The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs’ treatment.

USE OF PASSENGER LOCATION CARDS IN THE ERA OF THE COVID-19 PANDEMIC, AND THE PROCESSING OF PERSONAL DATA OF AIR PASSENGERS

Purpose. The aim of the article is to analyse the processing of personal data of air passengers during the SARS-CoV-2 pandemic in the context of doubts that have arisen in connection with the need for these passengers to provide their personal data as part of filling out the Passenger Location Card questionnaire. Method. The research method used in this study is case study. Findings. In the study, it was showed that firstly, the data of air passengers processed in relation to the application of the Passenger Location Card by the State Border Sanitary Inspectorate in Warsaw should be protected under the provisions of the General Regulation on the protection of personal data. Furthermore, their controller, i.e. the State Border Sanitary Inspectorate in Warsaw, did not fulfil its obligations in this regard. This, in effect, justifies the conclusion that the processing process not in accordance with the law on the protection of personal data. Research and conclusions limitations. The analysis concerned only passengers of aircrafts arriving and/or departing from airports located on the territory of the Republic of Poland. Practical implications. The analysis carried out in this study may provide a solution to the issues that have arisen in the public sector with regard to the processing of personal data collected from air passengers on the basis of the Passenger Location Card questionnaire and thus, the conclusions may prove useful for data controllers who should be aware of such problems, but also for air travellers as data subjects who should be protected by the General Data Protection Regulation and their rights in this regard. Originality. This analysis, if only for the reason that it is an analysis of a problem that has come to light relatively recently (March 2020), has so far, only been the subject of consideration in press articles.

ON SOME ASPECTS OF DATA PROTECTION IN SCIENTIFIC RESEARCH

This paper discusses issues related to gathering, processing and protection of personal data in scientific research. Highlights of the General Regulation on Data Protection and the European Code of Conduct for Research Intregrity concerning the regulatory and ethical aspects of research are presented.

Women's adversities

It is up to the State to promote appropriate measures to “guarantee fundamental rights and freedoms and the respect for the principles of a democratic law State”, in accordance with Article 9 (b) of the Constitution of the Portuguese Republic. Our objectives were to examine how the Portuguese legislator is attentive to the particularities of being a woman in matters such as hygiene, health, motherhood and parental education during the execution of sentences and we wanted to investigate the mechanisms triggered by the State for protection, as a preventive measure, of women as victims of crimes. We made research, in numerical terms, to know the rate of constituted women accused in criminal proceedings, as well as the number of convicted, from a set of recent and of reference official documentary sources, based on the existing statistical resources. We also made an analysis of the pertinent legislative diplomas, among them, the aforementioned Code of the Execution of Penalties and Freedom Deprivation Measures and the General Regulation of Prison Establishments. The fulfilment of a prison sentence implies vast and varied consequences, from personal to familiar, passing through social and professional consequences, among others. We concluded that compared to the male universe, the number of women accused and convicted is clearly lower. On the other hand, it is women who make up the largest share as victims of certain offenses. According to the 2019 Annual Report, authored by APAV, female victims amounted to 8,394.

Status of LLC Shareholder and Forms of Obtaining It (Comparative-legal Analysis)

The status of the LLC shareholder characterizes the legal status of the shareholder, its legal relationship with other shareholders, the LLC itself, management of the LLC, and third parties. Although the legal status of LLC shareholder (its rights and obligations) is prescribed under Georgian law, issues related to its definition are still relevant, as Georgian legislation is limited to general regulation only, and Georgian case law and legal literature are also characterized by the scarcity of consideration of shareholder status. The purpose of this article is to use comparative legal analysis to determine the essence of the status of the LLC shareholder, the grounds for its origin, and legal consequences. The article analyzes the concept of the status of the LLC shareholder, subjects of the status of the LLC shareholder, LLC share concept, the rights, and obligations connected to the status of the LLC shareholder, forms of receiving the status of the LLC shareholder and its period. Since the regulatory norms of Georgian LLC are the institute of logical synthesis created as a result of the reception of the norms of German law and the norms of US law, the article mainly provides a comparative analysis of the Georgian and German legal norms on the status of the LLC shareholder, as well as, to some extent, the US regulations.

Nonlegislative Justification

If moral theorists who otherwise disagree, all approach moral theorizing as a search for a set of desirable moral principles for the general regulation of behavior, then there is a sense in which they are all, as Parfit says, climbing the same mountain. But it is the wrong mountain. Morality should not be understood as hypothetical legislation; it is a mistake to set about constructing morality as if we were making law. Real legislators evaluate possible legal rules by considering the effects they would have. They can do this because enforcement and acceptance of law ensure a high level of compliance. Moral legislators have no reason to assume any particular level of acceptance; the effects of counterfactual acceptance of a principle are not morally relevant. The argument targets rule consequentialism and Scanlon’s official version of contractualism. The paper begins in a positive mode by arguing that a nonlegislative version of Scanlon’s approach, that seeks justification for conduct of such-and-such a kind in such-and-such circumstances by comparing the reasons in favor and the reasons others have to object, is a very attractive way to think about what we owe to each other.

MODERN LEGISLATION REGULATING STATUS OF LEGAL ENTITY

The article analyzes using the normative and systematic methods, as well as analysis and synthesis, the content of the statements of Constitution of the Kyrgyz Republic, Civil Code of the Kyrgyz Republic, Criminal Code of the Kyrgyz Republic, the Law of the Kyrgyz Republic «About Normative Legal Acts of the Kyrgyz Republic», the Law of the Kyrgyz Republic «On the Regulations of the Jogorku Kenesh of the Kyrgyz Republic» and the works of the legal scholars. It examined the provisions of laws adopted for general regulation and concludes they are serious problems, because of them there is a "blurring" of the contour of the legislation on legal entities in the article. The publication supports the opinion of the authors of the Concept for Development, according to which the regulation of the status of legal entities in the civil legal field can be characterized by a set of the laws and regula-tions in force in the Kyrgyz Republic, which do not always correspond to each other, as well as to the Civil Code. The low legal and technical level and ineffectiveness in practice are also shown by some adopted laws. It noted the Civil Code of the Kyrgyz Republic, adopted on May 8, 1996, created the new foundation for the regulation of legal entities, which was supplemented by many new laws over the next decades in the article. The authors come to the conclusion the fairly honest assessment can be applied to the established regulation – that with the main vector of development of the Concept of Civil Legislation in Kyrgyzstan, in general, there is an economic, social and well-grounded the logic and generally justifiable modern civil law in relation to legal entities. But at the same time, for many problems, correct solutions have not yet been found and no efficiency ratings have been given.

COVID Social Distancing and the Poor: An Analysis of the Evidence for England

Social distancing is a matter of individuals’ choices as well as of regulation. We analyse weekly panel data on such behaviour for English Upper Tier Local Authorities (UTLAs) from March to July 2020, paying attention to the influence of poverty, as measured by free school meals provision. Panel regressions suggest that, although more stringent regulation and slightly lagged local cases of infection increase social distancing, both effects are weaker in UTLAs with higher levels of poverty, in part because of poor housing, and also because shortage of money has forced the poor to keep working. Thus motivated, we develop a two-class (rich/poor) model, in which a Nash non-cooperative equilibrium arises from individual choices in a regulatory regime with penalties for non-compliance. The model yields results in keeping with the empirical findings, indicating the desirability of generous measures to furlough workers in low-paid jobs as a complement to the stringency of general regulation.

IMPLEMENTAÇÃO DA LEI GERAL DE PROTEÇÃO DE DADOS (LGPD) NO BRASIL: CONSIDERAÇÕES TECNOLÓGICAS

This article specifies the definition of the current General Law on Protection of Personal Data (LGPD) and the Law that served as inspiration, a General Regulation on Data Protection (GDPR). The purpose of the text is to demonstrate the relevance of these legislative devices to the lives of citizens today, when everything revolves around digital information. Methodologically, a literature review on the topic, present in physical and digital collections, is combined with a case study. As a result of the study, we saw that some technological considerations about the implementation of systems and their adequacy to the new Law, exemplify the ways of effectively applying the security of personal data.

Legal regulation of the use of digital technologies: theoretical reflections

In the article, based on the analysis of Russian laws on the use of digital technologies, the relationship between legal and digital regulation is considered, it turns out that information technologies are mechanical processes of algorithmic algorithms for individual transactions for the execution and execution of transactions carried out using electronic and other technical means. Experimental legal regimes are ways of introducing digital innovation into the canvas dof general regulation. The execution and execution of transactions using electronic other technical means does not lead to the creation of an electronic personality, since within the framework of the information system, operations with digital rights are carried out without human participation, and the digital rights themselves are the results of the transformation of ordinary civil rights and obligations into them, and the holder of digital rights is not a subject of law. The article explores the possibility of considering digital rights as objects of intellectual activity. Trust in machine technology is not equivalent to the good faith of the participants in legal relations.