Investigation of Cyprinid Herpesvirus 3 (CyHV-3) Disease Periods and Factors Influencing CyHV-3 Transmission in A Low Stocking Density Infection Trial

Cyprinid herpesvirus 3 (CyHV-3) is the etiological agent of koi herpesvirus disease (KHVD) and important pathogen of aquaculture and wild populations of common carp worldwide. Understanding the relative contributions of direct and indirect transmission of CyHV-3 as well as the factors that drive CyHV-3 transmission can clarify the importance of environmental disease vectors and is valuable for informing disease modeling efforts. To study the mechanisms and factors driving CyHV-3 transmission we conducted infection trials that determined the kinetics of KHVD and the contributions of direct and indirect forms of CyHV-3 transmission, as well as the contributions of contact rate, viral load, pathogenicity and contact type. The incubation period of KHVD was 5.88 + 1.75 days and the symptomatic period was 5.31 + 0.87 days. Direct transmission was determined to be the primary mechanism of CyHV-3 transmission (OR = 25.08, 95%CI = 10.73–99.99, p = 4.29 × 10−18) and transmission primarily occurred during the incubation period of KHVD. Direct transmission decreased in the symptomatic period of disease. Transmissibility of CyHV-3 and indirect transmission increased during the symptomatic period of disease, correlating with increased viral loads. Additionally, potential virulence-transmission tradeoffs and disease avoidance behaviors relevant to CyHV-3 transmission were identified.

Partisipasi Masyarakat Dalam Penerapan Program Sanitasi Total Berbasis Masyarakat Pilar Ke 1

Introduction: The high level of morbidity and mortality due to environmental disease is a public health problem in Indonesia. One of the causes is the behavior of open defecation. Depok Village RT 03 RW 1 is3 an area that still often defecates openly, which is as much as 11.9%. One of the government's in-depth solutions to this problem is through the triggering method. Methods: This research is a research with a qualitative approach with a case study approach. The sampling technique or the determination of informants used in this research is snowball sampling. Data collection is done by observation, in-depth interviews, and documentation. Data analysis in this study used the Miles and Huberman technique. Results: The results of this study indicate that community participation in the STBM program, the first pillar of the community in Depok Village RT 05 RW 13, the community has participated both in community participation in receiving information, discussing and making decisions, and community participation in obtaining authority to manage resources and make decisions. Conclusion: It is hoped that the community will continue to improve the behavior of stopping open defecation and success or the achievement of a program cannot be separated from the participation of the community alone. Discussion: Analyzing community participation in receiving information, discussing, making joint decisions between the community and outsiders, and community participation in obtaining the authority to manage resources and make decisions about the STBM program. Pancoran Mas Health Center, Depok City.

Some Emerging Opportunities of Nanotechnology Development for Soilless and Microgreen Farming

Global food demand has increased in tandem with the world’s growing population, prompting calls for a new sustainable agricultural method. The scarcity of fertile soil and the world’s agricultural land have also become major concerns. Soilless and microgreen farming combined with nanotechnology may provide a revolutionary solution as well as a more sustainable and productive alternative to conventional farming. In this review, we look at the potential of nanotechnology in soilless and microgreen farming. The available but limited nanotechnology approaches in soilless farming include: (1) Nutrients nanoparticles to minimize nutrient losses and improve nutrient uptake and bioavailability in crops; (2) nano-sensing to provide real-time detection of p H, temperature, as well as quantifying the amount of the nutrient, allowing desired conditions control; and (3) incorporation of nanoparticles to improve the quality of substrate culture as crop cultivation growing medium. Meanwhile, potential nanotechnology applications in soilless and microgreen farming include: (1) Plant trait improvement against environmental disease and stress through nanomaterial application; (2) plant nanobionics to alter or improve the function of the plant tissue or organelle; and (3) extending the shelf life of microgreens by impregnating nanoparticles on the packaging or other preservation method.

Lead: A concise review of its toxicity, mechanism and health effect

Heavy metal toxicity over the years has been proven to be a source of diverse health risks. Thou these metals, play certain biological roles, they are in excess amount get accumulated in the body and food chain displaying a chronic effect in the long run. Lead toxicity is an important environmental disease and its effects on the human body are devastating with its toxicity dependent upon the absorbed dose, the route of exposure as well as the duration of exposure. There is almost no function in the human body which is not affected by lead toxicity. Lead is highly persistent in the environment and because of its continuous use, its levels rise in almost every country particularly in developing countries like Nigeria where it occupies unique physical and chemical properties that make it suitable for a large number of applications. Various public health measures have been undertaken to control, prevent and treat lead toxicity occurring at various levels, such as occupational exposure, accidents and environmental factors. This article reviews the works listed in scientific literatures with recent updates regarding the toxicity of lead. Focus is also on the biomarkers of lead toxicity on the renal, hematological and oxidative stress conditions.

A Significant Question in Cancer Risk and Therapy: Are Antibiotics Positive or Negative Effectors? Current Answers and Possible Alternatives

Cancer is predominantly considered as an environmental disease caused by genetic or epigenetic alterations induced by exposure to extrinsic (e.g., carcinogens, pollutants, radiation) or intrinsic (e.g., metabolic, immune or genetic deficiencies). Over-exposure to antibiotics, which is favored by unregulated access as well as inappropriate prescriptions by physicians, is known to have led to serious health problems such as the rise of antibiotic resistance, in particular in poorly developed countries. In this review, the attention is focused on evaluating the effects of antibiotic exposure on cancer risk and on the outcome of cancer therapeutic protocols, either directly acting as extrinsic promoters, or indirectly, through interactions with the human gut microbiota. The preponderant evidence derived from information reported over the last 10 years confirms that antibiotic exposure tends to increase cancer risk and, unfortunately, that it reduces the efficacy of various forms of cancer therapy (e.g., chemo-, radio-, and immunotherapy alone or in combination). Alternatives to the current patterns of antibiotic use, such as introducing new antibiotics, bacteriophages or enzybiotics, and implementing dysbiosis-reducing microbiota modulatory strategies in oncology, are discussed. The information is in the end considered from the perspective of the most recent findings on the tumor-specific and intracellular location of the tumor microbiota, and of the most recent theories proposed to explain cancer etiology on the notion of regression of the eukaryotic cells and systems to stages characterized for a lack of coordination among their components of prokaryotic origin, which is promoted by injuries caused by environmental insults.

Hypersensitivity pneumonitis: clinical, radiological and pathological profile of 103 patients from North India

Hypersensitivity pneumonitis (HP) is an interstitial lung disease, commonly occurring due to exposure to various inciting agent related to occupation. Few studies have shown that it can also occur without any occupation exposure. In this study we are presenting clinical, radiological and bronchoscopic finding of 103 HP patients. We retrospective analysis of 5½ years HP patient’s data from a chest institute of India. The diagnosis of HP was considered with following criteria: i) known exposure to an inciting antigen; ii) presence of respiratory symptoms; iii) radiologic evidence of diffuse lung disease; iv) no other identifiable cause; v) lung biopsy specimen that demonstrated features of HP; and vi) bronchoalveolar lavage lymphocytosis (≥30%). The mean ±SD age was 47±12.8 years; 67% were female. The common symptoms were cough (97%) and dyspnea (91%). History of exposure to inciting agent was present in 61% with pigeon exposure being the most common (56%). Majority of patients (86%) were having chronic symptoms for >6 months. On 6MWT oxygen desaturation >4% was seen in 57% patients. Centrilobular nodules (61%) and ground glass opacity (47.5%) were common finding on HRCT chest. Bronchoalveolar lavage (BAL) lymphocytosis >30% was present in 48.5% and histopathological diagnosis HP on transbronchial lung biopsy (TBLB) and/or endobronchial lung biopsy (EBLB) was in 50% patients. HP is exposure related environmental disease, as it can occur without any occupational history. Bronchoscopy with BAL and lung biopsy should do in all suspected cases to confirm diagnosis in our country as it is less invasive, day care procedure with less complication.

Tunnel Monitoring and Measuring System Using Mobile Laser Scanning: Design and Deployment

The common statistical methods for rail tunnel deformation and disease detection usually require a large amount of equipment and manpower to achieve full section detection, which are time consuming and inefficient. The development trend in the industry is to use laser scanning for full section detection. In this paper, a design scheme for a tunnel monitoring and measuring system with laser scanning as the main sensor for tunnel environmental disease and deformation analysis is proposed. The system provides functions such as tunnel point cloud collection, section deformation analysis, dislocation analysis, disease extraction, tunnel and track image generation, roaming video generation, etc. Field engineering indicated that the repeatability of the convergence diameter detection of the system can reach ±2 mm, dislocation repeatability can reach ±3 mm, the image resolution is about 0.5 mm/pixel in the ballast part, and the resolution of the inner wall of the tunnel is about 1.5 mm/pixel. The system can include human–computer interaction to extract and label diseases or appurtenances and support the generation of thematic disease maps. The developed system can provide important technical support for deformation and disease detection of rail transit tunnels.