A Comparison of Initial Developments Between Explosive and Ordinary Mid-latitude Cyclones Off the East Asian Coast in Winter

Explosive cyclones (ECs) off the East Asian coast post challenges in forecasting and significant threats to human life and property. In searching for the key features that distinguish explosive cyclones (ECs) from ordinary extratropical cyclones (OCs), this study presents detailed comparison of winter ECs versus OCs in the perspective of potential vorticity (PV) using 10 years of reanalysis data with high temporal and spatial resolutions. ECs feature greater low-level baroclinity and stronger PV than OCs. The decomposition of local PV tendency shows the important contribution of cold advection (with correlation coefficient of 0.8) in the initial development of ECs. A stronger cold advection for ECs increases upstream static stability, leading to intrusion of higher PV along the steeper isentropic surfaces. The importance of cold advection is further proved by numerical experiments with the Weather Research and Forecast (WRF) model on a typical winter EC. The weakening of cold advection within low-troposphere in sensitivity experiment can significantly decrease PV and stop the cyclone from explosive deepening. In addition to the consensus that diabatic processes play important roles in the intensification of explosive cyclogenesis, this study emphasizes the importance of horizontal cold advection (which is also associated with baroclinic instability) in the preconditioning PV for explosive cyclogenesis.

Transcriptome Differences in Response Mechanisms to Low-Nitrogen Stress in Two Wheat Varieties

Nitrogen plays a crucial role in wheat growth and development. Here, we analyzed the tolerance of wheat strains XM26 and LM23 to low-nitrogen stress using a chlorate sensitivity experiment. Subsequently, we performed transcriptome analyses of both varieties exposed to low-nitrogen (LN) and normal (CK) treatments. Compared with those under CK treatment, 3534 differentially expressed genes (DEGs) were detected in XM26 in roots and shoots under LN treatment (p < 0.05, and |log2FC| > 1). A total of 3584 DEGs were detected in LM23. A total of 3306 DEGs, including 863 DEGs in roots and 2443 DEGs in shoots, were specifically expressed in XM26 or showed huge differences between XM26 and LM23 (log2FC ratio > 3). These were selected for gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The calcium-mediated plant–pathogen interaction, MAPK signaling, and phosphatidylinositol signaling pathways were enriched in XM26 but not in LM23. We also verified the expression of important genes involved in these pathways in the two varieties using qRT-PCR. A total of 156 transcription factors were identified among the DEGs, and their expression patterns were different between the two varieties. Our findings suggest that calcium-related pathways play different roles in the two varieties, eliciting different tolerances to low-nitrogen stress.

Tension vector and structure matrix associated force sensitivity of a 6-DOF cable-driven parallel robot

This paper investigates the force sensitivity of 6-DOF cable-driven parallel robots (CDPRs) in order to propose a better force measurement device. Kinematics and dynamics for a CDPR of n-DOF are deduced and formulated, and algorithms for calculating the cable tension are developed. Then, by defining geometrical parameters related to the dimensions and configurations of the CDPRs, optimal methods for determining force sensitivity with respect to the structure matrix and twist vector of the 6-DOF CDPRs with two different moving platforms (i.e. a cubic-shaped, and a flat moving platform) are proposed. By using numerical examples integrated with external twists obtained from wind tunnel tests, simulations and analysis for the two type of 6-DOF CDPRs are carried out. The simulation results help identify the optimal dimensions that can be used to design 6-DOF-CDPR-based force measuring devices with high force sensitivity. Experiment validation is also conducted to verify the method proposed in this paper.

GERDA and LEGEND: Probing the Neutrino Nature and Mass at 100 meV and beyond

The Gerda (GERmanium Detector Array) project, located at Laboratori Nazionali del Gran Sasso (LNGS), was started in 2005, a few years after the claim of evidence for the neutrinoless double beta decay (0νββ) of 76Ge to the ground state of 76Se: it is an ultra-rare process whose detection would directly establish the Majorana nature of the neutrino and provide a measurement of its mass and mass hierarchy. The aim of Gerda was to confirm or disprove the claim by an increased sensitivity experiment. After establishing the new technology of Ge detectors operated bare in liquid Argon and since 2011, Gerda efficiently collected data searching for 0νββ of 76Ge, first deploying the 76Ge-enriched detectors from two former experiments and later new detectors with enhanced signal-to-background rejection, produced from freshly 76Ge-enriched material. Since then, the Gerda setup has been upgraded twice, first in 2013–2015 and later in 2018. The period before 2013 is Phase I and that after 2015 is Phase II. Both the Gerda setup and the analysis tools evolved along the project lifetime, allowing to achieve the remarkable average energy resolution of ∼3.6 and ∼2.6 keV for Coaxial Germanium (Coax) detectors and for Broad Energy Germanium (BEGe), respectively, and the background index of 5.2−1.3+1.6 · 10−4 cts/(keV·kg·yr) in a 230 keV net range centered at Qββ. No evidence of the 0νββ decay at Qββ = 2039.1 keV has been found, hence the limit of 1.8·1026 yr on the half-life (T1/20ν) at 90% C.L. was set with the exposure of 127.2 kg·yr. The corresponding limit range for the effective Majorana neutrino mass mee has been set to 79–180 meV. The Gerda performances in terms of background index, energy resolution and exposure are the best achieved so far by 76Ge double beta decay experiments. In Phase II, Gerda succeeded in operating in a background free regime and set a world record. In 2017, the Legend Collaboration was born from the merging of the Gerda and Majorana Collaborations and resources with the aim to further improve the Gerda sensitivity. First, the Legend200 project, with a mass of up to 200 kg of 76Ge-enriched detectors, aims to further improve the background index down to <0.6 · 10−3 cts/(keV·kg·yr) to explore the Inverted Hierarchy region of the neutrino mass ordering, then the Legend1000 (1 ton of 76Ge-enriched) will probe the Normal Hierarchy. In this paper, we describe the Gerda experiment, its evolution, the data analysis flow, a selection of its results and technological achievements, and finally the design, features and challenges of Legend, the Gerda prosecutor.

Estimating the potential cooling effect of cirrus thinning achieved via the seeding approach

Cirrus thinning is a newly emerging geoengineering approach to mitigate global warming. To sufficiently exploit the potential cooling effect of cirrus thinning with the seeding approach, a flexible seeding method is used to calculate the optimal seeding number concentration, which is just enough to prevent homogeneous ice nucleation from occurring. A simulation using the Community Atmosphere Model version 5 (CAM5) with the flexible seeding method shows a global cooling effect of -1.36±0.18 W m−2, which is approximately two-thirds of that from artificially turning off homogeneous nucleation (-1.98±0.26 W m−2). However, simulations with fixed seeding ice nuclei particle number concentrations of 20 and 200 L−1 show a weak cooling effect of -0.27±0.26 W m−2 and warming effect of 0.35±0.28 W m−2, respectively. Further analysis shows that cirrus seeding leads to a significant warming effect of liquid and mixed-phase clouds, which counteracts the cooling effect of cirrus clouds. This counteraction is more prominent at low latitudes and leads to a pronounced net warming effect over some low-latitude regions. The sensitivity experiment shows that cirrus seeding carried out at latitudes with solar noon zenith angles greater than 12∘ could yield a stronger global cooling effect of −2.00 ± 0.25 W m−2. Overall, the potential cooling effect of cirrus thinning is considerable, and the flexible seeding method is essential.

Sensitivity Analysis of the Dust-Generation Algorithm in ADAM3 by Incorporating Surface-Wetness Effects

This study examined the surface-wetness effects in calculating dust generation in source regions, using Asian dust aerosol model version 3 (ADAM3; the control run; CNTL). Model sensitivity experiment was conducted in such a way that the dust generation in CNTL is compared against three ADAM3 versions with various surface-wetness effect schemes. The dust-generation algorithm in ADAM_RAIN utilizes precipitation, while the scheme in ADAM3_SM1 and ADAM3_SM2 employs soil water content to account for the surface-wetness effects on dust generation. Each run was evaluated for the spring (March–May) of 2020. ADAM3_SM1 shows the best performance for the dust source region in East Asia based on the root-mean-square error and the skill score, followed by ADAM3_SM2 and ADAM3_RAIN. Particularly, incorporation of the surface-wetness effects improves dust generation mostly in wet cases rather than dry cases. The three surface-wetness-effect runs reduce dust generation in the source regions compared to CNTL; hence, the inclusion of surface-wetness effects improves dust generation in the regions where CNTL overestimates dust generation.

TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation

Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affects pro-inflammatory mediator production and enhances analgesia in total. In this study, the analgesic and anti-inflammatory effects of HCRG21, the first peptide blocker of TRPV1, were demonstrated in a mice model of carrageenan-induced paw edema. HCRG21 in doses of 0.1 and 1 mg/kg inhibited edema formation compared to the control, demonstrated complete edema disappearance in 24 h in a dose of 1 mg/kg, and effectively reduced the productionof TNF-α in both doses examined. ELISA analysis of blood taken 24 h after carrageenan administration showed a dramatic cytokine value decrease to 25 pg/mL by HCRG21 versus 100 pg/mL in the negative control group, which was less than the TNF-α level in the intact group (40 pg/mL). The HCRG21 demonstrated potent analgesic effects on the models of mechanical and thermal hyperalgesia in carrageenan-induced paw edema. The HCRG21 relief effect was comparable to that of indomethacin taken orally in a dose of 5 mg/kg, but was superior to this nonsteroidal anti-inflammatory drug (NSAID) in duration (which lasted 24 h) in the mechanical sensitivity experiment. The results confirm the existence of a close relationship between TRPV1 activity and TNF-α production once again, and prove the superior pharmacological potential of TRPV1 blockers and the HCRG21 peptide in particular.

Understanding the Impacts of Upper-Tropospheric Cold Low on Typhoon Jongdari (2018) Using Piecewise Potential Vorticity Inversion

Typhoon Jongdari (2018) had an unusual looping path before making landfall in Japan, which posed a forecasting challenge for operational numerical models. The impacts of an upper-tropospheric cold low (UTCL) on the track and intensity of Jongdari are investigated using numerical simulations. The storm track and intensity are well simulated in the control experiment using the GFS analysis as the initial and boundary conditions. In the sensitivity experiment (RCL), the UTCL is removed from the initial-condition fields using the piecewise potential vorticity inversion (PPVI), and both the track and intensity of Jongdari change substantially. The diagnosis of potential vorticity tendency suggests that horizontal advection is the primary contributor for storm motion. Flow decomposition using the PPVI further demonstrates that the steering flow is strongly affected by the UTCL, and the looping path of Jongdari results from the Fujiwhara interaction between the typhoon and UTCL. Jongdari first intensifies and then weakens in the control experiment, consistent with the observation. In contrast, it undergoes a gradual intensification in the RCL experiment. The UTCL contributes to the intensification of Jongdari at the early stage by enhancing the eddy flux convergence of angular momentum and reducing inertial stability, and it contributes to the storm weakening via enhanced vertical wind shear at the later stage when moving closer to Jongdari. Different sea surface temperatures and other environmental conditions along the different storm tracks also contribute to the intensity differences between the control and the RCL experiments, indicating the indirect impacts of the UTCL on the typhoon intensity.

Drivers of the decadal variability of the North Ionian Gyre upper layer circulation during 1910–2010: a regional modelling study

A long simulation over the period 1901–2010 with an eddy-permitting ocean circulation model is used to study the variability of the upper layer circulation in the North Ionian Gyre (NIG) in the Eastern Mediterranean Sea (EMed). The model is driven by the atmospheric forcing from the twentieth century reanalysis data set ERA-20C, ensuring a consistent performance of the model over the entire simulation period. The main modes of variability known in the EMed, in particular the decadal reversals of the NIG upper layer circulation observed since the late 1980s are well reproduced. We find that the simulated NIG upper layer circulation prior to the observational period is characterized by long-lasting cyclonic phases with weak variability during years 1910–1940 and 1960–1985, while in the in-between period (1940–1960) quasi-decadal NIG circulation reversals occur with similar characteristics to those observed in the recent decades. Our simulation indicates that the NIG upper layer circulation is rather prone to the cyclonic mode with occasional kicks to the anticyclonic mode. The coherent variability of the NIG upper layer circulation mode and of the Adriatic Deep Water (AdDW) outflow implies that atmospheric forcing triggering strong AdDW formation is required to kick the NIG into an anticyclonic circulation 1–2 years later. A sensitivity experiment mimicking a cold winter event over the Adriatic Sea supports this hypothesis. Our simulation shows that it is the multi-decadal variability of the salinity in the Adriatic Sea that leads to periods where low salinity prevents strong AdDW formation events. This explains the absence of quasi-decadal NIG reversals during 1910–1940 and 1960–1985.

Ocean Circulation from the synergy of altimeter-derived and oceanic tracers observations

&lt;p&gt;Measuring the ocean surface currents at high spatio-temporal resolutions is crucial for scientific and socio-economic applications. Since the early 1990s, the synoptic and global-scale monitoring of the ocean surface currents has been provided by constellations of Radar Altimeters. The Altimeter observations enable to derive the geostrophic component of the surface currents with effective spatial-temporal resolutions O(100 km) and O(10 days), respectively. Therefore, only the largest mesoscale oceanic features can be accurately resolved. In order to enhance the altimeter system capabilities, we propose a synergistic use of high resolution, satellite-derived Sea Surface Temperature (SST), Chlorophyll concentrations (Chl) and Altimeter-derived currents. Our approach is tested in both global-scale and regional contexts.&lt;br&gt;At global scale, relying on past numerical studies, we perform a sensitivity experiment based on several gap-free SST datasets, emphasizing strengths and weaknesses in ocean currents applications. Overall, the comparison with in-situ measured currents shows that our synergistic method can improve the altimeter estimates up to 30% locally.&lt;br&gt;Then, our method is also implemented with Chl data in the&amp;#160; Mediterranean Sea, where the most energetic variable signals are found at spatio-temporal scales up to 10 km and few days. We test the method feasibility in an Observing System Simulation Experiment relying on model outputs of the European Copernicus Marine Service. Statistical analyses based on the 2017 daily data show that our approach can improve the altimeter-derived currents accuracy up to 50% at the basin scale, also enhancing the effective spatial-temporal resolutions up to 30 km and less than 10 days, respectively. The method efficiency decreases when the surface Chl patterns are dominated by the biological activity rather than the currents advection, which mostly occurs in the mid-February to mid-March time window. Preliminary tests on the method applicability to satellite-derived data are also presented and discussed.&lt;/p&gt;