RBCs), Hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in patients compared to control. Also, no significant differences were found in the white blood cell (WBC) between H. pylori infected and non-infected persons. Otherwise, there are significant differences (p 0.01) in lymphocytes, monocytes, granulocytes in the patients and healthy individuals. The results also found that there are significant statistical differences in some of the hematologic parameters among study groups according to their gender. The study concluded that Hb, RDW, lymphocytes, monocytes, granulocytes are decreased in H. Pylori infected patients suggesting that infection may have direct effects on blood parameters.

ASSESSMENT OF HEMATOLOGICAL INDICES AMONG WORKERS IN SILVER JEWELRY UNITS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i9.19809 ◽

2017 ◽

Vol 10 (9) ◽

pp. 144

Author(s):

Shalini Kv ◽

Ayyappa Das Mp

Keyword(s):

Tamil Nadu ◽

Hemoglobin Concentration ◽

Cross Sectional Study ◽

Control Group ◽

Differential Count ◽

Corpuscular Hemoglobin ◽

Cross Sectional ◽

Distribution Width ◽

Hematological Indices

Objective: Workers in the silver jewelry manufacturing units are exposed to heavy metals and toxic compounds during manufacturing. Hence, the present study aimed to assess the hematological indices among the workers in silver jewelry manufacturing units.Methods: A cross-sectional study was conducted in various silver jewelry manufacturing units located in Coimbatore, Tamil Nadu. One hundred and forty eight exposed and 35 unexposed (control) participants were included in this study. Their hematological indices were assessed.Results: There was significant (p<0.05) increase of serum silver (Ag) and hematological profile such as red blood cell (RBC), hematocrit, and the hemoglobin levels of exposure groups (B, C, D, and E) were found to be significantly decreased (p<0.05) compared to control group (A). There was also significant increase (p<0.05) in differential count and mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT), platelet distribution width (PDW), and mean platelet volume (MPV) levels in exposed groups (B, C, D, and E) than controls (A).Conclusion: Decrease in RBC indices and the increased differential count of MCH, MCHC, PLT, PDW, and MPV levels might be due to the exposure to Ag in the jewelry units. In view of these results, it appears that ionized Ag induces hematological disturbances and the present study clearly establish that there were minimal negative effects of Ag exposure on hematological indices.

The role of the platelet profile in the prediction of gestational diabetes

10.51271/kmj-0012 ◽

2021 ◽

pp. 50-54

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Gestational Diabetes ◽

Pregnant Women ◽

Body Mass ◽

First Trimester ◽

Oral Glucose ◽

Lymphocyte Ratio ◽

Objective: In our study, the results of oral glucose tolerance test (OGTT) and other hemogram parameters of pregnant women with and without gestational diabetes mellitus (GDM) were compared. The aim of our study is to investigate the benefit of these parameters in predicting GDM risk. Material and Method: The study was planned as a descriptive, retrospective and cross-sectional study. It was included 218 pregnant women who applied to the Gynecology and Obstetrics Clinic of Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital between January 01, 2019 and January 31, 2020. It was examined complete blood count parameters, ultrasound findings, complete urinalysis, first trimester blood glucose, body mass index, age, and gravide parameters the patients we included in the study. The results were analyzed retrospectively and was evaluated the statistical significance relationship with gestational diabetes. Results: There was no statistically significant difference in age, body mass index (BMI), obesity status and number of gravida between the pregnant women who were examined and those without GDM (p> 0.05). The hemoglobin, platelet count, mean platelet volume (MPV), mean corpuscular volume (MCV), mean corpuscular hemoglobine (MCH), and mean corpuscular hemoglobin concentration (MCHC) values, and neutrophil, lymphocyte, monocyte and basophil counts, urine density and femur length were statistically significant. There was no difference (p> 0.05). No statistically significant difference was found in terms of neutrophile lymphocyte ratio (NLR), neutrophile monocyte ratio (NMR), platelet lymphocyte ratio (PLR), monocyte eosinophil ratio (MER), platelet MPV ratio (PMPVR), and platelet neutrophile ratio (PNR) values (p> 0.05) Conclusion: HbA1c, hematocrit and blood glucose in the first trimester may be predictors of GDM. In addition, we think that further studies are needed in a prospective design in more patients in terms of others parameters.

Pesticides Residues in Blood Serum and Their Adverse Effects on Multi- Biomarkers in Occupationally Exposed Greenhouse Workers: A Cross-Sectional Study in Hamadan City, Iran

10.21203/rs.3.rs-727519/v1 ◽

2021 ◽

Author(s):

Mostafa Leili ◽

Abolfazl Ghafouri Khosrowshahi ◽

Jalal Poorolajal ◽

Fateme Samiee ◽

Mohammad Taghi Samadi ◽

...

Keyword(s):

Blood Serum ◽

Crop Production ◽

Severe Form ◽

Adult Males ◽

Corpuscular Hemoglobin ◽

Cross Sectional ◽

Pesticides Residues ◽

Greenhouse Workers

Abstract The cultivation of greenhouse crops is the most severe form of crop production in Iran, and vast quantities of unreasonable pesticides are being utilized to control pests. The residual level of blood pesticides and its correlation with multi- biomarkers were determined to evaluate the adverse health consequences on greenhouse workers in the Hamdan city of Iran. Participants were 180 adult males, including 90 greenhouse workers exposed to pesticides and 90 control individuals. The residue analyses revealed that 64 out of the 90 workers had residues of dichlorvos, diazinon, and chlorpyrifos in their blood serum; and 56.25% out of these workers were exposed for > 15 years period. The residues of all three pesticides were higher than the no observable adverse effect level (NOAEL) in all the exposure duration categories. Comparisons of hematological parameters showed that mean monocyte (P < 0.001), lymphocyte (P < 0.001) and platelet counts (P = 0.001), mean platelet volume (P = 0.002), and plateletcrit (PCT) (P < 0.001) were significantly higher in workers than in controls, whereas hemoglobin (HB) (P = 0.028), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentrations (MCHC) (P < 0.001) were lower in workers than controls. These results show that exposure to different pesticides was associated with alterations in some biochemical and hematological parameters. Prevention and intervention programs can be effective in eliminating pesticide-related alterations among agricultural workers.

Assessment of in Obsessive Compulsive Disorder

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1030915 ◽

2021 ◽

pp. 105-114

Author(s):

Sarah Alaa Mohsen ◽

Fatma Ahmed El Deeb ◽

Ehab Sayed Ramadan ◽

Mai Abd El-Raouf Eissa

Keyword(s):

Obsessive Compulsive Disorder ◽

Test Performance ◽

Age Of Onset ◽

Neuropsychological Test ◽

Control Group ◽

Obsessive Compulsive ◽

Cross Sectional ◽

Compulsive Disorder ◽

Group I ◽

Background: Obsessive compulsive disorder (OCD) is a common and potentially debilitating disorder. Neuropsychological assessment provides unique complementary information that is critical for evaluating higher cortical abilities. This study aimed to assess the neuropsychological functions in OCD patients which can then point to the brain structures or pathways and to study the correlation between these assessments and different clinical variables. Methods: This cross-sectional case control study had included sixty patients who were divided into two groups, Group I: thirty OCD patients diagnosed by DSM-IV and Group II: thirty healthy controls who were recruited from the community, matched with patients’ age, gender, and education. Results: The age of onset in our study was 19.13 ± 0.35 years, the mean duration was 7.44 ± 3.88 years, 40% of the studied cases had severe OCD symptoms and 33.3% of them were compulsive cleaners. There was a high significant difference between the two groups regarding WCST in favor of the control group. There was a high significant difference between the two groups regarding ROCF where the control group showed better results than the OCD patients. Conclusions: Neuropsychological test performance remains an informative and objective means of investigation, especially when applied to psychiatric disorders. The executive functions in OCD patients were impaired in comparison to the normal study subjects.

Dysmetabolic mechanisms of preeclampsia development

Obesity and metabolism ◽

10.14341/omet12330 ◽

2021 ◽

Vol 17 (4) ◽

pp. 346-356

Author(s):

I. S. Lipatov ◽

Yu. V. Tezikov ◽

A. R. Azamatov

Keyword(s):

Insulin Resistance ◽

Pregnant Women ◽

Metabolic Disorders ◽

Control Group ◽

Metabolic Disturbances ◽

Group Iii ◽

Inflammatory Status ◽

Group I

Background: An in-depth study of dismetabolic mechanisms in the genesis of pre-eclampsia (PE) has been updated because pregnancy is considered as a natural model of metabolic syndrome (MS), as well as the metabolic disorders are important in development of essential hypertension.Aims: to reveal clinical and laboratory parallels in pregnancy complicated by PE without MS and pregnancy proceeding on the background of MS to assess the role of metabolic disturbances in the development of PE.Materials and methods: 82 women with MS were examined in the dynamics of pregnancy and were divided into 2 groups depending on the implementation of PE: group I consisted of 50 women with PE on the background of MS, group II 32 women with MS without PE. We formed group III consisting of 44 pregnant women with PE without accompanying diseases to assess the pathogenetic value of metabolic disorders in the development of PE. The IV (control) group consisted of 30 healthy women with physiological pregnancy. Metabolic, hematological parameters, hormones, markers of the proinflammatory state, endothelial hemostasiological dysfunction, decidualization and placental angiogenesis, accumulation dynamics and distribution loci of adipose tissue were determined in all pregnant women.Results: In the groups of pregnant women with PE, changes similar to MS were revealed: pronounced diabetic and atherogenic disorders with the development of pathological insulin resistance, hyperinsulinemia and leptinemia, endothelial-platelet link hyperactivation, thrombotic and inflammatory status, visceral type of fat deposition, hyperuricemia, hypersympathicotonia. It is proved that in the hierarchy of mechanisms of PE formation, placental dysfunction is a secondary alteration factor, which additionally potentiates the insulin resistance increase and the effects of structural and functional destabilization of the vascular endothelium.Conclusions: The direction of metabolic changes during pregnancy, the common development of PE and MS indicate the important role of dismetabolic mechanisms in the formation of PE.

Blood Donation in Nigeria: Standard of the Donated Blood

Journal of Laboratory Physicians ◽

10.4103/0974-2727.105589 ◽

2012 ◽

Vol 4 (02) ◽

pp. 094-097 ◽

Cited By ~ 4

Author(s):

Nwogoh Benedict ◽

Awodu Omolade Augustina ◽

Bazuaye Godwin Nosakhare

Keyword(s):

Blood Donation ◽

Hemoglobin Concentration ◽

Corpuscular Hemoglobin ◽

Mean Cell Volume ◽

Benin City ◽

Cell Counts ◽

Significant Difference ◽

The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

Effects of Novel Coronavirus 2019 Infection on Antenatal Hematological Parameters in Pregnant Women

10.53350/pjmhs2115113279 ◽

2021 ◽

Vol 15 (11) ◽

pp. 3279-3284

Author(s):

Monika . ◽

Israt Saba Mari ◽

Monika Maheshwari ◽

Shahida Shaikh ◽

Qararo Shah Syed ◽

...

Keyword(s):

Antenatal Care ◽

Pregnant Women ◽

Urban Areas ◽

Research Evaluation ◽

Haematological Parameters ◽

Maternal Complications ◽

Cross Sectional ◽

Group I ◽

In Pregnancy

Background: Disturbance of haematological parameters is prevalent in pregnancy globally leading to a range of feto-maternal complications. Covid-19 infection has potential to enhance the severity of and complications impending due to anaemia in pregnancy. Objective: To determine the effects of Covid-19 infection on haematological parameters during antenatal care among pregnant women in rural Sindh. Study Design: Cross sectional study. Setting: Shaikh Zaid Institute, Chandka Medical College, Larkana. Duration: From March 1, 2021, and May 31, 2021. Materials and Method: A sample of 110 pregnant women, of 18-50 years of age, presenting in first through third trimester with single alive pregnancy, were included in the study after taking a valid written consent. The Research Evaluation Committee of SMBBMU- Larkana granted approval. Women having any haemoglobinopathy were excluded. Covid-19 test conducted through rt-PCR method. A standard questionnaire was used to collect data of two groups. Analysis was performed through SPSS Version-23. Descriptive and inferential statistics were calculated. Results: Mean ± SD age was 30.3 ± 6.99 (Range: 19 to 45) years. Both groups were identical in age. Mean ± SD gestational age was 28.12 ± 4.66 weeks (Range: 20-38). Covid-19 positive women had lower mean Hb (9.7 ± 2.11) than the covid-19 negative (10.54 ± 2.51; P = 0.158). Other haematological parameters like MCV, serum ferritin, TIBC, TLC & platelets were statistically different between groups. Women of eldest group i-e; in 41-50 years, from urban areas, second trimester (gest. age 13-24 weeks), and nulliparous had been affected more from covid-19 (P = 0.271, 0.748, 0.290 & 0.053). Frequency and severity of anaemia was more among Covid-19 positive women. Conclusion: Covid‐19 demands maternal healthcare to be extra vigilant to the haematological parameters of pregnant women during antenatal care till delivery. Keywords: Antenatal care, pregnancy, anaemia, haemoglobin, Covid‐19.

Distribution of thyroid peroxidase positivity and its effects on thyroid function in normal pregnant women during 1st trimester in Dhaka city

Update Dental College Journal ◽

10.3329/updcj.v4i1.21160 ◽

2014 ◽

Vol 4 (1) ◽

pp. 15-20

Author(s):

Ohida Sultanaa ◽

Nasim Jahan ◽

Nayma Sultana ◽

Farzana Mahmudad ◽

Tazdik G Chowdhurye

Keyword(s):

Pregnant Women ◽

Thyroid Function ◽

First Trimester ◽

Normal Pregnancy ◽

Control Group ◽

Thyroid Peroxidase ◽

Study Group ◽

Cross Sectional ◽

Total Study Population ◽

Group B

Objective: To measure the distribution of TPO-Ab positivity and to observe the effect of thyroid peroxidase positivity on thyroid function during first trimester in normal pregnancy. Method: A cross sectional among 120 subjects were taken in this study and divided into control and study groups. Control group (Group A) consisted of 60 healthy non pregnant women age ranged between 20 to 35 years. Study group (Group B) consisted of 60 normal pregnant women of same age range. Group B was further subdivided into group B1 and group B2according to the level of TPO-Ab. Group B1 consisted of TPO-Ab positive pregnant women and group B2 consisted of TPO- Ab negative pregnant women. Control group was selected from personal contacts and study group from Out Patient Department (OPD) of Obstetrics and Gynecology of Sir Salimullah Medical College and Mitford Hospital. For assessment of thyroid function, serum free thyroxine (FT4), thyroid stimulating hormone (TSH) were measured. Serum FT4, TSH were measured by Enzyme link immunosorbant (ELISA) method. Again, serum TPO-Ab of total study population and hCG of all the pregnant women were measured. Serum TPO-Ab by Micro particle Enzyme Immunoassay (MEIA) method and hCG was estimated by ELISA. Statistical analysis was done by SPSS version 17. Results: In this study, serum FT4 and was significantly (P<0.001) higher and TSH level was significantly (P<0.001) lower in normal pregnant women during 1st trimester in comparison to those of non pregnant women. Again, 18% of pregnant women showed TPO-Ab positivity. However, serum FT4 level was significantly (P<0.001) lower whereas, TSH level was significantly (p<0.001) higher in TPO-Ab positive pregnant women in comparison to those of TPO-Ab negative pregnant women. Conclusion: TPO-Ab positivity increases during 1st trimester of normal pregnancy which decreases the hyper functional state of thyroid hormones. So, thyroid screening should be done routinely during pregnancy. DOI: http://dx.doi.org/10.3329/updcj.v4i1.21160 Update Dent. Coll. j: 2014; 4 (1): 15-20