Replication Studies on Significant Differences in Personality Profiles of Securely and Insecurely Attached Psychotherapists and Dentists

This study contributes to the therapist variable in general and the personality profile of securely and insecurely attached psychotherapists and other healthcare professionals in particular. In a preceding study, it has been found that insecurely attached psychotherapists differ in nine personality styles from securely attached ones. The aim of the present study was to replicate these findings and to investigate whether they also apply to other health professions such as dentists. About 891 subjects from two German professional societies for hypnosis were surveyed online with a personality questionnaire [Personality Styles and Disorder Inventory (PSDI)] and an attachment questionnaire [Relationship Scale Questionnaire (RSQ)]. Since these subjects were interested in hypnosis and used it in their practice (HYP), 150 dentists without a hypnosis context (NONHYP) were studied as a control group with the same survey. The results of the preceding attachment study could be replicated: Insecurely attached healthcare professionals differed significantly from securely attached ones in the same nine (plus one, i.e., 10) personality styles if they use psychological methods including hypnosis. If they do not use psychological methods (like the NONHYP dentists), they differ in half of the personality styles. No within-sample and no between-sample differences have been found in the assertive/antisocial (AS) personality style. No within-sample differences have also been found in the conscientious/compulsive (ZW) and the intuitive/schizotypal (ST) personality styles. However, large between-sample differences were obvious in ZW and the ST. Both of the samples of the dentist were much more compulsive than the two psychotherapeutic samples. In addition, both of the HYP samples were much more schizotypal than the NONHYP samples. The latter is the general signature of those individuals who are interested in hypnosis and were metaphorically termed homo hypnoticus. It seems that AS, ZW, and ST are independent of attachment.

Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results

Background Relugolix is a once-daily, oral, nonpeptide, gonadotropin-releasing hormone receptor antagonist. The aim of this study was to evaluate safety of relugolix over 24 weeks in women with endometriosis-associated pain. Methods This phase 2, randomized, open-label, parallel-group extension study was conducted in 101 clinics in Japan. Patients (premenopausal females ≥ 20 years) who completed the preceding 12-week relugolix phase 2 study continued to receive relugolix (10 mg, 20 mg, or 40 mg), placebo, or leuprorelin (3.75 mg) for an additional 12 weeks. Relugolix was administered orally once daily, and leuprorelin subcutaneously once every 4 weeks. The primary outcome was safety, including bone mineral density (BMD) and treatment-emergent adverse events (TEAEs). Secondary endpoints included visual analog scale (VAS) scores for endometriosis-associated pain. Analysis sets were defined as all patients who were administered the study drug. Results Of 487 randomized patients in the preceding study, 397 enrolled in this extension study and continued to receive placebo (n = 77), relugolix 10 mg (n = 84), relugolix 20 mg (n = 78), relugolix 40 mg (n = 89), or leuprorelin (n = 69). Baseline characteristics were similar between extension study patients and patients in the preceding study. Frequency of TEAEs including metrorrhagia, menorrhagia, and hot flush was similar in the relugolix 40-mg and leuprorelin groups. Mean (SD) change in BMD from baseline at Week 24 was − 0.2 (1.99)% for placebo; − 1.6 (2.34)%, − 2.6 (2.94)%, and − 4.9 (2.91)% for the relugolix 10-mg, 20-mg, and 40-mg groups, respectively; and − 4.4 (2.16)% for leuprorelin. Mean ± SD change from baseline in mean VAS score (mm) for pelvic pain at end of treatment was − 3.2 ± 12.16 for placebo; − 6.8 ± 10.56, − 9.0 ± 11.84, and − 11.9 ± 11.26 for the relugolix 10-mg, 20-mg, and 40-mg groups, respectively; and − 12.7 ± 12.57 for leuprorelin. Estradiol levels decreased with increasing relugolix dose and remained below postmenopausal levels throughout the 24-week relugolix 40-mg treatment period. Conclusions Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis. The dose-dependent loss in BMD observed with relugolix treatment was expected due to an induced hypoestrogenic state. Relugolix demonstrated a similar benefit/risk profile to injectable therapy in this phase 2 study. Trial registration NCT01452685 (ClinicalTrials.gov, registered 17/10/2011).

‘Author’s Ghosts’: Manifestations of the Supernatural in Spark’s Early Fiction

This chapter examines the treatment of spectrality in Spark’s debut novel, The Comforters, as well as in a selection of early (and otherwise realistic) short stories. It discuss some of Spark’s earliest attempts to realise – to quote from her preceding study of John Masefield – ‘how sharp and lucid fantasy can be when it is deliberately intagliated on the surface of realism.’ The first half of the chapter concerns what is classified as the textual haunting, whereby the supernatural encounter is treated as an instance of metalepsis – a violation, that is, of the text’s diegetic boundaries, which is in some ways analogous to the ghost’s traversal of ontological ones. The chapter’s second section examines the significance of the ghost story as a vital means of critiquing forms of patriarchal power, along with conventional gender roles and their attendant expectations.

Tod und Trauer am Arbeitsplatz

The meaning of death and grief in labor law and working life - a highly current issue that has been greatly neglected in legal discussions to date. The study is characterised by a scientific-theoretical and a practical part. It examines the extent to which employers are required to improve the situation of grievers at the workplace as part of their corporate health management. The focus is on the distinction between mandatory and voluntary measures, with special differentiation between purely private and company-related bereavement. The author develops a model company agreement on the subject of death and grief which combines all the findings of the preceding study.

PrEP Nonadherence, White Coat Dosing, and HIV Risk Among a Cohort of MSM

Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the need for identifying and reducing barriers to PrEP adherence.

On the subsonic near-wake of a space launcher configuration with exhaust jet

The Ariane 5 failure flight 157 made clear that the loads in the base region of space launcher configurations were underestimated and its near-wake dynamics required more attention. In the recent years, many studies have been published on buffet/buffeting in the critical high subsonic flow regime. Nevertheless, not much experimental data are available on the interaction of the ambient flow with an exhaust jet over a wide subsonic Mach number range. Further, a preceding study without exhaust jet revealed questions regarding a similar distribution of the velocity and Reynolds stress in the near-wake if scaled with the reattachment length. Consequently, a generic space launcher configuration featuring a cold, supersonic, over-expanded jet is investigated experimentally in the vertical test section Cologne (VMK) by means of particle image velocimetry (PIV) for five subsonic Mach numbers ranging from 0.5 to 0.9 with corresponding Reynolds numbers between $$Re_{\text {D}}=0.8\times 10^6$$ReD=0.8×106 to $$1.6\times 10^6$$1.6×106. The velocity and Reynolds stress distribution are provided for the near-wake flow and additionally for the incoming boundary layer. Just as in the preceding study, self-similar features are found in the flow field as long as the separated shear layer reattaches on the solid nozzle wall. Substantial changes are then measured for an alternating (hybrid) reattachment between the solid nozzle wall and supersonic exhaust jet as found for Mach 0.8, one of them being the increased axial turbulence in the recirculation bubble due to a ‘dancing’ large-scale, clockwise-rotating vortex. Graphic abstract

Forgetting Is a Feature, Not a Bug: Intentionally Forgetting Some Things Helps Us Remember Others by Freeing Up Working Memory Resources

In the present study, we used an item-method directed-forgetting paradigm to test whether instructions to forget or remember one item affect memory for subsequently studied items. In two experiments ( Ns = 138 and 33, respectively), recall was higher when a word pair was preceded during study by a to-be-forgotten word pair. This effect was cumulative: Performance increased when more preceding study items were to be forgotten. The effect decreased when memory was conditioned on instructions for items appearing farther back in the study list. Experiment 2 used a dual-task paradigm that suppressed, during encoding, verbal rehearsal or attentional refreshing. Neither task removed the effect, ruling out that rehearsal or attentional borrowing is responsible for the advantage conferred from previous to-be-forgotten items. We propose that memory formation depletes a limited resource that recovers over time and that to-be-forgotten items consume fewer resources, leaving more resources available for storing subsequent items. A computational model implementing the theory provided excellent fits to the data.

GADD45γ Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes

ABSTRACTThe stress response genes encoding GADD45γ, and to a lesser extent GADD45β, are activated early in infection with herpes simplex virus 1 (HSV-1). Cells that had been depleted of GADD45γ by transfection of short hairpin RNA (shRNA) or in which the gene had been knocked out (ΔGADD45γ) yielded significantly less virus than untreated infected cells. Consistent with lower virus yields, the ΔGADD45γ cells (either uninfected or infected with HSV-1) exhibited significantly higher levels of transcripts of a cluster of innate immunity genes, including those encoding IFI16, IFIT1, MDA5, and RIG-I. Members of this cluster of genes were reported by this laboratory to be activated concurrently with significantly reduced virus yields in cells depleted of LGP2 or HDAC4. We conclude that innate immunity to HSV-1 is normally repressed in unstressed cells and repression appears to be determined by two mechanisms. The first, illustrated here, is through activation by HSV-1 infection of the gene encoding GADD45γ. The second mechanism requires constitutively active expression of LGP2 and HDAC4.IMPORTANCEPrevious studies from our laboratory reported that knockout of some innate immunity genes was associated with increases in the expression of overlapping networks of genes and significant loss of the ability to support the replication of HSV-1; knockout of other genes was associated with decreases in the expression of overlapping networks of genes and had no effect on virus replication. In this report, we document that depletion of GADD45γ reduced virus yields concurrently with significant upregulation of the expression of a cluster of innate immunity genes comprising IFI16, IFIT1, MDA5, and RIG-I. This report differs from the preceding study in an important respect; i.e., the preceding study found no evidence to support the hypothesis that HSV-1 maintained adequate levels of LGP2 or HDAC4 to block upregulation of the cluster of innate immunity genes. We show that HSV-1 causes upregulation of the GADD45γ gene to prevent the upregulation of innate immunity genes.

A Study on Consultant’s Social Value, Learning, Leadership Type Influence on Consulting Flow and Performance

The purpose of this study is to investigate consultants in ongoing consulting projects for smaller enterprises to implement an empirical study on the degree of influence of consultant value, consultant learning and consultant leadership type on consulting performance, which have not been mentioned in preceding study. The surveyed were consultants who had provided consulting service to smaller enterprises. For the study, a total of 223 sets of questionnaires were collected but 18 poorly-answered sets were excluded to utilize 205 sets for the study research. As a summary of the results, the social responsibility had a significant effect on consulting Flow whereas social support did not. learning motivation, learning intention and transformational/transactional/servant leadership on consulting Flow found that all of the variables had a significant effect on consulting Flow. In addition to that, social responsibility, support and learning motivation, learning intention and transformational/transactional/servant leadership on consulting satisfaction found that all of the variables significantly affected consulting satisfaction.